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Mitomycin C and capecitabine: An additional option as an advanced line therapy in patients with metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1913-1924页

作者： Gil Mullin Michal Sternschuss Yosef Landman aaron Sulkes Baruch Brenner Faculty of Medicine Tel-Aviv UniversityTel Aviv 6997801Israel Institute of Oncology Davidoff Cancer CenterBeilinson CampusPetah-Tikva 4941492Israel

BACKGROUND In recent years survival of patients with metastatic colorectal cancer(mCRC),though still limited,has improved significantly;clearly,when the disease becomes refractory to standard regimens,additional treatment options are *** have shown that mitomycin C(MMC),an antitumor antibiotic,and capecitabine,a precursor of 5-fluorouracil,may act synergistically in *** efficacy of MMC/capecitabine has been demonstrated in the first-line setting,but only a few small studies have tested it in the advanced-line setting,with contradictory *** a median of 2 MMC/capecitabine cycles(range 0.5-9.0).Thirty-four patients(28.6%)experienced grade≥3 toxicity,including 2(1.7%)with grade 4;there was no drug-related *** objective response rate was 0.8%,and the disease control rate,24.4%.Median progression-free survival(PFS)was 2.1 mo(range 0.2-20.3),and median overall survival,4.8 mo(range 0.2-27.5).The 6-month overall survival rate was 44%;8.7%of patients remained *** associated with longer PFS were lower gamma-glutamyl transferase level(P=0.030)and primary tumor location in the left colon(P=0.017).Factors associated with longer overall survival were lower gamma-glutamyl transferase level(P=0.022),left-colon tumor location(P=0.044),low-to-moderate histological grade(P=0.012),Eastern Cooperative Oncology Group performance status 0-1(P=0.036),and normal bilirubin level(P=0.047).CONCLUSION MMC/capecitabine is an active,available,and relatively safe regimen for use beyond standard lines of therapy in *** clinical and laboratory parameters can identify patients more likely to benefit.

关键词： Colorectal cancer Metastatic cancer Chemotherapy Mitomycin C/Capecitabine Advanced line treatment

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Editing landscapes:Experimental frameworks for territorial-based robotic fabrication

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Frontiers of Architectural Research 2023年第1期12卷 104-117页

作者： Karen Lee Bar-Sinai Tal Alon-Mozes aaron Sprecher Faculty of Architecture and Town Planning Technion-Israel Institute of TechnologyHaifa 3200003Israel

With the advent of on-site robotic tools,they can be deployed for editing landscapes e defined as the modulation of grounds with a high degree of sensitivity to matter and *** paper contributes a theoretical grounding and two experimental frameworks for territorial-based robotic *** experimental framework supports a robotic capacity for informing and forming grounds,demonstrated in relation to extreme territories using simulation *** frameworks include(1)a layer-sensitive modulation for protecting topsoil and(2)a performance-based robotic forming for creating wind *** each framework,the paper proposes a setup,an exploration method,and an evaluation *** on the presented frameworks,the paper outlines three potentials of territorialbased robotic fabrication:the capability to modulate grounds vertically,the possibility to perform cross-scalar forming,and the opportunity to form dynamic,performative *** paper concludes with potential ways in which robotic tools could be leveraged for advancing precise landscape editing across scales.

关键词： Landscape modulation Robotic fabrication Informing grounds Performative design Territorial-based design

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The Depression era

The Depression era

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作者： (1951-)Barlow aaron

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H_(2)mediated mixed culture microbial electrosynthesis for high titer acetate production from CO_(2)

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Environmental Science and Ecotechnology 2024年第3期19卷 125-131页

作者： Yanhong Bian aaron Leininger Harold D.May Zhiyong Jason Ren Department of Civil and Environmental Engineering Princeton University86 Olden StPrincetonNJ08544United States Andlinger Center for Energy and the Environment Princeton University86 Olden St.PrincetonNJ08544United States

Microbial electrosynthesis(MES)converts CO_(2)into value-added products such as volatile fatty acids(VFAs)with minimal energy use,but low production titer has limited scale-up and *** electron transfer via H_(2)on the MES cathode has shown a higher conversion rate than the direct biofilm-based approach,as it is tunable via cathode potential control and accelerates electrosynthesis from CO_(2).Here we report high acetate titers can be achieved via improved in situ H_(2)supply by nickel foam decorated carbon felt cathode in mixed community MES *** concentration of 12.5 g L^(-1)was observed in 14 days with nickel-carbon cathode at a poised potential of-0.89 V(*** hydrogen electrode,SHE),which was much higher than cathodes using stainless steel(5.2 g L^(-1))or carbon felt alone(1.7 g L^(-1))with the same projected surface area.A higher acetate concentration of 16.0 g L^(-1)in the cathode was achieved over long-term operation for 32 days,but crossover was observed in batch operation,as additional acetate(5.8 g L^(-1))was also found in the abiotic anode *** observed the low Faradaic efficiencies in acetate production,attributed to partial H_(2)utilization for *** selective acetate production with high titer demonstrated in this study shows the H_(2)-mediated electron transfer with common cathode materials carries good promise in MES development.

关键词： Microbial electrosynthesis Indirect electron transfer CO_(2)electrolysis VFAs production

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孔隙介质中含砷聚集物的三维成像

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西南交通大学学报 2011年第6期46卷 973-978页

作者：彭道平黄涛 aaron PACKMAN 西南交通大学地球科学与环境工程学院四川成都610031 美国西北大学土木与环境工程系伊利诺伊州埃文斯顿60208

为观测砷沉积导致的孔隙介质内部结构的改变,采用X射线差异微断层扫描技术,扫描从Loa流域获得的河床沉积物和实验室配制的含砷样品,对含砷聚集物在孔隙介质中的分布进行了成像分析.经过图像处理去除图像上的噪点和增强图像中砷的信息,... 详细信息

为观测砷沉积导致的孔隙介质内部结构的改变,采用X射线差异微断层扫描技术,扫描从Loa流域获得的河床沉积物和实验室配制的含砷样品,对含砷聚集物在孔隙介质中的分布进行了成像分析.经过图像处理去除图像上的噪点和增强图像中砷的信息,获得了孔隙介质中含砷聚集物的三维数据组;采用Avizo 6和Blob3D等工具,对三维数据组进行重建和可视化.成像显示:大量含砷聚集物沉积在介质孔隙和介质表面;不同尺寸聚集物的形态呈现出明显的多样化特征———小颗粒聚集物趋于球形,大颗粒聚集物则趋于扁平状.研究表明,该技术可在不破坏样品的前提下,实现对孔隙介质沉积前后内部结构变化的直接观测.

关键词：孔隙介质 X射线差异微断层扫描技术砷图像处理三维成像

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Comparative efficacy of gypsy moth(Lepidoptera:Erebidae)entomopathogens on transgenic blight-tolerant and wild-type American,Chinese,and hybrid chestnuts(Fagales:Fagaceae)

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Insect Science 2020年第5期27卷 1067-1078页

作者： aaron J.Brown Andrew E.Newhouse William A.Powell Dylan Parry Department of Environmental and Forest Biology College of Environmental Science and ForestryState University of New YorkSyracuseNY13210USA

American chestnut(Castanea dentata[Marsh.]Borkh.)was once the dominant hardwood species in Eastern North America before an exotic fungal pathogen,Cryphonec-tria parasitica(Murrill)Barr,functionally eliminated it across its *** promising approach toward restoring American chestnut to natural forests is development of blight-tolerant trees using genetic ***,transformation and related processes can result in unexpected and unintended phenotypic changes,potentially altering ecologi-cal *** assess unintended tritrophic impacts of transgenic American chestnut on plant herbivore interactions,gypsy moth(Lymantria dispar L.)caterpillars were fed leaf disks excised from two transgenic events,Darling 54 and Darling 58,and four control American chestnut *** disks were previously treated with an LDso dose of either the speces-specific Lymantria dispar multiple nucleopolyhedrovirus(LdMNPV)or the generalist pathogen Bacillus thuringiensis ***(Btk).Mortality was quantified and compared to water blank *** genotype had a strong efect on the efficacies of both *** mortality from Btk-treated foliage from only one transgenic event,Darling 54,differed from its isogenic progenitor,Ellis l,but was similar to an unre-lated wild-type American chestnut *** efficacy was unaffected by genetic *** suggest that although genetic modification of trees may affect interactions with other nontarget organisms,this may be due to insertion effects,and varia-tion amnon diMterent genvtypes(wlether uasgeic ul wild-typc)iupaults a giealci change in response than transgene presence.

关键词： Bacillus thuringiensis LdMNPV nontarget restoration tri-trophic unin-tended effects

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Evaluation and management of inherited disorders of surfactant metabolism

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Chinese Medical Journal 2010年第20期123卷 2943-2947页

作者： aaron Hamvas Edward Mallinckrodt Department of Pediatrics Washington University School of Medicine and St. Louis Children's Hospital St. Louis Missouri 63110 USA

Objective To review the pathophysiology, evaluation, management, and outcomes of children with inherited disorders of surfactant metabolism due to mutations in the genes encoding surfactant proteins-B or -C（SFTPB, SFTPC）, ATP binding cassette member A3 （ABCA3）, and thyroid transcription factor （NKX2.1）.Data sources Review of the literature, previous work from the author＇s and collaborators＇ laboratories, St. Louis Children＇s Hospital Lung Transplant *** selection Key articles in the field, author＇s *** Inherited disorders of surfactant metabolism present as acute, severe respiratory dysfunction in the neonatal period （SFTPB, ABCA3, NKX2.1） or as chronic respiratory insufficiency in later infancy and childhood which is of variable onset, severity, and course （SFTPC, ABCA3, NKX2.1）. Diagnosis is established with sequencing the relevant genes; lung biopsy with electron microscopy is a useful adjunct. For surfactant protein-B and ABCA3 deficiency presenting with acute neonatal disease, treatment options are limited to lung transplantation or compassionate care. For the more chronic presentations of surfactant protein-C, ABCA3, and NKX2.1 associated disease, the natural history is variable and therefore individualized, supportive care is appropriate,Conclusions Inherited disorders of surfactant metabolism are rare, but informative diseases that provide unique opportunities for understanding mechanisms of respiratory disease in newborns and children.

关键词： respiratory distress syndrome newborn genetics lung transplantation

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Role of cytokines in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第27期14卷 4280-4288页

作者： Fausto Sanchez-Muoz aaron Dominguez-Lopez Jesus K Yamamoto-Furusho Inflammatory Bowel Disease Clinic Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Vasco de Quiroga 15 colonia Sección XVI

Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), rep- resents a group of chronic disorders characterized by inflammation of the gastrointestinal tract, typically with a relapsing and remitting clinical course. Mucosal mac- rophages play an important role in the mucosal im- mune system, and an increase in the number of newly recruited monocytes and activated macrophages has been noted in the inflamed gut of patients with IBD. Activated macrophages are thought to be major con- tributors to the production of inflammatory cytokines in the gut, and imbalance of cytokines is contributing to the pathogenesis of IBD. The intestinal inflammation in IBD is controlled by a complex interplay of innate and adaptive immune mechanisms. Cytokines play a key role in IBD that determine T cell differentiation of Th1, Th2, T regulatory and newly described Th17 cells. Cytokines levels in time and space orchestrate the development, recurrence and exacerbation of the inflammatory process in IBD. Therefore, several cyto- kine therapies have been developed and tested for the treatment of IBD patients.

关键词： Cytokines Inflammatory bowel disease Crohn's disease Ulcerative colitis Inflammation

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Understanding electricity prices beyond the merit order principle using explainable AI

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Energy and AI 2023年第3期13卷 149-159页

作者： Julius Trebbien Leonardo Rydin Gorjao aaron Praktiknjo Benjamin Schafer Dirk Witthaut Forschungszentrum Julich Institute for Energy and Climate Research–Systems Analysis and Technology Evaluation(IEK-STE)52428 JülichGermany University of Cologne Institute for Theoretical PhysicsZülpicher Str.7750937 CologneGermany Faculty of Science and Technology Norwegian University of Life Sciences1432 AsNorway Chair for Energy System Economics Institute for Future Energy Consumer Needs and Behavior(FCN)E.ON Energy Research CenterRWTH Aachen UniversityMathieustr.1052074 AachenGermany Institute for Automation and Applied Informatics Karlsruhe Institute of Technology76344 Eggenstein-LeopoldshafenGermany JARA-ENERGY 52074 AachenGermany

Electricity prices in liberalized markets are determined by the supply and demand for electric power,which are in turn driven by various external influences that vary strongly in *** perfect competition,the merit order principle describes that dispatchable power plants enter the market in the order of their marginal costs to meet the residual load,*** difference of load and renewable *** market models are based on this principle when attempting to predict electricity prices,yet the principle is fraught with assumptions and simplifications and thus is limited in accurately predicting *** this article,we present an explainable machine learning model for the electricity prices on the German day-ahead market which foregoes of the aforementioned assumptions of the merit order *** model is designed for an ex-post analysis of prices and builds on various external *** SHapley Additive exPlanation(SHAP)values we disentangle the role of the different features and quantify their importance from empiric data,and therein circumvent the limitations inherent to the merit order *** show that load,wind and solar generation are the central external features driving prices,as expected,wherein wind generation affects prices more than solar ***,fuel prices also highly affect prices,and do so in a nontrivial ***,large generation ramps are correlated with high prices due to the limited flexibility of nuclear and lignite ***,we offer a model that describes the influence of the main drivers of electricity prices in Germany,taking us a step beyond the limited merit order principle in explaining the drivers of electricity prices and their relation to each other.

关键词： Electricity prices Merit order principle Explainable artificial intelligence Machine learning Fuel prices Energy market

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Efficient Convex Optimization Approaches to Variational Image Fusion

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Numerical Mathematics(Theory,Methods and Applications) 2014年第2期7卷 234-250页

作者： Jing Yuan Brandon Miles Greg Garvin Xue-Cheng Tai aaron Fenster Medical Imaging Lab Robarts Research InstituteUniversity of Western OntarioLondon ONCanada N6A 5B7 Department of Medical Imaging St Jospeh’s HealthCareLondon ONCanada Department of Mathematics University of BergenBergenNorway

Image fusion is an imaging technique to visualize information from multiple imaging sources in one single image,which is widely used in remote sensing,medical imaging *** this work,we study two variational approaches to image fusion which are closely related to the standard TV-L_(2) and TV-L_(1) image approximation *** investigate their convex optimization formulations,under the perspective of primal and dual,and propose their associated new image decomposition *** addition,we consider the TV-L_(1) based image fusion approach and study the specified problem of fusing two discrete-constrained images f_(1)(x)∈L_(1) and f_(2)(x)∈L_(2),where L_(1) and L_(2) are the sets of linearly-ordered discrete *** prove that the TV-L_(1) based image fusion actually gives rise to the exact convex relaxation to the corresponding nonconvex image fusion constrained by the discretevalued set u(x)∈L_(1)∪L_(2).This extends the results for the global optimization of the discrete-constrained TV-L_(1) image approximation[8,36]to the case of image *** a big numerical advantage of the two proposed dual models,we show both of them directly lead to new fast and reliable algorithms,based on modern convex optimization *** with medical images,remote sensing images and multi-focus images visibly show the qualitative differences between the two studied variational models of image *** also apply the new variational approaches to fusing 3D medical images.

关键词： Convex optimization primal-dual programming combinatorial optimization totalvariation regularization image fusion

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