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Long-term outcome of a moderately hypofractionated, intensity-modulated radiotherapy approach using an endorectal balloon for patients with localized prostate cancer

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Cancer Communications 2018年第1期38卷 136-144页

作者： Bin S.Teh Gary D.Lewis Weiyuan Mai Ramiro Pino hiromichi Ishiyama Edward Brian Butler Department of Radiation Oncology Houston Methodist HospitalCancer Centerand Research InstituteWeill Cornell Medical College6565 FanninSte#DB1-077HoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical Branch at GalvestonGalvestonTX 77555USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiology and Radiation Oncology Kitasato University School of MedicineSagamihara 252-0374Japan

Background:Technical advances in radiotherapy delivery have simultaneously enabled dose escalation and enhanced bladder and rectal ***,the optimal radiation fractionation regimen for localized prostate cancer is *** and clinical evidence suggest that hypofractionation may improve the therapeutic ratio of *** report our institutional outcomes using moderately hypofractionated,intensity-modulated radio-therapy(IMRT),and an endorectal balloon,with emphasis on long-term biochemical control and treatment-related adverse events in patients with localized prostate ***:Between January 1997 and April 2004,596 patients with cT1-T3 prostate cancer underwent IMRT using a moderate hypofractionation regimen(76.70 Gy at 2.19 Gy/fraction)with an endorectal *** D’Amico clas-sification,226(37.9%),264(44.3%),and 106(17.8%)patients had low-,intermediate-,or high-risk disease,*** majority of intermediate-and high-risk patients received androgen deprivation *** relapse-free survival(bRFS)was evaluated using 2005 Phoenix criteria and estimated using the Kaplan-Meier ***:The median follow-up was 62 *** 5-and 10-year bRFS rates were 92.7%and 87.7%.For low-,intermediate-,and high-risk patients,the 5-year bRFS rates were 96.9%,93.3%,and 82.0%,respectively;the 10-year bRFS rates were 91.4%,89.3%,and 76.2%,***-specific antigen,Gleason score,and T stage were significant predictors of bRFS(all P<0.01).The 5-year rates of severe(≥Grade 3)adverse events were very low:1.2%for gastrointestinal events and 1.1%for genitourinary ***:Long-term outcomes after moderately hypofractionated IMRT are *** hypofrac-tionation represents a safe,efficacious,alternative regimen in the treatment of localized prostate cancer.

关键词： Prostate cancer Intensity-modulated radiotherapy Moderate hypofractionation

A patient presenting painful chest wall swelling: Tietze syndrome

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World Journal of Emergency Medicine 2019年第2期10卷 122-124页

作者： Kohei Sawada Hiromi Ihoriya Taihei Yamada Tetsuya Yumoto Kohei Tsukahara Takaaki Osako hiromichi Naito Atsunori Nakao Department of Emergency Critical Care and Disaster Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Dear editor,Patients frequently visit the emergency room with acute chest *** some potentially life-threatening disorders may cause the pain,in approximately 80%of cases,the chest pain source is benign,and musculoskeletal chest pain accounts for nearly 20%– 50%of those cases.^[1–6]Thus,pain caused by benign and pathological conditions of the chest wall encountered in the emergency department is sometimes incorrectly attributed to angina pectoris or pleuritic and other serious cardiopulmonary diseases.

关键词： Patients frequently emergency room life-threatening

Camber Angle Control Method Corresponding to the Electric Vehicle Age

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Engineering（科研） 2014年第8期6卷 472-484页

作者： Takahiko Yoshino hiromichi Nozaki Department of Mechanical Engineering University of Kogakuin Tokyo Japan

In recent years, the conversion of vehicles to electric power has been accelerating, and if a full conversion to electric power is achieved, further advancements in vehicle kinematic control technology are expected. Therefore, it is thought that kinematic performance in the critical cornering range could be further improved by significantly controlling not only the steering angle but also the camber angle of the tires through the use of electromagnetic actuators. This research focused on a method of ground negative camber angle control that is proportional to the steering angle as a technique to improve maneuverability and stability to support the new era of electric vehicles, and the effectiveness thereof was clarified. As a result, it was found that in the critical cornering range as well, camber angle control can control both the yaw moment and lateral acceleration at the turning limit. It was also confirmed that both stability and the steering effect in the critical cornering range are improved by implementing ground negative camber angle control that is proportional to the steering angle using actuators. Dramatic improvements in cornering limit performance can be achieved by implementing ground negative camber angle control that is proportional to the steering angle.

关键词： Motion Control Automobile Vehicle Dynamics Maneuverability Camber Angle Control

Air-Pollutant-Philic Plants for Air Remediation

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Journal of Environmental Protection 2012年第10期3卷 1346-1352页

作者： Misa Takahashi hiromichi Morikawa Department of Mathematical and Life Sciences Graduate School of Science Hiroshima University Higashi-Hiroshima Japan

In this communication, we review our work over two decades on air-pollutant-philic plants that can grow with air pollutants as the sole nutrient source. We believe that such plants are instrumental in mitigating air pollution. Our target air pollutant has been atmospheric nitrogen dioxide (NO2), and our work on this subject has consisted of three parts: Variation in plants’ abilities to mitigate air pollutants among naturally occurring plants, genetic improvement of plants’ abilities to mitigate air pollutants, and the plant vitalization effect of NO2. So far, an estimation of the half-life of nitrogen derived from NO2 uptake in plants belonging to the 217 taxa studied to date has shown no plants to be naturally occurring air-pollutant-philic. However, we found that an enormous difference exists in plants’ ability to uptake and assimilate atmospheric NO2. Future studies on the causes of this process may provide an important clue to aid the genetic production of plants that are effectively air-pollutant-philic. Both genetic engineering of the genes involved in the primary nitrate metabolism and genetic modification by ion-beam irradiation failed to make plants air-pollutant-philic, but mutants obtained in these studies will prove useful in revealing those genes critical in doing so. During our study on air-pollutant-philic plants, we unexpectedly discovered that prolonged exposure of plants to a sufficient level of NO2 activates the uptake and metabolism of nutrients that fuel plant growth and development. We named this phenomenon “the plant vitalization effect of NO2” (PVEON). Investigations into the mechanisms and genes involved in PVEON will provide an important clue to making plants air-pollutant-philic in the future.

关键词： Air-Pollutant-Philic Plants Air Remediation Genetic Modification Nitrogen Dioxide NO2 Plant Vitalization Effect of NO2

Fibrinogen degradation product levels on arrival for trauma patients requiring a transfusion even without head injury

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World Journal of Emergency Medicine 2017年第2期8卷 106-109页

作者： Youichi Yanagawa Kouhci Ishikawa Kci Jitsuiki Toshihiko Yoshizawa Yasumasa Oodc Kazuhiko Omori hiromichi Ohsaka Department of Acute Critical Care Medicine Shizuoka HospitalJuntendo UniversityNagaoka Izunokuni City ShizuokaJapan

BACKGROUND: There have been few reports on the clinical significance of the fibrinogen degradation product(FDP) level in trauma patients with and without head injury. We retrospectively analyzed trauma patients with or without head injury to investigate the clinical signifi cance of the FDP ***: From April 2013 to June 2015, a medical chart review was retrospectively performed for all patients with trauma. The exclusion criteria included patients who did not receive a transfusion. The patients were divided into two groups: a FDP>100 group, which included patients who had an FDP level on arrival over 100 ng/m L, and a FDP≤100 ***: The ratio of open fractures and the prothrombin ratio in the FDP>100 group were significantly smaller than those observed in the FDP≤100 group. The average age, ratio of blunt injury, Injury Severity Score(ISS), volume of transfusion and mortality ratio in the FDP>100 group were signifi cantly greater than those in the FDP≤100 group. There was a weakly positive correlation between the FDP level and ISS(R=0.35, P=0.002), but it was not associated with the transfusion volume. The results of an analysis excluding patients with head injury showed a similar ***: The FDP levels may be a useful biochemical parameter for the initial evaluation of the severity of trauma and mortality even in blunt traumatized patients without head injury or with stable vital signs.

关键词： Fibrinogen degradation product Injury Severity Score Transfusion Mortality

Active Control Method for Critical Cornering Range

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Engineering（科研） 2014年第8期6卷 406-417页

作者： Takahiko Yoshino hiromichi Nozaki Department of Mechanical Engineering University of Kogakuin Tokyo Japan

It has been reported that steering systems with derivative terms have a heightened lateral acceleration and yaw rate response in the normal driving range. However, in ranges where the lateral acceleration is high, the cornering force of the front wheels decreases and hence becomes less effective. Therefore, we applied traction control for the inner and outer wheels based on the steering angle velocity to improve the steering effectiveness at high lateral accelerations. An experiment using a driving simulator showed that the vehicle’s yaw rate response improved for a double lane change to avoid a hazard;this improves hazard avoidance performance. Regarding improved vehicle control in the cornering margins, traction control for the inner and outer wheels is being developed further, and much research and development has been reported. However, in the total skid margin, where few margin remains in the forward and reverse drive forces on the tires, spinout is unavoidable. Therefore, we applied tire camber angle control to improve vehicle maneuverability in the total skid margin. An experiment using a driving simulator has confirmed that the vehicle’s lateral acceleration at the turning limit can be improved by controlling the camber angle. Because of this, camber angle control promises to be more effective than traction control for the inner and outer wheels. By applying this type of steering control, it is possible to increase maneuverability and stability in the cornering margins.

关键词： Motion Control Automobile Vehicle Dynamics Maneuverability Active Safety

Variable Gear Ratio Control Using Vehicle Body Slip Angle

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Engineering（科研） 2014年第8期6卷 439-448页

作者： Takahiko Yoshino hiromichi Nozaki Department of Mechanical Engineering University of Kogakuin Tokyo Japan

Vehicles with variable steering characteristics have long been studied and compared with those having typical fixed gear ratio steering, and the variable gear ratio properties are reported to have improved maneuverability and stability in high-speed lane changes and on slippery low-friction road surfaces. However, it is not clear how gear ratios should be set for individual vehicle characteristics. Therefore, the present study has investigated a variable steering gear system using body slip angle feedback for the purpose of improved maneuverability and stability in the critical cornering range and upwards, in excess of the critical limit, and into the countersteer range. The results of a driving simulator experiment show that the steering effect improves and maneuverability and stability increase in the critical cornering range and upwards, in excess of the critical limit, and into the countersteer range by applying linear-variable control to the steering ratio from a body slip angle of 5?. This result is seen both in double lane changes, such as in hazard avoidance, and in J-turns with long drifting. Moreover, it shows an improvement in drift controllability through prompt countersteering. Overall, the present system can enhance the driver’s hazard avoidance capability.

关键词： Motion Control Automobile Vehicle Dynamics Maneuverability Variable Gear Ratio

Evaluation study on properties of a macroporous silica-based CMPO extraction resin to be used forminor actinides separation from high level liquid waste

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Nuclear Science and Techniques 2011年第1期22卷 18-24页

作者： LIU Ruiqin WEI Yuezhou Daisuke Tozawa XU Yuanlai Shigekazu Usuda hiromichi Yamazaki Keizo Ishii Yuichi Sano Yoshikazu Koma School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Cyclotron and Radioisotope Center Tohoku UniversityAoba 6-3Aramaki-Aoba-kuSendaiMiyagi980-8578Japan Japan Atomic Energy Agency (JAEA) TokaiIbaraki319-1195Japan

Basic properties of a silica-based octyl(phenyl)-N,N-diisobutylcarbamoyl-methylphosphine oxide (CMPO) extraction resin (CMPO/SiO2-P) was *** behavior for some rare earth elements (RE) which are constituents of high level liquid waste (HLLW) and the long-term stability of the extraction resin in nitric acid solution were *** CMPO extraction resin was significantly stable in 3 mol·L?1 HNO3 solution at ***,the RE(III) were efficiently separated from non-adsorptive fission product (FP) elements such as Sr(II) in a column experiment using a highly nitric acid *** separation behaviors of the elements are considered to result from the difference in their adsorption and elution selectivity based on the complex formation with *** was no strong dependency of RE(III) separation efficiency on feed solution flow *** from the perspectives of the acid-resistant behavior of CMPO extraction resin and the elution kinetics for the metal ions with the extraction resin,the CMPO extraction resin can be used in the modified MAREC process for HLLW partitioning.

关键词：萃取树脂高放废液锕系元素分离性能大孔硅提取基础选择性吸附

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一种测定表面扩展黏度的新方法:真球气泡法

中国矿业大学学报 2020年第5期49卷 998-1005页

作者：许鹏军余仲达郑少波王炜 hiromichi Takebe KUSUHIRO Mukai 上海大学材料科学与工程学院省部共建高品质特殊钢冶金与制备国家重点实验室上海200072 武汉科技大学湖北省冶金二次资源工程技术研究中心湖北武汉430081 Ehime University Matsuyama 790-0826 Kyushu Institute of Technology Kyushu 804-8550

用真球气泡法测定表面扩展黏度,其测量精度高达97.50%.常温下采用真球气泡法测定浓度为1~10 mmol/L的十二烷基硫酸钠(SDS)表面活性剂溶液的表面扩展黏度κ值.结果表明:SDS浓度为1~4 mmol/L时κ快速增长,为4.0~8.3 mmol/L时κ增长幅度变... 详细信息

用真球气泡法测定表面扩展黏度,其测量精度高达97.50%.常温下采用真球气泡法测定浓度为1~10 mmol/L的十二烷基硫酸钠(SDS)表面活性剂溶液的表面扩展黏度κ值.结果表明:SDS浓度为1~4 mmol/L时κ快速增长,为4.0~8.3 mmol/L时κ增长幅度变小,8.3 mmol/L时κ达到峰值,之后κ随着SDS浓度的增大而减小;SDS浓度为4.0~8.3 mmol/L时,气泡稳定,即表面扩展黏度值达到稳定.通过真球气泡法测定表面张力,得到SDS表面活性剂溶液的发泡力稳定,即表面张力达到稳定时的浓度为5~6 mmol/L.因此当SDS表面活性剂作为泡沫浮选中的浮选药剂时,其最佳浓度为5~6 mmol/L.

关键词：真球气泡法表面张力表面扩展黏度 SDS表面活性剂气泡稳定性