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Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： ZHANG Yue XIao Yan-wei MA Jing-xin WANG ao-xue Department of Dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and ***:HaCaT cells were treated with *** proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration *** mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,***_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with *** expression of circ_0084443 was detected by ***:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

Flavor mixing and solution structures in Dyson–Schwinger equations for a two-flavor system

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Communications in Theoretical Physics 2024年第10期 64-77页

作者： xue-ao Chao Yu-xin Liu Department of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Collaborative Innovation Center of Quantum Matter Center for High Energy Physics Peking University

We solved the Dyson–Schwinger(DS) equations for a two-flavor system with symmetry to study its flavor mixing effects. Initially, we employed the point interaction model and bare vertex approximation to reveal the structure of the solutions. Using the point interaction model, the DS equations can be solved analytically, and we found that these solutions can be classified into three groups, each forming an ellipse. These solutions exhibit SO(2) symmetry, while the original SU(2)symmetry at the Lagrangian level is dynamically broken to SO(2), corresponding to the emergence of flavor mixing effects. However, this flavor mixing effect does not manifest in the final physical *** utilizing the system's SO(2) symmetry, we can diagonalize the propagators of the DS equations,eliminating the flavor mixing effect but causing the originally degenerate masses at the Lagrangian level to split. These mass eigenstates have identical quantum numbers but different masses. If we can correspond these to quark particles of different generations, we can explain why the three generations of quarks have different masses and obtain the corresponding quark mass spectrum. Finally, we provide the corresponding numerical results using a more realistic interaction model.

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CXCL7/CXCR2轴调控突触可塑性在肥胖相关认知功能障碍中的作用

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中国药理学通报 2024年第5期40卷 881-886页

作者：胡佳许傲雪胡锐薛琦黄春霞张野安徽医科大学第二附属医院麻醉与围术期医学科麻醉与围术期医学安徽普通高校重点实验室安徽合肥230601

目的从动物和细胞两个层面探讨趋化因子配体7[chemokine(C-X-C motif)ligand 7,CXCL7]/趋化因子受体2(CXCR2)轴在肥胖相关认知功能障碍中的作用机制。方法高脂饮食诱导的肥胖模型(diet-induced obesity,DIO),采用新物体识别实验检测认... 详细信息

目的从动物和细胞两个层面探讨趋化因子配体7[chemokine(C-X-C motif)ligand 7,CXCL7]/趋化因子受体2(CXCR2)轴在肥胖相关认知功能障碍中的作用机制。方法高脂饮食诱导的肥胖模型(diet-induced obesity,DIO),采用新物体识别实验检测认知水平;免疫荧光染色法观察海马小胶质细胞、星形胶质细胞的活化水平以及小鼠突触后密度蛋白95(postsynaptic density protein 95,PSD95)的含量。采用ELISA法测定海马组织CXCL7的含量;高尔基染色法测定海马神经元树突棘密度。其次,分别使用重组小鼠CXCL7和干扰CXCR2表达的si-RNA处理HT22小鼠海马神经元细胞系。用细胞免疫荧光染色法观察HT22细胞的CXCL7和PSD95的表达水平。结果与Ctrl组小鼠比较,DIO组小鼠在新物体识别实验中的辨别指数明显降低;伴有海马小胶质细胞、星形胶质细胞的活化水平明显升高,PSD95的含量减少,神经元的树突棘密度降低,CXCL7的含量明显升高。与DIO组小鼠相比,AWL组小鼠在新物体识别实验中的辨别指数明显升高。与Ctrl组细胞比,Ctrl+CXCL7组的PSD95水平降低;与Ctrl+CXCL7组细胞比,si-CXCR2+CXCL7组的PSD95水平升高。结论高脂饮食诱导肥胖小鼠的中枢神经炎症,进而引起认知功能障碍,可能是与CXCL7/CXCR2轴介导的突触可塑性改变有关。

关键词： CXCL7 CXCR2 肥胖认知功能障碍神经炎症

环北部湾广西水资源配置工程水土保持方案弃渣场设计

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广西水利水电 2024年第4期 139-141页

作者：黄傲雪广西水利电力勘测设计研究院有限责任公司南宁530023

介绍了生产建设项目水土保持方案管理办法出台的背景。在梳理相关水土保持方案编制要求的基础上,分析环北部湾广西水资源配置工程水土保持方案弃渣场设计的具体内容,提出减少工程弃渣及综合利用、弃渣场选址与防护等方案。

关键词：弃渣场选址防护设计弃渣减量综合利用环北部湾广西水资源配置工程

补骨脂改善APP/PS1小鼠学习记忆能力的尿液代谢组学研究

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药学学报 2024年第4期59卷 1010-1016页

作者：乔月薛傲张悦徐红丹李光赵继会胡晶张宁黑龙江中医药大学药学院黑龙江哈尔滨150040 无锡卫生高等职业技术学校药学系江苏无锡214028 中国医学科学院药用植物研究所云南分所云南景洪666100 湖南医药学院药学院湖南怀化418000

运用尿液非靶代谢组学探究补骨脂改善APP/PS1小鼠学习记忆能力的作用机制。所有动物实验均经过黑龙江中医药大学动物伦理委员会批准(批准号:2020092502)。将16只3月龄雄性APP/PS1小鼠随机分为模型组和补骨脂组(0.5 g·kg^(-1)),另取8只... 详细信息

运用尿液非靶代谢组学探究补骨脂改善APP/PS1小鼠学习记忆能力的作用机制。所有动物实验均经过黑龙江中医药大学动物伦理委员会批准(批准号:2020092502)。将16只3月龄雄性APP/PS1小鼠随机分为模型组和补骨脂组(0.5 g·kg^(-1)),另取8只同背景C57BL/6J小鼠作为空白组,以避暗实验和新物体识别实验为评价指标,通过超高效液相色谱-四级杆-飞行时间串联质谱(UPLC-Q-TOF-MS)测定各组小鼠尿液中内源性代谢物的变化,筛选差异代谢物,并进行代谢通路富集分析。实验结果显示,与模型组相比,补骨脂可明显减少APP/PS1小鼠的避暗潜伏期及错误次数(P<0.01),显著提高APP/PS1小鼠的新物体识别指数(P<0.01)。代谢组学分析鉴定出15个差异代谢物,补骨脂能显著回调9个差异代谢物。代谢通路分析显示,组氨酸代谢、柠檬酸循环、牛磺酸和次牛磺酸代谢和糖代谢途径是补骨脂发挥改善学习记忆能力作用的主要代谢途径。研究提示,补骨脂改善APP/PS1小鼠的学习记忆能力的机制可能与改善线粒体功能障碍、降低外周组胺水平、调节能量代谢紊乱及抗氧化水平等相关。

关键词：补骨脂阿尔茨海默病代谢组学能量代谢 APP/PS1小鼠

促进剂1,5-亚戊基二硫代氨基甲酸锌赋予天然橡胶的交联结构及均化应力作用

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高分子通报 2024年第2期37卷 238-244页

作者：肖小坤刘大晨朱博聪薛奥楠王志强沈阳化工大学材料科学与工程学院沈阳110142 蔚林新材料科技股份有限公司濮阳457000

以1,5-亚戊基二硫代氨基甲酸锌(ZPDC)为促进剂,对天然橡胶(NR)的交联结构和均化应力作用进行研究。研究发现,促进剂ZPDC配合NR的硫化胶交联键以多硫键为主,对比于同类促进剂二正丁基二硫代氨基甲酸锌(BZ)具有更高含量的多硫键,赋予橡胶... 详细信息

以1,5-亚戊基二硫代氨基甲酸锌(ZPDC)为促进剂,对天然橡胶(NR)的交联结构和均化应力作用进行研究。研究发现,促进剂ZPDC配合NR的硫化胶交联键以多硫键为主,对比于同类促进剂二正丁基二硫代氨基甲酸锌(BZ)具有更高含量的多硫键,赋予橡胶更好的均化应力作用,主要表现在抗撕裂性能的显著提升。此外,通过对NR配合促进剂ZPDC的硫化历程和力学性能的分析研究,发现适宜的硫化温度条件为120~130℃,用量为1.5~2.0 phr,硫化胶表现出最好的均化应力作用。

关键词：天然橡胶均化用力作用交联结构抗撕裂性能

Laparoscopic umbilical trocar port site endometriosis:A case report

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World Journal of Clinical Cases 2020年第8期8卷 1532-1537页

作者： xue ao Wei Xiong Shi-Qiao Tan Department of Obstetrics and Gynecology West China Second University HospitalKey Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationChengdu 610041Sichuan ProvinceChina

BACKGROUND Abdominal wall endometriosis can occur secondary to gynecological and obstetric pelvic laparotomy;however,this is a rare clinical *** are few cases of endometriosis involving the incision site of a laparoscopic surgery,especially for those of the endometrial nodule at the umbilical trocar port site where the camera is *** SUMMARY We describe the case of a 37-year-old woman who presented with a 2-year history of a tough swelling below the umbilicus,which presented periodical pain during *** patient had undergone laparoscopic ovarian cystectomy 4 years prior,and we theorized that the umbilical nodule was a complication of that laparoscopic *** analysis confirmed the diagnosis of abdominal umbilical scar endometriosis secondary to previous laparoscopic *** removal of the nodule followed by three cycles of leuprorelin was *** Abdominal mass and pain in women of childbearing age with a previous history of pelvic surgery should support consideration of endometriosis at the surgical site.

关键词： Endometriosis Laparoscopy Abdominal wall Scar endometriosis Ovarian cystectomy Case report

Zero-shot Fine-grained Classification by Deep Feature Learning with Semantics

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International Journal of Automation and computing 2019年第5期16卷 563-574页

作者： ao-xue Li Ke-Xin Zhang Li-Wei Wang The Key Laboratory of Machine Perception (MOE) School of Electronics Engineering and Computer SciencePeking University

Fine-grained image classification, which aims to distinguish images with subtle distinctions, is a challenging task for two main reasons: lack of sufficient training data for every class and difficulty in learning discriminative features for representation. In this paper, to address the two issues, we propose a two-phase framework for recognizing images from unseen fine-grained classes, i.e., zeroshot fine-grained classification. In the first feature learning phase, we finetune deep convolutional neural networks using hierarchical semantic structure among fine-grained classes to extract discriminative deep visual features. Meanwhile, a domain adaptation structure is induced into deep convolutional neural networks to avoid domain shift from training data to test data. In the second label inference phase, a semantic directed graph is constructed over attributes of fine-grained classes. Based on this graph, we develop a label propagation algorithm to infer the labels of images in the unseen classes. Experimental results on two benchmark datasets demonstrate that our model outperforms the state-of-the-art zero-shot learning models. In addition, the features obtained by our feature learning model also yield significant gains when they are used by other zero-shot learning models, which shows the flexility of our model in zero-shot finegrained classification.

关键词： Fine-grained image classification zero-shot learning deep feature learning domain adaptation semantic graph

脓毒症患者并发急性肾损伤的危险因素分析及Nomogram预测模型的构建

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广东医学 2024年第6期45卷 712-716页

作者：敖雪邓超侯宇吴生赞中南大学湘雅医学院附属海口医院重症医学科海南海口570208

目的分析脓毒症患者并发急性肾损伤的危险因素,并构建列线图(Nomogram)预测模型。方法选取2020年3月至2022年9月就诊的180例脓毒症患者为研究对象,根据患者是否并发急性肾损伤将其分为急性肾损伤组(n=75)和非急性肾损伤组(n=105)。采用... 详细信息

目的分析脓毒症患者并发急性肾损伤的危险因素,并构建列线图(Nomogram)预测模型。方法选取2020年3月至2022年9月就诊的180例脓毒症患者为研究对象,根据患者是否并发急性肾损伤将其分为急性肾损伤组(n=75)和非急性肾损伤组(n=105)。采用受试者工作特征(ROC)曲线分析连续性变量的预测价值;采用logistic回归分析影响脓毒症患者并发急性肾损伤的危险因素;采用内部数据验证Nomogram模型临床效能。结果两组患者在年龄等一般资料的比较中,差异无统计学意义(P>0.05)。与非急性肾损伤组相比,急性肾损伤组患者男性较多,肺部感染者较多,平均动脉压(MAP)、前降钙素水平较低,乳酸、白细胞计数、多器官功能衰竭(MODS)评分水平较高(P2.13 mmol/L)、白细胞计数(>15×10^(9)·L^(-1))、MODS评分(>6分)均为影响脓毒症患者并发急性肾损伤的危险因素(P0.07,Nomogram模型提供临床净收益。结论性别(男)、肺部感染(是)、MAP(≤89 mmHg)、乳酸(>2.13 mmol/L)、白细胞计数(>15×10^(9)·L^(-1))、MODS评分(>6分)均为影响脓毒症患者并发急性肾损伤的危险因素,且基于以上变量构建的Nomogram模型可以对患者并发急性肾损伤进行较好的预测。

关键词：脓毒症急性肾损伤危险因素 Nomogram预测模型

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Synthesis of 3D ordered macroporous indium tin oxide using polymer colloidal crystal template

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Science China(Technological Sciences) 2006年第5期49卷 537-546页

作者： ZHANG xue'ao MAN Yahui WANG Jianfang LIU Changli WU Wenjian College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China

Three-dimensional (3D) ordered macroporous indium tin oxide (ITO) is pre- pared using a polymer colloidal crystal template that is formed by self-assembly of the monodisperse poly(methyl methacrylate) (PMMA) microspheres. The morphologies and BET surface area of the macroporous material is examined by scanning electron micro- scope, transmission electron microscopy and N2 adsorption/desorption. Results indicate that the macroporous material has highly ordered arrays of the uniform pores replicated from the PMMA colloidal crystal template when the polymer colloidal crystal template is removed by calcinations at 500℃. The pore diameter (about 450 nm) of macroporous ITO slightly shrank to the PMMA microspheres. The BET surface area and pore volume of the macroporous material are 389 m2·g-1 and 0.36 cm3·g-1, respectively. Moreover, the macroporous ITO, containing 5 mol% Sn and after annealing under vacuum, shows the minimum resistivity of ρ = 8.2×10-3 Ω· cm. The conductive mechanism of macroporous ITO is discussed, and it is believed that the oxygen vacancies are the major factor for excellent electrical properties.

关键词： template synthesis, polymer colloidal crystal, indium tin oxide, three-dimensional order, macroporous material.