检索结果-南通市图书馆

VcRR2 regulates chilling-mediated flowering through expression of hormone genes in a transgenic blueberry mutant

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2019年第1期6卷 531-546页

作者： Tianyi Lin aaron Walworth Xiaojuan Zong Gharbia H.Danial Elise m.Tomaszewski Pete Callow Xiumei Han L.Irina Zaharia Patrick P.Edger Gan-yuan Zhong Guo-qing Song Plant Biotechnology Resource and Outreach Center Department of HorticultureMichigan State UniversityEast LansingMI 48824USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Aquatic and Crop Resource Development National Research Council of CanadaSaskatoonSK S7N 0W9Canada Grape Genetics Research Unit USDA-ARSGenevaNY 14456USA

The molecular mechanism underlying dormancy release and the induction of flowering remains poorly understood in woody ***-legacy is a valuable blueberry mutant,in which a transgene insertion caused increased expression of a RESPONSE REGULATOR 2-like gene(VcRR2).mu-legacy plants,compared with nontransgenic‘Legacy’plants,show dwarfing,promotion of flower bud formation,and can flower under nonchilling *** conducted transcriptomic comparisons in leaves,chilled and nonchilled flowering buds,and late-pink buds,and analyzed a total of 41 metabolites of six groups of hormones in leaf tissues of both mu-legacy and‘Legacy’*** analyses uncovered that increased VcRR2 expression promotes the expression of a homolog of Arabidopsis thaliana ENTCOPALYL DIPHOSPHATE SYNTHETASE 1(VcGA1),which induces new homeostasis of hormones,including increased gibberellin 4(GA4)levels in mu-legacy ***,increased expression of VcRR2 and VcGA1,which function in cytokinin responses and gibberellin synthesis,respectively,initiated the reduction in plant height and the enhancement of flower bud formation of the mu-legacy plants through interactions of multiple *** nonchilled flower buds,29 differentially expressed transcripts of 17 genes of five groups of hormones were identified in transcriptome comparisons between mu-legacy and‘Legacy’plants,of which 22 were chilling ***,these analyses suggest that increased expression of VcRR2 was collectively responsible for promoting flower bud formation in highbush blueberry under nonchilling *** report here for the first time the importance of VcRR2 to induce a suite of downstream hormones that promote flowering in woody plants.

关键词： collective insertion dwarf

Controversial role of arthroscopic meniscectomy of the knee: A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2016年第5期7卷 287-292页

作者： Austin Y Ha Robert m Shalvoy Anne Voisinet Jennifer Racine Roy K aaron Department of Orthopaedic Surgery Warren Alpert Medical School of Brown University

The role of arthroscopic partial meniscectomy(APm) in reducing pain and improving function in patients with meniscal tears remains controversial. Five recent highquality randomized controlled trials(RCTs) compared non-operative management of meniscal tears to APm, with four showing no difference and one demonstrating superiority of APm. In this review, we examined the strengths and weaknesses of each of these RCTs, with particular attention to the occurrence of inadvertent biases. We also completed a quantitative analysis that compares treatment successes in each treatment arm, considering crossovers as treatment failures. Our analysis revealed that each study was an excellent attempt to compare APm with non-surgical treatment but suffered from selection, performance, detection, and/or transfer biases that reduce confidence in its conclusions. While the RCT remains the methodological gold standard for establishing treatment efficacy, the use of an RCT design does not in itself ensure internal or external validity. Furthermore, under our alternative analysis of treatment successes, two studies had significantly more treatment successes in the APm arm than the non-operative arm although original intention-totreat analyses showed no difference between these two groups. Crossovers remain an important problem in surgical trials with no perfect analytical solution. With the studies available at present, no conclusion can be drawn concerning the optimal treatment modality for meniscal tears. Further work that minimizes significant biases and crossovers and incorporates sub-group and cost-benefit analyses may clarify therapeutic indications.

关键词： Arthroscopic partial meniscectomy meniscal tear Knee osteoarthritis Physical therapy Randomized controlled trial Crossover Bias

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

更好的一个（混音版）

疯狂英语（初中天地） 2005年第12期 4-5页

作者： aaron Carter

Give me half the chance I'll make you understand That what I got to give So much more that this Than you'll ever know I don't say what's on my mind But you'll find this out in time Don't always open up I'm not quick to

关键词： Be

A systematic review on embodiment and breast reconstruction:a patient-centered framework for evolving breast outcome measures

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plastic and Aesthetic Research 2023年第1期10卷 783-796页

作者： madeline G.Chin Sahand C.Eftekari Steven P.moura D’Andrea T.Donnelly Ellen C.Shaffrey Lucas Sears aaron m.Dingle Division of Plastic Surgery The Warren Alpert Medical School of Brown UniversityProvidenceRI 02903USA Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthMadisonWI 53705USA

Embodiment describes the sense of one’s own body,encompassing dimensions of being,having,and using a *** breast reconstruction,embodiment can be understood as how effectively the reconstructed breast replaces the patient’s missing *** there has been increasing attention in recent decades on understanding and measuring embodiment in the prosthetic limb,there is limited literature applying embodiment to the context of breast *** posit that the literature on prosthetic embodiment can be applied to evolving discussions on breast reconstruction outcomes and patient *** breast reconstruction techniques continue to evolve,such as advances in nerve coaptation and reinnervation of the breasts,the concept of embodiment may help broaden the scope of how patient outcomes can be more holistically *** systematic review examines existing literature on embodiment after breast reconstruction,summarizes embodiment and its subcomponents,and discusses how embodiment can be a helpful framework for the future of breast reconstruction outcome measures.

关键词： Embodiment breast reconstruction prosthetic embodiment

SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第9期30卷 1647-1651页

作者： Haifang Liu Yuanqiang Sun Zhaohui Li Ran Yang Jie Yang aaron Albert Aryee Xiaoge Zhang Jia Ge Lingbo Qu Yuehe Lin Institute of Chemical Biology and Clinical Application at The First Affiliated Hospital Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications Zhengzhou University Zhengzhou 450001 China School of mechanical and materials Engineering Washington State University Pullman WA 99164 United States

Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications.

关键词： Carbon dots Rationally design SciFinder database Ratiometric monitoring Intracellular pH

Integrated Soil Fertility management: Impact of mucunaand TithoniaBiomass on Tomato (Lycopersicon esculentumL.) Performance in Smallholder Farming Systems

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences 2015年第10期6卷 1176-1186页

作者： Christopher Ngosong Priscilla m. mfombep Akeme C. Njume aaron S. Tening Department of Agronomic and Applied molecular Sciences Faculty of Agriculture and Veterinary Medicine University of Buea Buea Cameroon Department of Agriculture Higher Technical Teachers’ Training College Kumba University of Buea Buea Cameroon

many views, paradigms and concepts have been advocated in recent decades on soil fertility and soil conservation across the globe in order to provide sustainable solutions to the rising food and nutrition insecurity while preserving the natural resource base. meanwhile, food and nutrition security in Sub-Saharan Africa (SSA) is mainly achieved through smallholder farming systems that are characterized by poor and declining soil fertility, which often leads to low crop yields and low income. Hence, a field trial was established to evaluate the impact of integrated soil fertility management (ISFm) practices on tomato yield and the farm-scale income in smallholder farming systems. The ISFm trial comprised a control with no input, mineral fertilizer, and organic treatments comprising sole mucuna and Tithonia biomasses as well as their combination (mucuna + Tithonia). Generally, tomato performance was better with organic plant biomass amendments, with significantly higher (P mucuna + Tithonia and sole Tithonia, followed by sole mucuna and mineral fertilizer compared to the control. meanwhile in comparison to the control, mucuna + Tithonia and sole Tithonia recorded 3.5 and 3.4 t ha-1 more yield, respectively, which was about twice the additional yield for sole mucuna and mineral fertilizer with 1.8 and 1.5 t ha-1, respectively (Tukey’s HSD, P mucuna + Tithonia and sole Tithonia, followed by sole mucuna and mineral fertilizer, as compared to the control (Tukey’s HSD, P P P mucuna + Tithonia biomass materials or their sole applications as basal mulch to improve tomato production. Thus, these organic amendments could be an alternative and sustainable integrated soil fertility management strategy to boost tomato production and farm-scale income without jeopardizing the sustainability of the environment. However, this requires more efforts to adapt the different ISFm techniques to the specific needs of smallholder farmers, coupled with effective dissemination strategies that

关键词： Integrated Soil Fertility management mucuna Tithonia mineral Fertilizer Tomato

Progressive βCell Failure in Type 2 Diabetes mellitus: microvascular Pancreatic Isletopathy?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Diabetes mellitus 2015年第1期5卷 21-27页

作者： Udaya m. Kabadi mary U. Kabadi Sommany Weber aaron Bubolz Edward Finnerty University of Iowa Carver College of medicine Iowa City Iowa USA VA medical Center Phoenix Arizona USA Des moines University Des Moines Iowa USA

Background: UKPDS suggested relentless deterioration of β cell function as a part of natural course of type 2 diabetes mellitus. However, the course was apparently not universal since many patients maintained glycemic goal (HbA1c β cell failure occurred around the same time as the time of onset of microvascular complications. Finally, the exact mechanism of progressive β cell failure remains to be defined. It is plausible that β cell failure may be due to fibrosis of pancreatic islets secondary to microangiopathy since no organ or tissue is exempt from this complication. Objective: To assess epidemiologic correlation between presence of b cell failure and microvascular complications by determining the prevalence of β cell failure in subjects with type 2 diabetes with increasing number of known microvascular complications. methods: 650 Subjects with ages 40-75 years and duration of Dm 4-23 years were divided into 4 groups according to number of microvascular complications, e.g. retinopathy, nephropathy, and neuropathy. β cell failure (β -?ve ) is defined as HbA1c > 7.0% with any therapy or HbA1c β cell function is deemed “preserved” (β + ve) with HbA1c b cell failure progressively rose with increasing number of microvascular complications from 0 to 2 with no further significant rise with 3 complications whereas subjects with preserved β cell function declined with increasing number of microvascular complications (p β cell failure (p β cell failure/β cell preserved with increasing number of microvascular complications as well as the greater duration of Diabetes. However, a significantly (p β cell failure persisted for rising number of microvascular complications even after eliminating the influence of age and duration of diabetes. Conclusion: β cell failure may be a manifestation of microvascular pancreatic isletopathy similar to other microvascular complications.

关键词： Type 2 Diabetes Beta Cell Failure Pancreatic Isletopathy

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKm supports antitumor immunity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & molecular Immunology 2024年第3期21卷 260-274页

作者： G.aaron Holling Colin A.Chavel Anand P.Sharda mackenzie m.Lieberman Caitlin m.James Shivana m.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew m.Intlekofer Richard m.Higashi Teresa W.m.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:massachusetts Institute of Technology BostonMA 02139USA Present address:melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the m1 isoform of pyruvate kinase in favor of PKm2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKm alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKm2

Chromium Differentially Affects Hydrogen Peroxide Distribution in Primary and Adventitious Roots of Arabidopsis thaliana L.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2020年第1期89卷 35-43页

作者： aaron Giovanni munguia-Rodriguez Jose Lopez-Bucio Gerardo Rangel Sanchez Leon Francisco Ruiz-Herrera Yazmin Carreon-Abud miguel martinez-Trujillo Instituto de Investigaciones Quimico-Biológicas Universidad Michoacana de San Nicolas de HidalgoEdificio B3Ciudad UniversitariaC.P58030MoreliaMichoacanMexico Facultad de Biologia Universidad Michoacana de San Nicolas de Hidalgo.Edificio RCiudad UniversitariaC.P58030 MoreliaMichoacanMexico

The post-embryonic growth of the Arabidopsis thaliana root system can be modified by different types of stress,such as sublethal concentrations of metals,which may induce the production of reactive oxygen species(ROS).In this study,the effects of different concentrations of potassium chromate(K_(2)CrO_(4))on the distribution and relative quantity of hydrogen peroxide(H_(2)O_(2))were determined in primary and adventitious roots in *** HyPer line *** line has a biosensor that specifically reports H_(2)O_(2) levels within tissues as *** root growth was inhibited at 100μm Cr(VI);in contrast,adventitious root formation was induced over the main root growth *** structures proliferated from 100-160μm Cr(VI),and much higher concentrations(180-200μm)of K_(2)CrO_(4) were required to affect their *** H_(2)O_(2) distributions were observed in the columella and lateral root cap of primary roots of plants grown in medium lacking dichromate,but following the development of toxicity symptoms,H_(2)O_(2) changed its distribution to the meristem and differentiation ***,adventitious roots had comparable H_(2)O_(2) distribution patterns in untreated plants and those exposed to Cr(VI)***,differential H_(2)O_(2) distribution correlates with the resistance of adventitious roots,but not primary roots,to dichromate and underlies cell reorganization at the apex to support growth.

关键词： Chromate hydrogen peroxide root growth meristem ion toxicity adaptation