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Treatment outcomes and adverse drug reactions among patients with drug-resistant tuberculosis receiving all-oral,long-term regimens:First record viewing report from Pakistan

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Asian Pacific Journal of Tropical Medicine 2023年第2期16卷 58-64,I0003页

作者： Hira Aslam Asad Omar Razia Fatima Usman Rasool Aashifa Yaqoob Waseem Ullah aamir khan Yusra Habib khan Tauqeer Hussain Mallhi Provincial Tuberculosis Control Program Punjab Pakistan Cardio-metabolic Division CCL Research Laboratories Lahore PunjabPakistan Common Management Unit National Tuberculosis Control Program of PakistanIslamabadPakistan Department of Pharmacy Practice Shifa College of Pharmaceutical SciencesShifa Tameer-e-Millat UniversityIslamabadPakistan Association for Social Development IslamabadPakistan Department of Clinical Pharmacy College of PharmacyJouf UniversitySakakaAl-Jouf ProvinceSaudi Arabia

Objective:To assess the effectiveness and adverse drug reactions of all-oral regimens for patients with multidrug-resistant ***:This retrospective study was conducted at 10 Programmatic Management of Drug Resistant Tuberculosis sites in Punjab province of *** receiving treatment for drug resistant tuberculosis from July 2019 to December 2020 with at least interim result i.e.6th month culture conversion or final outcomes(cured,complete,lost to follow-up,failure,death)available,were included in the *** was extracted from electronic data management *** the reporting and management of adverse drug events,active tuberculosis drug safety monitoring and management was implemented across all *** the data was analyzed using SPSS version ***:Out of 947 drug resistant tuberculosis patients included in this study,579(68%)of the patients had final outcomes *** these,384(67.9%)successfully completed their *** of 368(32%)patients who had their interim results available,all had their 6th month culture *** new medications was thought to result in serious adverse outcomes such as QT ***,this study did not record any severe adverse events among ***:All-oral regimens formulation guided by overall treatment effectiveness resulted in treatment outcomes comparable to those obtained with traditional injectable treatment.

关键词： All-oral long-term regimens Long-term regimens Bedaquiline Linezolid Clofazimine Drug resistant tuberculosis Treatment outcomes aDSM

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High-temperature stress suppresses allene oxide cyclase 2 and causes male sterility in cotton by disrupting jasmonic acid signaling

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The Crop Journal 2023年第1期11卷 33-45页

作者： aamir Hamid khan Yizan Ma Yuanlong Wu Adnan Akbar Muhammad Shaban Abid Ullah Jinwu Deng Abdul Saboor khan Huabin Chi Longfu Zhu Xianlong Zhang Ling Min National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina Department of Botany University of MalakandDir Lower 18800Khyber PakhtunkwaPakistan

Cotton(Gossypium spp.) yield is reduced by stress. In this study, high temperature(HT) suppressed the expression of the jasmonic acid(JA) biosynthesis gene allene oxide cyclase 2(GhAOC2), reducing JA content and causing male sterility in the cotton HT-sensitive line H05. Anther sterility was reversed by exogenous application of methyl jasmonate(MeJA) to early buds. To elucidate the role of GhAOC2 in JA biosynthesis and identify its putative contribution to the anther response to HT, we created gene knockout cotton plants using the CRISPR/Cas9 system. Ghaoc2 mutant lines showed male-sterile flowers with reduced JA content in the anthers at the tetrad stage(TS), tapetum degradation stage(TDS), and anther dehiscence stage(ADS). Exogenous application of MeJA to early mutant buds(containing TS or TDS anthers) rescued the sterile pollen and indehiscent anther phenotypes, while ROS signals were reduced in ADS anthers. We propose that HT downregulates the expression of GhAOC2 in anthers, reducing JA biosynthesis and causing excessive ROS accumulation in anthers, leading to male sterility. These findings suggest exogenous JA application as a strategy for increasing male fertility in cotton under HT.

关键词： Cotton(Gossypium hirsutum) Jasmonic acid Allene oxide cyclase 2 ROS CRISPR/Cas9 High-temperature stress

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Fingerprint matching,spoof and liveness detection:classification and literature review

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Frontiers of Computer Science 2021年第1期15卷 179-196页

作者： Syed Farooq ALI Muhammad aamir khan Ahmed Sohail ASLAM Department of Software Engineering University of Management and TechnologyLahore 54770Pakistan Department of Informatics and Systems University of Management and TechnologyLahore 54770Pakistan Department of Computer Science University of Management and TechnologyLahore 54770Pakistan

Fingerprint matching,spoof mitigation and liveness detection are the trendiest biometric techniques,mostly because of their stability through life,uniqueness and their least risk of *** recent decade,several techniques are presented to address these challenges over well-known *** study provides a comprehensive review on the fingerprint algorithms and techniques which have been published in the last few *** divides the research on fingerprint into nine different approaches including feature based,fuzzy logic,holistic,image enhancement,latent,conventional machine learning,deep learning,template matching and miscellaneous *** these,deep learning approach has outperformed other approaches and gained significant attention for future *** reviewing fingerprint literature,it is historically divided into four eras based on 106 referred papers and their cumulative citations.

关键词： computer society template matching fingerprint recognition survey deep learning machine learning

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Decolorization of Blue CL-BR dye by AOPs using bleach wastewater as source of H_2O_2

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Journal of Environmental Sciences 2007年第10期19卷 1183-1188页

作者： Abdullah Yasar Nasir Ahmad aamir Amanat Ali khan Anwer Yousaf Directorate of Research and Development University of the PunjabLahore-Pakistan41-Kamran BlockAUama lqbal TownLahore-Pakistan.

This research was focused on the investigation of the efficacy of advanced oxidation processes （Fenton, ozonation and UV/H2O2） for decolorization of reactive azo dye （Blue CL-BR） using bleach wastewater as possible source of H2O2. All the experiments were performed on the laboratory scale set-up. The results showed that colour removal efficiencies by UV or bleach （H2O2） alone were not so efficient. Fenton process with bleach wastewater was found to be the most effective at process conditions such as pH of 3 and HEO2/Fe^2＋ ratio of 24：1, resulting in 64% colour removal. Almost complete colour removal, i.e., 99% and 95% were achieved by UV//H2O2 and UV/bleach wastewater in 30 and 60 min, respectively. Ozonation proved an efficient method for decolorization of Blue CL-BR dye at alkaline pH. It was possible to achieve 98% colour removal with 30 min of ozonation at pH 9. The colour removal of dye was found to follow first order kinetics.

关键词： azo dye bleach wastewater Fenton hydrogen peroxide ozone

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Sludge granulation and efficiency of phase separator in UASB reactor treating combined industrial effluent

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Journal of Environmental Sciences 2007年第5期19卷 553-558页

作者： Abdullah Yasar Nasir Ahmad Muhammad Nawaz Chaudhry aamir Amanat Ali khan Directorate of Research and Development University of the Punjab41-Kamran BlockAllama Iqbal TownLahore-Pakistan.

Sludge granulation and the effect of gas-liquid-solid separator （GLSS） design on the efficiency of upflow anaerobic sludge blanket （UASB） and upflow anaerobic sludge filter （UASF） reactors, operating at HRTs ranging from 3 to 12 h was investigated. VSS/TS ratio gradually increased in both the reactors with increasing sludge age （from 0.5 to more than 0.7 for UASB reactor and 0.012 to 0.043 for UASF reactor）. X-Ray diffraction analysis of the UASF sludge showed the presence of expanding clays revealing its additional absorption capability. Fuoraphyllite and albite precipitation related to excellular polymers of the microbial shell structure, showed the extended growth of microorganisms during sludge granulation. A gradual decrease （82%-69%） in COD removal with decreasing HRT was apparent in UASF reactor. In case of UASB reactor, this decrease was marginal because addition of GLSS device significantly improved （14%-20%） the overall efficiency of the UASB reactor. GLSS enhanced the efficiency of the UASB reactor by increasing the settleability of suspended particles and accelerating the coagulation of colloidal particles due to the velocity gradient.

关键词： sludge granulation gas-liquid-solid (GLS) phase separator UASB microbial growth

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Right versus left fully robotic live donor nephrectomy and open kidney transplantation:Does the laterality of the donor kidney really matter?

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Asian Journal of Urology 2023年第4期10卷 453-460页

作者： Brianna Ruch Deki Tsering Chandra Bhati Dhiren Kumar Muhammad Saeed Seung Duk Lee aamir khan Daisuke Imai David Bruno Marlon Levy Adrian Cotterell Amit Sharma Hume-Lee Transplant Center Virginia Commonwealth UniversityRichmondVAUSA Division of Transplant Surgery University of MarylandBaltimoreMDUSA

Objective Robotic-assisted live donor nephrectomy(LDN)is being gradually adopted across transplant *** left donor kidney is preferred over right due to anatomical factors and ease of *** aimed to study donor and recipient outcomes after robotic procurement and subsequent open implantation of right and left *** All fully robotic LDNs and their corresponding open kidney transplants performed at our center between February 2016 and December 2021 were retrospectively *** Out of 196 robotic LDN(49[right]vs.147[left]),10(5.1%)donors had intra-operative events(6.1%[right]vs.4.8%[left],p=0.71).None of the LDN required conversion to open *** operative times were comparable for the two ***(13.3%)was the most common post-operative *** was no mortality in either LDN ***,we report our outcomes on 156 recipients(39 right and 117 left allografts)excluding robotic implants,exports,and pediatric *** were no significant differences between right and left kidney recipients with respect to 1-year post-transplant patient survival(100.0%vs.98.1%,p=0.45)or graft survival(93.9%vs.97.1%,p=0.11),or delayed graft function(7.7%vs.5.1%,p=0.55).Conclusion Non-hand-assisted robotic live donor nephrectomies can be safely performed with excellent *** LDN was not associated with higher incidence of complications compared to left *** implantation of robotically procured right renal allografts was not associated with higher risk of recipient complications.

关键词： Robotics Laparoscopy Donor nephrectomy Complication Renal transplant Outcome

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Histone H3 lysine 27 trimethylation suppresses jasmonate biosynthesis and signaling to affect male fertility under high temperature in cotton

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Plant Communications 2023年第6期4卷 96-112页

作者： Yanlong Li Miao Chen aamir Hamid khan Yizan Ma Xin He Jing Yang Rui Zhang Huanhuan Ma Chunyang Zuo Yawei Li Jie Kong Maojun Wang Longfu Zhu Xianlong Zhang Ling Min National Key Laboratory of Crop Genetic Improvement&Hubei Hongshan Laboratory Huazhong Agricultural UniversityWuhan 430070HubeiChina Institute of Economic Crops Xinjiang Academy of Agricultural SciencesUrumqi 830091XinjiangChina

High-temperature(HT)stress causes male sterility in crops,thus decreasing *** explore the possible contribution of histone modifications to male fertility under HT conditions,we defined the histone methylation landscape for the marks histone H3 lysine 27 trimethylation(H3K27me3)and histone H3 lysine 4 trimethylation(H3K4me3)by chromatin immunoprecipitation sequencing(ChIP-seq)in two differing upland cotton(Gossypium hirsutum)*** observed a global disruption in H3K4me3 and H3K27me3 modifications,especially H3K27me3,in cotton anthers subjected to *** affected the bivalent H3K4me3–H3K27me3 modification more than either monovalent *** determined that removal of H3K27me3 at the promoters of jasmonate-related genes increased their expression,maintaining male fertility under HT in the HT-tolerant variety at the anther dehiscence *** jasmonate homeostasis or signaling resulted in an anther indehiscence phenotype under *** suppression of H3K27me3 deposition increased jasmonic acid contents and maintained male fertility under *** summary,our study provides new insights into the regulation of male fertility by histone modifications under HT and suggests a potential strategy for improving cotton HT tolerance.

关键词： high temperature H3K27me3 H3K4me3 cotton anther jasmonate

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An integrated method for the rapid dewatering and solidification/stabilization of dredged contaminated sediment with a high water content

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Frontiers of Environmental Science & Engineering 2021年第4期15卷 229-240页

作者： Hefu Pu aamir khan Mastoi Xunlong Chen Dingbao Song Jinwei Qiu Peng Yang Institute of Geotechnical and Underground Engineering Huazhong University of Science and TechnologyWuhan430074China Department of Civil Engineering Quaid-e-Awam University of EngineeringSciences and TechnologySindh67450Pakistan

To more efficiently treat the dredged contaminated sediment(DCS)with a high water content,this study proposes an integrated method(called PHDVPSS)that uses the solidifying/stabilizing(S/S)agents and prefabricated horizontal drain(PHD)assisted by vacuum pressure(VP).Using this method,dewatering and solidification/stabilization can be carried out simultaneously such that the treatment time can be significantly shortened and the treatment efficacy can be significantly improved.A series of model tests was conducted to investigate the effectiveness of the proposed *** results indicated that the proposed PHDVPSS method showed superior performance compared to the conventional S/S method that uses Portland cement(PC)directly without prior *** 56-day unconfined compressive strength of DCS treated by the proposed method with GGBS-MgO as the binder is 12–17 times higher than that by the conventional S/S *** treated by the PHDVPSS method exhibited continuous decrease in leaching concentration of Zn with increasing curing *** reduction of Zn leachability is more obvious when using GGBS-MgO as the binder than when using PC,because GGBS-MgO increased the residual fraction and decreased the acid soluble fraction of *** microstructure analysis reveals the formation of hydrotalcite in GGBS-MgO binder,which resulted in higher mechanical strength and higher Zn stabilization efficiency.

关键词： Dredged contaminated sediment Dewatering Solidification/stabilization Vacuum preloading Prefabricated horizontal drain Heavy metal

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Double gallstone ileus

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Hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 437-439页

作者： aamir Z khan Joe Nariculum Stefano M Andreani Adam Stacey-Clear Department of Surgery East Surrey Hospital Canada AvenueRedhillSurreyRH1 5RHUK Whipps Cross Hospital LeytonstoneUK

BACKGROUND:Gallstone ileus remains a rare but important cause of intestinal obstruction. METHOD:We present a unique case of two gallstones causing intestinal obstruction at the same time. RESULTS:A 90-year-old lady presented with signs and symptoms of small bowel *** operation,two gallstones stuck at different points within the bowel were causing the obstruction and were removed. CONCLUSION:When operating on patients with small bowel obstruction from gallstone ileus,examination of the entire small bowel should be considered mandatory.

关键词： gallstones intestinal obstruction ileus

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Effects of the nitrification inhibitor nitrapyrin and the plant growth regulator gibberellic acid on yield-scale nitrous oxide emission in maize fields under hot climatic conditions

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Pedosphere 2021年第2期31卷 323-331页

作者： Khadim DAWAR Kamil SARDAR Mohammad ZAMAN Christoph MÜLLER Alberto SANZ-COBENA aamir khan Azam BORZOUEI Ana Gabriela PÉREZ-CASTILLO Department of Soil and Environmental Science University of Agriculture PeshawarPeshawa 25000(Pakistan) Soil and Water Management&Crop Nutrition Joint FAO/IAEA Division of Nuclear Techniques in Food&AgricultureP.O.Box 100Vienna A-1400(Austria) Institute of Plant Ecology Justus Liebig UniversityHeinrich-Buff-Ring 26Giessen D-35392(Germany) School of Biology and Environmental Science University College DublinBelfieldD04 V1W8(Ireland) Management of Environment and Agricultural Risks(CEIGRAM) ETSIAABUniversidad Poliécnica de MadridMadrid 28040(Spain) Agricultural Research School Nuclear Science and Technology Research InstituteP.O.Box 31465/1498Karaj(Iran) Environmental Pollution Research Center(CICA) University of Costa RicaMontes de Oca 11501(Costa Rica)

Nitrification inhibitors are widely used in agriculture to mitigate nitrous oxide(N_(2)O)emission and increase crop ***,no concrete information on their mitigation of N_(2)O emission is available under soil and environmental conditions as in Pakistan.A field experiment was established using a silt clay loam soil from Peshawar,Pakistan,to study the effect of urea applied in combination with a nitrification inhibitor,nitrapyrin(2-chloro-6-tri-chloromethyl pyridine),and/or a plant growth regulator,gibberellic acid(GA_3),on N_(2)O emission and the nitrogen(N)uptake efficiency of *** experimental design was a randomized complete block with five treatments in four replicates:control with no N(CK),urea(200 kg N ha^(-1))alone,urea in combination with nitrapyrin(700 g ha^(-1)),urea in combination with GA_3(60 g ha^(-1)),and urea in combination with nitrapyrin and GA_*** N_(2)O emission,yield,N response efficiency,and total N uptake were measured during the experimental *** treatment with urea and nitrapyrin reduced total N_(2)O emission by 39%–43%and decreased yield-scaled N_(2)O emission by 47%–52%,relative to the treatment with urea *** maize plant biomass,grain yield,and total N uptake increased significantly by 23%,17%,and 15%,respectively,in the treatment with urea and nitrapyrin,relative to the treatment with urea alone,which was possibly due to N saving,lower N loss,and increased N uptake in the form of ammonium;they were further enhanced in the treatment with urea,nitrapyrin,and GA_3 by 27%,36%,and 25%,respectively,probably because of the stimulating effect of GA_3 on plant growth and development and the reduction in biotic and abiotic *** results suggest that applying urea in combination with nitrapyrin and GA_3 has the potential to mitigate N_(2)O emission,improve N response efficiency,and increase maize yield.

关键词： fertilizer use efficiency greenhouse gas emission mitigation N response efficiency N uptake efficiency N_(2)O flux plant growth hormone urea

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