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A perspective on molecular and cellular biology-based developmental toxicology biomarkers

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BIOCELL 2023年第12期47卷 2579-2590页

作者： SUKHENDU DEY SANDIPAN PAL apurba ratan ghosh PALAS SAMANTA Department of Environmental Science The University of BurdwanBurdwanIndia Department of Environmental Science Aghorekamini Prakashchandra MahavidyalayaSubhas NagarIndia Department of Environmental Science Sukanta MahavidyalayaUniversity of North BengalDhupguriIndia

The process of development is intricate and couple-dependent ***,the study of molecular and cellular biology-based developmental toxicology biomarkers increasingly is becoming an important part of risk assessment and management of chemicals for detection of health outcomes and/or biological endpoint like cytotoxicity,cell death,***,the evolution of developmental toxicology field a number of tools/markers have been developed or addressed to deal with developmental outcomes,which can ultimately be used for the development of adverse outcome pathways(AOPs)of developmental *** a result,this paper provides an overview of the current state of developmental toxicology biomarkers and describes the strategies used in the selection and evaluation of such biomarkers in the context of developmental toxicity ***,we discuss about the biological markers that are directly linked to developmental toxicity with respect to future revolutionary ***,this chapter will address different associated outcomes of developmental exposure by intriguing advance *** discussion focuses on the challenges associated with the development of biomarkers for developmental toxicity and highlights some of the recent advances in this ***,the chapter concludes with a brief discussion of the future prospects for the use of molecular and cellular biology-based developmental toxicity *** the present state of the art will provide a succinct summary of recent developments of biomarkers of developmental toxicology.

关键词： Developmental toxicology Biomarkers Adverse outcome pathways

Integrative assessment of biomarker responses in teleostean fishes exposed to glyphosate-based herbicide(Excel Mera 71)

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Emerging Contaminants 2016年第4期2卷 191-203页

作者： Sukhendu Dey Palas Samanta Sandipan Pal Aloke Kumar Mukherjee Debraj Kole apurba ratan ghosh Ecotoxicology Lab Department of Environmental ScienceThe University of BurdwanGolapbagBurdwan 713104West BengalIndia Division of Environmental Science and Ecological Engineering Korea UniversityAnam-dongSungbuk-guSeoul 02841Republic of Korea Department of Environmental Science Aghorekamini Prakashchandra MahavidyalayaSubhasnagarBengaiHooghly 712611West BengalIndia P.G.Department of Conservation Biology Durgapur Govt.CollegeDurgapur 713214West BengalIndia

Present study deals with the effects of glyphosate-based herbicide,Excel Mera 71 on Anabas testudineus,Heteropnestes fossilis and Oreochromis niloticus in field conditions(1.85 kg/ha)based on anti-oxidative,metabolic and digestive *** this study following biomarkers viz.,acetylcholinesterase(AChE),lipid peroxidation(LPO),catalase(CAT),glutathione-S-transferase(GST),alkaline phosphatase(ALP),aspartate aminotransferase(AST),alanine aminotransferase(ALT),amylase,lipase and protease were investigated in gill,stomach,intestine,liver,kidney,brain,muscle and spinal cord of the concerned fish *** activities were significantly altered by glyphosate exposure after 30 days,these activities were tissue as well as species *** results suggested that these biomarkers could be used to assess the ecological risks of glyphosate on *** factor(BAF)studied in different aquatic natural macrophytes showed order of Alternanthera philoxeroides>Azolla pinnata>Lemna sp.(Minor)>Lemna sp.(Major)>Pistia stratiotes,while transfer factor(TF)showed the order of Pistia stratiotes>Alternanthera philoxeroides>Lemna *** factor(BCF)study showed maximum accumulation of glyphosate in liver,kidney or intestine,and minimum either in bone or stomach irrespective of fish *** integrated biomarker response(IBR),which uses a battery of biomarkers to calculate the standardized scores for each biomarker responses ranging from physiological to biochemical/molecular responses,was evaluated by combining the multiple biomarkers into a single value to evaluate quantitatively the toxicological effects of *** general,the multiple indices exhibited variations and *** was more affected than other fish species;maximum IBR value was observed for LPO and minimum in case of *** order of integrated biomarkers caused by glyphosate treatment was recorded as follows:LPO>Amylase>CAT>AST>Protease>Lipase>ALP>GST>AChE>ALT for ***,LP

关键词： Excel Mera 71 Biomarker Bioaccumulation factor(BAF) Bioconcentration factor(BCF) Transfer factor(TF) Integrated biomarker response(IBR)

Direct choline administration in semi-intensive pisciculture system: A positive contaminant

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Emerging Contaminants 2021年第1期7卷 22-34页

作者： Subhas Das Sukhendu Dey Atanu Patra Arghya Mandal Niladri Sekhar Mondal Debnarayan Chowdhury Koushik ghosh apurba ratan ghosh Ecotoxicology Laboratory Department of Environmental ScienceThe University of BurdwanBurdwanWest BengalIndia Panacea the Aqua Clinic(Aquaculture Laboratory Cum Training Centre)Galsi-II BlockPurba BardhamanDepartment of FisheriesGovt.of West BengalIndia Environmental Science Laboratory Department of Environmental ScienceNetaji Subhas Open UniversitySalt Lake CityWest BengalIndia Aquaculture Laboratory Department of ZoologyThe University of BurdwanBurdwanWest BengalIndia

Present work evaluated the possible impact of choline on metabolic enzymes of cultured fish species into a semi-intensive pond culture system,reared with Catla catla(catla),Labeo rohita(rahu),Clarias batracus(magur)and Anabas testudineus(climbing perch)for 90 days in two *** was added directly into the pond water periodically throughout the experimental *** water quality parameters of each experimental pond were monitored and were analyzed in 15 days interval throughout the experimental tenure in both the *** were compared with treatment as choline-fed and control as non-choline-fed conditions during breeding(June-Aug.)and dry(Nov.-Jan.)*** metabolic enzymes,viz.,LDH(Lactate dehydrogenase),MDH(Malate dehydrogenase),and G6PDH(Glucose-6-phosphate dehydrogenase)activities in the muscle,liver,and AchE(Acetylcholine esterase)activity in the brain and muscle revealed maximum significantly(p<0.01),but ALT(Alanine aminotransferase)and AST(Aspartate aminotransferase)activity showed significant(p<0.01)depletion in the muscle and liver in treatment-breeding(TB)*** fishes under treatment-dry(TD)condition presented significant(p<0.01)higher elevation in HK(Hexokinase)activity in the muscle and ***,the result of principal component analysis(PCA)depicted the positive as well as in some cases a negative correlation among the enzymatic activities both in dry and breeding ***,it can be inferred that choline enrichment in fishes can substantiate the well nutritionally balanced food-flesh for consumption under this farm culture and the choline behaved as a positive contaminant into the pond eco-system under the semi-intensive culture condition.

关键词： Choline Metabolic enzymes Principal component analysis Breeding and dry season

Dose specific responses of Anabas testudineus(Bloch)to anthracene(PAH):Haematological and biochemical manifestation

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Emerging Contaminants 2019年第1期5卷 232-239页

作者： Sukhendu Dey Palas Samanta Niladri Sekhar Mondal Debraj Kole Arghya Mandal Atanu Patra apurba ratan ghosh Ectoxicology Lab Department of Environmental ScienceThe University of BurdwanBurdwan713104West BengalIndia Research Institute of Basic Sciences Incheon National UniversityIncheon22012Republic of Korea Department of Marine Science Incheon National University119 Academy-roYeonsu-guIncheon22012Republic of Korea

Present work compared the toxicological responses of ***(Bloch)to anthracene exposure after treatment with two concentrations i.e.,25%(0.0075 mg/l)and 50%(0.015 mg/l)of LC50 value(0.030 mg/l)for different exposure periods of 1,5,10,15 and 21 day(s).An intensive comparison of the effects was made based on haematological and biochemical parameters of *** responses revealed significant increase in some blood parameters,viz.,WBC,%LYM,MCV,MCH and MCHC but RBC,Hb,PCV and PLT showed decreasing *** responses like CHOLES,PRO,ALB,Trig showed enhanced pattern in the initial exposure of day one then reduced gradually but GLU,GPT,Ca,ALP,HDL,and LDL showed reverse ***,integrated biomarker responses(IBR)indicated that the biochemical parameters are more useful in determining the anthracene stress on fish health than the haematological *** findings of this study suggested that the IBR analysis is a useful tool in monitoring quantitative(dose-specific)as well as qualitative(exposure-specific)responses to toxicological effects of anthracene exposure on fish health.

关键词： Anthracene Haematological and biochemical parameters IBR

Reliability and efficiency enhancement of a radial distribution system through value-based auto-recloser placement and network remodelling

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Protection and Control of Modern Power Systems 2023年第1期8卷 1-14页

作者： Bratati ghosh Ajoy Kumar Chakraborty Arup ratan Bhowmik Department of Electrical Engineering National Institute of Technology AgartalaJiraniaTripura 799046India

The electric distribution system(EDS)is prone to faults leading to power *** present energy market demands that electricity utilities invest more in different measures to improve the performance of the *** approach proposed here details a composite dual-phased methodology to improve the reliability and efficiency of the power delivered by the *** the first phase,the optimal allocation of auto-reclosers(AR)is undertaken by employing a newly formulated *** determination of the total number and location for AR placement is based on the economic analysis of two factors,i.e.,AR investment-maintenance cost and total benefit earned in terms of reliability improvement due to AR *** analysis also takes into account the impact of power outages on different load types,the load growth rate,and the inflation ***,to enhance the efficiency of the AR-incorpo-rated EDS,the technique of Radial Distribution System Remodelling is employed in the second *** method searches for a radial configuration that delivers power at minimum line *** phases comprising complex combinatorial operations are aided by a fresh hybrid of the Sine Cosine Algorithm,Krill Herd Algorithm,and a genetic operator of Differential *** results obtained from its application on the IEEE 69-bus distribution test system prove the credibility of the suggested formulation.

关键词： Auto-recloser placement Load flow Metaheuristic optimization algorithm Power loss minimization Reconfiguration Reliability assessment