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Mortality assessment for pancreas transplants in the United States over the decade 2008-2018

World Journal of Transplantation 2023年第4期13卷 147-156页

作者： Tambi Jarmi Emily Brennan Jacob Clendenon aaron C Spaulding Department of Transplant Mayo Clinic FloridaJacksonvilleFL 32224United States Health Science Research Mayo Clinic FloridaJacksonvilleFL 32224United States

BACKGROUND Pancreas transplant is the only treatment that establishes normal glucose levels for patients diagnosed with ***,since 2005,no comprehensive analysis has compared survival outcomes of:(1)Simultaneous pancreas-kidney(SPK)transplant;(2)Pancreas after kidney(PAK)transplant;and(3)Pancreas transplant alone(PTA)to waitlist *** To explore the outcomes of pancreas transplants in the United States during the decade *** Our study utilized the United Network for Organ Sharing Standard Transplant Analysis and Research ***-and post-transplant recipient and waitlist characteristics and the most recent recipient transplant and mortality status were *** included all patients with type I diabetes listed for pancreas or kidneypancreas transplant between May 31,2008 and May 31,*** were grouped into one of three transplant types:SPK,PAK,or *** The adjusted Cox proportional hazards models comparing survival between transplanted and non-transplanted patients in each transplant type group showed that patients who underwent an SPK transplant exhibited a significantly reduced hazard of mortality[hazard ratio(HR)=0.21,95%confidence intervals(CI):0.19-0.25]compared to those not *** PAK transplanted patients(HR=1.68,95%CI:0.99-2.87)nor PTA patients(HR=1.01,95%CI:0.53-1.95)experienced significantly different hazards of mortality compared to patients who did not receive a *** When assessing each of the three transplant types,only SPK transplant offered a survival advantage compared to patients on the waiting *** and PTA transplanted patients demonstrated no significant differences compared to patients who did not receive a transplant.

关键词： Pancreas transplant Simultaneous pancreas-kidney transplant Pancreas after kidney transplant Survival Diabetes mellitus Insulin

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Determining minimum sample size for the conditioned Latin hypercube sampling algorithm

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Pedosphere 2024年第3期34卷 530-539页

作者： Daniel D.SAURETTE Asim BISWAS Richard J.HECK Adam W.GILLESPIE aaron A.BERG School of Environmental Sciences University of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada) Ontario Ministry of Agriculture Food and Rural Affairs1 Stone Rd WestGuelph ON N1G 2Y4(Canada) Geography Environment&GeomaticsUniversity of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada)

In digital soil mapping(DSM),a fundamental assumption is that the spatial variability of the target variable can be explained by the predictors or environmental *** to adequately sample the predictors have been well documented,with the conditioned Latin hypercube sampling(cLHS)algorithm receiving the most attention in the DSM *** advances in sampling design,a critical gap remains in determining the number of samples required for DSM *** propose a simple workflow and function coded in R language to determine the minimum sample size for the cLHS algorithm based on histograms of the predictor variables using the Freedman-Diaconis rule for determining optimal bin *** preprocessing was included to correct for multimodal and non-normally distributed data,as these can affect sample size determination from the *** on a user-selected quantile range(QR)for the sample plan,the densities of the histogram bins at the upper and lower bounds of the QR were used as a scaling factor to determine minimum sample *** technique was applied to a field-scale set of environmental covariates for a well-sampled agricultural study site near Guelph,Ontario,Canada,and tested across a range of *** results showed increasing minimum sample size with an increase in the QR *** sample size increased from 44 to 83 when the QR increased from 50% to 95% and then increased exponentially to 194 for the 99%*** technique provides an estimate of minimum sample size that can be used as an input to the cLHS algorithm.

关键词： bin width digital soil mapping normal distribution quantile range sampling design

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Differences in pectoral fin spine morphology between vocal and silent clades of catfishes (Order Siluriformes): Ecomorphological implications

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Current Zoology 2010年第1期56卷 73-89页

作者： Ingrid M.KAATZ Donald J.STEWART aaron N.RJCE Phillip S.LOBEL Department of Environmental and Forest Biology SUNY College of Environmental Science and Forestry Department of Neurobiology and Behavior Cornell University Bioacoustics Research Program Cornell Laboratory of Ornithology Cornell University Department of Biology Boston University

Stridulatory sound-producing behavior is widespread across catfish families, but some are silent. To understand why, we compared spine morphology and ecotype of silent and vocal clades. We determined vocal ability of laboratory specimens during disturbance behavior. Vocal families had bony （not flexible or segmented） spines, well-developed anterior and/or posterior serrations, and statistically significantly longer spines. We compared morphology of the proximal end of the pectoral spine between vocal and silent species. For vocal taxa, microscopic rounded or bladed ridges or knobs were present on the dorsal process. Most silent species had reduced processes with exclusively smooth, convoluted, or honeycombed surfaces very similar to spine-locking surfaces, or they had novel surfaces （beaded, vacuolated, cobwebbed）. Most callichthyids had ridges but many were silent during disturbance. All doradid, most auchenipterid and most mochokid species were vocal and had ridges or knobs. Within the Auchenipteridae, vocal species had spines with greater weight and serration development but not length. Silent auchenipterids had thin, brittle, distally segmented spines with few microscopic serrations on only one margin and a highly reduced dorsal process lacking any known vocal morphology. Silent auchenipterids are derived and pelagic, while all vocal genera are basal and benthopelagic. This is the first phylogenetic evidence for stridulation mechanism loss within catfishes. Phylogenetic mapping of vocal ability, spine condition, and ecotype revealed the repeated presence of silence and vocal taxa, short and long spines, and ecotype shifts within clades. The appearance and loss of vocal behavior and supporting morphologies may have facilitated diversification among catfishes [Current Zoology 56 （1）： 73 89 2010].

关键词： Bioacoustic Defense mechanisms Historical biology Stridulation

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De novo ADGRV1 variant in a patient with ictal asystole provides novel clues for increased risk of SUDEP

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Acta Epileptologica 2023年第2期6卷 118-126页

作者： Tuo Ji aaron W.Downs Luong Dorris Ning Zhong SQZ Biotechnologies WatertownMA 02472USA Morrissey College of Arts and Sciences Boston CollegeChestnut HillMA 02467USA College of Medicine California Northstate UniversityElk GroveCA 95757USA Pediatric and Adolescent Medicine Residency of Mayo Clinic MNRochesterUSA Department of Neurology Kaiser Permanente Sacramento Medical CenterSacramentoCA 95825USA North Valley Comprehensive Epilepsy Program Kaiser Permanente Sacramento Medical CenterSacramentoCA 95825USA

Background Various cardiac and autonomic manifestations are frequently reported during *** the seizure-related arrhythmia,ictal tachycardia is the most common,followed by ictal bradycardia,with ictal asystole being the *** occurrence of ictal asystole may obscure the clinical presentation and delay the diagnosis,representing a life-threatening presentation of epilepsy,with an elevated risk of sudden unexpected death in epilepsy patients(SUDEP).These cardiac abnormalities are being increasingly recognized as the key to elucidating the mechanisms of *** presentation We present a 35-year-old man with a history of focal-onset seizures with impaired consciousness since his mid-20 *** developed different types of seizures for 2 years,described as tonic seizure and atonic seizure(drop attack).During such clinical events,he suffered from falls and cardiac ***,thorough cardiac electrophysiology and imaging workup failed to reveal a cardiac *** video electroencephalograph(EEG)monitoring was performed,and ictal bradycardia and ictal asystole were discovered.A cardiac pacemaker was implanted,and at 3-year follow-up,the patient did not suffer more atonic seizures,or *** tests discovered a de novo variant of Adhesion G Protein-Coupled Receptor V1(ADGRV1),which may provide a clue for the patient’s ictal asystole and the increased risk of *** Considering the important impact of ictal bradycardia and asystole on the morbidity and potential mortality of epileptic patients,it is important to simultaneously utilize EEG and electrocardiogram to confirm the *** case report highlights the link between the de novo variant of ADGRV1 and the ictal bradycardia/asystole phenotype and implicates the importance of genetic testing in adult epilepsy patients.

关键词： Ictal asystole Drug resistant epilepsy ADGRV1 SUDEP

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The influence of chemical composition on models of Type Ia supernovae

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Frontiers of physics 2013年第2期8卷 168-188页

作者： Alan C. Calder Brendan K. Krueger aaron P. Jackson Dean M. Townsley Department of Physics Astronomy The State University of New York - Stony Brook Stony BrookUSA NY 11794 New York Center for Computational Sciences The State University of New York - Stony Brook Stony BrookUSA NY 11794 National Research Council Research Associateship Program and Laboratories for Computational Physics and Fluid Dynamics Naval Research Laboratory WashingtonUSA DC 20375 Department of Physics and Astronomy The University of Alabama TuscaloosaUSA AL 35487

Type Ia supernovae are bright stellar explosions distinguished by standardizable light curves that allow for their use as distance indicators for cosmological studies. Despite the highly successful use of these events in this capacity, many fundamental questions remain. Contemporary research inves- tigates how properties of the progenitor system that follow from the host galaxy such as composition and age influence the brightness of an event with the goal of better understanding and assessing the intrinsic scatter in the brightness. We provide an overview of these supernovae and proposed progenitor systems, all of which involve one or more compact stars known as white dwarfs. We describe contemporary research investigating how the composition and structure of the progenitor white dwarf systematically influences the explosion outcome assuming the progenitor is a single white dwarf that has gained mass from a companion. We present results illustrating some of these systematic effects from our research.

关键词： hydrodynamics nuclear reactions nucleosynthesis abundances stars: supernovae:general stars: white dwarfs

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PETG:Applications in Modern Medicine

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Engineered Regeneration 2024年第1期5卷 45-55页

作者： Catherine Yan Corinne Kleiner aaron Tabigue Veer Shah Gregory Sacks Darshi Shah Vincent DeStefano Renaissance School of Medicine at Stony Brook University Stony BrookNYUSA Department of Biology Niagara UniversityLewistonNYUSA Stony Brook University Stony BrookNYUSA Department of Mechanical and Industrial Engineering Northeastern UniversityBostonMAUSA

Polyethylene terephthalate glycol,PETG,is a miscible,transparent thermoplastic known to have strong tensile properties,high ductility,as well as resistance to heat and chemical *** may be manufactured in several ways,most notably 3D printing *** such,PETG has emerged as a viable biomaterial for a variety of medical applications such as tissue engineering,dentistry,optometry,vascular health,cardiology,orthopedics,neurology,gynecology,and *** also serves a valuable role in biomedical research and engineering by offering improvements in cell studies,drug carriers,and anti-bacterial *** medical research and innovation utilizing PETG will better characterize its value as an inexpensive and versatile biomaterial.

关键词： Polyethylene terephthalate glycol Tissue Engineering 3D Printing Clinical Applications Biomedical Research

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The bearing of biological fitness in humans and crops upon the emergence and spread of agriculture

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Natural Science 2013年第4期5卷 1-6页

作者： aaron Rottenberg Department of Biotechnology Ort Braude College Karmiel Israel

Past studies discussing the origins of agriculture have mainly emphasized changes in environmental and human-behavior factors as possible explanations for the shift from foraging to farming. This paper focuses on how increase in the biological fitness of both farmers and crops enabled the rapid evolution and success of farmers and agriculture. It is shown that the first plants under domestication achieved their superior fitness mainly as a consequence of some of their genetic and life-history traits. It led these species to be extensively integrated into human subsistence and eventually dominate the farmers’ fields. Concurrently, the first farmers gained their enhanced fitness by producing food surplus and by acquiring extra social prestige and power, while materializing the tendency to higher reproduction rate, and eventually to the expansion of farming populations. The unbreakable dependence between high fitness crops and high fitness man, namely their coevolution is a key issue and a promising research area in the understanding of the human story and the origins of agriculture.

关键词： Fitness Prestige Agriculture Origin Founder Crops Coevolution

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Do You Know the Word? GameBoy Back

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英语角 2019年第15期 40-41页

作者： aaron 不详

小朋友们,你们有没有遇到过两个单词分开都认识,合在一起意思却完全不同的情况呢?有些词汇是不能直接从字面上去解释的。在Do You Know the Word?栏目中,QQ姐姐将会和你们一起去探索这些词汇背后的奥秘.

关键词： Do You Know the Word GameBoy Back

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Tracking IBU Through the Brewing Process:The Quest for Consistency

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中外酒业 2020年第1期 63-72页

作者： aaron Justus Director of R&D and Specialty Brewing Ballast Point Brewing

International Bitterness Units(IBUs)were measured with a spectrophotometer throughout the brewing process for a wide variety of beer *** of the data were collected at our 50BBL Scripps Ranch facility,although some data were also gathered from our 5 BBL R&D brewery and 150 BBL production *** was determined that mash hops add a small amount of IBUs to wort with an average utilization of 9.1%.As expected,60 min hop additions added substantially more IBUs;the average hop utilization was 44.0%.Whirlpool hops also contributed high IBUs w让h an average utilization of 29.9%.In addition,hot-side wet hopping had 8.0%utilization.A large amount of IBUs are lost during the first 2 days of *** were also observed during *** was discovered that high amounts of dry hopping resulted in an increase of ***,the average overall IBU loss in the cellar was 33.7%.

关键词： Utilization Hop rate IBU,Iso-α—acid,Spectrophotometer,Isomerization

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Control of modifiable risk factors and major adverse cardiovascular events in people with peripheral artery disease and diabetes

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World Journal of Diabetes 2021年第6期12卷 883-892页

作者： Jonathan Golledge aaron Drovandi Sophie Rowbotham Ramesh Velu Frank Quigley Jason Jenkins Queensland Research Centre for Peripheral Vascular Disease College of Medicine and DentistryJames Cook UniversityTownsville 4811QueenslandAustralia Department of Vascular and Endovascular Surgery Townsville University HospitalTownsville 4811QueenslandAustralia Department of Vascular Surgery Mater HospitalTownsville 4811QueenslandAustralia Department of Vascular Surgery The Royal Brisbane and Women's HospitalBrisbane 4000QueenslandAustralia

BACKGROUND People with diabetes and peripheral artery disease(PAD)have a high risk of major adverse cardiovascular events(MACE).Prior research suggests that medical therapies aimed to control modifiable risk factors are poorly implemented in patients with *** To examine the association between the control of modifiable risk factors,estimated by the novel PAD-medical score,and the incidence of MACE in people with PAD and *** Participants were recruited from out-patient clinics if they had a diagnosis of both PAD and *** of reversible risk factors was assessed by a new composite measure,the PAD-medical *** score takes into account the control of low-density lipoprotein cholesterol,blood pressure,blood glucose,smoking and prescription of an *** were followed to record incidence of myocardial infarction,stroke and cardiovascular death(MACE).The association of PAD-medical score with MACE was assessed using Cox proportional hazard analyses adjusting for age,sex and prior history of ischemic heart disease and *** Between 2002 and 2020,a total of 424 participants with carotid artery disease(n=63),aortic or peripheral aneurysm(n=121)or lower limb ischemia(n=240)were prospectively recruited,and followed for a median duration(inter-quartile range)of 2.0(0.2–4.4)*** 33(7.8%)participants had the optimal PAD-medical score of five,with 318(75%)scoring at least three out of *** were 89(21.0%)participants that had at least one MACE during the follow-up period.A one-unit higher PAD-medical score was associated with lower risk of MACE(HR=0.79,95%CI:0.63-0.98)after adjusting for other risk *** The PAD-medical score provides a simple way to assess the control of modifiable risk factors targeted by medical management aimed to reduce the incidence of MACE.

关键词： Peripheral artery disease Diabetes Major cardiovascular events Medical management Prospective study Clinical practice

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