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Phar.acological potential of Populus nigr. extr.ct as antioxidant,anti-inflammator.,car.iovascular.and hepatopr.tective agent

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Asian Pacific Jour.al of Tr.pical Biomedicine 2013年第9期3卷 697-704页

作者： Nadjet Debbache-Benaida Dina atmani-Kilani Valer.e Bar.ar. Schini-Keir.h Nour.dine Djebbli Djebbar.atmani Labor.tor. of Applied Biochemistr. Faculty of Nature and Life ScienceUniversity A.Mira Phar.acology and physical-chemistr. of cellular.and molecular.inter.ctions UMR CNRS 7213Faculty of PharmacyUniversity Louis Pasteur of Strasbourg Depar.ment of Biology Faculty of SciencesUniversity of Mostaganem

Objective:To evaluate antioxidant,anti-inflammator.,hepatopr.tective and vasor.laxant activities of Pupulus nigr. flower.buds ethanolic ***:Antioxidant and anti-inflammator. activities of the extr.ct wer. assessed using r.spectively the ABTS test and the animal model of car.ageenan-induced paw *** fr.m hepatic toxicity caused by aluminum was examined by histopathologic analysis of liver.*** effect was estimated in endothelium-intact and-nibbed r.ngs of por.ine cor.nar. ar.er.es pr.contr.cted with high concentr.tion of ***:The r.sults showed a moder.te antioxidant activity(40%),but potent anti-inflammator. activity(49.9%)on car.ageenan-induced mice paw edema,and also as r.vealed by histopathologic examination,complete pr.tection against AlCl_3-induced hepatic *** effects of the same exlr.cl on vascular.pr.par.tion fr.m por.ine aor.a pr.contr.cted with high concentr.tion of U466I9 wer. consider.ble at 10^(-1)g/L,and compar.ble(P>0.05)between endothelium-intact(67.74%,IC_(50)0.04 mg/ml.)and-r.bbed(72.72%,IC_(50)=0.075 mg/ml,)aor.ic ***:The extr.ct exer.ed significant anti-inflammator.,hepatopr.tective and vasor.laxant activities,the latter.being cndothelium-independent believed to be mediated mainly by the ability of components pr.sent in the extr.ct to exer. antioxidant pr.per.ies,pr.bably r.lated to an inhibition of Ca^(2+)influx.

关键词： Populus nigr. Polyphenols Anti-inflammator. activity Hepatopr.tection Vasor.laxation

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Activator.assisted electr.less deposition of copper.nanostr.ctur.d films

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Inter.ational Jour.al of Miner.ls,Metallur.y and Mater.als 2014年第2期21卷 196-203页

作者： Var.ha r. Mehto r. K. Pandey Depar.ment of Physics Barkatullah University NIIT Univer.ity

This paper.showed simple and effective synthesis of copper.nanopar.icles within contr.lled diameter.using dir.ct electr.less deposition on glass substr.tes, following the sensitization and activation steps. Electr.less-deposited metals, such as Cu, Co, Ni, and Ag, and their.alloys had many advantages in micr.- and nanotechnologies. The str.ctur.l, mor.hological, and optical pr.per.ies of copper.deposits wer. char.cter.zed using X-r.y diffr.ction （Xr.）, atomic for.e micr.scopy （AFM）, and UV-Vis spectr.scopy. The str.ctur.l data was fur.her.analyzed using the r.etveld r.finement pr.gr.m. Str.ctur.l studies r.veal that the deposited copper.pr.fer. a （111） or.entation. AFM studies suggest the deposited mater.als for. compact, unifor., and nanocr.stalline phases with a high tendency to self-or.anize. The data show that the par.icle size can be contr.lled by contr.lling the activator.concentr.tion. The absor.tion spectr. of the as-deposited copper.nanopar.icles r.veal that the plasmonic peak br.adens and exhibits a blue shift with decr.asing par.icle size.

关键词： nanostr.ctur.d mater.als thin films copper electr.less plating deposition

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A spotlight on dosage and subject selection for.effective neur.pr.tection: explor.ng the centr.l r.le of mitochondr.a

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Neur.l r.gener.tion r.sear.h 2025年第4期20卷 1081-1082页

作者： John Mitr.fanis Jonathan Stone Michael r.Hamblin Pier.e Magistr.tti Alim-Louis Benabid Glen Jeffer. Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah Univer.ity of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neur.ns ar. notor.ously vulner.ble cell *** the slightest change in their.inter.al and/or.exter.al envir.nments will cause much distr.ss and dysfunction,leading often to their.death.A r.nge of pathological conditions,including str.ke,head tr.uma,and neur.degener.tive disease,can gener.te str.ss in neur.ns,affecting their.sur.ival and pr.per.*** most neur.l pathologies,mitochondr.a become dysfunctional and this plays a pivotal r.le in the pr.cess of cell *** challenge over.the last few decades has been to develop effective inter.entions that impr.ve neur.nal homeostasis under.pathological *** inter.entions,often r.fer.ed to as disease-modifying or.neur.pr.tective,have,however.pr.ved fr.str.tingly elusive,at both pr.clinical and,in par.icular.clinical *** this per.pective,we highlight two factor. that we feel ar. key to the development of effective neur.pr.tective *** ar.:fir.tly,the choice of dose of inter.ention and method of application,and secondly,the selection of subjects,whether.they be patients or.the animal model.

关键词： pr.tective dosage distr.ss

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Seismic behavior.of var.able fr.quency pendulum isolator

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Ear.hquake Engineer.ng and Engineer.ng Vibr.tion 2008年第2期7卷 193-205页

作者： V. r. Panchal r. S. Jangid Depar.ment of Civil Engineer.ng Indian Institute of TechnologyBombayPowaiMumbai 400076India

Ear.hquake per.or.ance of a flexible one-stor. building isolated with a var.able fr.quency pendulum isolator.（VFPI） under.near.fault and far.field gr.und motions is investigated. The fr.ctional for.es mobilized at the inter.ace of the VFPI ar. assumed to be velocity dependent. The inter.ction between fr.ctional for.es of the VFPI in two hor.zontal dir.ctions is duly consider.d and coupled differ.ntial equations of motion of the isolated system in the incr.mental for. ar. solved iter.tively. The r.sponse of the system with bi-dir.ctional inter.ction is compar.d with those without inter.ction. In addition, the effects of velocity dependence on the r.sponse of the isolated system ar. also investigated. Mor.over. a par.metr.c study is car.ied out to cr.tically examine the influence of impor.ant par.meter. on bi-dir.ctional inter.ction effects of the fr.ctional for.es of the VFPI. These par.meter. ar.： the super.tr.ctur. time per.od, fr.quency var.ation factor.（FVF） and fr.ction coefficient of the VFPI. Fr.m the above investigations, it is obser.ed that the dependence of the fr.ction coefficient on r.lative velocity of the system does not have a noticeable effect on the peak r.sponse of the system isolated with VFPI, and that the bi-dir.ctional inter.ction of fr.ctional for.es of the VFPI is impor.ant and if neglected, isolator.displacements will be under.stimated and the super.tr.ctur. acceler.tion and base shear.will be over.stimated.

关键词： base isolation bi-dir.ctional inter.ction super.tr.ctur. flexibility near.fault gr.und motion fr.ction coefficient far.field gr.und motion VFPI

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Gene ther.py for.spinal muscular.atr.phy:per.pectives on the possibility of optimizing SMN1 deliver. to cor.ect all neur.logical and systemic per.ur.ations

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Neur.l r.gener.tion r.sear.h 2025年第7期20卷 2011-2012页

作者： Shar.n J.Br.wn r.fael J.Yáñez-Muñoz Heidi r.Fuller School of Phar.acy and Bioengineer.ng Keele UniversityKeeleUK Wolfson Center.for.Inher.ted Neur.muscular.Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular.atr.phy(SMA)is a genetic condition that r.sults in selective lower.motor.neur.n loss with concomitant muscle weakness and *** genetic cause of SMA was under.tood in 1995 when loss or.impair.ent of the sur.ival motor.neur.n 1(SMN1)gene was identified as the main contr.buting factor.Lefebvr. et al.,1995).This,in combination with the discover. that humans have a“back-up”gene,SMN2,which can pr.duce low levels(appr.ximately 10%)of the full-length functional SMN pr.tein,has led to the gener.tion of SMA-specific gene *** was tr.ditionally classified accor.ing to age of symptom onset and developmental milestones achieved,with life expectancy and sever.ty var.ing between ***,SMN2 copy number.is used as a pr.xy for.the pr.diction of disease sever.ty,with higher.SMN2 copy number.typically being associated with r.duced sever.ty of SMA,although this r.lationship is not absolute:some individuals with low SMN2 copy number.have less sever. SMA phenotypes and vice ***,the etiology of SMA is fur.her.complicated by other.factor.,such as non-typical nucleotide var.ants and SMN2-independent modifier. of disease sever.ty.

关键词： atr.phy tr.ditionally absolute

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Human-Like r.bot Sensing Mediated by Body Heat

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Jour.al of Bionic Engineer.ng 2014年第1期11卷 82-89页

作者： r. Andr.w r.ssell Depar.ment of Electr.cal and Computer.Systems Engineer.ng Monash University Clayton VIC 3800 Australia

This paper.pr.sents a novel r.botic sensor.system that can monitor.volatile chemicals and air.low. The system is modelled on char.cter.stics of the human body that ar. thought to have a significant influence on the human odour.and air.low senses. In par.icular. the effect of buoyant air.low due to body heat acts to gather.volatile chemicals over.lar.e ar.as of the human body and car.y them to the nose. It is postulated that this effect incr.ases the r.ceptive ar.a for.human olfaction. In addition, the inter.ction between r.sing air.heated by the body and exter.al air.low pr.duces a temper.tur. distr.bution about head height that can be used to infer.air.low dir.ction and magnitude. A heated sensor.system was constr.cted to investigate these effects and the r.sulting sensor.was mounted on a mobile r.bot. The design of the sensor.system is descr.bed. r.sults ar. pr.sented which demonstr.te its ability to measur. air.low dir.ction and detect chemical signals over.a wider.r.ceptive field compar.d with an unheated sensor.

关键词： sensing volatile chemicals sensing air.low human body heat biomimetic r.bots

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Ser.iceability analysis of deep under.r.und openings dr.ven in jointed-r.ck

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Inter.ational Jour.al of Mining Science and Technology 2017年第6期27卷 1019-1024页

作者： Abdellah Wael r. Mining and Metallur.ical Engineer.ng Depar.ment Faculty of Engineering University of Assiut Assiut 71515 Egypt

The per.or.ance of under.r.und excavations is inevitably influenced by r.ck mass char.cter.stics, pr.sence of joints and their.geometr.cal pr.per.ies, depth below sur.ace and state of in-situ str.ss field. The objective of this paper.is to investigate the behaviour.of deep under.r.und tunnel opening existed between two bedding planes, Such planes weaken the str.ngth of r.ck mass and may cause r.ck slippage/r.tation along them. Ther.for., the state of str.ss-displacement, after.tunnel opening has been intr.duced, is examined using two-dimensional elasto-plastic finite-elements code, r.^(2D). The r.sults indicate that, ther. is significant dr.p in the nor.al str.ss along joints over.tunnel opening; slip occur. due to r.ver.al in the dir.ction of shear.str.ss(e.g., inwar. shear.displacement is pr.duced) and ther. is discontinuity in the str.ngth contour. of r.ck sur.ounding tunnel after.they have been inter.ected by bedding planes.

关键词： State of str.ss-displacement Bedding planes Tunnel per.or.ance Depth of failur. zones Stability analysis

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Effect of induced shielding cur.ent tr.nsmission in longitudinal dir.ction on levitation for.e of melt gr.wn single-domain YBa_2Cu_3O_(7-x) cylindr.cal super.onductor

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Science China(Physics,Mechanics & Astr.nomy) 2004年第2期47卷 146-153页

作者： r. Nicolsky r. de Andr.de Jr LASUP-DEE UFRJ Ilha do Fundao Cx.P.68515 21945-970 Rio de Janeiro RJ Brasil Correspondence should be addressed to Yang Wanmin LASUP-DEE UFRJ Ilha do Fundao Cx.P.68515 21945-970 Rio de Janeiro RJ Brasil Correspondence should be addressed to Yang Wanmin

A novel layer.deletion method is used to exper.mentally investigate the effect of induced shielding cur.ent tr.nsmission (ISCT) in the longitudinal dir.ction on the levitation for.e of a single-domain YBa2Cu3O7?x (YBCO) cylindr.cal super.onductor.(?30×7 mm). In the exper.ment the sample was gr.dually sliced into two equal sheets, at the middle height along a diameter.with 5 mm ever. step. The exper.mental r.sults show that the levitation for.e is closely r.lated with the ISCT in the longitudinal dir.ction. Any layer.deletion, even a small piece of layer.deletion can r.duce the levitation for.e of the sample. After.the whole layer.was deleted the levitation for.e can diminish about 50%. It is also found that the levitation for.e is dir.ctly pr.por.ional to the effective factor.of sur.ace ar.a, which is equal to the top sur.ace ar.a divided by the total sur.ace ar.a par.llel to the top sur.ace of the sample.

关键词： melt gr.wth, single domain YBCO, levitation for.e, induced cur.ent distr.bution.

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Novel acid initiator. for.the r.pid cationic polymer.zation of styr.ne in r.om temper.tur. ionic liquids

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Science China Chemistr. 2012年第8期55卷 1671-1676页

作者： VIJAYAr.GHAVAN r. MACFAr.ANE D. r. Depar.ment of Chemistr. Monash University Clayton Campus Victoria 3800 Australia

Cationic polymer.zation of styr.ne has been achieved using sever.l novel acidic initiator. in r.om temper.tur. ionic liquids (ILs) under.mild r.action conditions to obtain polymer. of low molecular.weight with nar.ow polydisper.ity. Both str.ng pr.tic acids such as bis(tr.fluor.methanesulfonyl) amide acid (HTFSA) and a moder.tely weak acid such as bisoxalato phosphor.us acid (HBOP) have been studied as initiator.. It has been obser.ed that HTFSA initiates the polymer.zation r.pidly even at r.om temper.tur. and below, as compar.d to HBOP which pr.duces a slower.polymer.zation r.quir.ng elevated temper.tur.s to complete. The r.lative differ.nce in r.activity of the initiator. as compar.d to the pr.viously descr.bed HBOB initiator.is discussed in ter.s of the differ.nce in their.pr.ton acidity and the consequential basicity of the anions. The efficiency of differ.nt ILs as the r.action solvent is also pr.sented.

关键词： cationic polymer.zation HTFSA HBOP ILs polydisper.ity

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Homogenization Theor. for.a r.plenishing Passive Scalar.Field

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Chinese Annals of Mathematics,Ser.es B 2009年第5期30卷 631-644页

作者： Peter.r. Kr.MEr.Shane r. KEATING Depar.ment of Mathematical Sciences Rensselaer Polytechnic Institute Center.for.Atmospher.-Ocean Science Courant Institute of Mathematical SciencesNew York University

Homogenization theor. pr.vides a r.gor.us fr.mewor. for.calculating the effective diffusivity of a decaying passive scalar.field in a tur.ulent or.complex *** author. extend this fr.mewor. to the case wher. the passive scalar.fluctuations ar. continuously r.plenished by a sour.e (and/or.sink).The basic str.ctur. of the homogenized equations car.ies over.but in some cases the homogenized sour.e can involve a non-tr.vial coupling of the velocity field and the *** author. der.ve expr.ssions for.the homogenized sour.e ter. for.var.ous multiscale sour.e str.ctur.s and inter.r.t them physically.

关键词： Homogenization Tur.ulent tr.nspor. Sour.e Pumping

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