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Horticulture Research 2016年第1期3卷 59-67页

作者： Xuan Gao aaron E Walworth Charity mackie Guo-qing Song Department of Horticulture Plant Biotechnology Resource and Outreach CenterMichigan State UniversityEast LansingMI 48824USA Key Laboratory for the Conservation and Utilization of Important Biological Resources College of Life SciencesAnhui Normal UniversityWuhu 241000China

Flowering locus T(FT)is a primary integrator in the regulation of plant *** a blueberry(Vaccinium corymbosum L.)FT gene(VcFT)(herein VcFT-OX)resulted in early flowering and dwarfing in‘Aurora’plants(herein‘VcFT-Aurora’).In this study,we found that VcFT-OX reduced shoot regeneration from leaf *** investigate the potential roles of the phytohormone pathway genes associated with VcFT-OX,differentially expressed(DE)genes in leaf tissues of‘VcFT-Aurora’plants were annotated and analyzed using non-transgenic‘Aurora’plants as a *** DE floral genes,including the blueberry SUPPRESSOR of Overexpression of constans 1(VcSOC1)(gibberellin related),Abscisic acid responsive elements-binding factor 2(VcABF2)and protein related to ABI3/VP1(VcABI3/VP1)(ethylene-related),are present under both the phytohormone-responsive and the dwarfing-related Gene Ontology *** gene networks of the DE genes overall showed the molecular basis of the multifunctional aspects of VcFT overexpression beyond flowering promotion and suggested that phytohormone changes could be signaling molecules with important roles in the phenotypic changes driven by VcFT-OX.

关键词： Aurora dwarf blue

mitomycin C and capecitabine: An additional option as an advanced line therapy in patients with metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1913-1924页

作者： Gil mullin michal Sternschuss Yosef Landman aaron Sulkes Baruch Brenner Faculty of medicine Tel-Aviv UniversityTel Aviv 6997801Israel Institute of Oncology Davidoff Cancer CenterBeilinson CampusPetah-Tikva 4941492Israel

BACKGROUND In recent years survival of patients with metastatic colorectal cancer(mCRC),though still limited,has improved significantly;clearly,when the disease becomes refractory to standard regimens,additional treatment options are *** have shown that mitomycin C(mmC),an antitumor antibiotic,and capecitabine,a precursor of 5-fluorouracil,may act synergistically in *** efficacy of mmC/capecitabine has been demonstrated in the first-line setting,but only a few small studies have tested it in the advanced-line setting,with contradictory *** a median of 2 mmC/capecitabine cycles(range 0.5-9.0).Thirty-four patients(28.6%)experienced grade≥3 toxicity,including 2(1.7%)with grade 4;there was no drug-related *** objective response rate was 0.8%,and the disease control rate,24.4%.median progression-free survival(PFS)was 2.1 mo(range 0.2-20.3),and median overall survival,4.8 mo(range 0.2-27.5).The 6-month overall survival rate was 44%;8.7%of patients remained *** associated with longer PFS were lower gamma-glutamyl transferase level(P=0.030)and primary tumor location in the left colon(P=0.017).Factors associated with longer overall survival were lower gamma-glutamyl transferase level(P=0.022),left-colon tumor location(P=0.044),low-to-moderate histological grade(P=0.012),Eastern Cooperative Oncology Group performance status 0-1(P=0.036),and normal bilirubin level(P=0.047).CONCLUSION mmC/capecitabine is an active,available,and relatively safe regimen for use beyond standard lines of therapy in *** clinical and laboratory parameters can identify patients more likely to benefit.

关键词： Colorectal cancer metastatic cancer Chemotherapy mitomycin C/Capecitabine Advanced line treatment

Editing landscapes:Experimental frameworks for territorial-based robotic fabrication

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Frontiers of Architectural Research 2023年第1期12卷 104-117页

作者： Karen Lee Bar-Sinai Tal Alon-mozes aaron Sprecher Faculty of Architecture and Town Planning Technion-Israel Institute of TechnologyHaifa 3200003Israel

With the advent of on-site robotic tools,they can be deployed for editing landscapes e defined as the modulation of grounds with a high degree of sensitivity to matter and *** paper contributes a theoretical grounding and two experimental frameworks for territorial-based robotic *** experimental framework supports a robotic capacity for informing and forming grounds,demonstrated in relation to extreme territories using simulation *** frameworks include(1)a layer-sensitive modulation for protecting topsoil and(2)a performance-based robotic forming for creating wind *** each framework,the paper proposes a setup,an exploration method,and an evaluation *** on the presented frameworks,the paper outlines three potentials of territorialbased robotic fabrication:the capability to modulate grounds vertically,the possibility to perform cross-scalar forming,and the opportunity to form dynamic,performative *** paper concludes with potential ways in which robotic tools could be leveraged for advancing precise landscape editing across scales.

关键词： Landscape modulation Robotic fabrication Informing grounds Performative design Territorial-based design

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The Depression era

The Depression era

A review of ecological impacts of global climate change on persistent organic pollutant and mercury pathways and exposures in arctic marine ecosystems

作者： (1951-)Barlow aaron

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Current Zoology 2015年第4期61卷 617-628页

作者： melissa A. mCKINNEY Sara PEDRO Rune DIETZ Christian SONNE aaron T. FISK Denis ROY Bjorn m. JENSSEN Robert J. LETCHER Department of Natural Resources and the Environment University of Connecticut Storrs CT 06269 USA Center for Environmental Sciences and Engineering University of Connecticut Storrs CT 06269 USA Department of Bioscience Arctic Research Centre Aarhus University Roskilde DK-4000 Denmark Great Lakes Institute for Environmental Research University of Windsor Windsor ON N9B 3P4 Canada Department of Biology Norwegian University of Science and Technology Trondheim NO-7491 Norway Wildlife and Landscape Science Directorate Science and Technology Branch Environment Canada National Wildlife Research Centre Carleton University Ottawa ON K1A 0H3 Canada

Bioaccumulative and biomagnifying contaminants, such as persistent organic pollutants （POPs） and mercury （Hg）, have for decades been recognized as a health concern in arctic marine biota. In recent years, global climate change （GCC） and related loss of arctic sea ice have been observed to be driving substantial change in arctic ecosystems. This review summarizes findings documenting empirical links between GCC-induced ecological changes and alterations in POP and Hg exposures and pathways in arctic marine ecosystems. most of the studies have reported changes in POP or Hg concentrations in tissue in relation to GCC-induced changes in species trophic interactions. These studies have typically focused on the role of changes in abun- dance, habitat range or accessibility of prey species, particularly in relation to sea ice changes. Yet, the ecological change that re- suited in contaminant trend changes has often been unclear or assumed. Other studies have successfully used chemical tracers, such as stable nitrogen and carbon isotope ratios and fatty acid signatures to link such ecological changes to contaminant level variations or trends. Lower sea ice linked-diet changes/variation were associated with higher contaminant levels in some popula- tions of polar bears, ringed seals, and thick-billed murres, but the influence of changing trophic interactions on POP levels and trends varied widely in both magnitude and direction. We suggest that future research in this new area of GCC-linked ecotox- icology should focus on routine analysis of ancillary ecological metrics with POP and Hg studies, simultaneous consideration of the multiple mechanisms by which GCC and contaminant interactions can occur, and targeted research on changing exposures and toxicological effects in species known to be sensitive to both GCC and contaminants [Current Zoology 61 （4）： 617-628, 2015].

关键词： Climate change Ecological change Contaminants Trends Arctic marine ecosystems

Errors in visual estimation of flexion contractures during total knee arthroplasty

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World Journal of Orthopedics 2013年第3期4卷 120-123页

作者： Cale A Jacobs Christian P Christensen Peter W Hester David m Burandt aaron D Sciascia Lexington Clinic LexingtonKY 40504United States

AIm: To quantify and reduce the errors in visual estimation of knee flexion contractures during total knee arthroplasty(TKA).mETHODS: This study was divided into two parts: Quantification of error and reduction of error. To quantify error, 3 orthopedic surgeons visually estimated preoperative knee flexion contractures from lateral digital images of 23 patients prior to and after surgical draping. A repeated-measure analysis of variance was used to compare the estimated angles prior to and following the placement of the surgical drapes with the true knee angle measured with a long-arm goniometer. In an effort to reduce the error of visual estimation, a dual set of inclinometers was developed to improve intraoperative measurement of knee flexion contracture during TKA. A single surgeon performed 6 knee extension measurements with the device during 146 consecutive TKA cases. Three measurements were taken with the desired tibial liner trial thickness, and 3 were taken with a trial that was 2 mm thicker. An intraclass correlation coefficient(ICC) was calculated to assess the testretest reliability for the 3 measurements taken with the desired liner thickness, and a paired t test was used to determine if the knee extension measurements differed when a thicker tibial trial liner was ***: The surgeons significantly overestimated flexion contractures in 23 TKAs prior to draping and significantly underestimated the contractures after draping(actual knee angle = 6.1°± 6.4°, pre-drape estimate = 6.9°± 6.8°, post-drape estimate = 4.3°± 6.1°, P = 0.003). Following the development and application of the measurement devices, the measurements were highly reliable(ICC = 0.98), and the device indicated that 2.7°± 2.2° of knee extension was lost with the insertion of a 2 mm thicker tibial liner. The device failed to detect a difference in knee extension angle with the insertion of the 2 mm thicker liner in 9/146 cases(6.2%).CONCLUSION: We determined the amount of error assoc

关键词： Extension Knee Arthroplasty Flexion contracture

H_(2)mediated mixed culture microbial electrosynthesis for high titer acetate production from CO_(2)

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Environmental Science and Ecotechnology 2024年第3期19卷 125-131页

作者： Yanhong Bian aaron Leininger Harold D.may Zhiyong Jason Ren Department of Civil and Environmental Engineering Princeton University86 Olden StPrincetonNJ08544United States Andlinger Center for Energy and the Environment Princeton University86 Olden St.PrincetonNJ08544United States

microbial electrosynthesis(mES)converts CO_(2)into value-added products such as volatile fatty acids(VFAs)with minimal energy use,but low production titer has limited scale-up and *** electron transfer via H_(2)on the mES cathode has shown a higher conversion rate than the direct biofilm-based approach,as it is tunable via cathode potential control and accelerates electrosynthesis from CO_(2).Here we report high acetate titers can be achieved via improved in situ H_(2)supply by nickel foam decorated carbon felt cathode in mixed community mES *** concentration of 12.5 g L^(-1)was observed in 14 days with nickel-carbon cathode at a poised potential of-0.89 V(*** hydrogen electrode,SHE),which was much higher than cathodes using stainless steel(5.2 g L^(-1))or carbon felt alone(1.7 g L^(-1))with the same projected surface area.A higher acetate concentration of 16.0 g L^(-1)in the cathode was achieved over long-term operation for 32 days,but crossover was observed in batch operation,as additional acetate(5.8 g L^(-1))was also found in the abiotic anode *** observed the low Faradaic efficiencies in acetate production,attributed to partial H_(2)utilization for *** selective acetate production with high titer demonstrated in this study shows the H_(2)-mediated electron transfer with common cathode materials carries good promise in mES development.

关键词： microbial electrosynthesis Indirect electron transfer CO_(2)electrolysis VFAs production

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孔隙介质中含砷聚集物的三维成像

西南交通大学学报 2011年第6期46卷 973-978页

作者：彭道平黄涛 aaron PACKmAN 西南交通大学地球科学与环境工程学院四川成都610031 美国西北大学土木与环境工程系伊利诺伊州埃文斯顿60208

为观测砷沉积导致的孔隙介质内部结构的改变,采用X射线差异微断层扫描技术,扫描从Loa流域获得的河床沉积物和实验室配制的含砷样品,对含砷聚集物在孔隙介质中的分布进行了成像分析.经过图像处理去除图像上的噪点和增强图像中砷的信息,... 详细信息

为观测砷沉积导致的孔隙介质内部结构的改变,采用X射线差异微断层扫描技术,扫描从Loa流域获得的河床沉积物和实验室配制的含砷样品,对含砷聚集物在孔隙介质中的分布进行了成像分析.经过图像处理去除图像上的噪点和增强图像中砷的信息,获得了孔隙介质中含砷聚集物的三维数据组;采用Avizo 6和Blob3D等工具,对三维数据组进行重建和可视化.成像显示:大量含砷聚集物沉积在介质孔隙和介质表面;不同尺寸聚集物的形态呈现出明显的多样化特征———小颗粒聚集物趋于球形,大颗粒聚集物则趋于扁平状.研究表明,该技术可在不破坏样品的前提下,实现对孔隙介质沉积前后内部结构变化的直接观测.

关键词：孔隙介质 X射线差异微断层扫描技术砷图像处理三维成像

Comparative efficacy of gypsy moth(Lepidoptera:Erebidae)entomopathogens on transgenic blight-tolerant and wild-type American,Chinese,and hybrid chestnuts(Fagales:Fagaceae)

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Insect Science 2020年第5期27卷 1067-1078页

作者： aaron J.Brown Andrew E.Newhouse William A.Powell Dylan Parry Department of Environmental and Forest Biology College of Environmental Science and ForestryState University of New YorkSyracuseNY13210USA

American chestnut(Castanea dentata[marsh.]Borkh.)was once the dominant hardwood species in Eastern North America before an exotic fungal pathogen,Cryphonec-tria parasitica(murrill)Barr,functionally eliminated it across its *** promising approach toward restoring American chestnut to natural forests is development of blight-tolerant trees using genetic ***,transformation and related processes can result in unexpected and unintended phenotypic changes,potentially altering ecologi-cal *** assess unintended tritrophic impacts of transgenic American chestnut on plant herbivore interactions,gypsy moth(Lymantria dispar L.)caterpillars were fed leaf disks excised from two transgenic events,Darling 54 and Darling 58,and four control American chestnut *** disks were previously treated with an LDso dose of either the speces-specific Lymantria dispar multiple nucleopolyhedrovirus(LdmNPV)or the generalist pathogen Bacillus thuringiensis ***(Btk).mortality was quantified and compared to water blank *** genotype had a strong efect on the efficacies of both *** mortality from Btk-treated foliage from only one transgenic event,Darling 54,differed from its isogenic progenitor,Ellis l,but was similar to an unre-lated wild-type American chestnut *** efficacy was unaffected by genetic *** suggest that although genetic modification of trees may affect interactions with other nontarget organisms,this may be due to insertion effects,and varia-tion amnon dimterent genvtypes(wlether uasgeic ul wild-typc)iupaults a giealci change in response than transgene presence.

关键词： Bacillus thuringiensis LdmNPV nontarget restoration tri-trophic unin-tended effects

Type 1 diabetes:A predictable disease

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World Journal of Diabetes 2015年第3期6卷 380-390页

作者： Kimber m Simmons aaron W michels Barbara Davis Center for Childhood Diabetes University of Colorado Denver

Type 1 diabetes(T1D) is an autoimmune disease characterized by loss of insulin producing beta cells and reliance on exogenous insulin for survival.T1 D is one of the most common chronic diseases in childhood and the incidence is increasing,especially in children less than 5 years of *** individuals with a genetic predisposition,an unidentified trigger initiates an abnormal immune response and the development of islet autoantibodiesdirected against proteins in insulin producing beta *** are currently four biochemical islet autoantibodies measured in the serum directed against insulin,glutamic decarboxylase,islet antigen 2,and zinc transporter *** of islet autoantibodies occurs before clinical diagnosis of T1 D,making T1 D a predictable disease in an individual with 2 or more *** for islet autoantibodies is still predominantly done through research studies,but efforts are underway to screen the general *** benefits of screening for islet autoantibodies include decreasing the incidence of diabetic ketoacidosis that can be life threatening,initiating insulin therapy sooner in the disease process,and evaluating safe and specific therapies in large randomized clinical intervention trials to delay or prevent progression to diabetes onset.

关键词： Autoimmunity Autoantibodies Diabetesprevention Screening Type 1 diabetes