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Arterial embolization for iatrogenic *** bleeding from subcutaneous hypervascular tumor in prone position

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Chinese Journal of Traumatology 2010年第4期13卷 244-246页

作者： Seiji Morita Tomoatsu Tsuji Toru Sawamoto hiromichi Aoki Naoya Miura Hiroyuki Otsuka Sadaki Inokuchi Department of Emergency and Critical Care Medicine Tokai University School of Medicine 163 Shimokasuya Isehara-City Kanagawa Japan

Performing angiography in the prone position is a difficult technique; however it is useful in some emergency situation. We experienced a 60 years old male who was performed lipema excision on his back in his family doctor＇s clinic. Since massive arterial bleeding could not be controlled with manual astriction, he transferred to our hospital in prone position with hemodynamic instability. Operating field was not kept because of massive bleeding; therefore surgical treatment was impossible. We planed emergency arterial embolization （AE） in prone position. Hence we chose the left radial artery for vascular access. The left subclavicle arteriography showed many major and minor feeding arteries from left subclavicular and axillary arteries and a massive extravasation of the contrast medium. Three major feeding arteries were performed AE with gelatin sponge and steel coils, After AE, massive bleeding was controlled. He could discharge from our hospital on the 5th hospital day without any complication. Arterial embolization for lifethreatening bleeding from subcutaneous hypervascular tumor in the prone position is first report to our knowledge, and it is extremely rare. However we thought that this technique is useful for patients who could not turn in the supine position, e.g. massive bleeding during renal biopsy and penetrating trauma from back.

关键词： Angiography Prone position Neoplasms

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Fuel Gas Production from Biomass Sources by Radio Frequency In-Liquid Plasma Method

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Journal of Power and Energy Engineering 2015年第8期3卷 28-35页

作者： Ismail Rahim Shinfuku Nomura Shinobu Mukasa hiromichi Toyota Katsunori Kawanishi Yoshihiko Makiura Kazuhiko Kogoh Kunihiro Ohshima Susumu Katsuen Department of Engineering for Production and Environment Graduate School of Science and Engineering Ehime University Ehime Japan Department of Automotive Engineering Education State University of Makassar Makassar Indonesia KURABO Industries Ltd. Neyagawa Japan

Cellulose is a kind of saccharide that is the main component in cell walls of plants and therefore is the organic compound that exists in the largest amount in nature. The purpose of this experiment is to convert cellulose to a fuel. Radio frequency (RF) in-liquid plasma is generated in a cellulose distributed solution and a glucose solution, and the generation gas rate is measured. While hydrogen is the main gas generated by the plasma breakdown, carbon monoxide, carbon dioxide, and low-grade flammable gases are also produced. In the glucose water solution or the glucose distributed solution, the solution itself evaporates and decomposes inside the plasma but since the saccharides are non-volatile, they cannot penetrate into the plasma and are not decomposition. However, when the cellulose is at concentrations of 30 wt% or more, it becomes granular and can directly enter the plasma as a solid, where the plasma decomposes the cellulose itself, significantly increasing the amount of gas generated. In addition, the spectrometry of the plasma emission shows the solution after the creation of plasma has the ability to absorb ultraviolet light.

关键词： In-Liquid Plasma Radio Frequency Plasma Saccharide Hydrogen Decomposition

Strontium-89 Therapy for Breast Cancer Bone Metastases: Pain Relief Effects and Predictive Factors

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Advances in Breast Cancer Research 2018年第4期7卷 250-257页

作者： Yukinori Okada Tatsuyuki Abe Mio Shinozaki Shinjiro Sakaino hiromichi Gomi Yasuo Nakajima Yasuyuki Kojima Tomoko Uejima Koichiro Tsugawa Department of Radiology St. Marianna University School of Medicine Kawasaki Japan Department of Breast and Endocrine Surgery St. Marianna University School of Medicine Kawasaki Japan

In this study, we evaluate the analgesic effect of strontium-89 (Sr-89) for patients with breast cancer having multiple bone metastases and identify positive predictive factors. We retrospectively evaluated 15 patients who were administered Sr-89 for painful bone metastases from breast cancer at St. Marianna University Hospital between January 2010 and April 2014. For patients receiving multiple doses, only the first dose was evaluated. Pain relief was defined as a decrease in the score of the Numeric Rating Scale (NRS) or requirement of reduced doses of pain medication 1 - 2 months after being on Sr-89 administration. The associations between pain relief owing to Sr-89 and that owing to bone scan index, interval from bone metastasis onset to Sr-89 administration, zoledronate and denosumab treatment history, hormone therapy/aromatase inhibitor history, and chemotherapy history were assessed. A logistic model was used for statistical analysis. Pain relief was observed in 11 (73.3%) of 15 patients. No statistically significant value was observed between pain relief and bone scan index, interval from bone metastasis onset to Sr-89 administration, zoledronate and denosumab treatment history, hormone therapy/aromatase inhibitor history, and chemotherapy. Thus, Sr-89 was effective for 70% of patients with breast cancer bone metastases, although positive predictive factors for pain relief could not be determined.

关键词： Breast Cancer 89-Sr Analgesia

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用微安电流的接触电阻测量

中国检验检测 1991年第3期 49-51页

作者： hiromichi Yoshida 李红晖

1.前言接触电阻通常采用1—1000mA 的电流来测量。但由于表面被侵蚀产生的裂痕,诸如氧化和腐蚀,这样的电流似乎会引起接触电阻的降低。采用这种电流测出的电阻,实际上可能

关键词：相敏检波器电流接触电阻低通滤波器带通滤波器时间常数电流范围阻值

An oral fluoropyrimidine agent S-1 induced interstitial lung disease:A case report

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World Journal of Clinical Oncology 2011年第7期2卷 299-302页

作者： hiromichi Yamane Masahide Kinugawa Shigeki Umemura Yasuhiro Shiote Kenichiro Kudo Toshimitsu Suwaki Haruhito Kamei Nagio Takigawa Katsuyuki Kiura Division of Clinical Oncology Sumitomo-Besshi Hospital Cancer Center3-1 Ohji-choNiihamaEhime 792-8543Japan 4th Department of General Medicine Kawasaki Medical School2-1-80 NakasangeOkayama 700-8505Japan Department of Respiratory Medicine Okayama University Hospital2-5-1 Shikata-choOkayamaOkayama 700-8558Japan

A 66-year-old Japanese man with pancreatic cancer received eleven courses of gemcitabine *** tumor responded to gemcitabine until metastatic liver tumors ***,he was treated with S-1,an oral fluoropyrimidine anticancer agent,as salvage ***-two days after initiating S-1,he presented with dyspnea and *** computed tomography showed diffuse interstitial lesions with thickening of the alveolar septa and ground glass *** KL-6 level was elevated to 1,230 U/mL and he did not use any other drugs except ***,the development of interstitial lung disease(ILD)was considered to be due to *** blood oxygen pressure was 49.6 Torr in spite of oxygen administration(5 L/min).Steroid therapy improved his symptoms and the interstitial shadows on chest *** S-1-induced ILD has mostly been reported to be mild,clinicians should be aware that S-1 has the potential to cause fatal ILD.

关键词： Corticosteroid therapy Interstitial lung disease Pancreatic cancer S-1

Perforated appendiceal diverticulitis associated with appendiceal neurofibroma in neurofibromatosis type 1

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World Journal of Gastroenterology 2015年第33期21卷 9817-9821页

作者： Akihiko Ozaki Manabu Tsukada Kazuo Watanabe Masaharu Tsubokura Shigeaki Kato Tetsuya Tanimoto Masahiro Kami hiromichi Ohira Yukio Kanazawa Division of Surgery Minamisoma Municipal General Hospital Division of Diagnostic Pathology Fukushima Pathology Laboratory Division of Social Communication System for Advanced Clinical Research Institute of Medical ScienceUniversity of Tokyo Division of Internal Medicine Soma Central Hospital Jyoban Hospital of Tokiwakai Group Division of Endoscopy Minamisoma Municipal General Hospital

An appendiceal neurofibroma(ANF) is a rare neoplasm associated with neurofibromatosis type 1(NF-1),an inheritable neurocutaneous disorder that involves multiple systems including the intraabdominal *** diverticulitis occasionally ruptures in the absence of intense abdominal pain,which can lead to serious *** reports highlight the association between appendiceal diverticulum and appendiceal neoplasms; however,there is still little information on the association between appendiceal diverticulitis and ANF in NF-1.A 51-year-old Japanese male with NF-1 was referred to the division of surgery for mild right lower quadrant *** was suspected he had perforated acute appendicitis with periappendiceal abscess based on clinical manifestations and findings of computed *** emergency appendectomy was *** pathological examination revealed diffusely proliferated tumor cells of a neurofibroma,coexistent with multiple appendiceal diverticulums,leading to the diagnosis ofperforated appendiceal diverticulitis associated with *** he developed a remnant abscess,he recovered with the conservative treatments of antibiotics and *** case suggests that appendiceal diverticulitis might be a complication of appendiceal involvement of NF-1,and that it occasionally ruptures in the absence of intense abdominal *** should recognize that NF-1 can cause various abdominal manifestations.

关键词： Appendiceal diverticulum Appendiceal diverticuliti

Variant angina pectoris associated with FOLFOX4 therapy

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World Journal of Gastrointestinal Oncology 2011年第11期3卷 165-168页

作者： hiromichi Yamane Minoru Matsubara Shigeki Umemura Toshimitsu Suwaki Haruhito Kamei Nagio Takigawa Katsuyuki Kiura Mitsune Tanimoto Division of Clinical Oncology Sumitomo-Besshi Hospital Cancer Center Department of General Internal Medicine 4 Kawasaki Medical School2-1-80 Naka- sangeOkayama 700-8505Japan Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Department of Respiratory Medicine Okayama University Hospital Department of Hematology Oncology and Respiratory MedicineOkayama University Graduate School of Medicine

The patient was a 71-year-old man who underwent a right hemicolectomy for ascending colon cancer(pT3,pN1,pM0) and who opted not to receive adjuvant *** months later,multiple liver metastases *** therefore received FOLFOX4(5-fluorouracil/leucovorin and 85 mg/m 2 oxaliplatin) therapy,up to a total of 5 courses,and showed a partial *** receiving the sixth course of FOLFOX4,he complained of chest pain and systemic itching approximately 15 min after the start of *** electrocardiogram revealed typical signs of *** arteriography showed that the coronary arteries were *** the chest pain to be merely coincidental,we continued with the same ***,he again developed the same chest pain during the seventh cycle of FOLFOX4 and treatment was *** concluded that the patient's symptoms were due to acute coronary syndrome(ACS) associated with the FOLFOX4 *** angina as a type of ACS is a rare adverse effect of FOLFOX4. Clinicians should be aware of this potential adverse effect when monitoring patients receiving FOLFOX4.

关键词： FOLFOX4 Acute coronary syndrome Variant angina Allergy

对局限性前列腺癌患者采用直肠内球囊中度低分割调强放射治疗的长期结局

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癌症 2018年第12期37卷 523-532页

作者： Bin S.Teh Gary D.Lewis Weiyuan Mai Ramiro Pino hiromichi Ishiyama Edward Brian Butler Department of Radiation Oncology Houston Methodist Hospital Cancer Center and Research Institute Weill Cornell Medical College Department of Radiation Oncology The University of Texas Medical Branch at Galveston Department of Radiation Oncology Baylor College of Medicine Department of Radiology and Radiation Oncology Kitasato University School of Medicine

背景与目的放射治疗的技术进步使兼顾剂量递增和提升膀胱和直肠保留成为可能。然而,对于局限性前列腺癌的最佳辐射剂量分割方案尚不清楚。实验室和临床证据表明,低分割可提高放疗的治疗率。在此报道我们医院采用中度低分割调强放疗(inte... 详细信息

背景与目的放射治疗的技术进步使兼顾剂量递增和提升膀胱和直肠保留成为可能。然而,对于局限性前列腺癌的最佳辐射剂量分割方案尚不清楚。实验室和临床证据表明,低分割可提高放疗的治疗率。在此报道我们医院采用中度低分割调强放疗(intensity?modulated radiotherapy,IMRT)和直肠内球囊对局限性前列腺癌患者的治疗结局,重点关注患者的长期生化控制和治疗相关不良事件。方法从1997年1月到2004年4月,596例c T1–T3前列腺癌患者使用带直肠内球囊的中度低分割方案(76.70 Gy,2.19 Gy/次)进行IMRT。根据D'Amico分类低风险、中风险或高风险患者分别226(37.9%)例、264(44.3%)例和106(17.8%)例。大多数中、高风险患者接受雄激素剥夺治疗。使用2005年Phoenix标准评估无生化复发生存(biochemical relapse?freeSurvival,bRFS),并使用Kaplan?Meier法进行估算。结果中位随访时间为62个月。总的5年bRFS和10年bRFS率分别为92.7%和87.7%。低风险、中风险和高风险患者的5年bRFS率分别为96.9%、93.3%和82.0%,10年bRFS率分别为91.4%、89.3%和76.2%。前列腺特异性抗原、Gleason评分和T分期是bRFS的重要预测因子(均P<0.01)。重度(≥3级)不良事件的5年发生率非常低:胃肠道不良事件和泌尿生殖系统不良事件的发生率分别为1.2%和1.1%。结论中度低分割IMRT后的长期结局令人鼓舞。中度低分割是治疗局限性前列腺癌的安全、有效的替代方案。

关键词：前列腺癌调强放疗中度低分割

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Recovery of serum testosterone following neoadjuvant and adjuvant androgen deprivation therapy in men treated with prostate brachytherapy

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World Journal of Radiology 2015年第12期7卷 494-500页

作者： Hideyasu Tsumura Takefumi Satoh hiromichi Ishiyama Shuhei Hirano Kenichi Tabata Shinji Kurosaka Kazumasa Matsumoto Tetsuo Fujita Masashi Kitano Shiro Baba Kazushige Hayakawa Masatsugu Iwamura Department of Urology Kitasato University School of Medicine Department of Radiation Oncology Kitasato University School of Medicine

AIM: To investigate the time course of testosterone(T) recovery after cessation of androgen deprivation therapy(ADT) in patients treated with brachytherapy. METHODS: One-hundred and seventy-four patients treated between June 1999 and February 2009 were studied. Patients were divided into a short-term usage group(≤ 12 mo, n = 91) and a long-term usage group(≥ 36 mo, n = 83) according to the duration of gonadotropin-releasing hormone agonist therapy. Median follow-up was 29 mo in the short-term group and was 60 mo in the long-term ***: Cumulative incidence rates of T recovery to normal and supracastrate levels at 24 mo after cessationwere 28.8% and 74.6%, respectively, in the long-term usage group, whereas these values were 96.4% and 98.8% in the short-term usage group. T recovery to normal and supracastrate levels occurred significantly more rapidly in the short-term than in the long-term usage group(P < 0.001 and P < 0.001, respectively). Five years after cessation, 22.6% of patients maintained a castrate T level in the long-term usage group. On multivariate analysis, lower T levels(< 10 ng/d L) at cessation of ADT was significantly associated with prolonged T recovery to supracastrate levels in the longterm usage group(P = 0.002). CONCLUSION: Lower T levels at cessation of ADT were associated with prolonged T recovery in the longterm usage group. Five years after cessation of longterm ADT, approximately one-fifth of patients still had castrate T levels. When determining the therapeutic effect, especially biochemical control, we should consider this delay in T recovery.

关键词： Androgen deprivation Gonadotropinreleasing hormone agonist Prostate brachytherapy Prostate cancer Testosterone