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Localization and Associative Strength of Acid Polysaccharides in Coccoliths of <i>Pleurochrysis haptonemofera</i>(Haptophyta) Predicted from Their Extractability from Partially Decalcified Coccoliths

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Open Journal of Marine Science 2013年第1期3卷 48-54页

作者： Yasutaka Hirokawa Satoru Matsuzuka Sho Itayama Tatsuya Uchida Shoko Fujiwara Noriaki Ozaki hiromichi Nagasawa Mikio Tsuzuki Department of Applied Biological Chemistry Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan Department of Applied Biological Chemistry Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan Department of Biotechnology Akita Prefectural University Akita Japan School of Life Sciences Tokyo University of Pharmacy and Life Sciences Hachioji Japan School of Life Sciences Tokyo University of Pharmacy and Life Sciences Hachioji Japan 3Japan Science and Technology Agency CREST Tokyo Japan School of Life Sciences Tokyo University of Pharmacy and Life Sciences Hachioji Japan Faculty of Science and Engineering Waseda University Tokyo Japan

The coccolithophorids have calcified scales called coccoliths on their surface that include abundant acid polysaccharides. To determine the localization and associative strength of acid polysaccharides Ph-PS-1, -2, and -3 incoccoliths of Pleurochrysis haptonemofera, we analyzed the acid polysaccharides extracted with urea from partially decalcified coccoliths. On treatment of coccoliths with8.0 Murea at pH8.0 inboiling water, Ph-PS-2 was not extracted, but parts of Ph-PS-1 and -3 were from the surface without the crystal morphology being affected. When coccoliths were partially decalcified at various pHs (pH 8.0 - 5.0), Ph-PS-1, -3, and -2 were extracted with urea in that order as the calcite crystals dissolved. Detection of the acid polysaccharides using fluorescein-isothiocyanate-labeled lectin (ConA) and anti-Ph-PS-2 antibodies demonstrated that Ph-PS-2 exists on the surfaces of both untreated and urea-treated coccoliths. Moreover, NaClO-treatment under moderate conditions extracted only Ph-PS-1, -3, and part of Ph-PS-2 from coccoliths, without separation of the crystal units, suggesting that at least some part of Ph-PS-2 acts as a glue connecting crystal units and/or a crystal unit and a base plate inside coccoliths. These results suggest that Ph-PS-2 exists not only on the surface but also inside of the coccoliths, most of it being strongly bound to coccoliths, while Ph-PS-1 and -3 are weakly associated close to the coccolith surface, in that order from the surface. This strongly supports a scheme in which PS-2 type acid polysaccharides play an important role in the crystal nucleation and PS-3 type functions during crystal growth.

关键词： Acid Polysaccharide Calcification Coccolithophorid Localization Pleurochrysis haptonemofera Urea-Extraction

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奶粉生产和干燥工程学

中国乳品工业 1989年第1期17卷 41-45页

作者：林弘通吕钧日本东京农业大学生物产业学部

1.绪言牛奶是由大约90%的水分和10%的固形物组成的。因为这些固形物主要是由蛋白质、脂肪、碳水化合物等营养丰富的物质组成的,所以容易发生由微生物引起的腐败现象。因此为了提高牛奶的保存期,可通过于燥降低牛奶中的水分,制成奶粉,从... 详细信息

1.绪言牛奶是由大约90%的水分和10%的固形物组成的。因为这些固形物主要是由蛋白质、脂肪、碳水化合物等营养丰富的物质组成的,所以容易发生由微生物引起的腐败现象。因此为了提高牛奶的保存期,可通过于燥降低牛奶中的水分,制成奶粉,从而使贮藏的体积减少,同时也便于运输。

关键词：奶粉生产干燥工程学

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2021年版日本抗震性能化设计手册解读5:设计案例验证判定标准——设计案例的比较分析(一)

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建筑结构 2023年第4期53卷 29-31页

作者：盐手博道山下设计东京103-8542

经过验证证明,通过实力Ds和Qe对应的层间位移角所判定的抗震性能等级,与时程反应分析的抗震性能等级基本一致。

关键词：性能设计静力设计中低层建筑抗震性能等级层间位移角实力Ds

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Milnacipran for Attention-Deficit Hyperactivity Disorder Symptoms in Adult Asperger’s Disorder

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Open Journal of Psychiatry 2014年第3期4卷 195-201页

作者： Hirobumi Mashiko hiromichi Ishikawa Shuntaro Itagaki Yasuko Takanashi Norihiro Miyashita Takaaki Okano Shin-Ichi Niwa Hirooki Yabe Department of Neuropsychiatry School of Medicine Fukushima Medical University Fukushima City Japan

The efficacy of milnacipran for the treatment of ADHD symptoms in adult Asperger’s disorder patients was examined. Fifteen consecutive adult Asperger’s disorder patients with ADHD symptoms were treated with milnacipran for 8 weeks. Global Assessment of Functioning (GAF) and Conners’ Adult ADHD Rating Scales Objective Screening Version (CAARS-O-SV) were used for the assessment. The mean GAF scores in the 15 patients improved significantly. Inattention, inattention + hyperactivity/impulsivity and ADHD index in CAARS-O-SV were also significantly improved. Milnacipran might be useful for ADHD symptoms, exerting its effects by increasing serotonin and noradrenaline activities in Asperger’s disorder.

关键词： Milnacipran ADHD Asperger’s Disorder

Longitudinal rCBF Changes Measured with SPECT in Patients with Depression Undergoing Treatment

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Open Journal of Psychiatry 2017年第3期7卷 147-161页

作者： Norihiro Miyashita hiromichi Ishikawa Shuntarou Itagaki Yasuko Takanashi Takaaki Okano Hirobumi Mashiko Humio Shishido Shin-Ichi Niwa Fukushima Medical University School of Medicine Department of Neuropsychiatry Fukushima Japan Kumamoto Clinic of Psychosomatic Medicine Kumamoto Japan Fukushima Medical University School of Medicine Department of Radiology Fukushima Japan Department of Psychiatry Aizu Medical Center Fukushima Medical University Fukushima Japan

Regional cerebral blood flow (rCBF) studies of major depression have yielded variable results. The present study employed a longitudinal observation method to measure rCBF every 3 months during treatment. Thirteen patients with major depressive disorder underwent single-photon emission computed tomography (SPECT) with 99mTc-HMPAO three times over a 6-month period. rCBF was analyzed with the Statistical Parametric Mapping. The findings were compared to scans from 14 normal control subjects. Depression symptoms were rated using the Hamilton Rating Scale for Depression. At baseline, the main regions with lower rCBF compared to controls were the middle and inferior frontal gyri, superior temporal gyrus, and cingulate cortex. Three months later, despite significant improvement of depressive symptoms, decreased rCBF was observed in the same regions, but to lesser extent. At 6 months, depressive symptoms showed continued improvement, and rCBF in the superior temporal gyrus increased up to control levels, but rCBF in the temporal pole, cingulate, and inferior frontal gyrus remained low. The results of the present study suggest that there might be time- and state-dependent differences in rCBF recovery in patients with major depression.

关键词： Depression Regional Cerebral Blood Flow SPECT Dorsolateral Prefrontal Cortex Cingulate Cortex

Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects:how far shall we wander?

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Acta Pharmacologica Sinica 2019年第8期40卷 1119-1126页

作者： Qin Lu Sheng-ming Wang Yi-xiao Liu Hong Chen Rui Zhang Wen-hui Zhang Yuan-yuan Zou Jia-wei Zhou Xin-yi Guo Ying Zhang Teng-Li Huang Yu-hang Liu Si-qi Zhang Kyosuke Yamanishi hiromichi Yamanishi Hideaki Higashino Haruki Okamura Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of Medicine Hirakata Ryoikuen

Successful prevention and treatment of hypertension depend on the appropriate combination of antihypertensive drug therapy and nondrug lifestyle *** most hypertension guidelines recommend moderate-to high-intensity exercise,we decided to explore a mild yet effective type of exercise to add to hypertension management,especially in populations with complications or *** comparing the short-term cardiovascular effects of low-speed walking versus high-speed walking for 3 kilometers(km)(3 km/h versus 6 km/h)in young,healthy volunteers,we delivered low-speed walking(low-intensity walking,2.5 metabolic equivalents of task,METs)as exercise therapy in 42 prehypertensive and 43 hypertensive *** found that one session of 3 km low-intensity walking exerted a transient pressure-lowering effect as well as a mild negative chronotropic effect on heart rate in both the prehypertensive and hypertensive subjects;these short-term benefits on blood pressure and heart rate were accompanied by a brief increase in urine β-endorphin *** we prescribed regular low-intensity walking with a target exercise dose(exercise volume)of 500-1000 METs-min/week(50-60 min/day and 5-7 times/week)in hypertensive subjects in addition to their daily *** low-intensity walking also showed mild but significant blood pressure-lowering and heart rate-reducing effects in 7 hypertensive subjects within two *** is hypothesized that regular low-intensity exercise of the necessary dose could be taken as a pragmatic and supplementary medication for hypertension management.

关键词： hypertension prehypertension exercise medication low-intensity walking metabolic equivalent of task blood pressure heart rate urine β-endorphin

Unusual spontaneous improvement in Asian variant of intravascular large B-cell lymphoma

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Open Journal of Internal Medicine 2012年第1期2卷 15-18页

作者： Takashi Ninomiya Toru Nakamura Nobuharu Fujii Akio Hiraki Shigeki Umemura hiromichi Yamane Atsuko Shirakawa Haruhito Kamei Department of Hematology Oncology and Respiratory Medicine Okayama University Hospital Okayama Japan Department of Hematology Oncology and Respiratory Medicine Okayama University Hospital Okayama Japan Department of Medicine Sumitomo-Besshi Hospital Niihama Japan Department of Medicine Sumitomo-Besshi Hospital Niihama Japan Department of Pathology Sumitomo-Besshi Hospital Niihama Japan

The clinical course of the Asian variant of intravascular large B-cell lymphoma (AIVL) is generally very aggressive. We describe a case of AIVL demonstrating an unusual clinical course, with spontaneous improvement. An 81-year-old man with high-grade fever and thrombocytopenia was admitted to our hospital. Although we could not confirm the origin of his symptoms, they disappeared completely without intervention within 2 weeks. Three months later, however, thrombocytopenia reappeared and progressed. Finally, he was readmitted due to a subdural hemorrhage with high fever and he finally died of rapidly progressive multiple organ failure. Autopsy findings revealed the presence of B-cell lymphoma cells in microscopic vessels of many organs as well as hemophagocytosis in the bone marrow. He was diagnosed with AIVL with an unusual indolent clinical course with spontaneous improvement.

关键词： Lymphoma Intravascular Large B-Cell Lymphoma Spontaneous Improvement Hemophagocytosis

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直喷式柴油机中的HCCI燃烧

汽车与新动力 2005年第3期 25-30页

作者： Ryo Hasegawa hiromichi Yanagihara 王耀清

对直喷式柴油机中均质充量压燃（HCCI）的着火和燃烧控制进行了研究。研究中通过共轨喷油系统采用了两次喷油技术。第一次喷油用于燃油扩散的早喷,促使改变燃油量,以降低碳氢排放（即低温反应）。第二次喷油用作所有喷入燃油的着火引发... 详细信息

对直喷式柴油机中均质充量压燃（HCCI）的着火和燃烧控制进行了研究。研究中通过共轨喷油系统采用了两次喷油技术。第一次喷油用于燃油扩散的早喷,促使改变燃油量,以降低碳氢排放（即低温反应）。第二次喷油用作所有喷入燃油的着火引发物。已发现当早喷保持低温反应时,第二次喷油能够控制预混合气的着火。还发现随着增压压力的提高,着火定时稍有提前,压力升高率明显降低。压力升高率是影响这种燃烧运转极限的因素之一,因此产品发动机应用可变喷嘴涡轮增压器（VNT）可使增压压力得到控制。采用 X 光摄影法对喷束特性和燃烧分析图像进行了研究。没有观察到光焰,从 X 光照片上仅观察到由低温反应产生的脉动。在燃烧室内出现了许多着火点。采用这种燃烧,在第一次喷油和第二次喷油期间可以同时降低 NOx和烟度。这种 HCCI 概念由作者等人命名为成片均质燃烧系统（UNIBUS）,并在2000年8月被应用于日本市场的产品发动机（1KD-FTV、3L 4缸）中。

关键词：柴油机均质充量压燃喷油系统燃烧

A rare case of primary choriocarcinoma in the sigmoid colon

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World Journal of Gastroenterology 2013年第39期19卷 6683-6688页

作者： Hiromitsu Maehira Tomoharu Shimizu hiromichi Sonoda Eiji Mekata Tomoharo Yamaguchi Tohru Miyake Mitsuaki Ishida Tohru Tani Department of Surgery Shiga University of Medical ScienceShiga 520-2192Japan Department of Clinical Laboratory Medicine Shiga University of Medical ScienceShiga 520-2192Japan

Primary colorectal choriocarcinoma is an extremely rare neoplasm and is usually associated with a poor *** 13 cases of colorectal choriocarcinoma have previously been *** is no standard chemotherapeutic regimen for this tumor type.A 68-year-old man presented with melena and was diagnosed with sigmoid colonic adenocarcinoma with multiple liver *** underwent a laparoscopic *** revealed choriocarcinoma with a focal component of moderately differentiated adenocarcinoma of colon *** on the collagen gel droplet-embedded culture drug sensitivity test(CD-DST)results,mFOLFOX6 and bevacizumab were administered,which suppressed aggressive tumor growth for 4 *** patient died 9 mo after the initial *** study results suggest that the standard chemotherapy regimen for colorectal cancer might have suppressive effects against primary colorectal ***,CD-DST may provide,at least in part,therapeutic insight for the selection of appropriate antitumor agents for such patients.

关键词： Colon cancer Colorectal cancer Chemotherapy Culture drug sensitivity test Choriocarcinoma