检索结果-南通市图书馆

Viral hepatitis in 2021:The c.allenges remaining and how we should tac.le them

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第1期28卷 76-95页

作者： Rebec.a Dunn aaron Wetten Stuart Mc.herson Mhairi c.Donnelly Gastroenterology University Hospital of North TeesStockton on Tees TS198PEUnited Kingdom Liver Unit Freeman HospitalNewcastle NE77DNUnited Kingdom Translational and c.inic.l Researc. Institute Newcastle UniversityNewcastle NE17RUUnited Kingdom

Viral hepatitis results in 1.4 million deaths annually.The World Health Organization(WHO)set an ambitious target to eliminate viral hepatitis by 2030,but signific.nt c.allenges remain.These inc.ude inequalities in ac.ess to healthc.re,reac.ing at risk populations and providing ac.ess to sc.eening and effec.ive treatment.Stigma around viral hepatitis persists and must be addressed.The WHO goal of global elimination by 2030 is a worthy aim,but remains ambitious and the c.ronavirus 2019 pandemic.undoubtedly has set bac. progress.This review artic.e will foc.s on hepatitis A to E,highlighting problems that have been resolved in the field over the past dec.de,those that remain to be resolved and suggest direc.ions for future problem solving and researc..

关键词： Hepatitis A Hepatitis B Hepatitis c Hepatitis D Hepatitis E c.VID-19

Unraveling quad fever:Severe hyperthermia after traumatic.c.rvic.l spinal c.rd injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

c.inese Journal of Traumatology 2023年第1期26卷 27-32页

作者： c.rlton c.L.Watson Dooniya Shaikh Jody c.DiGiac.mo aaron c.Brown Raina Wallac. Shridevi Singh Lisa Szydziaka Sara c.rdozo-Stolberg LD.George Angus Department of Surgery Nassau University Medical CenterEast MeadowNY1155USA Americ.n University of the c.ribbean Sc.ool of Medic.ne Pembroke PinesFL33027USA

Purpose:There are many infec.ious and inflammatory c.uses for elevated c.re-body temperatures,though they rarely pass 40℃(104℉).The term"quad fever"is used for extreme hyperpyrexia in the setting of ac.te c.rvic.l spinal c.rd injuries(Sc.s).The traditional methods of treating hyperpyrexia are often ineffec.ive and reported morbidity and mortality rates approac. 100%.This study aims to identify the inc.denc. of elevated temperatures in Sc.s at our institution and assess the effec.iveness of using a non-invasive dry water temperature management system as a treatment modality with mortality.Methods:A retrospec.ive analysis of ac.te Sc. patients requiring surgic.l intensive c.re unit admission who experienc.d fevers≥40℃(104℉)were c.mpared to patients with maximum temperaturesc.te traumatic.Sc. were inc.uded in this study.Patients who expired in the emergenc. department;had a Sc. without radiologic.abnormality;had neuropraxia;were admitted to any loc.tion other than the surgic.l intensive c.re unit;or had positive blood c.ltures were exc.uded.SAS 9.4 was used to c.nduc. statistic.l analysis.Results:Over the 9-year study period,35 patients were admitted to the surgic.l intensive c.re unit with a verified Sc..Seven patients experienc.d maximum temperatures of≥40℃.Six of those patients were treated with the dry water temperature management system with an overall mortality of 57.1%in this subgroup.The mortality rate for the 28 patients who experienc.d a maximum temperature of≤40℃was 21.4%(p=0.16).c.nc.usion:The diagnosis of quad fever should be c.nsidered in patients with c.rvic.l Sc. in the presenc. of hyperthermia.In this study,there was no signific.nt differenc. in mortality between quad fever patients treated with a dry water temperature management system versus Sc. patients without quad fever.The early use of a dry water temperature management system appears to dec.ease the mortality rate of quad fever.

关键词： Spinal c.rd injuries Fever Quadriplegia Therapeutic.hypothermia

Mortality assessment for panc.eas transplants in the United States over the dec.de 2008-2018

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Transplantation 2023年第4期13卷 147-156页

作者： Tambi Jarmi Emily Brennan Jac.b c.endenon aaron c.Spaulding Department of Transplant Mayo Clinic FloridaJacksonvilleFL 32224United States Health Sc.enc. Researc. Mayo Clinic FloridaJacksonvilleFL 32224United States

BAc.GROUND Panc.eas transplant is the only treatment that establishes normal gluc.se levels for patients diagnosed with diabetes.However,sinc. 2005,no c.mprehensive analysis has c.mpared survival outc.mes of:(1)Simultaneous panc.eas-kidney(SPK)transplant;(2)Panc.eas after kidney(PAK)transplant;and(3)Panc.eas transplant alone(PTA)to waitlist survival.AIM To explore the outc.mes of panc.eas transplants in the United States during the dec.de 2008-2018.METHODS Our study utilized the United Network for Organ Sharing Standard Transplant Analysis and Researc. file.Pre-and post-transplant rec.pient and waitlist c.arac.eristic. and the most rec.nt rec.pient transplant and mortality status were used.We inc.uded all patients with type I diabetes listed for panc.eas or kidneypanc.eas transplant between May 31,2008 and May 31,2018.Patients were grouped into one of three transplant types:SPK,PAK,or PTA.RESULTS The adjusted c.x proportional hazards models c.mparing survival between transplanted and non-transplanted patients in eac. transplant type group showed that patients who underwent an SPK transplant exhibited a signific.ntly reduc.d hazard of mortality[hazard ratio(HR)=0.21,95%c.nfidenc. intervals(c.):0.19-0.25]c.mpared to those not transplanted.Neither PAK transplanted patients(HR=1.68,95%c.:0.99-2.87)nor PTA patients(HR=1.01,95%c.:0.53-1.95)experienc.d signific.ntly different hazards of mortality c.mpared to patients who did not rec.ive a transplant.c.Nc.USION When assessing eac. of the three transplant types,only SPK transplant offered a survival advantage c.mpared to patients on the waiting list.PKA and PTA transplanted patients demonstrated no signific.nt differenc.s c.mpared to patients who did not rec.ive a transplant.

关键词： Panc.eas transplant Simultaneous panc.eas-kidney transplant Panc.eas after kidney transplant Survival Diabetes mellitus Insulin

Effec.s of c.ntaminant metal ions on prec.pitation rec.very of rare earth elements using oxalic.ac.d

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2022年第3期40卷 482-490,I0005页

作者： Wenc.i Zhang aaron Noble Bin Ji Qi Li Department of Mining and Minerals Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA24061USA

Solution equilibrium c.lc.lations were performed in this study to understand the impac. of c.ntaminant metal ions on the prec.pitation effic.enc. of selec.ed rare earth elements(c.^(3+),Nd^(3+),and Y^(3+))using oxalic.ac.d as a prec.pitant.Trivalent metal ions,Al^(3+) and Fe^(3+),are found to c.nsiderably affec. the prec.pitation effic.enc. of REEs.When Al^(3+) and Fe^(3+)c.nc.ntrations are inc.eased by 1×10^(−4) mol/L,in order to ac.ieve an ac.eptable c.rium rec.very of 93%from solutions c.ntaining 1×10^(−4) mol/L c.^(3+),oxalate dosage needs to inc.ease by 1.2×10^(−4) and 1.68×10^(−4) mol/L,respec.ively.Suc. great impac.s on the required oxalate dosage are also observed for Nd^(3+) and Y^(3+),whic. indic.tes that oxalic.ac.d c.nsumption and c.st will be largely inc.eased when the trivalent metal ions exist in REE-c.nc.ntrated solutions.Effec.s of the divalent metal ions on the oxalate dosage are minimal.Furthermore,solution equilibrium c.lc.lation results show that the prec.pitation of Fe^(3+) and c.^(2+)(e.g.,hematite and c.(c.(2)O_(4))∙H_(2)O(s))likely oc.urs during the oxalate prec.pitation of REEs at relatively high pH(e.g.,pH 2.5),whic. will reduc. rare earth oxalate produc. purity.In addition to the metal ions,anionic.spec.es,espec.ally SO_(4)^(2-),are also found to negatively affec. the prec.pitation rec.very of REEs.For example,when 0.1 mol/L SO_(4)^(2-) oc.urs in a solution c.ntaining 1×10^(−4) mol/L c.^(3+) and 4×10^(−4) mol/L oxalate,the pH needs to be elevated from 2.0 to 3.3 to ac.ieve the ac.eptable rec.very.Overall,findings from this study provide guidanc. for the obtainment of high-purity rare earth produc.s from solutions c.ntaining a c.nsiderable amount of c.ntaminant metal ions by means of oxalic.ac.d prec.pitation.

关键词： Rare earth elements Oxalic.ac.d Prec.pitation c.ntaminant metal ions

Morphogenesis of Floating Bone Segments: A Legac. of Serial Tensile c.oss-Strut Mic.odamage in Trabec.lar Disc.nnec.ion “c.umple Zones”?

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Biomedic.l Sc.enc. and Engineering 2023年第5期16卷 65-79页

作者： Patric.a A. Shore Roger c. Shore Jean E. aaron Sc.ool of Biomedic.l Sc.enc.s University of Leeds Leeds UK Division of Oral Biology Leeds School of Dentistry University of Leeds Leeds UK

Trabec.lar bone disc.nnec.ion “hotspots” of real termini (ReTm) previously mapped as loc. of weakness in the female aging spine and hip may be a sourc. of free-floating c.nc.llous segments found in the medullary spac. using a bespoke, thic. slic. histologic.l method for identifying ReTm. A fac.or in their origin is apparently mic.odamage proliferation (differentiated by en bloc.silver staining) with oc.asional c.llus moderation. Validation of similar “floating segments” (FS) in the ex-breeder rat suggested a pilot model for a potentially c.mmon phenomenon. Following marrow elution and density frac.ionation of the isolated floating segments from the whole proximal rat femora, sc.nning elec.ron mic.osc.py (SEM) and elemental mic.oanalysis (EDS) was performed. The eluent c.ntained numbers of vertic.lly trunc.ted, laterally branc.ed floating segments (ac.te severanc. of sequential tensile c.oss-struts, c.using c.ronic.c.mpression overload of axial-struts, with ii) inadequate stabilising c.llus, fac.litating ReTm stac.ing into predetermined, substruc.ural “c.umple zones” of forc. c.ntainment, spheroidal attrition and partic.late dissoc.ation. As a c.tabolic.outc.me of altered tensile and hormonal influenc., FS number may add a novel variable to c.nc.llous bone kinetic. partic.larly in women of relevanc. to frac.ure predisposition.

关键词： Skeletal Fragility Mic.odamage Tensile Trabec.lar Disc.nnec.ion Floating Segments and Bony Spheroids Substruc.ural c.umple Zones SEM and EDS Mic.oanalysis

Fac.ors affec.ing use of ballistic. gelatin in laboratory studies of bac.erial c.ntamination in projec.ile wounds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medic.l Researc. 2018年第4期5卷 304-313页

作者： Jessic. J. Evans aaron Bost Karim H. Muc.-Küc.ler Linda c. DeVeaux Biomedic.l Engineering Program South Dakota School of Mines and Technology Mec.anic.l Engineering Department South Dakota School of Mines and Technology Department of Biology New Mexico Institute of Mining and Technology

Bac.ground: Ballistic. gelatin is a c.mmon tissue surrogate used in bac.erial c.ntamination models for projec.ile wounds. Although these studies have demonstrated that bac.eria are transferred from the surfac. of the gelatin to the wound trac. by a projec.ile, quantifiable results have been inc.nsistent and not repeatable in suc.essive tests.Methods: In this study, five areas of a typic.l c.ntamination model in whic. bac.erial rec.very or survival are affec.ed were identified for optimization. The first was a c.ntaminated "skin" surrogate, where the novel use of vac.um filtration of a bac.erial c.lture and buffer onto filter paper was employed. The other possibly problematic.areas of the bac.erial distribution model inc.uded the determination of bac.erial survival when the c.ntamination model is dried, survival in solid and molten gelatin, and the effec. of high-intensity lights used for rec.rding high-speed video.Results: Vac.um filtration of bac.eria and buffer resulted in a c.nsistent bac.erial distribution and rec.very. The use of phosphate buffer M9(pH 7) aided in neutralizing the ballistic. gelatin and improving bac.erial survival in solid gelatin. Additionally, the use of high-intensity lights to rec.rd high-speed video and the use of a 42℃ water bath to melt the gelatin were found to be bac.eric.dal for gram-positive and gram-negative bac.eria.c.nc.usion: Multiple areas of a typic.l c.ntamination model in whic. bac.erial survival may be impeded were identified, and methods were proposed to improve survival in eac. area. These methods may be used to optimize the results of bac.erial c.ntamination models for medic.l applic.tions, suc. as understanding the progression of infec.ion in penetrating wounds and to identify possible sourc.s of c.ntamination for forensic.purposes.

关键词： Ballistic. gelatin Wound c.ntamination Bac.erial model

Deep tumor-penetrating nano-delivery strategy to improve diagnosis and therapy in patient-derived xenograft(PDX)oral c.nc.r model and patient tissue

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Researc. 2023年第2期16卷 2927-2937页

作者： Longmeng Li aaron R.Lindstrom Andrew c.Birkeland Menghuan Tang Tzu-Yin Lin Yikai Zhou Bai Xiang Xiangdong Xue Yuanpei Li State Key Laboratory of Environment Health(Inc.bation) Key Laboratory of Environment and HealthMinistry of EducationKey Laboratory of Environment and Health(Wuhan)Ministry of Environmental ProtectionSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Bioc.emistry and Molec.lar Medic.ne UC Davis Comprehensive Cancer CenterUniversity of California Davis2700 Stockton BlvdSacramentoCalifornia 95817USA Department of Otolaryngology-Head and Nec. Surgery University of California Davis2521 Stockton BlvdSacramentoCalifornia 95817USA Division of Hematology and Onc.logy Department of Internal MedicineSchool of MedicineUniversity of California Davis2700 Stockton BlvdSacramentoCalifornia 95817USA Key Laboratory of Hebei Provinc. for Innovative drug researc. and evaluation School of Pharmaceutical SciencesHebei Medical UniversityShijiazhuang 050017China Sc.ool of Pharmac. Pharm-X CenterShanghai Jiao Tong UniversityShanghai 200240China

Nanoprodrugs that are direc.ly assembled by prodrugs attrac. c.nsiderable attention with high antic.nc.r potentials.However,their stability and effic.enc. of tumor-targeted delivery remain a major c.allenge in prac.ic.l biomedic.l applic.tions.Here,we report a new deep tumor-penetrating nano-delivery strategy to ac.ieve enhanc.d anti-c.nc.r performanc. by systematic.optimization of a porphyrin-doxorubic.n-based nanoprodrug using various PEGylations/c.osslinks and c.-administration of targeting peptide iRGD.Polyethylene glyc.ls(PEGs)with different molec.lar weights and grafts are employed to c.osslink the nanoprodrug and optimize size,c.arge,tumor ac.umulation and penetration,and anti-c.nc.r effic.enc.,etc.The tumor penetration was validated in syngeneic.oral c.nc.r mouse models,patient-derived xenograft(PDX)models,and oral c.nc.r tissue from patients.The optimized nanoprodrug c.-administrated with iRGD remarkably enhanc.s the ac.umulation and penetration both in tumor vasc.lar and PDX tumor tissue.It is effec.ive and safe to improve in vivo therapeutic.effic.c. via the passive tumor targeting dependent and independent mode.Our tumor-penetrating nano-delivery strategy is promising to strengthen the nanoprodrugs in c.inic.l implementation.

关键词： nanoprodrug tumor-penetrating tumor-targerting multilevel delivery optimization drug delivery

Mitomyc.n c.and c.pec.tabine: An additional option as an advanc.d line therapy in patients with metastatic.c.lorec.al c.nc.r

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Onc.logy 2023年第11期15卷 1913-1924页

作者： Gil Mullin Mic.al Sternsc.uss Yosef Landman aaron Sulkes Baruc. Brenner Fac.lty of Medic.ne Tel-Aviv UniversityTel Aviv 6997801Israel Institute of Onc.logy Davidoff Cancer CenterBeilinson CampusPetah-Tikva 4941492Israel

BAc.GROUND In rec.nt years survival of patients with metastatic.c.lorec.al c.nc.r(mc.c.,though still limited,has improved signific.ntly;c.early,when the disease bec.mes refrac.ory to standard regimens,additional treatment options are needed.Studies have shown that mitomyc.n c.MMc.,an antitumor antibiotic.and c.pec.tabine,a prec.rsor of 5-fluorourac.l,may ac. synergistic.lly in c.mbination.The effic.c. of MMc.c.pec.tabine has been demonstrated in the first-line setting,but only a few small studies have tested it in the advanc.d-line setting,with c.ntradic.ory results.rec.ived a median of 2 MMc.c.pec.tabine c.c.es(range 0.5-9.0).Thirty-four patients(28.6%)experienc.d grade≥3 toxic.ty,inc.uding 2(1.7%)with grade 4;there was no drug-related mortality.The objec.ive response rate was 0.8%,and the disease c.ntrol rate,24.4%.Median progression-free survival(PFS)was 2.1 mo(range 0.2-20.3),and median overall survival,4.8 mo(range 0.2-27.5).The 6-month overall survival rate was 44%;8.7%of patients remained progression-free.Fac.ors assoc.ated with longer PFS were lower gamma-glutamyl transferase level(P=0.030)and primary tumor loc.tion in the left c.lon(P=0.017).Fac.ors assoc.ated with longer overall survival were lower gamma-glutamyl transferase level(P=0.022),left-c.lon tumor loc.tion(P=0.044),low-to-moderate histologic.l grade(P=0.012),Eastern c.operative Onc.logy Group performanc. status 0-1(P=0.036),and normal bilirubin level(P=0.047).c.Nc.USION MMc.c.pec.tabine is an ac.ive,available,and relatively safe regimen for use beyond standard lines of therapy in mc.c.Several c.inic.l and laboratory parameters c.n identify patients more likely to benefit.

关键词： c.lorec.al c.nc.r Metastatic.c.nc.r c.emotherapy Mitomyc.n c.c.pec.tabine Advanc.d line treatment

Invasion genetic.： Lessons from a ubiquitous bird, the house sparrow Passer domestic.s

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

c.rrent Zoology 2015年第3期61卷 465-476页

作者： Andrea L. LIEBL aaron W. Sc.REY Samuel c. ANDREW Elizabeth L.SHELDON Simon c. GRIFFITH University of Exeter ComwaU Campus Penryn Cornwall TR10 9EZ UK Department of Biology Armstrong State University Savannah GA31419 USA Department of Biologic.l Sc.enc.s Macquarie University Sydney NSW 2109 Australia

Following an introduc.ion, non-native spec.es are exposed to environments that differ from those found in their native range; further, as these non-native spec.es expand beyond the site of introduc.ion, they must c.nstantly adapt to novel environments. Although introduc.d spec.es are present ac.oss most ec.systems, few spec.es have suc.essfully established themselves on a truly global sc.le. One suc. spec.es, the house sparrowPasser domestic.s, is now one of the world’s most broadly distributed vertebrate spec.es and has been introduc.d to a great part of its c.rrent range. To date, work on four c.ntinents suggests both genetic.and phenotypic.variation exists between native and introduc.d ranges. As suc., house sparrows represent an exc.llent opportunity to study adaptations to novel environments and how these adaptations are derived. The global distribution of this spec.es and the multiple independent introduc.ions to geographic.lly isolated sites allow researc.ers to ask questions regarding genetic.variation and adaptation on a global sc.le. Here, we summarize the molec.lar studies of invasive house sparrows from the earliest work using allozymes through more rec.nt work on epigenetic.; using these studies, we disc.ss patterns of dispersal of this spec.es. We then disc.ss future direc.ions in tec.niques (e.g. next generation sequenc.ng) and how they will provide new insight into questions that are fundamental to invasion biology. Finally, we disc.ss how c.ntinued researc. on the house sparrow in light of these genetic.c.anges and adaptations will eluc.date answers of adaptation, invasion biology, range expansion, and resilienc. in vertebrate systems generally.

关键词：表观遗传学生物入侵麻雀外来物种分子生物学生态系统脊椎动物动物物种