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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González luis Fernando lópez-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel lomas Claudio Bueno Rosario Amaya JoséAntonio lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-león Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia lanseros-Tenllado Carmina lópez Isabel lópez Álvaro lópez-Barrios luis F.lópez-Cortés Rafael luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell long-COVID

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标准西班牙语 4

2010年

作者： nieves García Fernández 曹羽菲改 Pedro Gomis Blanco[编] 陆经生缪建华 Jesús Sánchez lobato

本书内容包括：西班牙语习题及参考答案。

ISBN: (纸本)9787107231186

本书内容包括：西班牙语习题及参考答案。

关键词：西班牙语

来源：畅想之星图书光盘版（南... 评论

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标准西班牙语 4

left Ventricle Postinfarction Pseudoaneurysm: Anatomical Forms and Surgical Management

2010年

作者： nieves García Fernández 曹羽菲改 Pedro Gomis Blanco[编] 陆经生缪建华 Jesús Sánchez lobato

本书内容包括：自测练习、总词汇表、课文词汇表、参考译文、参考答案等。

ISBN: (纸本)9787107231018

本书内容包括：自测练习、总词汇表、课文词汇表、参考译文、参考答案等。

关键词：西班牙语

来源：畅想之星图书光盘版（南... 评论

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Surgical Science 2014年第4期5卷 138-145页

作者： J. M. Garrido A. Ferreiro J. F. Rodríguez-Vázquez P. Prada S. Verdugo J. Silva S. lópez-Checa I. Sánchez-Montesinos Departamento de Anatomía y Embriología Humana II Facultad de Medicina Universidad Complutense de Madrid Madrid Spain Departamento de Anatomía y Embriología Humana Facultad de Medicina Universidad de Granada Granada Spain Servicio de Cirugía Cardiovascular HU Ramón y Cajal Departamento de Ciencias Morfológicas Universidad Europea de Madrid Madrid Spain Servicio de Cirugía Cardiovascular HU Ramón y Cajal Madrid Spain Servicio de Cirugía Cardiovascular HU Virgen de las Nieves Granada Spain

Introduction: left Ventricle Postinfarction Pseudoaneurysm (lVPS)—false aneurysm occurs after a free-wall rupture contained by the adjacent pericardium. lVPS lacks the normal structure of the ventricular wall and disrupts the normal chamber anatomy. However, the natural history, clinical presentation and surgical outcome are still unclear. For that reason, it is necessary to describe the most relevant anatomical characteristics of lVPS and the appropriate surgical strategies currently applied. Methods: We reviewed the anatomical characteristics of several patients diagnosed of lVPS and the surgical technique performed. In this work two different anatomical types of lVPS are described in detail, with the surgical and structural implications for left ventricle reconstruction. Results: There are two different anatomical forms of lVPS: 1) Typical pseudoaneurysm, with a small gateway neck between the left Ventricle and the false aneurysm chamber (Figure 1(A));2) Atypical pseudoaneurysm, in which the anatomical defect is bigger, without well-defined edges, extends over a large segment of infarcted and thinned myocardial tissue. In both cases, the therapeutics targets and the surgical techniques used were directed to restore the normal geometry of left Ventricle, keeping the optimal mitral valve function. Conclusions: The surgical key-step is to preserve or to remodel the ventricular chamber anatomy. This fact restores the ventricular geometry, not only removing the wall discontinuity that generated the pseudoaneurysm. Nevertheless, final prognosis depends on the underlying ischemic cardiomyopathy and mechanical complications, such us mitral regurgitation or ventricular septal defect.

关键词： Ventricular Anatomy left Ventricle Pseudoaneurysm Surgical Treatment Ventricular Remodelling Restore of left Ventricle Morphology and Function of left Ventricle Ischemic Cardiomyopathy

Duodenal duplication cyst and pancreas divisum causing acute pancreatitis in an adult male

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World Journal of Gastrointestinal Endoscopy 2010年第9期2卷 318-320页

作者： Eduardo Redondo-Cerezo Julio Pleguezuelo-Díaz Mercedes lópez de Hierro José F Macias-Sánchez Cristina Violo Ubia María Del Mar Martín-Rodríguez Javier De TeresaGalván Endoscopy Unit Gastroenterology DepartmentHospital Universitario Virgen de las NievesAvenida de las Fuerzas Armadas 2Granada 18014Spain

Duodenal duplication cysts are rare congenital abnormalities which are more commonly diagnosed in infancy and ***,in rare cases,these lesions can remain asymptomatic until *** combination of duplication cyst and pancreas divisum is extremely rare and both conditions have been linked with acute recurrent *** present the case of a 37 years-old patient who presented with repeated episodes of acute *** means of magnetic resonance imaging and endoscopic ultrasonography we discovered a duplication cyst whose cavity received drainage from the dorsal *** opening the cyst cavity to the duodenal lumen with a needle knife the patient presented no further episodes in the clinical *** literature findings and therapeutic options for these abnormalities are discussed with regard to the presented case.

关键词： Duplication cyst Pancreas divisum Acute recurrent pancreatitis Endoscopic ultrasonography

Volatile Components in the Flower, Pedicellate Ovary and Aqueous Residue of <i>Cymbidium</i>sp. (ORCHIDACEAE)

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Journal of Analytical Sciences, Methods and Instrumentation 2013年第4期3卷 212-218页

作者： Víctor García Gaytán María de las nieves Rodríguez Mendoza Marcos Soto Hernández libia I. Trejo-Téllez Martha E. Pedraza Santos Guadalupe Valdovinos Ponce Facultad de Agrobiología “Presidente Juárez” Uruapan México 4Postgrado en Fitosanidad Colegio de Postgraduados Texcoco México. Postgrado en Botánica Colegio de Postgraduados Texcoco México Postgrado en Edafología Colegio de Postgraduados Texcoco México Postgrado en Fitosanidad Colegio de Postgraduados Texcoco México. Víctor García Gaytán

Cymbidium sp. has several ornamental, medicinal and cosmetic uses. Essential oils were obtained through extraction by hydrodistillation of flower and pedicellate ovary. The chromatographic profile was obtained by thin layer chromatography (TlC), combined with gas chromatography-mass spectrometry (GC/MS), for the identification and relative quantification of various substances in three samples from the orchid (flower, pedicellate ovary and aqueous residue). With TlC, five compounds were identified in the flower, with the most abundant being terpineol, linalool and zingiberene, and five in the pedicellate ovary, with borneol, cineole, and β-bisabolene being in the greatest concentration, while for the aqueous residue, the most abundant was geraniol. Using GC/MS, 25 volatile components associated with the flower were identified, of which the most abundant were linalool (22.92%), 4-methyl-phenol (15.07%) and p-Menth-1-en-8-ol (12.32%). In pedicellate ovaries, 13 components were identified, with the most abundant being 4-methyl-phenol (31.24%), bicycle [4.4.0] dec-1-ene, 2-isopropyl-5-methyl-9-methylene-(17.74%) and 2-hexanone (10.24%), while in the aqueous residue 18 components were found, with the most abundant being 4-methyl-phenol (18.71%) and 2- cyclohexen-1-ol (14.60%).

关键词： Thin layer Chromatography Gas Chromatography Orchidaceae Hydrodistillation

Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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Molecular Plant 2022年第11期15卷 1826-1826页

作者： Cristina Navarro Cristian Mateo-Elizalde Thotegowdanapalya CMohan Eduardo Sánchez-Bermejo Oscar Urrutia María nieves Fernández-Muñiz JoséMGarcía-Mina Riansares Muñoz Javier Paz-Ares Gabriel Castrillo Antonio leyva 不详

(Molecular Plant 14,1489-1507;September 6,2021)In the“Accession numbers”section in the originally published version of our manuscript,we mistakenly listed At5g44570 as the Arabidopsis Genome Initiative locus identif... 详细信息

关键词： Arabidopsis identifier stability

Determinants of percutaneous coronary intervention success in repeat chronic total occlusion procedures following an initial failed attempt

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World Journal of Cardiology 2017年第4期9卷 355-362页

作者： Cecilia Cuevas Nicola Ryan Alicia Quirós Juan Gustavo Del Angel nieves Gonzalo Pablo Salinas Pilar Jiménez-Quevedo luis Nombela-Franco Ivan Nunez-Gil Antonio Fernandez-Ortiz Carlos Macaya Javier Escaned Cardiovascular Institute Hospital Clinico San Carlos28040 MadridSpain

AIM To investigate the rates and determinants of success of repeat percutaneous coronary intervention(PCI) following an initial failed attempt at recanalising the chronic total occlusions(CTO) *** In 445 consecutive first attempt CTO-PCI procedures in our institution,procedural failure occurred in 149(33.5%). Sixty-four re-PCI procedures were performed in 58 patients(39%) all had a single CTO. Procedural and outcome data in the re-PCI population was entered into the institutional database. A retrospective analysis of clinical,angiographic and procedural data was performed. RESUlTS Procedural success was achieved in 41(64%) procedures. Univariate analysis of clinical and angiographic characteristics showed that re-PCI success was associated with intravascular ultrasound(IVUS) guidance(19.5% vs 0%,P = 0.042),while failure was associated with severecalcification(30.4% vs 9.7%,P = 0.047) and a JCTO score > 3(56.5% vs 17.1% P = 0.003). Following multiple regression analysis the degree of lesion complexity(J-CTO score > 3),IVUS use,involvement of an experienced CTO operator and lAD CTO location were significant predictors of successful re-PCI. Overall the complication rate was low,with the only MACCE two periprocedural MI's neither of which required intervention. CONClUSION Re-PCI substantially increases the overall success rate of CTO revascularization. Predictors of re-PCI success included the use of IVUS,the involvement of an experienced CTO operator in the repeat attempt and the location of the CTO.

关键词： Repeat percutaneous coronary intervention Chronic total occlusion

Biological and Chemical Control in Rot Root in Avocado by Phytophthora cinnamomi Rands

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Journal of Agricultural Science and Technology(A) 2012年第7期2卷 882-887页

作者： Ma. Blanca nieves lara-Chavez Teresita del Carmen Avila-Val Jestus Alejandro Guerrero-Tejeda Francisco Said Barriga-Gonzalez Eulalio Venegas-Gonzalez Salvador Aguirre-Paleo Margarita Vargas-Sandoval Hector Guillen Andrade Satul Rodriguez-lopez Universidad Michoacana de San Nicolas de Hidalgo Facultad de Agrobiologla "Presidente Juarez" Uruapan Michoacan C.P.60190 Mexico

＂Avocado sadness＂ caused by the Oomycete Phytophthora cinnamomi Rands, is one of the main diseases affecting this fruit crop in Michoacan, M6xico, without having an efficient control strategy for that. In this research three Trichoderma isolates and Ridomil Gold 4E fungicide were tested in avocado trees infected with this pathogen using the growing and coloring vegetative flow growing. Results were analyzed with an experimental design completely random with four treatments and repetitions. Different responses were presented form avocado trees to each treatment. Trichoderma erinaceum Bissett, Kubicek ＆ Szackacs treatment was the best controlling disease in trees with grade II and III damage. Trichoderma aggressivum Samuels ＆ W. Gams controlled better in trees with grade III damage. At last, Trichoderma arundinaceum Zafari, Graef. and Samuels were the best controlling trees with the highest grade damage. Fungicide Ridomil Gold 4E controlled the disease in trees with the lowest grade damage （I and II）, their medias were similar to witness.

关键词： Biological and chemical control Trichoderma aggressivum T. erinaceum T. arundinaceum Ridomil Gold 4E.