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Massive ascites as a presenting manifestation of chronic lymphocytic leukemia

World Journal of Gastroenterology 2008年第22期14卷 3594-3597页

作者： Neelam Siddiqui Saeed Al-Amoudi aamer aleem Maha Arafah Layla Al-Gwaiz Department of Medicine College of Medicine King Khalid University Hospital King Saud University Riyadh Saudi Arabia Department of Pathology College of Medicine King Khalid University Hospital King Saud University Riyadh Saudi Arabia

Ascites is not an uncommon manifestation of certain solid tumors like gastrointestinal malignancies, ovarian cancer and breast cancer. However, it is unusual to encounter ascites in patients with hematological malignancies especially chronic leukemia. The patient described here presented with massive ascites and blood lymphocytosis. Further studies confirmed the diagnosis of chronic lymphocytic leukemia with ascites. The ascitic fluid was exudative, consisting of mature-looking B-lymphocytes, which were morphologically and immunophenotypically similar to peripheral blood and bone marrow cells. The patient was treated with chemotherapy and achieved a good response and diminution of ascitic fluid accumulation.

关键词： Ascites Chronic lymphocytic leukemia

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Frequency of Bcr-Abl Fusion Oncogene Splice Variants Associated with Chronic Myeloid Leukemia (CML)

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Journal of Cancer Therapy 2011年第2期2卷 176-180页

作者： Zafar Iqbal Fatima Manzoor Mudassar Iqbal Shahid Ali Nadeem Sheikh Mahwish Khan aamer aleem Tanveer Akhtar Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group Health Sciences Research Laboratories

BCR-ABL fusion oncogene originates from the reciprocal translocation of chromosome 9 and 22 t(9;22) (q34;q11). It translates a chimeric protein, p210, characterized by constitutive activation of its tyrosine kinase, which triggers leukemogenic pathways resulting in onset of chronic myeloid leukemia (CML). In CML, the classic fusion is b2a2 or b3a2 fusing exon 13 (b2) or exon 14 (b3) of BCR to exon 2 (a2) of ABL. The type of bcr/abl transcripts may be associated with different prognosis and hence useful in therapeutic plan. This study was conducted to calculate the frequency of these splice variants as the frequencies of different fusion oncogenes associated with leukaemia can vary in different geographical regions due to interplay of genetic variation in different ethnic populations, diverse environmental factors and living style. A very sensitive nested RT-PCR was established to detect BCR-ABL splice variants in CML. Sensitivity of RT-PCR assay was of the order of 10–6. Thirty CML patients were subjected to BCR-ABL analysis. Out of 30 Pakistani patients, 19 (64%) expressed b3a2 while 11 (36%) expressed b2a2 transcript. This shows that BCR-ABL splice variants differ in their frequencies which may have an effect on biology and implications for prognosis and management of BCR-ABL positive Leukemias.

关键词： BCR-ABL positive Leukemia Leukemia genetics Philadelphia Chromosome Chronic Myeloid Leukemia BCR-ABL Alternative Splicing BCR-ABL splice variants Leukemia alternative splicing Pharmacogenetics

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