检索结果-南通市图书馆

Suppressing tawny crazy ant (Nylanderia fulva) by RNAi technology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2020年第1期27卷 113-121页

作者： Jia meng Jiaxin Lei Andrew Davitt Jocelyn RHolt Jian Huang Roger Gold Edward L Vargo aaron mtarone Keyan Zhu-Salzman College of Plant Protection Fujian Agricultural and Forestry UniversityFuzhouFujianChina Department of Entomology Texas A&M UniversityCollege StationTexasUSA Institute for Plant Genomics&Biotechnology Texas A&M UniversityCollege StationTexasUSA

A bstract The tawny crazy ant(Nylanderia fulva)is a new invasive pest in the United *** present,its management mainly relies on the use of synthetic insecticides,which are generally ineffective at producing lasting control of the pest,necessitating alternative environmentally friendly *** this study,we evaluated the feasibility of gene silencing to control this ant *** housekeeping genes encoding actin(NfActin),coatomer subunit β (NfCOPP),arginine kinase(NfArgK),and V-type proton ATPase subunits A(NfvATPaseA),B(NfvATPaseB)and E(NfvATPaseE)were *** analysis revealed high sequence similarity to homologs from other ant species,particularly the Florida carpenter ant(Camponotus floridanus).To silence these genes,vector L4440 was used to generate six specific RNAi constructs for bacterial ***-inactivated,dsRNA-expressing Escherichia coli were incorporated into artificial *** ants exhibited reduced endogenous gene expression after feeding on such diet for 9 ***,only ingestion of dsRNAs of NfCOPfi(a gene involved in protein trafficking)and NfArgK(a cellular energy reserve regulatory gene in invertebrates)caused modest but significantly higher ant mortality than the *** results suggest that bacterially expressed dsRNA can be orally delivered to ant cells as a mean to target its *** efficacy is necessary for the RNAi-based approach to be useful in tawny crazy ant management.

关键词： artificial diet gene silencing housekeeping gene Nylanderia fulva RNAi survival rate

Evaluation of large language models for the classification of medical device software

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and manufacturing 2024年第5期7卷 819-822页

作者： Yu Han aaron Ceross Florence Bourgeois Paulo Savaget Jeroen H.m.Bergmann Department of Engineering Science University of OxfordOld Road CampusOxford OX37QDUK Harvard-mIT Center for Regulatory Science Harvard Medical SchoolBostonMAUSA Computational Health Informatics Program(CHIP) Boston Children’s HospitalBostonMAUSA Department of Technology and Innovation The University of Southern DenmarkOdenseDenmark

Amidst the rapidly expanding integration of large language models(LLms)across various sectors(ranging from everyday applications to specialized fields demanding stringent regulatory adherence),our investigation seeks to determine how well these models can support medical device software *** device classification functions to systematically categorize devices according to their designated use,associated risk levels,and requisite regulatory oversight,thereby providing a structured framework for ensuring safety and efficacy as mandated by regulatory authorities.

关键词： everyday demanding thereby

Assessing gully erosion and rehabilitation using multi temporal LiDAR DEms:Case study from the Great Barrier Reef catchments,Australia

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Soil and Water Conservation Research 2024年第1期12卷 184-199页

作者： Sana Khan Rebecca Bartley Anne Kinsey-Henderson aaron Hawdon The Commonwealth Scientific and Industrial Research Organisation(CSIRO) Environment1 James Cook DrDouglas4814Australia The Commonwealth Scientific and Industrial Research Organisation(CSIRO) EnvironmentGPO Box 2583BrisbaneQLD4001Australia

millions of dollars are being spent on gully rehabilitation to help reduce excess fine sediment delivery to the Great Barrier Reef(GBR).There is an urgent need for(i)prioritisation of active gullies for rehabilitation and(ii)the development of methodologies to inform the effectiveness of *** this study we analyse DEms of Difference derived from 0.5 m resolution 2-3 year interval multi-temporal LiDAR data collected pre and post rehabilitation at three variable gully morphologies in the Burdekin *** analysis indicates that the highest annual average fine sediment erosion rates for the untreated control gullies occur at the linear gully(53.38 t ha^(-1)y^(-1))followed by linear-alluvial gully(34.24 t ha^(-1)y^(-1))and least at the alluvial gully(14.41 t ha^(-1)y^(-1)).The proportional loss or export of fine sediment from the gullies in their un-treated condition ranges from∼68 to 90%of what is eroded,and when the gullies are treated the proportion of fine sediment that is retained in the gully proportional to what is eroded increases to∼60%at all *** pre-treatment baseline erosion rates,and additional post treatment LiDAR captures,it is difficult to quantify the treatment *** results offer insights in the erosion mechanisms within different geomorphic gully morphologies and rehabilitation effects in these erosional *** study provides crucial knowledge of gully dynamics that can be coupled with other lines of evidence for better prioritisation of rehabilitation in the GBR catchments.

关键词： Digital elevation models (dis)connectivity Restoration Geomorphic change detection Geomorphic effectiveness GIS

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKm supports antitumor immunity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & molecular Immunology 2024年第3期21卷 260-274页

作者： G.aaron Holling Colin A.Chavel Anand P.Sharda mackenzie m.Lieberman Caitlin m.James Shivana m.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew m.Intlekofer Richard m.Higashi Teresa W.m.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:massachusetts Institute of Technology BostonMA 02139USA Present address:melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the m1 isoform of pyruvate kinase in favor of PKm2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKm alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKm2

毛瑟在中国:中正式的前身——m1924标准型步枪

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

轻兵器 2024年第2期 36-39页

作者： aaron Zou 不详

受《凡尔赛条约》的限制,一战后的德国仅允许保留西姆森公司(Simson&Co)生产的军用步枪。同时,比利时和捷克斯洛伐克通过战争赔偿的形式获得了制造和出口毛瑟式步枪的权利,两国生产的毛瑟式步枪迅速占领了世界市场,毛瑟公司失去了原本... 详细信息

受《凡尔赛条约》的限制,一战后的德国仅允许保留西姆森公司(Simson&Co)生产的军用步枪。同时,比利时和捷克斯洛伐克通过战争赔偿的形式获得了制造和出口毛瑟式步枪的权利,两国生产的毛瑟式步枪迅速占领了世界市场,毛瑟公司失去了原本利润丰厚的收入。

关键词：毛瑟公司战争赔偿标准型捷克斯洛伐克世界市场步枪比利时

The role of estradiol in male reproductive function

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2016年第3期18卷 435-440,I0009页

作者： michael Schulster aaron m Bernie Ranjith Ramasamy Department of Urology New York-Presbyterian Hospital Weill Cornell Medical College New York USA Department of Urology Miller School of Medicine University of Miami Miami FL USA.

Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual function. Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis. Estrogen receptors, as well as aromatase, the enzyme that converts testosterone to estrogen, are abundant in brain, penis, and testis, organs important for sexual function. In the brain, estradiol synthesis is increased in areas related to sexual arousal. In addition, in the penis, estrogen receptors are found throughout the corpus cavernosum with high concentration around neurovascular bundles. Low testosterone and elevated estrogen increase the incidence of erectile dysfunction independently of one another. In the testes, spermatogenesis is modulated at every level by estrogen, starting with the hypothalamus-pituitary-gonadal axis, followed by the Leydig, Sertoli, and germ cells, and finishing with the ductal epithelium, epididymis, and mature sperm. Regulation of testicular cells by estradiol shows both an inhibitory and a stimulatory influence, indicating an intricate symphony of dose-dependent and temporally sensitive modulation. Our goal in this review is to elucidate the overall contribution of estradiol to male sexual function by looking at the hormone＇s effects on erectile function, spermatogenesis, and libido.

关键词： estrogen testosterone spermatogenesis erectile function estrogen receptor aromatase

Experimental Analysis of Atypically Long Finned Oscillating Heat Pipe for Ventilation Waste Heat Recovery Application

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2020年第3期29卷 667-675页

作者： mAHAJAN Govinda CHO Heejin SmITH aaron THOmPSON Scott m. Rheem manufacturing MontgomeryAL 36109USA Department of mechanical Engineering Mississippi State UniversityMsissippi StateMS 39762USA Department of mechanical Engineering Auburn UniversityAubumnAL 36849USA

Oscillating heat pipes(OHP)which are constructed from a serpentine-arranged capillary tube possess a desirable aerodynamic form factor and provide for relatively high heat transfer rates via cyclic evaporation and condensation of an encapsulated working fluid with no internal wicking structure *** last two decades,OHP has been extensively investigated for its potential application in thermal management of various *** study presents an experimental investigation on the heat transfer performance of an atypically long finned *** heat transfer performance of the proposed OHP was analyzed and compared with a bare tube OHP with similar overall *** show that a unit row of finned OHP filled with n-pentane with fill ratio of 70%can recover up to(400±40)W of heat from a typical waste exhaust air *** additional pressure drop due to fins was estimated to be(6.8±2)Pa resulting in an increase of 1–2 W of fan power *** average heat recovery rate via finned OHP was found to be almost 80%more than bare tube OHP filled with same working fluid with same fill ratio.

关键词： oscillating heat pipe waste heat recovery ventilation

Cytokinin-mediated nuclear shuttling of mYB3R4 regulates cell division

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

molecular Plant 2021年第5期14卷 720-721页

作者： m.Arif Ashraf aaron m.Rashotte Department of Biology University of Massachusetts AmherstAmherstMA 01003USA Department of Biological Sciences Auburn UniversityAuburnAL 36849USA

The plant hormone cytokinin,an N6-substituted adenine derivative,was first discovered by Carlos miller and Folke Skoog nearly 70 years ago as being able to promote cell *** then,there have been great advances in our understanding of cytokinin biosynthesis,perception and signaling,and expanded roles across plant growth and development(Schaller et al.,2014).However,the molecular mechanism underlying cytokinin-mediated cell division for which this hormone was first identified is still poorly *** ***-mediated nuclear import of mYB3R4.

关键词： Figure expanded mediated

Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2015年第6期7卷 899-921页

作者： aaron B Bradford Patrick m mcNutt Cell/molecular Biology Branch US Army Medical Research Institute of Chemical DefenseAberdeen Proving Grounds-EAMD 21010United States

Functional synaptogenesis and network emergence are signature endpoints of neurogenesis. These behaviors provide higher-order confirmation that biochemical and cellular processes necessary for neurotransmitter release, post-synaptic detection and network propagationof neuronal activity have been properly expressed and coordinated among cells. The development of synaptic neurotransmission can therefore be considered a defining property of neurons. Although dissociated primary neuron cultures readily form functioning synapses and network behaviors in vitro, continuously cultured neurogenic cell lines have historically failed to meet these criteria. Therefore, in vitro-derived neuron models that develop synaptic transmission are critically needed for a wide array of studies, including molecular neuroscience, developmental neurogenesis, disease research and neurotoxicology. Over the last decade, neurons derived from various stem cell lines have shown varying ability to develop into functionally mature neurons. In this review, we will discuss the neurogenic potential of various stem cells populations, addressing strengths and weaknesses of each, with particular attention to the emergence of functional behaviors. We will propose methods to functionally characterize new stem cell-derived neuron(SCN) platforms to improve their reliability as physiological relevant models. Finally, we will review how synaptically active SCNs can be applied to accelerate research in a variety of areas. Ultimately, emphasizing the critical importance of synaptic activity and network responses as a marker of neuronal maturation is anticipated to result in in vitro findings that better translate to efficacious clinical treatments.

关键词： Synapses Neurotransmission In vitrotechniques Induced pluripotent stem cells Neuronalnetworks Neurogenesis Neural stem cells Embryonicstem cells Induced neurons