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A review of ecological impacts of global climate change on persistent organic pollutant and mercury pathways and exposures in arctic marine ecosystems

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Current Zoology 2015年第4期61卷 617-628页

作者： melissa A. mCKINNEY Sara PEDRO Rune DIETZ Christian SONNE aaron T. FISK Denis ROY Bjorn m. JENSSEN Robert J. LETCHER Department of Natural Resources and the Environment University of Connecticut Storrs CT 06269 USA Center for Environmental Sciences and Engineering University of Connecticut Storrs CT 06269 USA Department of Bioscience Arctic Research Centre Aarhus University Roskilde DK-4000 Denmark Great Lakes Institute for Environmental Research University of Windsor Windsor ON N9B 3P4 Canada Department of Biology Norwegian University of Science and Technology Trondheim NO-7491 Norway Wildlife and Landscape Science Directorate Science and Technology Branch Environment Canada National Wildlife Research Centre Carleton University Ottawa ON K1A 0H3 Canada

Bioaccumulative and biomagnifying contaminants, such as persistent organic pollutants （POPs） and mercury （Hg）, have for decades been recognized as a health concern in arctic marine biota. In recent years, global climate change （GCC） and related loss of arctic sea ice have been observed to be driving substantial change in arctic ecosystems. This review summarizes findings documenting empirical links between GCC-induced ecological changes and alterations in POP and Hg exposures and pathways in arctic marine ecosystems. most of the studies have reported changes in POP or Hg concentrations in tissue in relation to GCC-induced changes in species trophic interactions. These studies have typically focused on the role of changes in abun- dance, habitat range or accessibility of prey species, particularly in relation to sea ice changes. Yet, the ecological change that re- suited in contaminant trend changes has often been unclear or assumed. Other studies have successfully used chemical tracers, such as stable nitrogen and carbon isotope ratios and fatty acid signatures to link such ecological changes to contaminant level variations or trends. Lower sea ice linked-diet changes/variation were associated with higher contaminant levels in some popula- tions of polar bears, ringed seals, and thick-billed murres, but the influence of changing trophic interactions on POP levels and trends varied widely in both magnitude and direction. We suggest that future research in this new area of GCC-linked ecotox- icology should focus on routine analysis of ancillary ecological metrics with POP and Hg studies, simultaneous consideration of the multiple mechanisms by which GCC and contaminant interactions can occur, and targeted research on changing exposures and toxicological effects in species known to be sensitive to both GCC and contaminants [Current Zoology 61 （4）： 617-628, 2015].

关键词： Climate change Ecological change Contaminants Trends Arctic marine ecosystems

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Comparative efficacy of gypsy moth(Lepidoptera:Erebidae)entomopathogens on transgenic blight-tolerant and wild-type American,Chinese,and hybrid chestnuts(Fagales:Fagaceae)

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Insect Science 2020年第5期27卷 1067-1078页

作者： aaron J.Brown Andrew E.Newhouse William A.Powell Dylan Parry Department of Environmental and Forest Biology College of Environmental Science and ForestryState University of New YorkSyracuseNY13210USA

American chestnut(Castanea dentata[marsh.]Borkh.)was once the dominant hardwood species in Eastern North America before an exotic fungal pathogen,Cryphonec-tria parasitica(murrill)Barr,functionally eliminated it across its *** promising approach toward restoring American chestnut to natural forests is development of blight-tolerant trees using genetic ***,transformation and related processes can result in unexpected and unintended phenotypic changes,potentially altering ecologi-cal *** assess unintended tritrophic impacts of transgenic American chestnut on plant herbivore interactions,gypsy moth(Lymantria dispar L.)caterpillars were fed leaf disks excised from two transgenic events,Darling 54 and Darling 58,and four control American chestnut *** disks were previously treated with an LDso dose of either the speces-specific Lymantria dispar multiple nucleopolyhedrovirus(LdmNPV)or the generalist pathogen Bacillus thuringiensis ***(Btk).mortality was quantified and compared to water blank *** genotype had a strong efect on the efficacies of both *** mortality from Btk-treated foliage from only one transgenic event,Darling 54,differed from its isogenic progenitor,Ellis l,but was similar to an unre-lated wild-type American chestnut *** efficacy was unaffected by genetic *** suggest that although genetic modification of trees may affect interactions with other nontarget organisms,this may be due to insertion effects,and varia-tion amnon dimterent genvtypes(wlether uasgeic ul wild-typc)iupaults a giealci change in response than transgene presence.

关键词： Bacillus thuringiensis LdmNPV nontarget restoration tri-trophic unin-tended effects

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Temporally resolving premixed turbulent flame structures using self-supervised adversarial reconstruction of CH-PLIF

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能源与人工智能(英文) 2023年第1期11卷 51-62页

作者： Ji-Hun Oh aaron W.Skiba Stephen D.Hammack Constandinos m.mitsingas Campbell D.Carter Tonghun Lee Department of mechanical Science and Engineering University of Illinois at Urbana-ChampaignIL61801United States U.S.Air Force Research Laboratory Wright-Patterson Air Force BaseOH45433United States Army Research Lab Aberdeen Proving GroundMD21005United States

Understanding the turbulence-flame interaction is crucial to model the low-emission combustors developed for energy and propulsion applications. To this end, a novel frame interpolation (FI) method is proposed to better resolve the spatiotemporal evolution of premixed turbulent flame structures. The framework is completely selfsupervised, agnostic to optical flow, and driven by leveraging transferrable feature knowledge at lower speeds and adversarial learning to statistically map the flame dynamics across frames. The method is successfully applied on a 10 kHz CH planar laser-induced fluorescence (PLIF) dataset of highly wrinkled premixed flames with turbulent Reynolds numbers (ReT ) of 1100, 1400, and 7900, by down-sampling the image sequence to 5 kHz and restoring the sequence back to 10 kHz via FI. All reconstructions recovered important flame events and displayed excellent resemblance of the corrugated CH-layer geometries to that of the ground truths, with average intersection over union (IoU) and structural similarity index (SSIm) scores of 0.49 and 0.82, which are above the high-similarity baselines of 0.36 and 0.75, respectively. The wrinkling parameters (WP) of the flames also matched the ground truths, wherein R2 was roughly 0.95 for ReT = 1100 and 1400 and 0.85 for ReT = 7900 (lower due to the turbulence-induced uncertainties). The FI is further iteratively repeated to 40 kHz on the ReT = 7900 flames to facilitate pocket analysis by confidently linking their origin of formation, thus, enabling distinction from 3D tunnels, and improving statistical characterization of their consumption speeds. Given that the object features do not exhibit highly turbulent motions with regard to the initial time step, the proposed FI method is shown to be highly accurate and useful to analyzing finite-resolution experimental image sets including, but not restricted to, CH-PLIF.

关键词： Self-supervised frame interpolation Premixed turbulent flames Planar laser-induced fluorescence Generative adversarial networks Pocket behavior

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A field guide for aging passerine nestlings using growth data and predictive modeling

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Avian Research 2021年第2期12卷 141-149页

作者： Audrey A.Sanchez Andrew W.Bartlow Allison m.Chan Jeanne m.Fair aaron A.Skinner Kelly Hutchins maria A.musgrave Emily m.Phillips Brent E.Thompson Charles D.Hathcock Environmental Stewardship Los Alamos National LaboratoryLos AlamosNMUSA Biosecurity and Public Health Los Alamos National LaboratoryLos AlamosNMUSA Water Program N3BLos AlamosNMUSA

Background:Accurate nestling age is valuable for studies on nesting strategies,productivity,and impacts on repro-ductive *** aging guides consist of descriptions and photographs that are time consuming to read and subjective to *** Western Bluebird(Sialia mexicana)is a secondary cavity-nesting passerine that nests in coniferous and open deciduous *** box programs for cavity-nesting species have provided suitable nesting locations and opportunities for data collection on nestling growth and ***:We developed models for predicting the age of Western Bluebird nestlings from morphometric meas-urements using model training and *** were developed for mass,tarsus,and two different culmen ***:Our models were accurate to within less than a day,and each model worked best for a specific age *** mass and tarsus models can be used to estimate the ages of Western Bluebird nestlings 0-10 days old and were accurate to within 0.5 days for mass and 0.7 days for *** culmen models can be used to estimate ages of nest-lings 0-15 days old and were also accurate to within less than a *** daily mean,minimum,and maximum values of each morphometric measurement are provided and can be used in the field for accurate nestling age estimations in real ***:The model training and validation procedures used here demonstrate that this method can create aging models that are highly *** methods can be applied to any passerine species provided sufficient nest-ling morphometric data are available.

关键词： Cavity-nesting Nest boxes Nestling development Predictive models Western Bluebird

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Role of cytokines in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第27期14卷 4280-4288页

作者： Fausto Sanchez-muoz aaron Dominguez-Lopez Jesus K Yamamoto-Furusho Inflammatory Bowel Disease Clinic Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Vasco de Quiroga 15 colonia Sección XVI

Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), rep- resents a group of chronic disorders characterized by inflammation of the gastrointestinal tract, typically with a relapsing and remitting clinical course. mucosal mac- rophages play an important role in the mucosal im- mune system, and an increase in the number of newly recruited monocytes and activated macrophages has been noted in the inflamed gut of patients with IBD. Activated macrophages are thought to be major con- tributors to the production of inflammatory cytokines in the gut, and imbalance of cytokines is contributing to the pathogenesis of IBD. The intestinal inflammation in IBD is controlled by a complex interplay of innate and adaptive immune mechanisms. Cytokines play a key role in IBD that determine T cell differentiation of Th1, Th2, T regulatory and newly described Th17 cells. Cytokines levels in time and space orchestrate the development, recurrence and exacerbation of the inflammatory process in IBD. Therefore, several cyto- kine therapies have been developed and tested for the treatment of IBD patients.

关键词： Cytokines Inflammatory bowel disease Crohn's disease Ulcerative colitis Inflammation

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Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 866-876页

作者： Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani m Babiker aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali mcBride Department of medicine Hematology and Medical OncologyUniversity of Arizona Cancer CenterTucsonAZ 85724United States Department of medicine Internal Medicine Residency ProgramUniversity of ArizonaTucsonAZ 85725United States UC San Diego Health moores Cancer Center La JollaCA 92093United States University of Arizona College of Pharmacy TucsonAZ 85725United States

BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(mB)complications during anticoagulation treatment have an associated increase ***-VTE remains a challenging clinical scenario with mB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer *** To evaluate patient risk factors,effectiveness(VTE)and safety(mB)of DOACs and low molecular weight heparin(LmWH)in patients with active *** A retrospective chart review of patients receiving DOACs and LmWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was *** criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or *** Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and mB *** ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk *** A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were *** median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active ***-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).mB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LmWH P=0.0423;all other P=NS).Significant predictors of a prim

关键词： Direct oral anticoagulants Low molecular weight heparin Gastrointestinal cancer Venous thromboembolism Cancer associated thrombosis Clinical risk

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magnetically controlled growing instrumentation for early onset scoliosis: Caution needed when interpreting the literature

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World Journal of Orthopedics 2019年第11期10卷 394-403页

作者： Kenneth aaron Shaw Justin m Hire Scott Kim Dennis P Devito michael L Schmitz Joshua S murphy Department of Orthopaedic Surgery Dwight D.Eisenhower Army Medical CenterFort GordonGA 30905United States Department of Orthopaedic Surgery General Leonard Wood Army Community HospitalFort Leonard WoodMO 65473United States University of Tennessee Health Science Center MemphisTN 38163United States Department of Pediatric Orthopaedic Surgery Children’s Healthcare of AtlantaScottish Rite CampusAtlantaGA 30342United States

BACKGROUND magnetically controlled growing rods(mCGR) are a novel treatment option for early onset scoliosis(EOS). Although the complication profile with mCGR use has been reviewed, these reviews do not take into account important implants modifications, termed iterations, that were made due to early on postoperative complications is not well reported or *** To assess the effect of mCGR implant iterations on post-operative complications in *** A systematic review was performed to identify studies investigating mCGR specifically for the treatment of EOS, refined to those reporting the implant iteration, specifically the incorporation of the keeper plate to the implant *** with mixed implant iteration usage were excluded. Complications following surgery were recorded as well as potential risk factors and compared between implant *** Although 20 articles were identified for inclusion, 5 included mixed implant iteration leaving a total of 271 patients identified through 15 clinical studies thatmet inclusion criteria. The average follow-up was 25.4-mo. Pre-keeper plate implants were utilized in 3 studies with a total of 49 patients. Overall, 115(42.4%)post-operative complications were identified, with 87% defined as major. The addition of the keeper plate significantly decreased the rate of post-operative complications per study(35.7% vs 80.6%, P = 0.036), and the rate of distraction failure(8.1% vs 40.8%, P = 0.02). Unplanned reoperation occurred in 69(26.7%)patients but was not different between implant iteration cohorts(25.5% without keeper plate vs 27.1% with keeper plate, P = 0.92).CONCLUSION mCGR for EOS has a cumulative complication rate of 42.4% but this is significantly reduced to 35.7% when reviewing only keeper-plate enabled implants. However, 25% of published articles included mixed implant *** studies should discern between implants iterations when reporting on the usage of mCGR for EOS.

关键词： Complications Early onset scoliosis magnetically controlled growing instrumentations Keeper plate Reoperation Systematic review

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In memoriam： Wissam S. Al-Hashimi

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Episodes 2005年第4期28卷 300-300页

作者： John m. aaron IUGS Web manager 2504 Charlestown Lane Reston VA USA 20191

Dr. Wissam S. Al-Hashimi has died. His daughter, Tara, reports that he was kidnapped early in the morning of August 24 while on his way to work. The ransom demanded by his abductors was paid by his family, but to no avail. He died of two bullet wounds to his head. Because his identification was taken from him, it took his family two weeks to find his body in a Baghdad hospital. Tragic indeed, and senseless.

关键词： WissamS.A1-Hashimi 地质学家学术成就地质工作

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Fecal microbiota transplant and dermatologic disorders:A retrospective cohort study assessing the gut microbiome’s role in skin disease

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World Journal of Dermatology 2021年第1期9卷 1-10页

作者： Ashley m Snyder James Abbott m Kyle Jensen aaron m Secrest Department of Dermatology University of UtahSalt Lake CityUT 84132United States Department of Population Health Sciences University of UtahSalt Lake CityUT 84108United States Division of Pediatric Gastroenterology Hepatology and NutritionDepartment of PediatricsUniversity of UtahSalt Lake CityUT 84113United States

BACKGROUND There is indication that fecal microbiota transplant(FmT)has the potential to alter the course of chronic skin disease,but few studies have investigated this phenomenon beyond case *** with larger sample sizes is needed to provide a more thorough assessment of possible associations and to establish a broader foundation upon which to base *** To identify associations between FmT and skin conditions,particularly infectious and inflammatory etiologies,and the role of dermatology *** We conducted a retrospective cohort study involving a chart review of all patients whom received FmT between January 2013 and December 2019 at a single academic medical *** follow-up was assessed for the two years after FmT or through march 2020 for more recent *** diagnoses and visits within the study time frame were recorded and assessed for *** study was exploratory in *** statistics were calculated,and the t-test,Pearson’s chi-squared test,and Fisher’s exact test were used to calculate P *** median age was 38(range,17-90).In total,109 patients who underwent 111 fecal microbiota transplant events were ***-six events(23.4%)involved a dermatology office visit post-procedure,and of these events,20 out of the 26(76.9%)had an infectious or inflammatory skin *** mean time to first visit was 10.0(±7.0)*** most common diagnoses were dermatophyte,wart(s),and dermatitis,though no specific diagnoses predominated in a way indicating FmT had a significant *** patients with a post-FmT skin disease diagnosis had a history of Crohn’s disease compared to those without(P=0.022),but results could be affected by a small sample *** Our study is limited by its retrospective nature,but the findings allow a glimpse at dermatologic conditions *** significant associations were found,but potential associations between FmT and skin disease should

关键词： Fecal microbiota transplantation Infections Inflammation microbiota Skin diseases Retrospective studies

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Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer’s disease

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Translational Neurodegeneration 2022年第1期11卷 566-587页

作者： Christopher Daniel morrone aaron Yenhsin Lai Jossana Bishay mary Elizabeth Hill JoAnne mcLaurin Biological Sciences Sunnybrook Research InstituteTorontoON M4N 3M5Canada Department of Laboratory medicine and Pathobiology Temerty Faculty of MedicineUniversity of TorontoTorontoON M5S 1A8Canada

Background: Patient-to-patient variability in the degree to which β-amyloid, tau and neurodegeneration impact cognitive decline in Alzheimer’s disease (AD) complicates disease modeling and treatment. However, the underlying mechanisms leading to cognitive resilience are not resolved. We hypothesize that the variability in cognitive function and loss relates to neuronal resilience of the hippocampal GABAergic network. methods: We compared TgF344-AD and non-transgenic littermate rats at 9, 12, and 15 months of age. Neurons, β-amyloid plaques and tau inclusions were quantified in hippocampus and entorhinal cortex. Somatostatin (SST) and parvalbumin (PVB) interneurons were traced to examine hippocampal neuroplasticity and cognition was tested in the Barnes maze. Results: The 9-month-old TgF344-AD rats exhibited loss of neurons in the entorhinal cortex and hippocampus. Hippocampal neuronal compensation was observed in 12-month TgF344-AD rats, with upregulation of GABAergic interneuronal marker. By 15 months, the TgF344-AD rats had robust loss of excitatory and inhibitory neurons. β-Amyloid and tau pathology accumulated continuously across age. SST interneurons exhibited tau inclusions and atrophy from 9 months, whereas PVB interneurons were resilient until 15 months. The hippocampal PVB circuit underwent neuroplastic reorganization with increased dendritic length and complexity in 9- and 12-month-old TgF344- AD rats, before atrophy at 15 months. Strikingly, 12-month-old TgF344-AD rats were resilient in executive function and cognitive flexibility. Cognitive resilience in TgF344-AD rats occurred as maintenance of function between 9 and 12 months of age despite progressive spatial memory deficits, and was sustained by PVB neuroplasticity. Conclusions: Our results demonstrate the inherent neuronal processes leading to cognitive maintenance, and describe a novel finding of endogenous cognitive resilience in an AD model.

关键词： Alzheimer’s disease TgF344-AD rat GABAergic interneuron Parvalbumin Somatostatin Barnes maze Hippocampus Neuronal compensation Cognitive resilience

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