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KIFC1 overexpression promotes prostate cancer cell survival and proliferation in vitro by clustering of amplified centrosomes via interaction with Centrin 2

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BIOCELL 2021年第5期45卷 1369-1391页

作者： anzana parvin BANG-HONG WEI SHUANG-LI HAO WAN-XI YANG FU-QING TAN The Sperm Laboratory College of Life SciencesZhejiang UniversityHangzhou310058China The First Affiliated Hospital College of MedicineZhejiang UniversityHangzhou310003China Department of Biotechnology and Genetic Engineering Faculty of Biological SciencesIslamic UniversityKushtia7003Bangladesh

Mitotic kinesin KIFC1 plays critical roles in mitosis by regulating the spindle length,pole formation,and known for clustering extra centrosomes in cancer *** clustering is associated with the survival of cancer cells,but this phenomenon remains obscure in prostate cancer(PCa).The present study demonstrated that PCa cells showed centrosome amplification and clustering during interphase and mitosis,***1 is highly expressed in PCa cells and tumor tissues of prostatic adenocarcinoma(PAC)***-regulation of KIFC1 facilitated the PCa cell survival in vitro by ensuring bipolar mitosis through clustering the multiple centrosomes,suggesting centrosome clustering could be a leading cause of prostate ***,the silencing of KIFC1 resulted in normal centrosome number or multipolar mitosis by inhibiting the clustering of amplified centrosomes in PCa ***,knockdown of KIFC1 by RNAi in PCa cells reduced cancer cell survival,and ***1 interacted with centrosome structural protein Centrin 2 in clustering of amplified centrosomes in PCa cells to ensure the bipolar mitotic spindle *** of Centrin 2 in PCa cells inhibited the centrosome amplification and ***,up-regulated KIFC1 promotes PCa cell proliferation via progression of cell cycle possibly through aberrant activation of cyclin dependent kinase 1(Cdk1).Therefore,KIFC1 can be a prognostic marker and therapeutic target of PCa for inhibiting the cancer cell proliferation.

关键词： KIFC1 Centrosome clustering Centrosome amplification Prostate cancer

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Comparative study between the effect of <i>Momordica charantia</i>(wild and hybrid variety) on hypoglycemic and hypolipidemic activity of alloxan induced type 2 diabetic long-evans rats

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Journal of Diabetes Mellitus 2012年第1期2卷 131-137页

作者： Subbroto Kumar Saha Md. Ezazul Haque Dipa Islam Md. Matiar Rahman Md. Rezuanul Islam anzana parvin Shahedur Rahman Department of Biotechnology & Genetic Engineering Islamic University Kushtia Bangladesh

This study was undertaken to evaluate the hypoglycemic and hypolipidemic effect of Momordica charantia (wild and hybrid variety) powder on alloxan induced type 2 diabetic male Long-Evans rats. Oral feeding of the M. charantia powder slightly decreased serum total cholesterol, triglyceride levels and LDL-cholesterol compared with wild, hybrid and standard drug. M. charantia wild variety showed more significant (p M. charantia did not show any significant effect on HDL-cholesterol and liver glycogen. Thus, results of the study prove that the wild variety of M. charantia fruit have potent antidiabetic and antilipidemic property.

关键词： Type 2 Diabetes Mellitus Momordica Charantia Alloxan Hypoglycemic Effect Hypolipidemic Effect Glibenclamide

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