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GSTP1 (Ile105Val) Gene Polymorphism: Risk and Treatment Response in Chronic Myeloid Leukemia

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Journal of Cancer Therapy 2014年第1期5卷 1-10页

作者： Shereen Elhoseiny Mohamed El-Wakil Mohamed Fawzy aya Abdel Rahman Department of Clinical and Chemical Pathology Beni Suef Teaching Hospital Beni Suef University Beni Suef Egypt Department of Clinical Oncology Beni Suef Teaching Hospital Beni Suef University Beni Suef Egypt Department of Pediatric Oncology National Cancer Institute Cairo University Egypt

Background: Genetic variation influencing individual susceptibility to chemical carcinogens is one of the main factors leading to cancer development. The glutathione S-transferases (GSTs) are a family of enzymes belonging to phase II enzymes involved in detoxification of xenobiotics. A significant relationship is observed between the risk of developing cancer and genetic polymorphisms within GSTs. Methods: In this study, we investigated the influence of inherited GSTP1 (Ile105Val) gene polymorphism on the susceptibility to CML in Egypt in 40 CML patients (20 children and 20 adults), together with 40 healthy controls using a [PCR-RFLP] assay. Results: We found that the mutant type (IIe/Val, Val/Val) was significantly higher in CML patients (67.5%) compared to controls (35%) (p = 0.004);[odds ratio 3.9;95% CI: 1.5 - 9.7]. The mutant type was associated with more advanced phases in disease and with both worse hematological and cytogenetic responses when compared to the wild type (p = 0.03, p = 0.05, and p 0.001, respectively). Conclusion: GSTP1 (Ile105Val) gene polymorphism conferred a significant association with increased risk of CML and is associated with worse prognosis. Further studies on the functional consequences of this genetic polymorphism would pave the way to declare its role in the pathogenesis of CML or as a possible predictor for response to therapy.

关键词： CML GSTs GSTP1 (Ile105Val)

Impact of time from diagnosis to chemotherapy in advanced gastric cancer: A Propensity Score Matching Study to Balance Prognostic Factors

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World Journal of Gastrointestinal Oncology 2019年第1期11卷 28-38页

作者： Tsutomu Nishida aya Sugimoto Ryo Tomita Yu Higaki Naoto Osugi Kei Takahashi Kaori Mukai Tokuhiro Matsubara Dai Nakamatsu Shiro Hayashi Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada Department of Gastroenterology Toyonaka Municipal Hospital

BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer(A-GC).AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in *** This single-center retrospective study examined consecutive patients with A-GC between April 2012 and July 2018. In total, 110 patients with stage Ⅳ A-GC who underwent chemotherapy were enrolled. We defined the wait time(WT) as the interval between diagnosis and chemotherapy initiation. We evaluated the influence of WT on overall survival(OS).RESULTS The mean OS was 303 d. The median WT was 17 d. We divided the patients into early and elective WT groups, with a 2-wk cutoff point. There were 46 and 64 patients in the early and elective WT groups, respectively. Compared with the elective WT group, the early WT group had significantly lower albumin(Alb)levels and higher neutrophil/lymphocyte ratios and C-reactive protein(CRP)levels but not a lower performance status. The elective WT group underwent more combination chemotherapy than did the early WT group. OS was different between the two groups(230 d vs 340 d, respectively). Multivariate analysis revealed that higher CRP levels, lower Alb levels and monotherapy were significantly related to a poor prognosis. To minimize potential selection bias,patients in the elective WT group were 1:1 propensity score matched with patients in the early WT group; no significant difference in OS was found(303 d vs 311 d, respectively, log-rank P = 0.9832).CONCLUSION A longer WT in patients with A-GC does not appear to be associated with a worse prognosis.

关键词： Advanced gastric cancer Waiting time Chemotherapy Prognosis Overall survival

Serotonin 2C Receptor Alternative Splicing in a Rat Model of Orofacial Neuropathic Pain

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Neuroscience & Medicine 2012年第1期3卷 69-74页

作者： aya Nakae Kunihiro Nakai Tatsuya Tanaka Ko Hosokawa Takashi Mashimo Center for Medical Research and Education Osaka University Graduate School of Medicine Department of Anesthesiology & Intensive Care Osaka University Graduate School of Medicine Department of Plastic Surgery Osaka University Graduate School of Medicine

Abnormal serotonin 2C receptor (5HTR2C) alternative splicing and RNA editing are involved in the etiology of pain disorders. Functional 5HTR2C can only be generated when alternative exon Vb is included within the mRNA;the small nucleolar RNA RBII-52 is complementary to exon Vb and promotes its inclusion. The expression of HBII-52 (the human equivalent of RBII-52) is reduced in Prader-Willi syndrome, patients of which have a high pain threshold. Here, we measured the pain threshold in a rat model of orofacial neuropathic pain and related it to the expression levels of wild-type and variant 5HTR2C and RBII-52. We generated an infraorbital nerve loose ligation model of neuropathic pain in rats and measured the pain threshold of the animals using mechanical stimulation with von Frey filaments. We then sacrificed the animals and examined the RNA levels of 5HTR2C and RBII-52 in the cervical spinal cord by real-time PCR. On post-injury day 28, pain threshold values in injured rats were significantly lower than in sham-operated or na?ve animals. The levels of total and exon Vb-skipped 5HTR2C mRNA were significantly lower in injured rats than in that sham-operated or na?ve rats, and the ratio of exon Vb-skipped 5HTR2C to total 5HTR2C was significantly higher. There were no significant differences in RBII-52 expression among the groups. Our data suggest that neuropathic pain induces serotonergic dysfunction mediated by 5HTR2C alternative splicing. 5HTR2C might be subject to complicated and fine regulation both by RNA editing and by alternative splicing.

关键词： Orofacial Neuropathic Pain Prader-Willi Syndrome Serotonin 2C Receptor Alternative Splicing SnoRNA RBII-52 RNA Editing Spinal Cord

Effects of Fiber Supplementation for Four Weeks on Athletic Performance in Japanese College Athletes: A Case Study—Measurement of the Athletic Performance, Salivary Biomarkers of Stress, and Mood, Affect Balance

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Health 2017年第3期9卷 556-567页

作者： Fusako Sugiyama Takuji Yamaguchi Ailing Hu aya Kobayashi Hiroyuki Kobayashi Department of Hospital Administration Graduate School of Medicine Juntendo University Tokyo Japan Palm International Shonan Kanagawa Japan Institute of Next Generation SMILE Tokyo Japan Center for Advanced Kampo Medicine and Clinical Research Graduate School of Medicine Juntendo University Tokyo Japan

Aim: In this study, we explored the effects of dietary fiber on athletic performance. Methods: Twenty healthy college athletes (male/female, 1/1) consumed 6 grams of dietary fiber (Fiberpro, Taiyo Lab Inc., Tokyo) daily for four weeks and were evaluated for their athletic performance, salivary biomarkers of stress (α-amylase activity pre-post exercise, cortisol, melatonin, and secretory immunoglobulin A (SIgA) levels), and mood/affect using the Profile of Mood State 2nd edition (POMS 2®). Measurements were taken at baseline (before supplementation), at Week 4 (after 4 weeks of supplementation), and at Week 8 (4 weeks after the completion of supplementation). Results: Results showed that athletic performance and exercise-induced elevation in salivary α-amylase activity improved with Fiberpro supplementation in both men and women. Further, the Anger-Hostility scale in POMS was significantly elevated in men;in women, an increase in Vigor-Activity score, a single index of positive mood, was noted. These findings suggest that Fiberpro may induce differential affective responses in men and women. Meanwhile, Fiberpro did not affect the normal diurnal changes in salivary melatonin and SIgA levels, but it appeared to augment the normal circadian patterns of cortisol, an effect that persisted for a month without Fiberpro intake. We propose that boosting fiber intake in young, healthy athletes may improve gut microbiota and confer resilience against stress.

关键词： Athletic Performance Dietary Fiber Salivary Assay Stress

Tyrosine kinase inhibitors and human epidermal growth factor receptor-2 positive breast cancer

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World Journal of Clinical Oncology 2023年第5期14卷 198-202页

作者： aya Abunada Zaid Sirhan Anita Thyagarajan Ravi P Sahu Department of Pharmacy Sidra MedicineDoha 0000Qatar Department of Pharmacology and Toxicology Boonshoft School of Medicine Wright State UniversityDaytonOH 45435United States

The body of evidence investigating human epidermal growth factor receptor-2(HER2)directed therapy in patients with breast cancer(BC)has been growing within the last ***,the use of tyrosine kinase inhibitors(TKIs)has been of particular interest in the treatment of human *** literature commentary is intended to highlight the most recent findings associated with the widely-studied TKI agents and their clinical significance in improving the outcomes of HER2 positive BC.

关键词： Human epidermal growth factor receptor-2 positive breast cancer Tyrosine kinase inhibitors Lapatinib Pyrotinib Tucatinib Trastuzumab

Fast and Accurate Detection of Masked Faces Using CNNs and LBPs

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Computer Systems Science & Engineering 2023年第12期47卷 2939-2952页

作者： Sarah M.Alhammad Doaa Sami Khafaga aya Y.Hamed Osama El-Koumy Ehab R.Mohamed Khalid M.Hosny Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Computer Science Department Sinai UniversityArishNorth SinaiEgypt Department of Information Technology Faculty of Computers and InformaticsZagazig UniversityZagazigEgypt

Face mask detection has several applications,including real-time surveillance,biometrics,*** face masks is also helpful for crowd control and ensuring people wear them *** monitoring personnel,it is impossible to ensure that people wear face masks;automated systems are a much superior option for face mask detection and *** paper introduces a simple and efficient approach for masked face *** architecture of the proposed approach is very straightforward;it combines deep learning and local binary patterns to extract features and classify themasmasked or *** proposed systemrequires hardware withminimal power consumption compared to state-of-the-art deep learning *** proposed system maintains two *** first,this work extracted the local features of an image by using a local binary pattern descriptor,and then we used deep learning to extract global *** proposed approach has achieved excellent accuracy and high *** performance of the proposed method was tested on three benchmark datasets:the realworld masked faces dataset(RMFD),the simulated masked faces dataset(SMFD),and labeled faces in the wild(LFW).Performancemetrics for the proposed technique weremeasured in terms of accuracy,precision,recall,and *** indicated the efficiency of the proposed technique,providing accuracies of 99.86%,99.98%,and 100%for RMFD,SMFD,and LFW,***,the proposed method outperformed state-of-the-art deep learning methods in the recent bibliography for the same problem under study and on the same evaluation datasets.

关键词： Convolutional neural networks face mask detection local binary patterns deep learning computer vision social protection Keras OpenCV TensorFlow Viola-Jones

A case of endometrial cancer presenting with malignant spinal cord compression

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Open Journal of Obstetrics and Gynecology 2013年第5期3卷 445-447页

作者： Shigeki Taga Mari Sawada aya Nagai Dan Yamamoto Ryoji Hayase Department of Obstetrics and Gynecology National Hospital Organization Fukuyama Medical Center Fukuyama Japan

Malignant spinal cord compression (MSCC) rarely presents in patients with endometrial cancer. It usually occurs months or years after the diagnosis of the primary tumor. A 65-year-old woman presented with a huge uterine tumor suspecting leiomyosarcoma. She underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Histopathological examination revealed mixed carcinoma (small cell carcinoma and endometrioid adenocarcinoma) of the endometrium. She presented with upper abdominal pain, back pain, cystoplegia and paraplegia of lower extremities postoperatively. Magnetic resonance imaging revealed bone metastasis with destruction of the eighth thoracic vertebral body as the sites of metastasis. Vertebrectomy and irradiation therapy were performed for the lesion. Although she received systemic chemotherapy consisting of paclitaxel and carboplatin, she died 4 months after hysterectomy.

关键词： Malignant Spinal Cord Compression Endometrial Cancer

Mechanical Ventilation Outcomes at the NICU at EL-Zahraa University Hospital

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Open Journal of Pediatrics 2020年第4期10卷 732-743页

作者： aya Abdelkader Othman Zeinab Farag Oshaib Marwa El-Hady Abd El Moneim Bachelor of Medicine and Surgery Mansoura University Mansoura Egypt Pediatrics and Neonataology Department Faculty of Medicine for Girls Al-Azhar University Cairo Egypt Pediatric and Neonataology Department Al Zahraa University Hospital Faculty of Medicine for Girls Al-Azhar University Cairo Egypt

Background: Mechanical ventilation (MV) is one of the most common therapies in the neonatal Intensive Care Unit (NICU) and is associated with increased morbidity and mortality. MV is a complex and highly specialized area in neonatology that has several complications related to different modes, techniques, and devices. Aim of the Study: To detect the causes of morbidity and mortality in mechanically ventilated neonates and to correlate the neonatal morbidity and mortality with gestational age, birth weight and duration of MV. Patients and Methods: This prospective observation analytical study was carried out on 110 neonates who were admitted to NICU at Al-Zahraa university hospital on MV during the period from March 2019 to March 2020. All neonates were followed up till the time of discharge with record of any complications during mechanical ventilation. Detailed medical history, examination to detect indication of MV and laboratory, radiological investigations were recorded. As regard the general characterization of studied neonates, 64 (58.2%) were males while the rest 46 (41.8%) were females, 50 (45.4%) were full term (37 - 42 wks), 42

关键词： Mechanical Ventilation Respiratory Distress Syndrome VAP

Umami: An Alternative Japanese Approach to Reducing Sodium While Enhancing Taste Desirability

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Health 2021年第6期13卷 629-636页

作者： Shuhei Nomura aya Ishizuka Shiori Tanaka Daisuke Yoneoka Hisayuki Uneyama Kenji Shibuya Department of Global Health Policy Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Health Policy and Management School of Medicine Keio University Tokyo Japan Epidemiology and Prevention Group Center for Public Health Sciences National Cancer Center Tokyo Japan Graduate School of Public Health St. Luke’s International University Tokyo Japan Ajinomoto Co. Inc. Tokyo Japan Soma COVID Vaccination Medical Center Fukushima Japan

COVID-19 has highlighted the underlying global burden from non-communicable diseases (NCDs) and the lack of resiliency in health systems to tackle highly preventable risk factors, which have left populations vulnerable to acute health crises. The persistent issue of unhealthy behaviors, particularly those related to a high-sodium diet, suggests inadequate policy attention and insufficient funding for public health and behavioral research. This year, Japan will host the Tokyo Nutrition for Growth (N4G) Summit 2021. The summit is being held in the era of COVID-19, offering a historic opportunity to make a difference on the global health agenda for food and nutrition and to reaffirm the global commitment to prevent future health crises by addressing the growing burden of NCDs and building better prepared and more resilient health systems. This perspective article suggests that we, global health researchers and decision-makers, should rethink the value of using “Umami” substances as candidates for a practical salt-reducing alternative that originated in Japan (while maintaining the affordability, accessibility, availability, and desirability of healthy food). Reduced salt intake will help address the global syndemic of COVID-19 pandemic and high rates of hypertension, heart diseases, diabetes, and other NCDs. By addressing these issues, it will make countries more resilient to future pandemic threats.

关键词： Umami Sodium Reduction Desirability Eating Behavior