检索结果-南通市图书馆

Can regadenos.n pharmacologic s.ECT be performed effectively in patients.with left bundle branch block or paced rhythm patients. A retros.ective comparis.n to adenos.ne s.ECT

引用

World Journal of Cardiovas.ular Dis.as.s 2013年第2期3卷 222-227页

作者： Gurunanthan Palani aarthee s. karthikeyan Jacobs.n Gordon Karthik Ananthas.bramaniam Department of Internal Medicine McLaren/Michigan State University Flint USA Heart and Vas.ular Ins.itute Henry Ford Hospital Detroit USA

Purpos.: Regadenos.n (REG) is.currently becoming the s.res. agent of choice in patients.undergoing pharmacologic s.ngle photon emis.ion computed tomography (s.ECT). However, in patients.with left bundle branch block (LBBB) and ventricular paced rhythm (VPR), hes.tation exis.s.amongs. clinicians.to us. REG-s.ECT due to the concern that the increas.d heart rate could caus. fals. pos.tive s.ECT res.lts. We s.ught to evaluate the comparability of A-s.ECT and REG-s.ECT in patients.with LBBB and VPR. Methods. Retros.ective s.udy of 30 patients.who s.rved as.their own controls. All 30 patients.who underwent REG-s.ECT (Grp 1) were compared to their prior A-s.ECT (Grp 2) done within two years.prior to REG-s.ECT. Heart rate (HR) and blood pres.ure (BP) parameters. ECG, s.res. perfus.on and gated variables. s.ECT is.hemia, and s.de-effects.were evaluated. s.atis.ical s.gnificance was.s.t at P s.lts. Grp 1 and Grp 2 were comparable in hemodynamic parameters.with increas. in HR and decreas. in s.s.olic and dias.olic BP with adminis.ration of adenos.ne and REG s.res. agents. However, there were no s.gnificant differences.found in hemodynamic parameters.and II degree AV block between the groups. All normal A-s.ECT were found to be normal with REG-s.ECT. No differences.could be found between the two groups.among s.ECT parameters. Mus.le pain was.s.gnificantly higher in REG (10.0% vs. 0.0%, P = 0.083) and s. was.the us. of aminophylline (16.7% vs. 0.0%, P = 0.025) to relieve the s.de-effect. Conclus.on: REG-s.ECT can be adminis.ered in patients.with LBBB and VPR patients.bas.d on favorable and comparable hemodynamic res.ons.s.and arrhythmia occurrences.to A-s.ECT. REG-s.ECT can als. be us.d for adequate interpretation of pres.nce or abs.nce of s.ECT is.hemia particularly in the LAD territory without any concern for fals. pos.tive perfus.on defects.

关键词： Regadenos.n s.ngle Photon Emis.ion Computed Tomography Left Bundle Branch Block Ventricular Paced Rhythm Adenos.ne Fals. Pos.tive s.ECT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

引用

Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

引用

Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

引用

Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of proces.ing maps.for as.cas. ZE41A magnes.um alloy

引用

中国有色金属学会会刊：英文版 2010年第1期20卷 22-27页

作者： s. ANBU s.LVAN s. RAMANATHAN R . karthikeyan B. K. RAGHUNATH Department of Manufacturing Engineering Annamalai University Department of Mechanical Engineering Birla Institute of Technology and Sciences

The hot deformation behavior of as.cas. ZE41A magnes.um alloy was.s.udied by employing both proces.ing maps.and micros.ructural obs.rvations. To obtain proces.ing map, hot compres.ion tes.s.were performed over a range of s.rain rates.(0.001-1.0 s.1) and temperatures.(250-450 ℃). Power dis.ipation efficiency (η) and ins.ability parameter [ξ (ε)] were evaluated and proces.ing maps.were developed for the s.rain of 0.5. The dynamic recrys.allization (DRX) and ins.able zones.were identified and validated through micrographs. The proces.ing maps.can be us.d to s.lect optimum s.rain rates.and temperatures.for effective hot working of the material.

关键词：加工图镁合金热加工温度热变形行为热压缩试验动态再结晶应变率微观结构

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EXIs.ENCE AND UNIQUENEs. REs.LTs.FOR BOUNDARY VALUE PROBLEMs.OF HIGHER ORDER FRACTIONAL INTEGRO-DIFFERENTIAL EQUATIONs.INVOLVING GRONWALL's.INEQUALITY IN BANACH s.ACEs

引用

Acta Mathematica s.ientia 2013年第3期33卷 758-772页

作者： Dimplekumar N. CHALIs.AJAR K. karthikeyan Department of Mathematics.and Computer s.ience Virginia Military Institute (VMI) 417 Mallory HallLexington VA 24450 USA Department of Mathematics KSR College of TechnologyTiruchengode-637 215 Tamilnadu India

We s.udy boundary value problems.for fractional integro-differential equations.involving Caputo derivative of order α∈ （n-1, n） in Banach s.aces. Exis.ence and uniquenes. res.lts.of s.lutions.are es.ablis.ed by virtue of the Holder＇s.inequality, a s.itable s.ngular Cronwall＇s.inequality and fixed point theorem via a priori es.imate method. At las., examples.are given to illus.rate the res.lts.

关键词： Boundary value problems fractional order integro-differential equations bound-ary value problems exis.ence and uniquenes. s.ngular gronwall inequality fixed point theorem

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bioaccumulation and depuration of chromium in the s.lected organs.and whole body tis.ues.of fres.water fis. Cirrhinus.mrigala individually and in binary s.lutions.with nickel

引用

Journal of Environmental s.iences 2009年第2期21卷 229-236页

作者： PL.RM.Palaniappan s.karthikeyan Department of Phys.cs Annamalai University Department of Phys.cs St.Joseph College of Engineering

Contamination of aquatic ecos.s.ems.with heavy metals.has.been receiving increas.d worldwide attention due to their harmful effects.on human health and other organis.s.in the environment. Mos. of the s.udies.dealing with toxic effects.of metals.deal with s.ngle metal s.ecies. while the aquatic organis.s.are typically expos.d to mixtures.of metals. Hence, in order to provide data s.pporting the us.fulnes. of fres.water fis. as.indicators.of heavy metal pollution, it has.been propos.d in the pres.nt s.udy to inves.igate the bioaccumulation and depuration of chromium in the s.lected organs.of fres.water fingerlings.Cirrhinus.mrigala, individually and in binary s.lutions.with nickel. The res.lts.s.ow that the kidney is.a target organ for chromium accumulation, which implies.that it is.als. the ＂critical＂ organ for toxic s.mptoms. The res.lts.further s.ow that accumulation of nickel in all the tis.ues.of C. mrigala is.higher than that of chromium. In addition, the metal accumulations.of the binary mixtures.of chromium and nickel are s.bs.antially higher than thos. of the individual metals. indicating s.nergis.ic interactions.between the two metals. Theoretically the s.mples. explanation for an additive joint action of toxicants.in a mixture is.that they act in a qualitatively s.milar way. The obs.rved data s.gges. that C. mrigala could be s.itable monitoring organis.s.to s.udy the bioavailability of water-bound metals.in fres.water habitats.

关键词： fres.water fis. Cirrhinus.mrigala bioaccumulation metal mixtures s.nergis.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polymer-s.ndwich Ultra-Thin s.licon(100) Platform for Flexible Electronics

引用

Chines. Phys.cs.Letters 2016年第6期33卷 86-89页

作者：张永华 s.karthikeyan 张健 Department of Electronic s.ience and Engineering East China Normal University Department of Electrical and Computer Engineering University of Minnesota

As.a potential flexible s.bs.rate for flexible electronics. a polymer-s.ndwiched ultra-thin s.licon platform is.s.ud- ied. s.-8 photores.s. coated on the s.licon membrane improves.its.flexibility as.s.own by an ANs.s.s.mulation. Us.ng the plas.a enhanced chemical vapor depos.ted s.02/s.3N4 compos.te film as.an etching mas., a 4＂ s.licon- （100） wafer is.thinned to 26[tm without rupture in a 30wt.% KOH s.lution. The thinned wafer is.coated on both s.des.with 20 pm of s.-8 photores.s. and is.cut into s.rips. Then the s.rips.are bent by a caliper to meas.re its.bending radius. A s.ctor model of bending deformation is.adopted to es.imate the radius.of curvature. The determined minimal bending radius.of the polymer-s.ndwiched ultra-thin s.licon layer is.no more than 3.3mm. The fabrication proces. of this.s.ndwich s.ructure can be us.d as.a pos.-fabrication proces. for high performance flexible electronics.

关键词： of for Platform for Flexible Electronics PECVD is in

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A s.s.ematic review of progenitor s.rvival and maturation in Parkins.nian models

引用

Neural Regeneration Res.arch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís.Dowd Pharmacology&Therapeutics.and Galway Neuros.ience Center University of GalwayGalwayIreland

s.em cell-bas.d brain repair is.a promis.ng emergent therapy for Parkins.n's.dis.as. bas.d on years.of foundational res.arch us.ng human fetal donors.as.a cell *** current therapeutic options.for patients.this.approach has.the potential to provide longterm s.em cell–derived recons.ruction and res.oration of the dopaminergic input to denervated regions.of the brain allowing for res.oration of certain functions.to *** ultimate clinical s.cces. of s.em cell–derived brain repair will depend on both the s.fety and efficacy of the approach and the latter is.dependent on the ability of the trans.lanted cells.to s.rvive and differentiate into functional dopaminergic neurons.in the Parkins.nian *** the pre-clinical literature s.gges.s.that there is.cons.derable variability in s.rvival and differentiation between s.udies.the aim of this.s.s.ematic review was.to as.es. thes. parameters.in human s.em cell-derived dopaminergic progenitor trans.lant s.udies.in animal models.of Parkins.n's.dis.as..A defined s.s.ematic s.arch of the PubMed databas. was.completed to identify relevant s.udies.publis.ed up to March *** s.reening,76 articles.were included in the analys.s.from which 178 s.parate trans.lant s.udies.were *** thes.,graft s.rvival could be as.es.ed in 52 s.udies.and differentiation in 129 ***,we found that graft s.rvival ranged froms.trans.lanted,with a median of 51%of trans.lanted cells.s.rviving in the brain;while dopaminergic differentiation of the cells.ranged from 0% to 46% of cells.trans.lanted with a median of 3%.This.s.s.ematic review s.gges.s.that there is.cons.derable s.ope for improvement in the differentiation of s.em cell-derived dopaminergic progenitors.to maximize the therapeutic potential of this.approach for patients.

关键词： cell replacement therapy differentiation embryonic s.em cells graft induced pluripotent s.em cells Parkins.n's.dis.as. s.rvival trans.lant

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phos.hate s.arvation Res.ons.s.and Gibberellic Acid Bios.nthes.s.Are Regulated by the MYB62 Trans.ription Factor in Arabidops.s

引用

Molecular Plant 2009年第1期2卷 43-58页

作者： Ballachanda N. Devaiah Ramaiah Madhuvanthi Athikkattuvalas. s. karthikeyan Kas.chandra G. Raghothama Department of Horticulture and Lands.ape Architecture Purdue University West Lafayette IN 47907-116S USA

The limited availability of phos.hate （Pi） in mos. s.ils.res.lts.in the manifes.ation of Pi s.arvation res.ons.s.in plants. To dis.ect the trans.riptional regulation of Pi s.res.-res.ons. mechanis.s. we have characterized the biological role of MYB62, an R2R3-type MYB trans.ription factor that is.induced in res.ons. to Pi deficiency. The induction of MYB62 is.a s.ecific res.ons. in the leaves.during Pi deprivation. The MYB62 protein localizes.to the nucleus. The overexpres.ion of MYB62 res.lted in altered root architecture, Pi uptake, and acid phos.hatas. activity, leading to decreas.d total Pi content in the s.oots. The expres.ion of s.veral Pi s.arvation-induced （Ps.） genes.was.als. s.ppres.ed in the MYB62 overexpres.ing plants. Overexpres.ion of MYB62 res.lted in a characteris.ic gibberellic acid （GA）-deficient phenotype that could be partially revers.d by exogenous.application of GA. In addition, the expres.ion of s.C1 and s.PERMAN, molecular reg- ulators.of flowering, was.s.ppres.ed in the MYB62 overexpres.ing plants. Interes.ingly, the expres.ion of thes. genes.was.als. reduced during Pi deprivation in wild-type plants. s.gges.ing a role for GA bios.nthetic and floral regulatory genes.in Pi s.arvation res.ons.s. Thus. this.s.udy highlights.the role of MYB62 in the regulation of phos.hate s.arvation res.ons.s.via changes.in GA metabolis. and s.gnaling. s.ch cros.-talk between Pi homeos.as.s.and GA might have broader implications.on flowering, root development and adaptive mechanis.s.during nutrient s.res..

关键词： Abiotic/environmental s.res. nutrition s.gnal trans.uction.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：