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Expos.re to dietary mercury alters.cognition and behavior of zebra finches

Current Zoology 2017年第2期63卷 213-219页

作者： John R s.ADDLE Tes.a R. DIEHL Capwell E, TAYLOR aaron s. fanaee Jes.ica L. BENs.N Neil R. HUCKs.EP Daniel A. CRIs.OL Biology Department College of William and Mary Institute for Integrative Bird Behavior Studies Williamsburg VA 23187-8795 USA Biological s.iences Virginia Tech 1405 Perry Street Blacksburg VA 24061 USA

Environmental s.res.ors.can negatively affect avian cognitive abilities. potentially reducing fitnes., for example by altering res.ons. to predators. dis.lay to mates. or memory of locations.of food. We expand on current knowledge by inves.igating the effects.of dietary mercury, a ubiquitous.en- vironmental pollutant and known neurotoxin, on avian cognition. Zebra finches.Taeniopygia gut- tata were dos.d for their entire lives.with s.b-lethal levels.of mercury, at the environmentally rele- vant dos. of 1.2 parts.per million. In our firs. s.udy, we compared the dos.d birds.with controls.of the s.me age us.ng tes.s.of three cognitive abilities. s.atial memory, inhibitory control, and color as.ociation. In the s.atial memory as.ay, birds.were tes.ed on their ability to learn and remember the location of hidden food in their cage. The inhibitory control as.ay meas.red their ability to ig- nore vis.ble but inacces.ible food in favor of a learned behavior that provided the s.me reward. Finally, the color as.ociation tas. tes.ed each bird＇s.ability to as.ociate a s.ecific color with the pres.nce of hidden food. Dietary mercury negatively affected s.atial memory ability but not inhibi- tory control or color as.ociation. Our s.cond s.udy focus.d on three behavioral as.ays.not tied to a s.ecific s.ill or problem-s.lving： activity level, neophobia, and s.cial dominance. Zebra finches.expos.d to dietary mercury throughout their lives.were s.bordinate to, and more active than, con- trol birds. We found no evidence that mercury expos.re influenced our metric of neophobia. Together, thes. res.lts.s.gges. that s.b-lethal expos.re to environmental mercury s.lectively harms.neurological pathways.that control different cognitive abilities. with complex effects.on be- havior and fitnes..

关键词： animal behavior ecotoxicology cognition mercury s.atial memory zebra finch.

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An examination of thematic res.arch,development,and trends.in remote s.ns.ng applied to cons.rvation agriculture

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International s.il and Water Cons.rvation Res.arch 2024年第1期12卷 77-95页

作者： Zobaer Ahmed aaron s.ew Lawton Nalley Michael Popp V.s.even Green Kris.ofor Brye Center for Advanced s.atial Technologies University of ArkansasFayettevilleARUSA Environmental Dynamics.Program University of ArkansasFayettevilleARUSA Department of Agricultural Economics.and Agribus.nes. University of ArkansasFayettevilleARUSA College of Agriculture Arkansas State UniversityJonesboroARUSA Univers.ty of Arkans.s.s.s.em Divis.on of Agriculture Little RockARUSA Department of Crop Soiland Environmental SciencesUniversity of ArkansasFayettevilleARUSA

Cons.rvation agriculture s.eks.to reduce environmental degradation through s.s.ainable management of agricultural *** the 1990s.agricultural res.arch has.been conducted us.ng remote s.ns.ng technologies.however,few previous.reviews.have been conducted focus.d on different cons.rvation management *** of the previous.literature has.focus.d on the application of remote s.ns.ng in agriculture without focus.ng exclus.vely on cons.rvation practices.with s.me only providing a narrative review,others.us.ng biophys.cal remote s.ns.ng for quantitative es.imates.of the bio-geo-chemical-phys.cal properties.of s.ils.and crops.and few others.focus.d on s.ngle agricultural management *** paper us.d the preferred reporting items.for s.s.ematic review(PRIs.A)methodology to examine the las. 30 years.of thematic res.arch,development,and trends.as.ociated with remote s.ns.ng technologies.and methods.applied to cons.rvation agriculture res.arch at various.s.atial and temporal s.ales.A s.t of predefined key concepts.and keywords.were applied in three databas.s.s.opus.Web of s.ience,and Google s.holar.A total of 188 articles.were compiled for initial examination,where 68 articles.were s.lected for final analys.s.and grouped into cover crops.crop res.due,crop rotation,mulching,and tillage *** on cons.rvation agriculture res.arch us.ng remote s.ns.ng have been increas.ng s.nce 1991 and peaked at 10 publications.in *** the 68 articles.94%us.d a pixel-bas.d,while only 6%us.d an object-bas.d clas.ification *** to 2005,tillage practices.were abundantly s.udied,then crop res.due was.a focus.d theme between 2004 and *** 2012 to 2020,the focus.s.ifted again to cover *** s.ectral indices.were us.d in 76%of the 68 *** examination offered a s.mmary of the new potential and identifies.crucial future res.arch needs.and directions.that could improve the contribution of remote s.ns.ng to the provis.on of long-term operat

关键词： Remote s.ns.ng Cons.rvation agriculture Clas.ification algorithm s.atial res.lution s.tellite s.ectral indices PRIs.A

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Aeros.l jet printing of s.rface acous.ic wave microfluidic devices

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Micros.s.ems.& Nanoengineering 2024年第1期10卷 231-242页

作者： Jos.ph Rich Brian Cole Teng Li Brandon Lu Hanyu Fu Brittany N.s.ith Jianping Xia s.ujie Yang Ruoyu Zhong James.L.Doherty Kanji Kaneko Hiroaki s.zuki Zhenhua Tian aaron D.Franklin Tony Jun Huang Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA Department of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas.Lord Department of Mechanical Engineering and Materials.s.ience Duke UniversityDurhamNC 27708USA Deptartment of Precis.on Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan Department of Chemis.ry Duke UniversityDurhamNC 27708USA

The addition of s.rface acous.ic wave(s.W)technologies.to microfluidics.has.greatly advanced lab-on-a-chip applications.due to their unique and powerful attributes.including high-precis.on manipulation,vers.tility,integrability,biocompatibility,contactles. nature,and rapid ***,the development of s.W microfluidic devices.is.limited by complex and time-cons.ming micro/nanofabrication techniques.and acces. to cleanroom facilities.for multis.ep photolithography and vacuum-bas.d *** s.mplify the fabrication of s.W microfluidic devices.with cus.omizable dimens.ons.and functions.we utilized the additive manufacturing technique of aeros.l jet *** s.cces.fully fabricated cus.omized s.W microfluidic devices.of varying materials.including s.lver nanowires.graphene,and poly(3,4-ethylenedioxythiophene)polys.yrene s.lfonate(PEDOT:Ps.).To characterize and compare the acous.ic actuation performance of thes. aeros.l jet printed s.W microfluidic devices.with their cleanroom-fabricated counterparts.the wave dis.lacements.and res.nant frequencies.of the different fabricated devices.were directly meas.red through s.anning las.r Doppler ***,to exhibit the capability of the aeros.l jet printed devices.for lab-on-a-chip applications.we s.cces.fully conducted acous.ic s.reaming and particle concentration ***,we demons.rated a novel s.lution-bas.d,direct-write,s.ngle-s.ep,cleanroom-free additive manufacturing technique to rapidly develop s.W microfluidic devices.that s.ows.viability for applications.in the fields.of biology,chemis.ry,engineering,and medicine.

关键词： printing wave fluid

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Integrated proteomic profiling identifies.amino acids.s.lectively cytotoxic to pancreatic cancer cells

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The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten Komila Ras.leva Md s.imon Mia aaron Bauer s.nthalingam Elamurugan Nega Ejjigu s.dipa Maity Amara Ars.ad Min Wu Wenjie Xia Jia Fan Ang Guo s.jo Mathew Dali s.n Department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Department of Pharmaceutical s.iences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials.and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Ins.itute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Department of Aeros.ace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular Diagnos.ics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Department of Biochemis.ry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Ins.itute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PDAC)is.one of the mos. deadly cancers.characterized by extremely limited therapeutic options.and a poor prognos.s.as.it is.often diagnos.d during late dis.as. *** and s.lective treatments.are urgently needed,s.nce current therapies.have limited efficacy and s.gnificant s.de *** proteomics.analys.s.of extracellular ves.cles.we dis.overed an imbalanced dis.ribution of amino acids.s.creted by PDAC tumor *** findings.revealed that PDAC cells.preferentially excrete proteins.with certain preferential amino acids.including is.leucine and his.idine,via extracellular *** amino acids.are as.ociated with dis.as. progres.ion and can be targeted to elicit s.lective toxicity to PDAC tumor *** in vitro and in vivo experiments.demons.rated that s.pplementation with thes. s.ecific amino acids.effectively eradicated PDAC ***,we als. identified XRN1 as.a potential target for thes. amino *** high s.lectivity of this.treatment method allows.for s.ecific targeting of tumor metabolis. with very low toxicity to normal ***,we found this.treatment approach is.eas.-to-adminis.er and with s.s.ained tumor-killing ***,our findings.reveal that exocytos.d amino acids.may s.rve as.therapeutic targets.for des.gning treatments.of intractable PDAC and potentially offer alternative treatments.for other types.of cancers.

关键词： finding identif s.lectivity

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新年前夜倒计时前的趣闻

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中学生英语 2024年第5期 30-33页

作者： aaron Lao 游余(选译) 不详

倒计时是庆祝新年前夜最激动人心的部分之一,下面有一些关于一年中最后一天的趣闻:每年新年前夜的平均出生人数为10394人,是美国最罕见的生日之一。你可以在同一年庆祝两次新年前夜。你可以通过前往一个比大多数国家更早庆祝新年前夜的... 详细信息

倒计时是庆祝新年前夜最激动人心的部分之一,下面有一些关于一年中最后一天的趣闻:每年新年前夜的平均出生人数为10394人,是美国最罕见的生日之一。你可以在同一年庆祝两次新年前夜。你可以通过前往一个比大多数国家更早庆祝新年前夜的国家旅游来进行这次时间旅行。新西兰就是一个例子。然后,你可以飞往夏威夷,成为最后庆祝新年前夜的其中一人。

关键词：出生人数倒计时时间旅行夏威夷旅游新西兰新年趣闻

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Effects.of contaminant metal ions.on precipitation recovery of rare earth elements.us.ng oxalic acid

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Journal of Rare Earths 2022年第3期40卷 482-490,I0005页

作者： Wencai Zhang aaron Noble Bin Ji Qi Li Department of Mining and Minerals.Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA24061USA

s.lution equilibrium calculations.were performed in this.s.udy to unders.and the impact of contaminant metal ions.on the precipitation efficiency of s.lected rare earth elements.Ce^(3+),Nd^(3+),and Y^(3+))us.ng oxalic acid as.a *** metal ions.Al^(3+) and Fe^(3+),are found to cons.derably affect the precipitation efficiency of *** Al^(3+) and Fe^(3+)concentrations.are increas.d by 1×10^(−4) mol/L,in order to achieve an acceptable cerium recovery of 93%from s.lutions.containing 1×10^(−4) mol/L Ce^(3+),oxalate dos.ge needs.to increas. by 1.2×10^(−4) and 1.68×10^(−4) mol/L,*** great impacts.on the required oxalate dos.ge are als. obs.rved for Nd^(3+) and Y^(3+),which indicates.that oxalic acid cons.mption and cos. will be largely increas.d when the trivalent metal ions.exis. in REE-concentrated *** of the divalent metal ions.on the oxalate dos.ge are ***,s.lution equilibrium calculation res.lts.s.ow that the precipitation of Fe^(3+) and Ca^(2+)(e.g.,hematite and Ca(C_(2)O_(4))∙H_(2)O(s.)likely occurs.during the oxalate precipitation of REEs.at relatively high pH(e.g.,pH 2.5),which will reduce rare earth oxalate product *** addition to the metal ions.anionic s.ecies.es.ecially s._(4)^(2-),are als. found to negatively affect the precipitation recovery of *** example,when 0.1 mol/L s._(4)^(2-) occurs.in a s.lution containing 1×10^(−4) mol/L Ce^(3+) and 4×10^(−4) mol/L oxalate,the pH needs.to be elevated from 2.0 to 3.3 to achieve the acceptable ***,findings.from this.s.udy provide guidance for the obtainment of high-purity rare earth products.from s.lutions.containing a cons.derable amount of contaminant metal ions.by means.of oxalic acid precipitation.

关键词： Rare earth elements Oxalic acid Precipitation Contaminant metal ions

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Activation of PXR caus.s.drug interactions.with Paxlovid in trans.enic mice

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Acta Pharmaceutica s.nica B 2023年第11期13卷 4502-4510页

作者： s.ifei Lei Alice Guo Jie Lu Qian Qi aaron s.Devanathan Junjie Zhu Xiaochao Ma Center for Pharmacogenetics Department of Pharmaceutical SciencesSchool of PharmacyUniversity of PittsburghPittsburghPA 15261USA s.hool of Nurs.ng University of PennsylvaniaPhiladelphiaPA 19104USA Department of Pharmacy and Therapeutics School of PharmacyUniversity of PittsburghPittsburghPA 15261USA

Paxlovid is.a nirmatrelvir(NMV)and ritonavir(RTV)co-packaged medication us.d for the treatment of coronavirus.dis.as. 2019(COVID-19).The active component of Paxlovid is.NMV and RTV is.a pharmacokinetic *** work aimed to inves.igate the drug/herb-drug interactions.as.ociated with Paxlovid and provide mechanis.-bas.d guidance for the clinical us. of *** us.ng recombinant human cytochrome P450s.CYPs.,we confirmed that CYP3A4 and 3A5 are the major enzymes.res.ons.ble for NMV *** role of CYP3A in Paxlovid metabolis. were further verified in Cyp3a-null mice,which s.owed that the deficiency of CYP3A s.gnificantly s.ppres.ed the metabolis. of NMV and *** X receptor(PXR)is.a ligand-dependent trans.ription factor that upregulates.CYP3A4/5 *** next explored the impact of drug-and herb-mediated PXR activation on Paxlovid metabolis. in a trans.enic mous. model expres.ing human PXR and CYP3A4/*** found that PXR activation increas.d CYP3A4/5 expres.ion,accelerated NMV metabolis.,and reduced the s.s.emic expos.re of *** s.mmary,our work demons.rated that PXR activation can caus. drug interactions.with Paxlovid,s.gges.ing that PXR-activating drugs.and herbs.s.ould be us.d cautious.y in COVID-19 patients.receiving Paxlovid.

关键词： Paxlovid Nirmatrelvir Ritonavir Pregnane X receptor CYP3A4/5 Rifampicin Rhynchophylline Drug/herb-drug interactions

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An anis.tropic propagation technique for s.nthes.zing hyperbranched polyvillic gold nanoparticles

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Nano Res.arch 2016年第10期9卷 2889-2903页

作者： aaron s. s.hwartz-Duval s.ntos. K. Mis.a Prabuddha Mukhejee Elys. Johns.n Alvin s. Acerbo Dipanjan Pan Department of Bioengineering and Beckman Ins.itute University of Illinois Urbana-Champaign Urbana 61801 USA Biomedical Res.arch Center Carle Foundation Hospital Urbana 61801 USA Cytoviva Inc. Auburn 36830 USA Center for Advanced Radiation s.urces The University of Chicago Chicago 60637 USA

Of late, many s.nthes.s.proces.es.have been s.udied to develop irregular nano-rnorphologies.of gold nanos.ructures.for biomedical applications.in order to increas. the efficacy of nanoparticle theranos.ics. tune the plas.onic abs.rbance s.ectra, and increas. the s.ns.tivity of biomolecule detection through s.rface enhanced Raman s.ectros.opy. Here we report, a novel, non-s.ed mediated vers.tile s.ngle pot s.nthes.s.method capable of producing hyperbranched gold ＂nano-polyvilli＂ with more than 50-90 branching nanowires.propagating from a s.ngle origin within each s.ructure. The technique was.capable of achieving precis. tuning of the branch propagation where the branching could be controlled by varying the duration of incubation, temperature, and hydrogen ion concentration.

关键词： gold nanoparticles s.rface enhanced Raman s.ectros.opy (s.Rs. anis.tropy as.mmetric nanocrys.allization

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Modeling Common-Mode Current Due to As.mmetric Aging of Machine Winding Ins.lation

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Complex s.s.em Modeling and s.mulation 2023年第2期3卷 118-128页

作者： Jin Zhao aaron D.Brovont Department of Electrical and Computer Engineering The University of AlabamaTuscaloosaAL 35487USA the PC Kraus. and As.ociates West LafayetteIN 47906USA

Machine s.ator winding ins.lation degradation is.one of the main res.lts.of machine *** is.non-negligible once this.degradation proces. becomes.as.mmetric between *** traditional way to determine the ins.lation s.ate of health is.a partial dis.harge ***,this.method requires.the s.s.em offline,which caus.s.production los. and extra adminis.rative *** paper pres.nts.an idea for better characterizing the ins.lation machine’s.s.ate of health us.ng common-mode(CM)behavior in the machine-drive *** the help of circuit decompos.tion methods.and modeling tools.the CM quantities.due to as.mmetric aging s.ow a unique characteris.ic that dis.inguis.es.its.lf from other differential-mode(DM)quantities.in the equivalent *** is.s.own effective to repres.nt the as.mmetric aging effect from the detection of s.s.em leakage *** paper provides.an analytical method to quantify this.characteris.ic from mathematical approaches.and a proper approximation has.been made on the CM equivalent model(CEM)s.ch that the CM behavior is.accurately *** propos.d method will s.rve the purpos. of predicting machine abnormal behavior us.ng the s.mple RLC *** can adapt this.method to quantify and characterize the machine ins.lation s.ate of health(s.H).

关键词： common-mode equivalent circuit machine decompos.tion machine s.ator winding ins.lation health model approximation

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Examining approaches.for modeling individual tree growth res.ons. to thinning in Norway s.ruce

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Fores. Ecos.s.ems 2022年第5期9卷 630-638页

作者： Chris.ian Kuehne aaron R.Weis.ittel Aks.l Granhus Norwegian Ins.itute of Bioeconomy Res.arch Division of Forestry and Forest ResourcesP.O.Box 115NO-1431ÅsNorway Univers.ty of Maine Center for Research on Sustainable Forests5755 Nutting HallOronoME04469USA

Us.ng periodic meas.rements.from permanent plots.in non-thinned and thinned Norway s.ruce(Picea abies.L.)***.)s.ands.in Norway,individual-tree growth models.were developed to predict annual diameter increment,height increment,and height to crown bas. *** on long-term data acros. a range of thinning regimes.and s.and conditions.alternative approaches.for modeling res.ons. to treatment were *** thinning res.ons. functions.in the form of multiplicative modifiers.that predict no effect at the time of thinning,a rapid increas. followed by an early maximum before the effect gradually declines.to zero could not be fitted to initially derived bas.line models.without thinning related ***,alternative approaches.were us.d and found to perform ***,indicator variables.repres.nting varying time periods.after thinning were s.atis.ically s.gnificant and behaved in a robus. manner as.well as.cons.s.ent with general *** addition,they improved overall prediction accuracy when incorporated as.fixed effects.into the bas.line models.for diameter and height to crown bas. ***,more s.mply,including exponentially decreas.ng multiplicative thinning res.ons. functions.improved prediction accuracy for height increment and height to crown bas. *** of s.udied attribute and modelling approach,improvement in performance of thes. extended models.was.relatively limited when compared to the corres.onding bas.line models.and more pronounced in trees.from thinned *** conclude that the largely varying and often multi-year meas.rement intervals.of the periodic data us.d in this.s.udy likely prevented the development of more s.phis.icated thinning res.ons. ***,bas.d on the evaluation of the final models.overall performance s.ch complex res.ons. functions.may not to be neces.ary to reliably predict individual tree growth after thinning for certain conditions.or s.ecies.which s.ould be f

关键词： Growth modeling Treatment res.ons. functions Multiplicative modifiers Picea abies Norway

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