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Multi-Material ALE with AMR for Modeling Hot Plasmas and Cold Fragmenting Materials

Plasma Science and Technology 2015年第2期17卷 117-128页

作者： Alice KONIGES Nathan MASTERS aaron fisher David EDER Wangyi LIU Robert ANDERSON David BENSON Andrea BERTOZZI Lawrence Berkeley National Laboratory Lawrence Livermore National Laboratory Jacobs School of Engineering 9500 Gilman Dr.UCSDLa JollaCA 92093USA Department of Mathematics 520 Portola PlazaUCLALos AngelesCA 90095USA

We have developed a new 3D multi-physics multi-material code, ALE-AMR, which combines Arbitrary Lagrangian Eulerian （ALE） hydrodynamics with Adaptive Mesh Refinement （AMR） to connect the continuum to the microstructural regimes. The code is unique in its ability to model hot radiating plasmas and cold fragmenting solids. New numerical techniques were developed for many of the physics packages to work efficiently on a dynamically moving and adapting mesh. We use interface reconstruction based on volume fractions of the material components within mixed zones and reconstruct interfaces as needed. This interface reconstruction model is also used for void coalescence and fragmentation. A flexible strength/failure framework allows for pluggable material models, which may require material history arrays to determine the level of accumulated damage or the evolving yield stress in J2 plasticity models. For some applications laser rays are propagating through a virtual composite mesh consisting of the finest resolution representation of the modeled space. A new 2nd order accurate diffusion solver has been implemented for the thermal conduction and radiation transport packages. One application area is the modeling of laser/target effects including debris/shrapnel generation. Other application areas include warm dense matter, EUV lithography, and material wall interactions for fusion devices.

关键词： multi-physics simulations arbitrary lagrangian eulerian hydrodynamics,adaptive mesh refinement fragmentation laser ray tracing NIF

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Truth lies below: A case report and literature review of typical appearing polyps yet with an atypical diagnosis

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World Journal of Gastrointestinal Endoscopy 2019年第1期11卷 54-59页

作者： aaron fisher Edward Yousif Marc Piper Department of Internal Medicine University of Michigan Medical School Department of Internal Medicine Division of GastroenterologyProvidence-Providence Park Hospital Michigan State University College of Human Medicine

BACKGROUND Enteropathy associated T-cell lymphoma(EATL) is a rare form of peripheral Tcell lymphoma and makes up less than 5% of gastrointestinal lymphomas. EATL can be divided into type 1 which is associated with celiac disease, and monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL), formally type 2, which is not associated with celiac *** SUMMARY We present a 60-year-old African American female, without celiac disease, who presented with abdominal pain, diarrhea, and 30 lb. weight loss over a 3 month period. She was subsequently diagnosed with EATL throughout her entire gastrointestinal tract. She is currently undergoing chemotherapy with EOCH(Etoposide, Oncovin, Cyclophosphamide, and Hydroxydaunorubicin). EATL is most common in the Asian and Hispanic population yet the incidence in African Americans is uncertain and emphasizes the rarity of this case. A literature review was included to further emphasize similarities and differences between our case and previously reported cases of *** The patient was diagnosed with EATL, immunochemical testing was not conclusive for MEITL however was suggestive of the disease.

关键词： Enteropathy associated T-cell lymphoma Monomorphic epitheliotropic intestinal T-cell lymphoma Peripheral T-cell lymphoma Gastrointestinal lymphoma Endoscopy Case report Literature review

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Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity

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World Journal of Gastroenterology 2017年第8期23卷 1387-1396页

作者： Hadar Goldvaser Noa Katz Shroitman Irit Ben-Aharon Ofer Purim Yulia Kundel Daniel Shepshelovich Tzippy Shochat aaron Sulkes Baruch Brenner Institute of Oncology Davidoff Cancer CenterBeilinson HospitalRabin Medical Center Sackler Faculty of Medicine Tel Aviv University Division of Medical Oncology and Hematology Princess Margaret Cancer Centre and the Department of MedicineUniversity of Toronto Department of Medicine A Beilinson HospitalRabin Medical Center Statistical Consulting Unit Beilinson HospitalRabin Medical Center

To characterize colorectal cancer (CRC) in octogenarians as compared with younger *** single-center, retrospective cohort study which included patients diagnosed with CRC at the age of 80 years or older between 2008-2013. A control group included consecutive patients younger than 80 years diagnosed with CRC during the same period. Clinicopathological characteristics, treatment and outcome were compared between the groups. fisher’s exact test was used for dichotomous variables and χ2 was used for variables with more than two categories. Overall survival was assessed by Kaplan-Meier survival analysis, with the log-rank test. Cancer specific survival (CSS) and disease-free survival were assessed by the Cox proportional hazards model, with the Fine and Gray correction for non-cancer death as a competing *** study included 350 patients, 175 patients in each group. Median follow-up was 40.2 mo (range 1.8-97.5). Several significant differences were noted. Octogenarians had a higher proportion of Ashkenazi ethnicity (64.8% vs 47.9%, P < 0.001), a higher rate of personal history of other malignancies (22.4% vs 13.7%, P = 0.035) and lower rates of family history of any cancer (36.6% vs 64.6%, P < 0.001) and family history of CRC (14.4% vs 27.3%, P = 0.006). CRC diagnosis by screening was less frequent in octogenarians (5.7% vs 20%, P < 0.001) and presentation with performance status (PS) of 0-1 was less common in octogenarians (71% vs 93.9%, P < 0.001). Octogenarians were more likely to have tumors located in the right colon (45.7% vs 34.3%, P = 0.029) and had a lower prevalence of well differentiated histology (10.4% vs 19.3%, P = 0.025). They received less treatment and treatment was less aggressive, both in patients with metastatic and non-metastatic disease, regardless of PS. Their 5-year CSS was worse (63.4% vs 77.6%, P = 0.009), both for metastatic (21% vs 43%, P = 0.03) and for non-metastatic disease (76% vs 88%, P = 0.028).CONCLUSI

关键词： Colon Rectum Elderly Octogenarian Age

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Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 866-876页

作者： Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride Department of Medicine Hematology and Medical OncologyUniversity of Arizona Cancer CenterTucsonAZ 85724United States Department of Medicine Internal Medicine Residency ProgramUniversity of ArizonaTucsonAZ 85725United States UC San Diego Health Moores Cancer Center La JollaCA 92093United States University of Arizona College of Pharmacy TucsonAZ 85725United States

BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase ***-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer *** To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active *** A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was *** criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or *** Chi-squared test was used for overall and the fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB *** ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk *** A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were *** median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active ***-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a prim

关键词： Direct oral anticoagulants Low molecular weight heparin Gastrointestinal cancer Venous thromboembolism Cancer associated thrombosis Clinical risk

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Fecal microbiota transplant and dermatologic disorders:A retrospective cohort study assessing the gut microbiome’s role in skin disease

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World Journal of Dermatology 2021年第1期9卷 1-10页

作者： Ashley M Snyder James Abbott M Kyle Jensen aaron M Secrest Department of Dermatology University of UtahSalt Lake CityUT 84132United States Department of Population Health Sciences University of UtahSalt Lake CityUT 84108United States Division of Pediatric Gastroenterology Hepatology and NutritionDepartment of PediatricsUniversity of UtahSalt Lake CityUT 84113United States

BACKGROUND There is indication that fecal microbiota transplant(FMT)has the potential to alter the course of chronic skin disease,but few studies have investigated this phenomenon beyond case *** with larger sample sizes is needed to provide a more thorough assessment of possible associations and to establish a broader foundation upon which to base *** To identify associations between FMT and skin conditions,particularly infectious and inflammatory etiologies,and the role of dermatology *** We conducted a retrospective cohort study involving a chart review of all patients whom received FMT between January 2013 and December 2019 at a single academic medical *** follow-up was assessed for the two years after FMT or through March 2020 for more recent *** diagnoses and visits within the study time frame were recorded and assessed for *** study was exploratory in *** statistics were calculated,and the t-test,Pearson’s chi-squared test,and fisher’s exact test were used to calculate P *** Median age was 38(range,17-90).In total,109 patients who underwent 111 fecal microbiota transplant events were ***-six events(23.4%)involved a dermatology office visit post-procedure,and of these events,20 out of the 26(76.9%)had an infectious or inflammatory skin *** mean time to first visit was 10.0(±7.0)*** most common diagnoses were dermatophyte,wart(s),and dermatitis,though no specific diagnoses predominated in a way indicating FMT had a significant *** patients with a post-FMT skin disease diagnosis had a history of Crohn’s disease compared to those without(P=0.022),but results could be affected by a small sample *** Our study is limited by its retrospective nature,but the findings allow a glimpse at dermatologic conditions *** significant associations were found,but potential associations between FMT and skin disease should

关键词： Fecal microbiota transplantation Infections Inflammation Microbiota Skin diseases Retrospective studies

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