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Development of image motion compensation system for 1.3 m telescope at Vainu Bappu Observatory

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Research in Astronomy and Astrophysics 2020年第1期20卷 93-106页

作者： Sreekanth Reddy Vallapureddy Ravinder Kumar Banyal Sridharan Rengaswamy P Umesh Kamath aishwarya Selvaraj Indian Institute of Astrophysics

We developed a tip-tilt system to compensate the turbulence induced image motion for the 1.3 m telescope at Vainu Bappu Observatory,at *** instrument is designed to operate at the visible wavelength band(480-700 nm)with a field of view of 1′×1′.The tilt corrected images have demonstrated up to ≈57% improvement in image resolution and a corresponding peak intensity increase by a factor of ≈2.8.A closed-loop correction bandwidth of ≈26 Hz has been achieved with on-sky tests and the root mean square motion of the star image has been reduced by a factor of ~*** results are consistent with theoretical and numerical predictions of wave-front aberrations caused by atmospheric turbulence and image quality improvement expected from a real-time control *** this paper,we present details of the instrument design,laboratory calibration studies and quantify its performance on the telescope.

关键词： adaptive optics atmospheric effects high angular resolution

Measurements of atmospheric turbulence parameters at Vainu Bappu Observatory using short-exposure CCD images

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Research in Astronomy and Astrophysics 2019年第5期19卷 123-132页

作者： Sreekanth Reddy V. Ravinder Kumar Banyal Sridharan R. aishwarya Selvaraj Indian Institute of Astrophysics

We report atmospheric turbulence parameters, namely atmospheric seeing, tilt-anisoplanatic angle(θ_0) and coherence time(Τ_0), measured under various sky conditions, at Vainu Bappu Observatory in Kavalur. Bursts of short exposure images of selected stars were recorded with a high-speed, frame-transfer CCD mounted on the Cassegrain focus of a newly commissioned 1.3 m telescope. The estimated median seeing is ≈ 1.85 " at wavelength of ～ 600 nm, the image motion correlation between different pairs of stars is ～44% for θ0≈ 36" and mean Τ_0 is ≈ 2.4 ms. This work was motivated by the design considerations and expected performance of an adaptive optics system that is currently being planned for the telescope.

关键词： atmospheric effects turbulence instrumentation:adaptive optics catalogs methods:observational

In vitro antioxidant activities of selected seaweeds from Southeast coast of India

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Asian Pacific Journal of Tropical Medicine 2011年第3期4卷 205-211页

作者： Gopalraj Karthikai Devi Karunamoorthy Manivannan Ganapathy Thirumaran Fatimson Arockiya aarthi Rajathi Perumal Anantharaman Centre of Advanced Study in Marine Biology Faculty of Marine SciencesAnnamalai UniversityParangipettai-608502Tamil NaduIndia Institute of Hydrobiology Jinan UniversityGuangzhou-510638China

Objective:In vitro antioxidant activities of three selected Indian seaweeds viz.,Halimeda tuna(***),Turbinaria conoides(***) and Gracilaria foliifera(***) were ***:Total antioxidant activity,total phenolic content,and reducing power of crude methanol and diethyl ether extracts were ***:Total phenolic content and total antioxidant activity were higher(1.231±0.173 mg GAE/g,1.675±0.361 mg GAE/g) in *** *** power of crude methanol extract increased with concentrations of the *** Fourier transform-infra red spectrum analysis revealed the presence of polyphenolic *** seaweed extracts displayed moderate antioxidant activity compared to gallic acid ***:The seaweeds could be considered for curing diseases from oxidative deteriorations.

关键词： FT-IR Reducing power Seaweeds Total phenolic content Total antioxidant activity

Recent advances in transition-metal catalyzeddirected C–H functionalization with fluorinatedbuilding blocks

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Organic Chemistry Frontiers 2022年第6期9卷 1742-1775页

作者： Haritha Sindhe Bharatkumar Chaudhary Neelanjan Chowdhury Akshay Kamble Vivek Kumar aishwarya Lad Satyasheel Sharma Department of Medicinal Chemistry National Institute of Pharmaceutical Education and ResearchAhmedabad(NIPER-A)GandhinagarGujarat-382355India Department of Natural Products National Institute of Pharmaceutical Education and ResearchAhmedabad(NIPER-A)GandhinagarGujarat-382355India

The increasing demand for the development of unprecedented routes to access fluorinated molecules hasled researchers to perform intriguing research around the world. In this context, fluorinating reagents andfluorinated building blocks have been the two pillars for the generation of diverse organic ***, synthetic approaches involving transition-metal catalyzed C–H functionalization have tremendously evolved in the past two decades. Looking towards the great potential of the C–H functionalizationstrategy to maximize atom- and step-economy, the approach has been utilized for the synthesis of fluorinated molecules. Moreover, Fluorinated building blocks have been used in organic synthesis over the pastseveral decades;however newer strategies to use these building blocks have recently been explored. In thisreview, we have presented the advances made in the recent past in transition-metal catalyzed directed C–Hfunctionalization with various fluorinated building blocks. The understanding of the mechanistic aspects ofdirected C–H activation has led to efficient design of newer protocols for cross-couplings involving fluorinated building blocks as one of the coupling partners. Furthermore, it has been observed that in almost allcases the outcome of the reaction is greatly influenced by the effect of fluorine.

关键词： catalyzed directed transition

Recent Advances in Forensic Odontology:An Overview

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Journal of Forensic Science and Medicine 2021年第3期7卷 105-108页

作者： P.aishwarya Menon N.Anoop Kumar House Surgeon PSM College of Dental Science and ResearchThrissur Department of Oral Pathology and Microbiology PSM College of Dental Science and ResearchThrissurKeralaIndia

Forensic odontology is a branch of forensic sciences that uses the skill of a dentist in personal identification during mass calamities,sexual assault,and child abuse to name a *** odontology is an evolving science and has a greater scope of *** advances in the field of genetics and molecular biology have contributed to the rapid growth of forensic *** case of a crime scene,forensic odontologists play a major role in investigating and interpreting dental *** odontologists utilize the knowledge of dentistry in bite mark analysis,fixation of identity in mass disasters,and age ***,the duty and responsibility of forensic odontologists has increased in recent ***,practicing dentists and dental students should be made aware of the available newer technologies and its use in forensic *** article gives an overview of recent advances used in identification in forensic dentistry.

关键词： Denture DNA facial reconstruction forensic odontology microscopy tongue prints

Synthesis of silver nanoparticles using leaves of Catharanthus roseus *** and their antiplasmodial activities

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Asian Pacific Journal of Tropical Biomedicine 2012年第7期2卷 574-580页

作者： Ponarulselvam S Panneerselvam C Murugan K aarthi N Kalimuthu K Thangamani S Department of Zoology School of Life SciencesBharathiar University DRDO-BU Center for Life Sciences Division of EntomologyBharathiar University

Objective:To develop a novel approach for the green synthesis of silver nanoparticles using aqueous leaves extracts of Catharanthus roseus(***) *** which has been proven aclive against malaria parasite Plasmodium falciparum(***).Methods:Characterizations were determined by using ultraviolet-visible(UV-Vis) spectrophotometry,scanning electron microscopy(SEM).energy dispersive X-ray and X-ray ***:SLM showed the formation of silver nanoparticles with an average size of 35-55 nm.X-ray diffraction analysts showed that the particles were crystalline in nature with face centred cubic structure of the hulk silver with the broad peaks at 32.***.46.4 and ***:It can be concluded that the leaves of *** can he good source for synthesis of silver nanoparticle which shows aiitiplasmodial activity against *** important outcome of the study will he the development of value added products from medicinal plants *** lor hionicdical and nanotechnology based industries.

关键词： Silver nanoparticles Catharanthus roseus Plasmodium falciparum Antiplasmodial activity

A Comparative Study of Email Forensic Tools

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Journal of Information Security 2015年第2期6卷 111-117页

作者： Vamshee Krishna devendran Hossain Shahriar Victor Clincy Department of Compute Science Kennesaw State University Kennesaw GA USA

Over the last decades, email has been the major carrier for transporting spam and malicious contents over the network. Email is also the primary source of numerous criminal activities on the Internet. Computer Forensics is a systematic process to retain and analyze saved emails for the purpose of legal proceedings and other civil matters. Email analysis is challenging due to not only various fields that can be forged by hackers or malicious users, but also the flexibility of composing, editing, deleting of emails using offline (e.g., MS Outlook) or online (e.g., Web mail) email applications. Towards this direction, a number of open source forensics tools have been widely used by the practitioners. However, these tools have been developed in an isolated manner rather than a collaborative approach. Given that email forensic tool users need to understand to what extent a tool would be useful for his/her circumstances and conducting forensic analysis accordingly. In this paper, we examine a set of common features to compare and contrast five popular open source email forensic tools. The study finds that all email forensic tools are not similar, offer diverse types of facility. By combining analysis tools, it may be possible to gain detailed information in the area of email forensic.

关键词： Email Forensic Header and Content Analysis Data Recovery Search Option Visualization

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5159-5183页

作者： Vivek Panwar aishwarya Singh Manini Bhatt Rajiv K.Tonk Shavkatjon Azizov Agha Saquib Raza Shinjinee Sengupta Deepak Kumar Manoj Garg Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesShoolini UniversitySolanHimachal Pradesh173229India Amity Institute of Molecular Medicine and Stem Cell Research(AIMMSCR) Amity University Uttar PradeshSector-125NoidaUttar Pradesh201313India Department of Biomedical Engineering Indian Institute of TechnologyRoparPunjab140001India Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)New Delhi110017India Laboratory of Biological Active Macromolecular Systems Institute of Bioorganic ChemistryAcademy of Sciences UzbekistanTashkent100125Uzbekistan Faculty of Life Sciences Pharmaceutical Technical University100084TashkentUzbekistan Rajive Gandhi Super Speciality Hospital TahirpurNew Delhi110093India

The mammalian target of rapamycin(mTOR)is a protein kinase that controls cellular metabolism,catabolism,immune responses,autophagy,survival,proliferation,and migration,to maintain cellular *** mTOR signaling cascade consists of two distinct multi-subunit complexes named mTOR complex 1/2(mTORC1/2).mTOR catalyzes the phosphorylation of several critical proteins like AKT,protein kinase C,insulin growth factor receptor(IGF-1R),4E binding protein 1(4E-BP1),ribosomal protein S6 kinase(S6K),transcription factor EB(TFEB),sterol-responsive element-binding proteins(SREBPs),Lipin-1,and Unc-51-like autophagy-activating *** signaling plays a central role in regulating translation,lipid synthesis,nucleotide synthesis,biogenesis of lysosomes,nutrient sensing,and growth factor *** emerging pieces of evidence have revealed that the constitutive activation of the mTOR pathway due to mutations/amplification/deletion in either mTOR and its complexes(mTORC1 and mTORC2)or upstream targets is responsible for aging,neurological diseases,and human ***,we provide the detailed structure of mTOR,its complexes,and the comprehensive role of upstream regulators,as well as downstream effectors of mTOR signaling cascades in the metabolism,biogenesis of biomolecules,immune responses,and ***,we summarize the potential of long noncoding RNAs(lncRNAs)as an important modulator of mTOR ***,we have highlighted the potential of mTOR signaling in aging,neurological disorders,human cancers,cancer stem cells,and drug ***,we discuss the developments for the therapeutic targeting of mTOR signaling with improved anticancer efficacy for the benefit of cancer patients in clinics.

关键词： metabolism homeostasis mTOR

Statins in Alcoholic and Non-Alcoholic Fatty Liver Disease and Chronically Elevated Liver Enzymes

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International Journal of Clinical Medicine 2022年第7期13卷 229-252页

作者： Arigapudi aishwarya Oroszi Terry Boonshoft School of Medicine Wright State University Dayton USA

The prevalence of alcoholic liver disease and non-alcoholic liver disease patients has nearly doubled over the past decades worldwide. Alcoholic liver disease among patients with chronic liver disease has increased with arisen due to alcohol consumption and obesity. The diagnosis plays a crucial role in treating such conditions based on the stages of liver functioning. The elevated liver enzymes are the key characterizing of identifying the alcoholic liver disease (ALD) and NAFLD. Later on, there is a progression of the disease conditions by developing fibrosis and cirrhosis, leading to liver carcinoma. The other state, steatohepatitis, is associated with an increase in liver-related and can lead to mortality. Risk factors for both diseases are growing, leading to various complications in health. There is no specific treatment up to date for these conditions, but statins play a crucial role in managing several liver disease conditions. The commonly used drug is hydroxymethylglutaryl coenzyme A (HMG Co-A) reductase inhibitors. It is also known as statins, which help normalize liver enzymes in patients with elevated plasma aminotransferases. As a result, external liver damage is considered safe for the liver as the Statin medication at low to moderate dose usage. OBJECTIVES: The main scope of this review is to study the various factors like pharmacological actions, adverse events, and biochemical and liver cell imaging results in patients with ALD and NAFLD. The different types of statins used in alcoholic and non-alcoholic patients’ clinical data for the safety of the statin therapy were concluded in this review. Fatty liver changes of both liver disease conditions were studied using different drugs. The other liver enzymes like Alanine transaminase (ALT), Aspartate transaminase (AST), Gamma-glutamyl Transferase (GGT), and the effectiveness of Statin therapy are considered vital concepts in this review.

关键词： Statin Therapy Liver Enzymes Alcohol Steatosis Fibrosis Hepatocellular Carcinoma Liver toxicity Steatohepatitis