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Long-Term Follow-Up of Microsurgical Reconstruction for Pelvic Tumor Focusing on Spinal Deformity and Quality of Life

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Journal of Cancer Therapy 2014年第4期5卷 354-362页

作者： Soichi Ejiri Shin-ichi Kikuchi Takahiro Tajino ryoichi Kawakami Michiyuki Hakozaki Shin-ichi Konno Department of Orthopaedic Surgery Fukushima Medical University School of Medicine Fukushima Japan

Background: To provide patients with a superior quality of life (QOL) after their pelvic tumor resection, ensuring the stability of the trunk as well as satisfactory lower extremity function is important. Although microsurgical reconstructions for the pelvic ring and hip are used clinically, the details of postoperative long-term spinal deformity and QOL remain unclear. Methods: The patients were 66- and 43-year-old men and a 43-year-old woman. The mean postoperative follow-up period was 134 months. The surgical procedures performed on these patients were: pelvic ring reconstruction using a double-barreled free vascularized fibular graft (FVFG) in Patient 1;simultaneous pelvic ring reconstruction using FVFG and hip arthrodesis in Patient 2;and latissimus dorsi free flap without pelvic ring reconstruction in Patient 3. As indicators of spinal deformity, we measured the Cobb angle, thoracic kyphosis angle, lumbar lordosis angle, pelvic angle on the sagittal plane, and sagittal plane balance using whole spine radiography. To assess the patients’ QOL, we examined the International Society of Limb Salvage (ISOLS) score, the Roland-Morris Disability Questionnaire (RDQ), activities of daily living (ADL) satisfaction using a visual analogue scale (VAS), and the SF-36. Results: Spinal alignment in the frontal plane worsened in order from Patient 1 to 3. Spinal alignment and pelvic tilt in the sagittal plane were at appropriate levels in Patients 1 and 2. The trunk tilt in the sagittal plane was at an appropriate level only in Patient 1. In the QOL assessment, the function of the affected limb worsened in order from Patient 1 to 3. RDQ scores were lower than the national norm in Patients 2 and 3. With respect to ADL satisfaction and the SF-36, Patient 3 had a markedly low VAS, physical functioning, role-physical, and role-emotional scores. Conclusion: In the long-term clinical course after pelvic tumor resection, in order to obtain satisfactory spinal alignment and QOL, pelvi

关键词： Pelvic Tumor Pelvic Ring Reconstruction Quality of Life Spinal Deformity Vascularized Fibular Graft

STRUCTURE OF THE ELECTRIFIED IONIC LIQUID|WATER INTERFACE STUDIED BY SECOND HARMONIC GENERATION

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STRUCTURE OF THE ELECTRIFIED IONIC LIQUID|WATER INTERFACE ST...

Spinal Epidural Cavernous Hemangioma of the Thoracic Spine: A Case Report

第十二届北京分析测试学术报告会暨展览会(BCEIA 2007)

作者： Naoya NISHI ryoichi ISHIMATSU Yukinori YASUI Masahiro YAMAMOTO Takashi KAKIUCHI Department of Energy and Hydrocarbon Chemistry Graduate School of Engineering Kyoto University

Two-phase systems composed of water(W)and hydrophobic room-temperature ionic liquids(ILs)have been studied by many researchers for possible applications such as liquid-liquid extraction and two-phase *** far,we have studied the IL-W two-phase systems from the electrochemical viewpoint[1-4].Some of characteristics of the IL-W two-phase systems we found,such as high selectivity of dibenzo-18-crown-6 to Kover Na[1]and adsorptivity of hydrophilic anions at the

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Open Journal of Orthopedics 2015年第10期5卷 311-318页

作者： ryoichi Fukano Yasuaki Iida Keiji Hasegawa Yuichirou Yokoyama Akihito Wada Shigeta Takeuchi Kazutoshi Shibuya Hiroshi Takahashi Department of Orthopaedic Surgery Toho University School of Medicine Tokyo Japan Department of Pathology Toho University School of Medicine Tokyo Japan

Cavernous hemangiomas can arise in any region of the body, including the central nervous system. Spinal cavernous hemangiomas account for 5% - 12% of all cases of vertebral vascular malformation. Most of these are of vertebral origin, and cases that are non-vertebral in origin are rare. We encountered a patient with a relatively rare spinal epidural cavernous hemangioma of the thoracic spine that was non-vertebral in origin. The patient was a 63-year-old man. He had become aware of bilateral leg pain and numbness about 2 months earlier, and gait disturbance appeared gradually thereafter. On MRI, a lesion showing iso-intensity on T1-weighted imaging and high intensity on T2-weighted imaging was detected at the 7th thoracic vertebra. On gadolinium contrast-imaging, the lesion was found to be a homogenously-enhanced dumbbell-shaped extradural spinal neoplasm protruding from the left 7th/8th thoracic intervertebral foramen. A neurogenic tumor was suspected based on myelography and MRI findings, and complete tumorectomy was performed, which improved the lower limb symptoms and gait disturbance. The histopathological diagnosis was cavernous hemangioma. Epidural hemangiomas arise from the vertebra in many cases, and pure spinal epidural cavernous hemangiomas are rare. It is difficult to make a preoperative diagnosis because there are no specific imaging findings that can differentiate these tumors. It may be important to consider this disease before surgery in the differential diagnosis of epidural tumors.

关键词： Epidural Cavernous Hemangioma Thoracic Spine Myelopathy

Development of vesicovaginal fistula caused by vaginal adenosis: A case report

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Open Journal of Obstetrics and Gynecology 2013年第5期3卷 435-437页

作者： Tasuku Mariya Takahiro Suzuki Shutaro Habata Motoki Matsuura Miwa Suzuki ryoichi Tanaka Tsuyoshi Saito Department of Obstetrics and Gynecology Sapporo Medical University Sapporo Japan

Introduction: Vaginal adenosis is one of the rare diseases of the vagina, and almost all patients are asymptomatic. We report a case of spontaneous vaginal adenosis, which caused vesicovaginal fistula. Case Presentation: Our patient was a 25-year-old Japanese woman. She was admitted to our hospital, and her chief complaint was continuous urine flow from the vagina. We found a tumor with a vesicovaginal fistula in her vagina. Subsequent cytological analysis of vaginal smears showed a normal vaginal mucosa. The patient underwent tumor resection and a fistula patch. Pathological diagnosis was adenosis of the vagina, even though the patient had no known history of intrauterine diethylstilbestrol exposure or Müllerian developmental abnormalities. Conclusion: The clinical course of our case was a malignant tumor, which invasively bored a hole in the vaginal wall forming a vesicovaginal fistula, even though it was a benign lesion. Therefore, overzealous treatment should be avoided in this case.

关键词： Vaginal Adenosis Vesicovaginal Fistula Surgical Repair Urine Continence

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运动能力对老年人医疗费的影响

体育与科学 2009年第6期30卷 60-63+76页

作者：杨光永富良一沈阳师范大学体育科学学院东北大学医学系

近年,随着"少子高龄"现象的产生,老年人医疗费利用率呈逐年上升的趋势。而体育锻炼是改善生理功能水平、提高运动能力、降低跌倒骨折意外发生率、减少医疗消耗、延缓衰老进程最有效手段。但运动能力水平对老年人医疗费影响的相关研究报... 详细信息

近年,随着"少子高龄"现象的产生,老年人医疗费利用率呈逐年上升的趋势。而体育锻炼是改善生理功能水平、提高运动能力、降低跌倒骨折意外发生率、减少医疗消耗、延缓衰老进程最有效手段。但运动能力水平对老年人医疗费影响的相关研究报道还很少。本研究以日本仙台鹤谷地区70岁以上的国民健康保险加入者904名为对象,针对老年人的运动能力进行了现场监测。并通过日本宫城县国民健康保险科的协助,对平均每人每月所消耗的医疗费,进行了37个月的前瞻性队列调查。结果显示,男性下肢肌肉力量和十米最大步行速度的优秀组老年人平均每人每月消耗的医疗费均明显低于其他三组;而女性下肢肌肉力量、十米最大步行速度和起立行走计时测试优秀组的老年人平均每人每月消耗的医疗费也明显低于其他各组;此外,无论男女,综合运动能力优秀组的老年人平均每人每月所使用的医疗费均显示出低消耗的倾向。提示,体育锻炼作为改善老年人生理机能水平,提高运动能力,降低跌倒骨折的发生率,抑制医疗费增长起到了重要的作用。

关键词：运动能力老年人医疗费

Antithrombin Ⅲ injection via the portal vein suppresses liver damage

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World Journal of Gastroenterology 2012年第16期18卷 1884-1891页

作者： Masayuki Miyazaki Masaki Kato Masatake Tanaka Kosuke Tanaka Shinichiro Takao Motoyuki Kohjima Tetsuhide Ito Munechika Enjoji Makoto Nakamuta Kazuhiro Kotoh ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Gastroenterology Kyushu Medical CenterNational Hospital OrganizationFukuoka 810-0065Japan Department of Clinical Pharmacology Faculty of Pharmaceutical SciencesFukuoka UniversityFukuoka 814-0180Japan

AIM:To investigate the effects of antithrombin Ⅲ(AT Ⅲ) injection via the portal vein in acute liver ***:Thirty rats were intraperitoneally challenged with lipopolysaccharide(LPS) and D-galactosamine(GalN) and divided into three groups:a control group;a group injected with AT Ⅲ via the tail vein;and a group injected with AT Ⅲ via the portal *** Ⅲ(50 U/kg body weight) was administrated 1 h after challenge with LPS and *** levels of inflammatory cytokines and fibrin degradation products,hepatic fibrin deposition,and hepatic mRNA expression of hypoxiarelated genes were ***:Serum levels of alanine aminotransferase,tumor necrosis factor-α and interleukin-6 decreased significantly following portal vein AT Ⅲ injection compared with tail vein injection,and control *** vein AT Ⅲ injection reduced liver cell destruction and decreased hepatic fibrin *** treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme ***:A clinically acceptable dose of AT Ⅲ injection into the portal vein suppressed liver damage,probably through its enhanced anticoagulant and antiinflammatory activities.

关键词： Antithrombin Ⅲ Acute liver failure Intravascular coagulation Portal vein

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平衡的方法

科学新闻 2022年第3期 63-64页

作者： ryoichi Fujiwara 倪伟波小石城阿肯色大学医学科学中心药学院

“享受你的生活，不要担心工作。”医生这样告诉我。最近，我搬到德国做访问学者，希望能再买一份处方安眠药，此前已经服用一年多了。医生花了将近一个小时听我的故事。然后，令我惊讶的是，他说不会再给我开处方药了。他说我需要重新...

“享受你的生活，不要担心工作。”医生这样告诉我。最近，我搬到德国做访问学者，希望能再买一份处方安眠药，此前已经服用一年多了。医生花了将近一个小时听我的故事。然后，令我惊讶的是，他说不会再给我开处方药了。他说我需要重新思考自己的生活和工作方式，而不是依赖药物。我觉得自己正在失去生命支持——但我很快就知道他是对的。我在东京做了5年的助理教授。我加班，周末也要工作——管理实验室、撰写资助申请和教学。这很有挑战性，也很有趣。我以为一切都很顺利。

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A Case of Septic Arthritis of the Shoulder Joint That Developed after Suprascapular Nerve Block

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Open Journal of Orthopedics 2020年第2期10卷 25-32页

作者： Taihei Go Toshiyuki Tsutsui Yasuaki Iida Katsunori Fukutake ryoichi Fukano Kosei Ishigaki Masayuki Sekiguchi Hiroshi Takahashi Department of Orthopedics Toho University Tokyo Japan Department of Orthopedics Sagamihara Chuo Hospital Kanagawa Japan Department of Orthopedics Omori Red Cross Hospital Tokyo Japan Department of Orthopedics Japan Community Health Care Organization Tokyo Kamata Medical Center Tokyo Japan

Septic arthritis of the shoulder is uncommon in the immunocompetent patient with no previous risk factors for joint infection. We treated an immunocompetent patient who developed septic arthritis of the shoulder after suprascapular nerve block for pain due to rotator cuff tear. An 80-year-old man with no underlying disease visited a nearby orthopedics clinic with complaint of left shoulder joint pain. Left suprascapular nerve block was performed, but the pain gradually aggravated. On the day after the block, he had a fever of 39°C and came to our department. On examination, enlargement and tenderness were present at the injection site. Cellulitis at the site was suspected. He was admitted and administration of a cephem anti-biotic was started. Pain subsequently decreased. Magnetic resonance imaging (MRI) performed 4 days after hospitalization showed massive effusion close to the injection site. The effusion spread into the joint cavity through the tear site of the supraspinatus. Septic arthritis of the shoulder was strongly suspected, open irrigation and debridement were performed 11 days after hospitalization. After surgery, pain immediately improved. In our case the extra-articular infection caused by suprascapular nerve block considered to spread into the shoulder joint cavity through the site of rotator cuff tear, although there have been no reports of such cases. This case suggests the possibility that patients with rotator cuff tear may easily develop septic arthritis because extra-articular infection may spread into the joint cavity through the site of tear.

关键词： Septic Arthritis of the Shoulder Joint Suprascapular Nerve Block Rotator Cuff Tear

Molecular interactions between anticancer drugs and iodinated contrast media: An in vitro spectroscopic study

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Journal of Biomedical Science and Engineering 2012年第1期5卷 24-33页

作者： ryoichi Ishii Hiromu Mori Kenji Matsumura Norio Hongo Hiro Kiyosue Shunro Matsumoto Takeshi Yoshimi Seiji Ujiie 不详

Purpose: The purpose of this study is to assess molecular interactions between several anticancer drugs and an iodinated contrast medium by Fourier transform infrared spectroscopy (FT-IR) and ultraviolet-visible spectroscopy (UV-Vis). Materials and Methods: Iopamidol (IPM) was used as an iodinated contrast medium, and mitomycin C (MTI), epirubicin hydrochloride (EPI), cisplatin (CDDP), 5-fluorouracil (5FU), irinotecan hydrochloride (CPT11), gemcitabine hydrochloride (dFdC), carboplatin (CBDCA), oxaliplatin (1OHP), paclitaxel hydrochloride (TAX) and docetaxel trihydrate (TXT) were used as anticancer drugs. For FT-IR, the purified IPM was mixed stoichiometrically with each anticancer drug as well as with a combination of MTI and EPI. After measuring each separated sample and the mixtures, the spectra of the mixtures were compared with the spectra of the sum of pure samples or the combination. For UV-Vis, IPM and anticancer drugs were dissolved in pure water;subsequently for the titration experiments, the mixtures were prepared by varying the molar ratio. IR absorption corresponds to stretching vibrations between atoms having covalent bonding, whereas UV-Vis spectra depend on molecular dynamics and shapes. Both UV-Vis and IR spectra change when there are molecular interactions such as aromatic ring stacking and hydrogen bonding. Result: IPM exhibited molecular interactions with MTI, EPI, CDDP, dFdC, CBDCA, 1OHP, TAX and TXT, as well as with the combination of MTI and EPI on FT-IR. However, molecular interactions were not observed on UV-Vis. Conclusion: Several anticancer drugs have molecular interactions with IPM, which could be clinically utilized for superselective intraarterial infusion chemotherapy.

关键词： Blast Molecular Interactions Anticancer Drugs Iodinated Contrast Medium Fourier Transform Infrared (FT-IR) Spectroscopy Ultraviolet-Visible (UV-Vis) Spectroscopy