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Modelling the impact of antimalarial quality on the transmission of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum

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Infectious Disease Modelling 2017年第2期2卷 161-187页

作者： Aleisha R.Brock Joshua V.Ross Scott Greenhalgh David P.Durham Alison Galvani Sunil parikh Adrian Esterman School of Nursing&Midwifery University of South AustraliaAdelaideSAAustralia School of Mathematical Sciences The University of AdelaideAdelaideSAAustralia Department of Mathematics and Statistics Queen's UniversityKingstonONCanada Center for Infectious Disease Modeling and Analysis Yale School of Public HealthNew HavenCTUSA Yale School of Public Health New HavenCTUSA Sansom Institute for Research Health University of South AustraliaAdelaideSAAustralia Australian Institute of Tropical Health and Medicine James Cook UniversityCairnsQLDAustralia

Background:The use of poor quality antimalarial medicines,including the use of nonrecommended medicines for treatment such as sulfadoxine-pyrimethamine(SP)monotherapy,undermines malaria control and elimination ***,the use of subtherapeutic doses of the active ingredient(s)can theoretically promote the emergence and transmission of drug resistant ***:We developed a deterministic compartmental model to quantify the impact of antimalarial medicine quality on the transmission of SP resistance,and validated it using sensitivity analysis and a comparison with data from Kenya collected in *** modelled human and mosquito population dynamics,incorporating two Plasmodium falciparum subtypes(SP-sensitive and SP-resistant)and both poor quality and good quality(artemether-lumefantrine)antimalarial ***:The model predicted that an increase in human malaria cases,and among these,an increase in the proportion of SP-resistant infections,resulted from an increase in poor quality SP antimalarial use,whether it was full-or half-dose SP ***:Our findings suggest that an increase in poor quality antimalarial use predicts an increase in the transmission of *** highlights the need for stricter control and regulation on the availability and use of poor quality antimalarial medicines,in order to offer safe and effective treatments,and work towards the eradication of malaria.

关键词： Deterministic compartmental model Falsified antimalarial medicine Substandard antimalarial treatments Antimalarial quality Plasmodium falciparum malaria Drug resistance

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科技共同体应对人类共同挑战的路径选择

科技导报 2021年第16期39卷 19-24页

作者： Sudip parikh Sandrine Dixson-Decleve Dan Dorner 冯子健美国科学促进会(AAAS) 罗马俱乐部清洁能源部长级会议(CEM) 中华预防医学会

进人现代社会,人类相互依赖性不断增强,世界已成为一个休戚与共的命运共同体。当前人类社会面临着气候变化、自然灾害、能源环境、生命健康等诸多全球性的挑战。如何超越局限,探索真理,成为科技共同体共同的使命;如何面对当前挑战和未... 详细信息

进人现代社会,人类相互依赖性不断增强,世界已成为一个休戚与共的命运共同体。当前人类社会面临着气候变化、自然灾害、能源环境、生命健康等诸多全球性的挑战。如何超越局限,探索真理,成为科技共同体共同的使命;如何面对当前挑战和未来之变是科技共同体共同贡献的重要内容;这也是当今科技共同体应该思考的问题。

关键词：相互依赖性命运共同体科技共同体能源环境气候变化自然灾害路径选择探索真理

Total laparoscopic removal of accessory gallbladder:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2015年第12期7卷 398-402页

作者： Yaniv Cozacov Gokulakkrishna Subhas Michael Jacobs Janak parikh Department of Surgery Providence Hospital and Medical Centers

Accessory gallbladder is a rare congenital anomaly occurring in 1 in 4000 births, that is not associated with any specific symptoms. Usually this cannot be diagnosed on ultrasonography and hence they are usually not diagnosed preoperatively. Removal of the accessory gallbladder is necessary to avoid recurrence of symptoms. H-type accessory gallbladder is a rare anomaly. Once identified intra-operatively during laparoscopic cholecystectomy, the surgery is usually converted to open. By using the main gallbladder for liver traction and doing a dome down technique for the accessory gallbladder, we were able to perform the double cholecystectomy with intra-operative cholangiogram laparoscopically. Laparoscopic cholecystectomy was performed in 27-year-old male for biliary colic. Prior imaging with computer tomography-scan and ultrasound did not show a duplicated gallbladder. Intraoperatively after ligation of cystic artery and duct an additional structure was seen on its medial aspect. Intraoperative cholangiogram confirmed the patency of intra-hepatic and extra-hepatic biliary ducts. Subsequent dissection around this structure revealed a second gallbladder with cystic duct(H-type). Pathological analysis confirmed the presence of two gallbladders with features of chronic cholecystitis. It is important to use cholangiogram to identify structural anomalies and avoid complications.

关键词： Gallstones Cholangiogram Laparoscopiccholecystectomy Accessory gallbladder Duplicatedgallbladder

Innovative Approach to Increase Name Plate Capacity of Oil and Gas Gathering Centre

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Journal of Energy and Power Engineering 2015年第10期9卷 860-865页

作者： Chirag parikh Abdulaziz Al-Saeed Bader Mahmoud Raj iv Kukreja Production Operations (North Kuwait) Team Kuwait Oil Company Ahmadi 61008 Kuwait

Purpose： The oil and gas gathering and processing facility of Kuwait Oil Company is built with a nameplate capacity of X MBOPD （thousand barrels oil per day） with 50% water cut. However, the facility was operating with a water cut of 35%. This comprehensive technical study was conducted to evaluate possibility of increasing oil processing capacity of this facility in line with current lower water cut and other operational flexibilities available in the facility without utilizing its design margin. Topic： This paper shares an innovative approach to increase name plate capacity of oil and gas processing facility utilizing available operational flexibility and operational margins with minor modification. It shares a case study where facility capacity is increased by around 19% without utilizing design margins of equipment or pipeline. Method： The study includes theoretical verification and analysis of all major equipment and piping to identify available capacity and limitation, in order to utilize available additional margin and to propose debottleneck options to overcome limitations. Achievement： The study confirmed that, facility name plate capacity can be revised from X MBOPD （with 50% w.c （water cut）） to X ＋ 32 MBOPD （with： 45% w.c） minor modification in separator and utilizing margin available in feed specification ofdesalter trains.

关键词： Debottlenecking capacity enhancement production.

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垂直铺网混棉非织造布的压缩性能

产业用纺织品 2005年第11期23卷 32-35,39页

作者： D.V. parikh 刘丽妍

在过去的15年里捷克共和国Liberec工业大学(TUL)开发了一种新技术,即把质量差的合成纤维用于生产垂直铺网高蓬松非织造布.该新技术包括梳理、梳理纤网的垂直铺网以及用例如聚酯或聚丙烯纤维等合成纤维与低熔点的皮芯共聚酯粘合纤维进行... 详细信息

在过去的15年里捷克共和国Liberec工业大学(TUL)开发了一种新技术,即把质量差的合成纤维用于生产垂直铺网高蓬松非织造布.该新技术包括梳理、梳理纤网的垂直铺网以及用例如聚酯或聚丙烯纤维等合成纤维与低熔点的皮芯共聚酯粘合纤维进行气流热粘合.粘合纤维通过粘合作用使高蓬松非织造布成为一个整体.用于垂直铺网(P-laid)以及交叉铺网(C-laid)的梳理纤网铺层形式分别如图1(a)和(b)所示.

关键词：交叉铺网非织造布垂直压缩性能合成纤维混棉粘合作用捷克共和国聚丙烯纤维工业大学

无铬Co-Cu/SBA-15催化剂催化生物质衍生α-,β-不饱和醛加氢制醇（英文）

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催化学报 2015年第7期36卷 933-942页

作者： Sanjay Srivastava Pravakar Mohanty Jigisha K.parikh Ajay K.Dalai S.S.Amritphale Anup K.Khare DepartmentofChemicalEngineering S.V.NationalInstituteofTechnologylchchhanathSURAT-395007GujaratIndia DepartmentofChemicalEngineering IndianInstituteofTechnologyNewDelhi-l10016India SardarPatelRenewableEnergyResearchInstitute(SPRERI) VVNagarGujarat388120India CatalysisandChemicalReactionEngineeringLaboratories DepartmentofChemicalandBiologicalEngineeringUniversityofSaskatchewanSaskatoonSaskatchewanS7N5/t9Canada AdvancedMaterialandProcessesResearchInstitute(AMPRI CouncilofScientific&IndustrialResearch(CSIR)Bhopa1462054India

Cr-free bi-metallic SBA-15-supported Co–Cu catalysts were examined in the conversion of biomass-derived α-, β-unsaturated aldehyde(furfural) to value-added chemical furfuryl alcohol(FOL).Co–Cu/SBA-15 catalysts with a fixed Cu loading of 10 wt% and varying Co loadings(2.5, 5, and 10 wt%) were prepared by the impregnation method. The catalysts were characterized by X-ray diffraction, N2 sorption, H2 temperature-programmed reduction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, high-resolution transmission electron microscopy, CO chemisorption, and inductively coupled plasma mass spectrometry. The influence of different reaction parameters such as temperature, pressure, catalyst dosage, and furfural concentration on the catalyst performance was evaluated. Relative to catalysts supported on amorphous silica, the current SBA-15-supported Co–Cu catalysts displayed higher performance, attaining a furfural conversion of 99% and furfuryl alcohol selectivity of 80%. The catalytic reactions were conducted in a 100-mL autoclave at 170 °C and 2 MPa H2 pressure for 4 h.

关键词： SBA-15 催化剂用量不饱和醛 Cu 电感耦合等离子体质谱法 Cr 糠醇高分辨透射电子显微镜

Healthcare delivery interventions to reduce cancer disparities worldwide

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World Journal of Clinical Oncology 2020年第9期11卷 705-722页

作者： James C Dickerson Meera V Ragavan Divya A parikh Manali I Patel Department of Internal Medicine Stanford UniversityStanfordCA 94305United States Division of Oncology Department of MedicineStanford UniversityStanfordCA 94305United States Center for Health Policy/Primary Care Outcomes Research Stanford UniversityStanfordCA 94305United States VA Palo Alto Health Care System Palo AltoCA 94306United States

Globally,cancer care delivery is marked by inequalities,where some economic,demographic,and sociocultural groups have worse outcomes than *** this review,we sought to identify patient-facing interventions designed to reduce disparities in cancer care in both high-and low-income *** found two broad categories of interventions that have been studied in the current literature:Patient navigation and *** has the strongest evidence base for reducing disparities,primarily in cancer *** outcomes with navigation interventions have been seen in both high-and low-income *** interventions remain an active area of exploration,primarily in high income countries,with the best evidence being for the remote delivery of palliative *** research is needed to identify the most efficacious,costeffective,and scalable interventions to reduce barriers to the receipt of cancer care globally.

关键词： Intervention Cancer Disparity Health services research Global oncology Navigation Telehealth

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Cirrhosis and stroke

中华物理医学与康复杂志 2017年第11期39卷 855-855页

作者： parikh NS Navi BB Schneider Y

BACKGROUND AND OBJECTIVE While studies have shown cirrhosis to be associated with extrahepatic hemorrhagic and thrombot-ic processes, the cerebrovascular complications of cirrhosis are not well understood. This study ... 详细信息

关键词：肝外出血肝硬化血管并发症治疗方法保健知识

Detection of dengue NS1 antigen,alongside IgM plus IgG and concurrent platelet enumeration during an outbreak

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Asian Pacific Journal of Tropical Medicine 2011年第8期4卷 672-672页

作者： Subhash C Arya Nirmala Agarwal Satish C parikh Sant Parmanand Hospital Delhi

During the late incubation period or initial phase of dengue virus infection,laboratory confirmation is through viral isolation in cell culture and/or molecular investigations, or immunofluorescence,or immunohistochemistry[1].The dengue virus non-structural antigen NSl that would develop before the appearance of dengue IgM and/or IgG is emerging as a suitable option for dengue diagnosis[2].Platelet therapy is a standard clinical practice for dengue patients with severe thrombocytopenia[3].However,during introductory screening,platelet count is not being done in many cases. This results in delays of platelet therapy. In the course of the current(2010) spurt of dengue in New Delhi[4],simultaneous screening for NSl,IgM and IgG and platelet enumeration has been introduced at the

关键词： IgM IgG Detection of dengue NS1 antigen,alongside IgM plus IgG and concurrent platelet enumeration during an outbreak NS