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Kaempferol and docetaxel diminish side population and down-regulate some cancer stem cell markers in breast cancer cell line MCF-7

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BIOCELL 2017年第2期41卷 33-40页

作者： SARA SOLTANIAN HELIA RIAHIRAD athareh pabarja MOHAMMAD REZA KARIMZADEH KOLSOUM SAEIDI Department of Biology Faculty of ScienceShahid Bahonar University of KermanKermanIran Department of Medical Genetics Afzalipour School of MedicineKerman University of Medical SciencesKermanIran Student Research Committee Kerman University of Medical SciencesKermanIran Department of Medical Genetics Kerman University of Medical SciencesKermanIran

Cancer stem cells(CSCs)are a small subpopulation of cancer cells whose resistance to chemotherapy and radiotherapy plays a pivotal role in treatment failure,tumor recurrence and ***,the ability of many phytochemicals in targeting of CSCs has been *** is a plant phytoestrogen that was recognized as a useful agent for targeting cancer cells by apoptosis induction,cell cycle arrest and inhibition of angiogenesis,migration,and invasion of cancer *** this study,we compared the effect of docetaxel as a common breast cancer chemotherapy drug and kaempferol on MCF-7 breast *** showed that both docetaxel and kaempferol caused a dose-dependent reduction in cell *** 123 dye staining and flow cytometry analysis revealed that after docetaxel and kaempferol treatment,SP cells proportion of MCF-7 decreased to 11.83±2.2% and 3±0.25% respectively relative to proportion of untreated control cells(23±3.2%).Moreover,real time PCR results showed that kaempferol treatment of MCF-7 was more effective than docetaxel in down-regulating the CSC-associated markers(***4,nanog,abcb1 and aldh1a1).Taken together,these results indicate that kaempferol is an effective anti-CSCs agent,therefore it may be a therapeutic strategy for eradicating breast cancer through the elimination of CSCs.

关键词： Breast cancer Cancer stem like cells Kaempferol Docetaxel

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