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Effect of Ion Temperature Variation in Two-Ion Species Magnetized Plasma Sheath

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材料科学与工程（中英文A版） 2017年第6期7卷 320-326页

作者： Rabindra Chaulagain Roshan Chalise Raju khanal Amrit Campus Tribhuvan University Lainchaur Kathmandu-16 Nepal Central Department of Physics Tribhuvan University Kirtipur-3 Kathmandu Nepal

脑室给予不同剂量的Capsazepine对LPS致大鼠发热过程的影响

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中国药理学通报 2015年第1期31卷 35-38页

作者： Bibek khanal 施蓓 Puja Paudel 张璠秦鑫曹宇中国医科大学基础医学院生理学教研室辽宁沈阳110001

目的在大鼠侧脑室内给予不同剂量的瞬时受体电位香草酸受体1(transient receptor potential vanilloid 1,TRPV1)拮抗剂Capsazepine,观察对LPS致热过程的影响。方法在侧脑室内预先给与3种剂量Capsazepine,随之腹腔给与LPS致热。在腹腔内... 详细信息

目的在大鼠侧脑室内给予不同剂量的瞬时受体电位香草酸受体1(transient receptor potential vanilloid 1,TRPV1)拮抗剂Capsazepine,观察对LPS致热过程的影响。方法在侧脑室内预先给与3种剂量Capsazepine,随之腹腔给与LPS致热。在腹腔内埋植发射子遥测体温变化过程,同时应用荧光测定法检测下丘脑细胞内钙离子浓度的变化,Western blot方法检测TRPV1表达水平。结果随着Capsazepine剂量增大,LPS致大鼠发热水平升高,下丘脑细胞内钙离子浓度减少,TRPV1表达水平降低。结论 Capsazepine作用于大鼠下丘脑,可使LPS诱导的发热水平提高,此效应可能与TRPV1的作用有关。

关键词：发热瞬时受体电位香草酸受体1 Capsazepine LPS 下丘脑 Ca^2+

Climate change on the southern slope of Mt. Qomolangma （Everest） Region in Nepal since 1971

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Journal of Geographical Sciences 2013年第4期23卷 595-611页

作者：祁威张镱锂高俊刚杨续超刘林山 Narendra R.khanal Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Meteorology Zhejiang Meteorological Bureau Hangzhou 310017 China Central Department of Geography Tribhuvan University Kathmandu Nepal

Based on monthly mean, maximum, and minimum air temperature and monthly mean precipitation data from 10 meteorological stations on the southern slope of the Mt. Qomolangma region in Nepal between 1971 and 2009, the spatial and temporal characteristics of climatic change in this region were analyzed using climatic linear trend, Sen＇s Slope Estimates and Mann-Kendall Test analysis methods. This paper focuses only on the southern slope and attempts to compare the results with those from the northern slope to clarify the characteristics and trends of climatic change in the Mt. Qomolangma region. The results showed that：（1） between 1971 and 2009, the annual mean temperature in the study area was 20.0℃, the rising rate of annual mean temperature was 0.25℃/10a, and the temperature increases were highly influenced by the maximum temperature in this region. On the other hand, the temperature increases on the northern slope of Mt. Qomolangma region were highly influenced by the minimum temperature. In 1974 and 1992, the temperature rose noticeably in February and September in the southern region when the increment passed 0.9℃. （2） Precipitation had an asymmetric distribution; between 1971 and 2009, the annual precipitation was 1729.01 mm. In this region, precipitation showed an increasing trend of 4.27 mm/a, but this was not statistically significant. In addition, the increase in rainfall was mainly concentrated in the period from April to October, including the entire monsoon period （from June to September） when precipitation accounts for about 78.9% of the annual total. （3） The influence of altitude on climate warming was not clear in the southern region, whereas the trend of climate warming was obvious on the northern slope of Mt. Qomolangma. The annual mean precipitation in the southern region was much higher than that of the northern slope of the Mt. Qomolangma region. This shows the barrier effect of the Himalayas as a whole and Mt. Qomolangma in particular.

关键词： climate change Mann-Kendall analysis Mt. Qomolangma region Koshi River Nepal

1971-2009年珠穆朗玛峰地区尼泊尔境内气候变化

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地理学报 2013年第1期68卷 82-94页

作者：祁威张镱锂高俊刚杨续超刘林山 Narendra Raj khanal 中国科学院地理科学与资源研究所北京100101 中国科学院大学北京100049 浙江省气象科学研究所杭州310017 尼泊尔特里布文大学地理学院

利用珠穆朗玛峰南坡尼泊尔境内(科西河流域)的10个气象站1971-2009年月平均气温、月平均最高、最低气温和逐月降水资料,采用线性趋势、Sen斜率估计、Mann-Kendall等方法分析区域气候变化状况及其时空特征,并与珠穆朗玛峰北坡地区气候进... 详细信息

利用珠穆朗玛峰南坡尼泊尔境内(科西河流域)的10个气象站1971-2009年月平均气温、月平均最高、最低气温和逐月降水资料,采用线性趋势、Sen斜率估计、Mann-Kendall等方法分析区域气候变化状况及其时空特征,并与珠穆朗玛峰北坡地区气候进行比较,分析了珠穆朗玛峰地区气候变化的特征与趋势。结果表明:(1)1971-2009年间,珠穆朗玛峰南坡年平均气温为20.0℃,线性升温率为0.25℃/10a,与北坡主要受年平均最低气温影响相反,增幅主要受年平均最高气温升高的影响,并且在1974年及1992年间出现两次显著增温,增温特别明显的月份为2月和9月;(2)该地区降水变化的局地性较强,近40年间年平均降水量为1729.01mm,年平均降水量以每年约4.27mm的线性增幅有所增加,但并不显著,且降水月变化和季变化特征均不明显;(3)由于珠穆朗玛峰南坡受到季风带来暖湿气流和喜马拉雅山阻挡的双重影响,珠峰南坡的年平均降水量远高于北坡;(4)珠穆朗玛峰南坡气温变暖的海拔依赖性并不明显,且南坡地区的变暖趋势并没有北坡变暖趋势明显。

关键词：气候变化 Mann—Kendall分析珠穆朗玛峰地区科西河流域尼泊尔

Initial Experience on Anatomical Snuff Box Approach for Coronary Angiogram &Percutaneous Coronary Intervention in a Tertiary Care Center Nepal

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World Journal of Cardiovascular Diseases 2018年第12期8卷 578-587页

作者： Ratna Mani Gajurel Ravi Sahi Hemant Shrestha Sanjeev Thapa Rajaram khanal Department of Cardiology Manmohan Cardio Vascular Thoracic and Transplant Centre (MCVTC) Institute of Medicine TUTH Maharajgunj Nepal

Introduction: Coronary Angiogram and Percutaneous Coronary Interventions are commonly performed via the femoral route. Then, transradial coronary catheterization became a popular & default technique due to less vascular access site complications and bleeding as compared to femoral route. Distal puncture of the radial artery through the anatomical snuff box access, however, has recently been shown potential benefit, like comfort to patients and operators, as well as maintenance of blood flow through the superficial palmar arch, in case of radial artery occlusion. Our aim was to evaluate the safety and feasibility of this new approach. Methods: A cross-sectional observational prospective study of patients underwent invasive diagnostic or therapeutic coronary procedures through the distal trans-radial access and traditional radial access. The primary endpoints were to access difficulties and in-hospital access-site related complications. Results: In 2 months, 190 patients underwent coronary procedures, of which 82 (43%) were selected in both distal transradial & traditional radial group. In 2(2.4%) & 3 (3.6%) cases, distal radial & traditional radial access cannulation was unsuccessful respectively (p >0.05). The mean age was 57.7 ± 10 & 57.2 ± 10 years in successful distal transradial & traditional radial cases respectively. There were no any major vascular complications in distal transradial group while there were 2 vascular complications in traditional radial group (p > 0.05). Conclusions: Distal transradial access is feasible and safe in selected cases, when performed by experienced operators. Larger case series and randomized trials are required to determine its efficacy in reducing vascular complications when comparing to the traditional technique.

关键词： CAD: Coronary Artery Disease CAG: Coronary Angiogram PCI: Percutaneous Coronary Intervention Radial Artery: RA

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科西河跨境流域水旱灾害与防治

地球科学进展 2012年第8期27卷 908-915页

作者：胡桂胜陈宁生 Narendra khanal 韩大为中国科学院山地灾害与地表过程重点实验室中国科学院水利部成都山地灾害与环境研究所四川成都610041 中国科学院大学北京100049 尼泊尔特里布文大学地理学院尼泊尔加德满都英国布里斯托尔大学土木学院英国

科西河流域是恒河的一个重要支流,地跨中国、尼泊尔和印度3个国家,流域面积7.15万km2,流域具有世界上最大的高差(从海拔8 848 m的珠穆朗玛峰到海拔60 m的恒河平原),最为完整的气候、土壤和植被带谱。流域发育有罕见的多类型水旱灾害,主... 详细信息

科西河流域是恒河的一个重要支流,地跨中国、尼泊尔和印度3个国家,流域面积7.15万km2,流域具有世界上最大的高差(从海拔8 848 m的珠穆朗玛峰到海拔60 m的恒河平原),最为完整的气候、土壤和植被带谱。流域发育有罕见的多类型水旱灾害,主要有冰湖溃决、洪水、干旱、水土流失等。通过实地调查这一代表性跨界流域的水文、气象、地质、地貌、土壤植被和区域社会经济等基本特征并结合已有的研究资料,揭示流域冰湖溃决、洪水、干旱等水旱灾害的特征和时空发育规律。流域冰湖溃决灾害集中于科西河流域上级支流,灾害损失巨大,并由于溃决洪水的侵蚀,沿途链状滑坡泥石流灾害发育;洪水灾害主要集中于流域下游,在相对较高标准的防洪体系中,洪水灾害是自然因素和人为因素相结合产生的,并造成流域水土流失严重;干旱灾害范围大,年内持续时间长,并且由于人口增加和生态退化进一步严重化。最后,依据流域水旱灾害特点,提出一系列减灾策略与措施。

关键词：科西河跨界流域冰湖溃决洪水干旱

Tumor targeted mesoporous silica-coated gold nanorods facilitate detection of pancreatic tumors using Multispectral optoacoustic tomography

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Nano Research 2015年第12期8卷 3864-3877页

作者： Anil khanal Christopher Ullum Charles W Kimbrough Nichola C. Garbett Joseph A. Burlison Molly W. McNally Phillip Chuong Ayman S. EI-Baz Jacek B. Jasinski Lacey R. McNally Department of Medicine University of Louisville Louisville KY 40202 USA Deportment of Surgery University of Louisville Louisville KY 40292 USA Speed School of Engineering University of Louisville Louisville KY40292 USA

Multispectral optoacoustic 断层摄影术(MSOT ) 是在传统的形式上提供几个优点的一种新兴的成像技术，特别地处于它解决在显微镜的规模上的深度的光对比的能力。当潜在的应用包括临床的阀值由当前的技术设置了的下面的肿瘤的早察觉时... 详细信息

Multispectral optoacoustic 断层摄影术(MSOT ) 是在传统的形式上提供几个优点的一种新兴的成像技术，特别地处于它解决在显微镜的规模上的深度的光对比的能力。当潜在的应用包括临床的阀值由当前的技术设置了的下面的肿瘤的早察觉时，肿瘤特定的对比代理人的缺乏限制 MSOT 成像的使用。因此，我们与 polyacrylic 酸(泛美航空公司) 或 aminefunctionalized mesoporous 硅石(MS ) 由涂层金牌 nanorods (GNR ) 构造了高度稳定的 nano 对比代理人。Syndecan-1，被显示了指向像胰岛素的生长因素 1 受体(IGF1-R )( 在胰腺的肿瘤的 upregulated ) ，在泛美航空公司涂的 GNR (PAA-GNRs ) 或 MS 涂的 GNR (MS-GNRs ) 的表面上被结合创造指向肿瘤的 nanoparticles。在 vitro， nanoparticles 指向的肿瘤与流动 cytometry 被估计。在 S2VP10L 房间(为 IGF1-R 积极) ， syndecan-1 MS-GNRs (Syndecan-MS-GNRs ) 在 OA 信号表明了增加， 10x，与 syndecan-1 PAAGNR (Syndecan-PAA-GNRs ) 相比。最小的绑定在 MiaPaca-2 房间被观察(为 IGF1-R 否定) 。在 vivo，肿瘤 Syndecan-MS-GNRs 的特定的指向用鼠科的 orthotopic 被评估胰腺的癌症模型。Syndecan- MS-GNRs 比在象肝那样的离开目标机关在胰腺的肿瘤以内表明了显著地更大的累积。与 IGF1-R 否定 MiaPaca-2 房间植入的老鼠没表明指向的特定的肿瘤。在摘要，我们报导指向的 nano 对比代理人(Syndecan-MS-GNRs ) 能成功地检测 orthotopic 有在用 MSOT 的 vivo 有约束力的最小的离开目标的胰腺的肿瘤。

关键词：光声层析成像介孔二氧化硅胰腺肿瘤纳米棒多光谱检测胰岛素样生长因子1 流式细胞仪

Assessment of Phytochemical, Antioxidant and Antimicrobial Activities of Some Medicinal Plants from Kaski District of Nepal

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American Journal of Plant Sciences 2020年第9期11卷 1383-1397页

作者： Lekha Nath khanal Khaga Raj Sharma Yuba Raj Pokharel Surya Kant Kalauni Central Department of Chemistry Tribhuvan University Kirtipur Kathmandu Nepal Faculty of Life Science and Biotechnology South Asian University New Delhi India

Medicinal plants have been known to treat simple to life-threatening diseases in different communities of Nepal for many years. This study aims to analyze the phytochemicals as plant secondary metabolites, evaluate the antioxidant and antibacterial activities of Rubus ellipticus, Ziziphus mauritiana, Pyrus pashia, and Drynaria coronans extracts that are commonly being used as traditional medicine. Phytochemical analysis was performed to investigate the plant’s secondary metabolites such as polyphenols, alkaloids, flavonoids, terpenoids, reducing sugar, glycosides, tannins, carotene, phytosterols, coumarins, saponins, and anthracenes. The methanol extracts of the plants were used to evaluate the in vitro antioxidant activity by using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical and the antibacterial activity against Staphylococcus aureus (ATCC 25923), Klebsiella pneumoniae (ATCC 700603), <

关键词： Medicinal Plant Phytochemical Antioxidant Antibacterial Activity Resazurin

喜马拉雅中部甘达基河流域尼泊尔国鸟(棕尾虹雉)生境分布变化

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Journal of Resources and Ecology 2020年第2期11卷 223-231页

作者： Raju RAI Basanta PAUDEL 谷昌军 Narendra Raj khanal 中国科学院地理科学与资源研究所陆地表层格局与模拟重点实验室北京100101 中国科学院大学资源与环境学院北京100049

甘达基河流域(Gandaki River Basin,GRB)是喜马拉雅中部地区的一部分,该地区栖息着许多珍稀的野生动物。由于气候和人类活动的影响,许多珍稀保护物种的生境处于危险之中。本研究基于最大熵(MaxEnt)模型,运用生物气候、土地覆被和DEM数据... 详细信息

甘达基河流域(Gandaki River Basin,GRB)是喜马拉雅中部地区的一部分,该地区栖息着许多珍稀的野生动物。由于气候和人类活动的影响,许多珍稀保护物种的生境处于危险之中。本研究基于最大熵(MaxEnt)模型,运用生物气候、土地覆被和DEM数据,分析各环境要素对棕尾虹雉(Lophophorusimpejanus)的生境适宜性的影响,评估棕尾虹雉现在状况和未来栖息地分布的变化。研究表明,目前棕尾虹雉的高度适宜栖息地面积约为749 km^2,主要分布在流域北部、东部和西部,尤其是郎塘国家公园、马纳斯卢峰自然保护区和安纳布尔纳峰自然保护区等保护区内。到2050年,棕尾虹雉的高度适宜栖息地面积将减少至561 km^2,主要在流域北部和西北部(即Chhyo,Tatopani,Humde和Chame地区)。未来环境变化的模拟表明,由于适宜栖息地面积的减少,棕尾虹雉面临的生存风险将增加。

关键词：气候变化土地覆被棕尾虹雉生境变化甘达基河流域