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Post liver transplant recurrence in patients with hepatocellular carcinoma:not necessarily the end of the road!

Hepatoma Research 2020年第10期6卷 60-74页

作者： Prashant Bhangui Sanjay Yadav as soin Medanta Institute of Liver Transplantation and Regenerative Medicine Medanta-The MedicityGurgaonDelhi NCR 122001India

Aim:We analysed outcomes using multimodality therapy in patients with hepatocellular carcinoma(HCC)recurrence post living donor liver transplantation(LDLT).Methods:Of 2363 LDLT’s performed between 2005 to mid 2018,435(18.4%)were for HCC within our expanded selection criteria(absence of extrahepatic disease and vascular invasion,irrespective of tumor size and number).Survival after recurrence,and prognostic factors for these patients were ***:Of 435 LDLT patients,51%had HCC beyond Milan and 43%beyond UCSF criteria at the time of ***-LT AFP>100 ng/mL and tumour FDG-18 PET avidity predicted overall survival(OS),whereas pre-LT AFP>100 ng/mL,UCSF criteria,and FDG-18 PET avidity predicted recurrence-free *** patients(23%)developed HCC recurrence at a median time of 16 months(range 2-108 months)post ***(53%),liver(37%),and bone(21%)were the most common sites of ***-five patients received tyrosine kinase inhibitors(TKI)after recurrence and 62 received mTOR inhibitors(protocol-based after LDLT,or post recurrence).Surgical resection of metastases was performed in 14 patients,15 received stereotactic body radiotherapy,and 18 underwent ablation(radiofrequency,microwave ablation,transarterial chemoembolisation,or percutaneous ethanol injection).One-and 3-yr OS after recurrence were 57%,and 24%respectively,with a maximum post recurrence survival of 7.5 *** recurrence within one year after LDLT(P=0.004,HR=2.38,95%CI:1.325-4.276),AFP>200 ng/mL at the time of recurrence(P=0.02,HR=2.075,95%CI:1.121-3.841),and recurrence at multiple sites(P=0.047,HR=1.831,95%CI:1.009-3.321)were poor prognostics factors for post recurrence *** management of recurrence using combined medical,surgical,ablative treatments and radiotherapy significantly improved survival compared to the use of TKI’s or mTORi’s alone,or in ***:In patients accepted for LDLT beyond the conventional size-number criteria,even after HC

关键词： Living donor liver transplantation hepatocellular carcinoma recurrence multimodality treatment outcomes prognostic factors

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Fullerene(C_(60)) Nanowires: The Preparation,Characterization, and Potential Applications

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Energy & Environmental Materials 2020年第4期3卷 469-491页

作者： Xiao Fan Navneet soin Haitao Li Hua Li Xiaohong Xia Junfeng Geng Institute for Materials Research and Innovation Institute for Renewable Energy and Environmental TechnologiesUniversity of BoltonBolton BL35ABUK School of Engineering Ulster UniversityNewtownabbey Belfast BT370QBUK School of Chemistry and Chemical Engineering Jiangsu Normal UniversityXuzhou 221116China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China School of Materials Science and Engineering Hubei UniversityWuhan 430062China

Fullerene(C_(60))nanowires have attracted significant attention in the past two decades due to their outstanding chemical and physical properties,which render the material a wide range of potential *** effort has been devoted to exploring the growth methods,structural and compositional characterizations,and application-related investigations of this novel carbon ***,we present a review of C_(60)nanowires in which we will first describe the recent development in the material preparations,analytical techniques,crystal structures,chemical compositions,and the investigations of polymerization ***,we will discuss the mechanistic studies on the nanowires’growth as the mechanism research is of great importance for their size control,large-scale preparation,and for the exploration of applications in a wide range of ***,we will discuss the potential applications in several directions,including optical,electrical,mechanical,and biological fields,as well as our perspectives to future developments.

关键词： C_(60)nanowires fullerene nanotechnology nanowire science

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Increased expression of PELP1 in human sperm is correlated with decreased semen quality

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Asian Journal of Andrology 2018年第5期20卷 425-431页

作者： Izabela Skibinska Miroslaw Andrusiewicz Michal soin Magdalena Jendraszak Paulina Urbaniak Piotr Jedrzejczak Malgorzata Kotwicka Department of Cell Biology Faculty of Health Sciences Poznan University of Medical Sciences Rokietnicka 5D Poznan 60-806 Poland Division of Infertility and Reproductive Endocrinology Faculty of Medicine I Poznan University of Medical Sciences Polna 33 Poznan 60-535 Poland.

Proline-, glutamic acid-, and leucine-rich protein 1 （PELP1） is a scaffolding protein involved in both genomic and nongenomic estrogen signal transduction pathways. To date, the role of PELP1 protein has yet to be characterized in human sperm and has not been associated with sperm parameters. To confirm the presence of PELP1 in human sperm, fresh semen samples were obtained from 178 donors. The study was designed to establish both mRNA and protein presence, and protein cellular localization. Additionally, the number of PELP1-positive spermatozoa was analyzed in men with normal and abnormal semen parameters. Sperm parameters were assessed according to the World Health Organization （WHO） 2010 standards. The presence of PELP1 in spermatozoa was investigated using four precise, independent techniques. The qualitative presence of transcripts and protein was assessed using reverse transcription-polymerase chain reaction （RT-PCR） and western blot protocols, respectively. The cellular localization of PELP1 was investigated by immunocytochemistry. Quantitative analysis of PELP1-positive cells was done by flow cytometry. PELP1 mRNA and protein was confirmed in spermatozoa. Immunocytochemical analysis identified the presence of PELP1 in the midpieces of human sperm irrespective of sperm parameters. Becton Dickinson fluorescence-activated cell sorting （FACSCalibur^Tm） analysis revealed a significantly lower number of PELP1-positive cells in males with normal semen parameters versus abnormal samples （42.78% ± 11.77% vs 61.05% ± 21.70%, respectively; P = 0.014）. The assessment of PELP1 may be a time-saving method used to obtain information about sperm quality. The results of our study suggest that PEPL1 may be utilized as an indicator of sperm quality; thereby, PELP1 may be an additional biomarker useful in the evaluation of male infertility.

关键词： male infertility proline glutamic acid- and leucine-rich protein 1 semen parameters sperm quality spermatozoa

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Critical Update on the Diagnosis and Management of COVID-19 in Advanced Cirrhosis and Liver Transplant Recipients

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 947-959页

作者： Cyriac Abby Philips Mohamed Rela Arvinder Singh soin Subhash Gupta Sudhindran Surendran Philip Augustine Department of Clinical and Translational Hepatology and The Monarch Liver Laboratory The Liver InstituteCenter of Ex-cellence in Gastrointestinal SciencesRajagiri HospitalAluvaKeralaIndia Institute of Liver Disease and Liver Trans-plantation Dr.Rela Institute&Medical CentreBharath Institute of Higher Education and ResearchChennaiIndia In-stitute of Liver Transplantation and Regenerative Medicine MedantaThe MedicityGurgaonIndia Max Centre for Liver and Biliary Sciences Max Saket HospitalNew DelhiIndia Gastrointestinal Surgery and Solid Organ Transplantation Amrita Institute of Medical Sciences and Research CentreAmrita Vishwa VidyapeethamKochiKeralaIndia Gastroen-terology and Advanced GI Endoscopy Center of Excellence in Gastrointestinal SciencesRajagiri HospitalAluvaKeralaIndia

The novel coronavirus disease 2019(COVID-19)pandemic has impacted health care worldwide,with specific patient populations,such as those with diabetes,cardiovascular disease,and chronic lung disease,at higher risk of infection and others at higher risk of disease *** with decompensated cirrhosis fall into the latter category and are a unique group that require specific treatment and management decisions because they can develop acute-on-chronic liver *** liver transplant recipients,the atypical immunity profile due to immunosuppression protects against downstream inflammatory responses triggered by *** exhaustive review discusses the outcomes associated with COVID-19 in patients with advanced cirrhosis and in liver transplant *** focus on the immunopathogenesis of COVID-19,its correlation with the pathogenesis of advanced liver disease,and the effect of immunosuppression in liver transplant recipients to provide insight into the outcomes of this unique patient population.

关键词： Coronavirus Cirrhosis Portal hypertension Acute-on-chronic liver failure Sepsis Hepatic encephalopathy Multiple-organ failure Critical care

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Accuracy of preoperative CT liver volumetry in living donor hepatectomy and its clinical implications

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 167-174页

作者： Sanjay Goja Sanjay Kumar Yadav Amardeep Yadav Tarun Piplani Amit Rastogi Prashant Bhangui Sanjiv Saigal Arvinder Singh soin Institute of Liver Transplant and Regenerative Medicine MedantaThe MedicityGurgaonDelhi(NCR)India Department of Radiology and Nuclear Medicine MedantaThe MedicityGurgaonDelhi(NCR)India

Background: An accurate preoperative volumetric assessment of donor liver is essential for successful living donor liver transplant by ensuring adequate remnant and graft recipient weight ratio (GRWR). Methods: The study cohort consisted of 744 right lobe (RL), 65 left lobe (LL) and 33 left lateral sector (LLS) grafts from July 2010 to January 2014. A semi-automated interactive commercial software called AW Volume share 6 was used for volumetry. Bland Altman plot was used for assessing the agreement between estimated graft weight (EGW) and actual graft weight (AGW). Results: There was no statistically significant difference between EGW and AGW for RL graft weight (722±134 vs. 717±126 gm;P=0.06). Although Bland Altman graph showed that 95% limits of agreement was more in LL (?164 to +110) than RL (?156 to +147) and LLS grafts (?137 to +239), CT scan significantly overestimated LL graft weight (EGW =460±118 gm vs. AGW =433±102 gm;P=0.003) and underestimated LLS graft weight (EGW =203±48 gm vs. AGW =254±49 gm;P<0.001). Conclusions: CT volumetry overestimate LL graft and underestimate LLS graft weight. This should be factored in when selecting LL graft by taking higher GRWR.

关键词： Liver transplantation graft weight CT volumetry living donor

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Transition from open to robotic assisted liver resection:A retrospective comparative *** experience of laparoscopic liver resections needed?

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Laparoscopic, Endoscopic and Robotic Surgery 2019年第4期2卷 94-98页

作者： Sanjay Goja Sanjay Kumar Yadav Rohan Jagat Chaudhary Manoj Kumar Singh Arvinder Singh soin Institute of Liver Transplantation and Regenerative Medicine Medanta-The MedicityGurugram122001India Liver Transplant Narayan Health City BengaluruIndia

Objective:The authors present outcomes of robotic liver resections in comparison with open technique questioning the need to have experience of laparoscopy for such procedures before transition to robotic *** and methods:Retrospective review of liver resections done robotically from February 2015 to June 2017 compared to matched control cohort of open cases from January 2012 to December ***:Twenty-one patients in the study groupwere comparedwithmatched control of 42 open cases(1:2 ratio).The types of procedure were similar in both the *** were 4 left lateral hepatectomy,3 left hepatectomy,and 1 left hepatectomy with hepatico-jejunostomy,3 right hepatectomy,3 right posterior sectorectomy,4 bisegmentectomy and 4 *** were 9 patients with primary liver cancer,2 each with livermetastasis and carcinoma gall bladder and 8 patients had benign liver *** blood losswas 370±311ml in the robotic group compared to 451±330ml in control group(p=0.06).Minor complications developed in 19.0%of robotic cases compared to 40.5%in open surgery,while major complications occurred in 4.7%of robotic cases compared to 7.1%of open *** hospital staywas 5.3±0.8 days for the robotic group and 7.7±4.2 days for open group(p=0.02).Local tumor recurrence occurred in 1 out of 13 resections done for malignancy in the robotic group and 7 out of 26 in the open ***:This study highlights the utility of surgical robots for segmental and complex liver resections with equivalent outcomes and decreased length of hospital stay compared to open surgery without having experience of same with the laparoscopy.

关键词： Robotic Liver resection Open surgery

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基维察镍铜矿的电磁研究

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物探化探译丛 1996年第A期 77-80页

作者： soin.,HT 崔霖沛

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采用130nm工艺技术的2．4Ghz CMOS浮动有源电感LNA的设计

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磁性元件与电源 2018年第11期 141-144,156页

作者： M.Muhamad N.soin H.Ramiah 马来西亚玛拉工艺大学(UiTM)电气工程学院吉隆坡马来亚大学工程学院

本文介绍了CMOS有源电感集成电路的设计和优化。这种有源电感器采用silterra0．13μm技术，并使用Cadence Virtuoso和Spectre RF进行仿真。该有源电感的中心频率为2.4GHz，符合IEEE 802．11b／g／n标准。为了减小硅芯片尺寸，在低噪声... 详细信息

本文介绍了CMOS有源电感集成电路的设计和优化。这种有源电感器采用silterra0．13μm技术，并使用Cadence Virtuoso和Spectre RF进行仿真。该有源电感的中心频率为2.4GHz，符合IEEE 802．11b／g／n标准。为了减小硅芯片尺寸，在低噪声放大器LNA电路中使用有源电感代替无源电感。该电感器通过低噪声放大器电路进行测试和分析。并已经进行了基于LNA电路的有源和无源电感之间的比较。结果表明，该有源电感器在不牺牲噪声系数和LNA增益的情况下，芯片尺寸显著缩小，面积为73％，这是LNA中最重要的标准。最佳低噪声放大器提供20．7dB的功率增益（S21），噪声系数（NF）为2.1dB。

关键词：有源电感 CMOS LNA 技术设计低噪声放大器 802.11b/g Virtuoso

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