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The medicinal chemistry of Urtica dioica L.:from preliminary evidence to clinical studies supporting its neuroprotective activity

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Natural Products and Bioprospecting 2023年第1期13卷 585-595页

作者： Prabhakar Semwal Abdur Rauf ahmed Olatunde Pooja Singh Mohamed Y.Zaky Md.Mozahidul Islam anees ahmed khalil Abdullah S.M.Aljohani Waleed Al Abdulmonem Giovanni Ribaudo Department of Biotechnology Graphic Era Deemed to be University566/6 Bell RoadClement TownDehra DunIndia Department of Chemistry University of SwabiSwabiPakistan Department of Medical Biochemistry Abubakar Tafawa Balewa UniversityBauchiNigeria Molecular Physiology Division Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Oncology Division Department of Biomedical and Clinical ScienceFaculty of MedicineLinköping UniversityLinköpingSweden Department of Environmental Management SESMIndependent UniversityBangladeshBashundhara R/ADhakaBang-ladesh University Institute of Diet and Nutritional Sciences Faculty of Allied Health SciencesThe University of LahoreLahorePakistan Department of Veterinary Medicine College of Agriculture and Veterinary MedicineQassim UniversityBuraydahSaudi Arabia Department of Pathology College of Med-icineQassim UniversityBuraydahSaudi Arabia Department of Molecular and Translational Medicine University of BresciaBresciaItaly

Urtica dioica is a perennial herb from the family of Urticaceae that is commonly known as stinging *** plant is widespread in Europe,Africa,America,and a part of Asia,as it adapts to different environments and climatic *** leaves,stalk,and bark of *** found applications in the field of nutrition,cosmetics,textile,pest control and *** this connection,bioactive chemical constituents such as flavonoids,phenolic acids,amino acids,carotenoids,and fatty acids have been isolated from the *** this review,we aim at providing an updated and comprehensive overview of the contributions in literature reporting computational,in vitro,pre-clinical and clini-cal data supporting the therapeutic applications of *** evidence shows that *** constituents and extracts can provide neuroprotective effects by acting through a combination of different molecular mecha-nisms,that are discussed in the *** findings could lay the basis for the identification and design of more effective tools against neurodegenerative diseases.

关键词： Urtica dioica Neuroprotection Natural compounds Flavonoids Medicinal chemistry

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Reversal of multidrug resistance and antitumor promoting activity of 3-oxo-6β-hydroxy-β-amyrin isolated from Pistacia integerrima

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BIOCELL 2021年第1期45卷 139-147页

作者： ABDUR RAUF SAUD BAWAZEER MUSLIM RAZA EMAN EL-SHARKAWY MD.HABIBUR RAHMAN MOHAMED A.EL-ESAWI GHIAS UDDIN BINA SSIDDIQUI anees ahmed khalil JOSEPH MOLNAR AKOS CSONKA DIÁNA SZABÓ HAROON KHAN MOHAMMAD SMUBARAK TAIBI BEN HADDA MUDYAWATI KAMARUDDIN SEEMA PATEL Department of Chemistry University of SwabiAnbar23561Khyber Pakhtunkhwa Pakistan Department of Pharmaceutical Chemistry Faculty of PharmacyUmm Al-Qura UniversityMakkah24211Saudi Arabia State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China Chemical Departments Faculty of ScienceNorthern Borders UniversityArar91431Saudi Arabia Department of Pharmacy Southeast UniversityBanani-1213DhakaBangladesh Department of Global Medical Science Wonju College of MedicineYonsei UniversitySeoulSouth Korea Botany Department Faculty of ScienceTanta UniversityTanta31527Egypt Institute of Chemical Sciences University of PeshawarPeshawar25120Pakistan H.E.J.Research Institute of Chemistry International Center for Chemical and Biological SciencesUniversity of KarachiKarachi75270Pakistan University Institute of Diet and Nutritional Sciences Faculty of Allied Health SciencesThe University of LahoreLahore54000Pakistan Department of Medical Microbiology and Immunobiology Faculty of MedicineUniversity of SzegedSzeged6700Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery Faculty of MedicineUniversity of SzegedSzeged6700Hungary Department of Pharmacy Abdul Wali Khan UniversityMardan23200Pakistan Department of Chemistry The University of JordanAmman11942Jordan LCM Laboratory Faculty of SciencesMohamed First UniversityOujda60000Morocco Institution of Health Science of Tahirah Al Baeti Bulukumba South Sulawesi92352Indonesia Bioinformatics and Medical Informatics Research Center San Diego State UniversitySan Diego92182USA

The bioactive triterpenoid 3-oxo-6-β-hydroxy-β-amyrin(1)has been isolated from multiple plant *** this study,chloroform fraction of Pistacia integerrima extract was processed for the isolation of the *** compound identity was confirmed by advanced spectroscopy technique.X-ray crystallography was applied for molecular structure *** addition,compound 1 was screen for its activity on reversal of MDR(multidrug resistance)mediated by P-gp(P-glycoprotein).This was accomplished by using rhodamine123 exclusion on multidrug-resistant human ABCB1 gene transfected mouse T-lymphoma cell *** revealed that MDR reversing effect was comparable to verapamil as positive control in *** of TPA-induced tumor promotion with 3-oxo-6β-hydroxy-β-amyrin led to reduction in the applied anti-tumor promotion *** chemo-preventive effect of 3-oxo-6β-hydroxy-β-amyrin was comparable to curcumin as positive control based on the reduction of immediate early tumor antigen *** docking by applying Autodock Vina 1 and i-GEMDOCK v 2.1 tools indicated that compound 1 gives good docking results,as determined by their fitness score and ***,results showed that compound 1 isolated from Pistacia integerrima precisely attached to a region where co-crystallized ligand for receptor previously *** findings may explain the use of Pistacia integerrima plant extracts as an anticancer agent in folk medicine.

关键词： Pistacia integerrima Anti-tumor properties X-ray crystallography POM Molecular docking

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Challenges to establishing and maintaining kidney transplantation programs in developing countries:What are the coping strategies?

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World Journal of Methodology 2024年第2期14卷 1-16页

作者： Rabea ahmed Gadelkareem Amr Mostafa Abdelgawad Nasreldin Mohammed Mohammed Ali Zarzour Mahmoud khalil ahmed Reda Hisham Mokhtar Hammouda Department of Urology Assiut Urology and Nephrology HospitalFaculty of MedicineAssiut UniversityAssiut 71515Egypt

Kidney transplantation(KT)is the optimal form of renal replacement therapy for patients with end-stage renal ***,this health service is not available to all patients,especially in developing *** deceased donor KT programs are mostly absent,and the living donor KT centers are ***-center studies presenting experiences from developing countries usually report a variety of *** review addresses these challenges and the opposing strategies by reviewing the single-center experiences of developing *** financial challenges hamper the infrastructural and material availability,coverage of transplant costs,and qualification of medical *** sociocultural challenges influence organ donation,equity of beneficence,and regular follow-up *** interests and motives for transplantation may result from high medicolegal responsibilities in KT practice,intense potential psychosocial burdens,complex qualification protocols,and low productivity or compensation for KT *** medical literacy about KT advantages is prevalent among clinicians,patients,and the *** inefficient organizational and regulatory oversight is translated into inefficient healthcare systems,absent national KT programs and registries,uncoordinated job descriptions and qualification protocols,uncoordinated on-site investigations with regulatory constraints,and the prevalence of commercial KT *** challenges resulted in noticeable differences between KT services in developed and developing *** coping strategies can be summarized in two main mechanisms:The first mechanism is maximizing the available resources by increasing the rates of living kidney donation,promoting the expertise of medical personnel,reducing material consumption,and supporting the establishment and maintenance of KT *** latter warrants the expansion of the public sector and the elimination of non-ethical KT *** second mechanism is recru

关键词： Challenges Coping strategies Developing countries Kidney transplantation Low resources Single-center

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Effect of Diabetes Self-Management Education on Glycaemic Control in Sudanese Adults with Type 2 Diabetes

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Journal of Biosciences and Medicines 2024年第3期12卷 316-327页

作者： Sahar Moawia Balla Elnour Tayseer Abdelmotalib ahmed Taha Haiam Abdalla Wadatalla Ziryab Zainelabdin Mohamed Elmahdi Marwah Isam Abdulmajeed Mohammedahmed Rowa Abdelmonem Sidig Hamadto Nahla Yousif Osman Mohammed Saeed Omnia Mubarak Saad Abdallah Sulafa Abdelbagi Mustafa ahmed Hanady Abdelhameed ahmed Mohamed Sarah khalil Fathi khalil Family Medicine Health Gates Primary Care Riyadh SAU Family Medicine Dhaman Health Assurance Hospitals Company Kuwait KWT Family Medicine First Health Cluster Riyadh SAU Emergency Department Sheikh Khalifa Medical City Abudahbi ARE Family Medicine University of Medical Sciences and Technology Khartoum SDN Family Medicine Sudan Medical Specialization Board-Sudan Khartoum SDN Family Medicine Ultra Care Home Care Company Riyadh SAU Medicine Department Health Gates Primary Care Riyadh SAU Family Medicine Mouwasat Hospital Madinah SAU

Research Background: The high prevalence of diabetes in Sudan, estimated at 16%, highlights the importance of effective health education in diabetes management. Diabetes self-management education has been identified as a crucial tool in enhancing the knowledge, attitudes, and abilities necessary for self-management among individuals with diabetes. Aim: To assess the impact of diabetes self-management education on medication adherence and glycemic control in Sudanese adults with type 2 diabetes before and 3 months after the DSME intervention. Method: The study was conducted in Sudan between September 2022 and March 2023, it was an interventional, one-group, pre- and post-test study that aimed to assess the impact of diabetes self-management education (DSME) on medication adherence and diabetes control in Sudanese adults with type 2 diabetes. The research was conducted in primary health care centers in six cities in Sudan and involved 244 participants. The data entry and statistical analysis were conducted using the Statistical Package for Social Sciences version 27.0. A paired t test was used for analysis. Results: The study included 244 participants, 67% of whom were males. The age mean ± SD was 48.6 ± 9.3 years, and 85.3% of participants were married. Age at onset of diabetes mean ± SD was 40.60 ± 7.81 years;44.6% had diabetes for less than 5 years;and 84.1% had a positive family history of diabetes mellitus. The levels of poor, low, and partial adherence to medication decreased by 8.2%, 4%, and 20.6%, respectively, after the intervention. The levels of good and high medication regime adherence increased by 13% and 19.8%, respectively;BMI decreased by 1.1 ± 0.73 kg/m2 (p = 0.005). The fasting blood sugar decreased by 69 ± 32.9 mg/dl (p = 0.049), and the glycated hemoglobin decreased by 1.21 ± 0.28% (p = 0.001). Conclusions: The findings of this study reinforce the importance of patient education in improving glycemic control and enhancing self-management

关键词： Sudan Adherence Intervention Education Self-Management Diabetes

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The Role of Electrocardiogram DETERMINE Score in Prediction of Coronary Artery Disease Severity

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World Journal of Cardiovascular Diseases 2024年第9期14卷 567-580页

作者： Ismail N. El-Sokkary Essam ahmed khalil Mohammed Wael Badawi Ibrahim K. Gamil Shousha Abdalla A. Elsebaey Mohamed Kamal Rehan Mahmoud Ibrahim Elshamy Yasser ahmed Sadek Department of Cardiovascular & Thoracic Surgery Faculty of Medicine Al-Azhar University Cairo Egypt Department of Cardiology Al-Azhar University Cairo Egypt Department of Internal Medicine Beni-Sueif University Beni Suef Egypt Department of Radiology Al-Azhar University Cairo Egypt Department of Cardiology Helwan University Cairo Egypt

Background: A major cause of mortality and disability on a global scale is myocardial infarction (MI). These days, the most reliable way to detect and measure MI is via cardiovascular magnetic resonance imaging (CMR). Aims and Objectives: To evaluate the effectiveness of the Electrocardiogram DETERMINE Score in predicting the severity of coronary artery disease (CAD) in patients who have experienced an Acute Myocardial Infarction (AMI) & to assess improvements in left ventricular function at 6 months following coronary artery bypass grafting (CABG). Subjects and Methods: This Observational cohort study was done at the Cardiology and Radiology department and cardiac surgery department, Al-Azhar university hospitals and Helwan University hospital. The study involved 700 cases who patients diagnosed with Acute Myocardial Infarction and fulfilled specific criteria for selection. Result: There was highly statistically significant relation between Myocardial infarction size and ECG Marker Score as mean infarct size elevated When the number of ECG markers increased. There was a highly statistically significant relation between myocardial infarct segments, myocardial infarction size and improvement of cardiac function 6 months post-CABG. Conclusion: The study found that larger myocardial infarctions corresponded with higher DETERMINE Scores. It concluded that an ECG-based score better estimates infarct size than LVEF alone. Additionally, there was a significant statistical correlation between the size and segmentation of myocardial infarction and better cardiac function six months after CABG.

关键词： Electrocardiogram DETERMINE Score Coronary Artery Disease Outcome Acute Myocardial Infarction Coronary Artery Bypass Grafting

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A Comparative Analysis on Surgical Outcomes and Complications of Endoscopic and Open Vein Harvesting Techniques

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Open Journal of Thoracic Surgery 2024年第2期14卷 29-39页

作者： Mohammed Fawzy Eltaweel Ismail N. El-Sokkary ahmed Alherazi Mohamed Wael Badawi Mohammed G. Abdellatif Bahaa A. Elkhonezy Ibrahim K. Gamil Haytham Mohamed Abd El Moaty Sarra Sadmi Mahmoud khalil Department of Cardiothoracic Surgery Faculty of Medicine Menoufia University Shibin El Kom Egypt Department of Cardiovascular & Thoracic Surgery Faculty of Medicine Al-Azhar University Cairo Egypt Department of Cardiothoracic Surgery Faculty of Medicine Alexandria University Alexandria Egypt Faculty of Medicine University of Algiers Algiers Algeria Department of Cardiac Surgery Sabah Al-Ahmed Cardiac Center Al-Amiri Hospital Kuwait City Kuwait

Objective: The great saphenous vein (GSV) is commonly used as a conduit for grafting during CABG surgery, and open GSV harvesting (OVH), commonly used with long incision to expose the vein. However, endoscopic vein harvesting (EVH) is an alternative approach, utilizing specialized instruments and small incisions to harvest the vein. Methods: A retrospective analysis was conducted on a cohort of patients who underwent Coronary artery bypass graft (CABG) requiring great saphenous vein (GSV) harvesting which was done by EVH or OVH procedures. Demographic variables, including age and gender, were assessed for both groups. Intraoperative variables such as the number of grafts, cardiopulmonary bypass time, X clamp time, and type of procedure were analyzed. Postoperative variables, including infection and bleeding rates, were also evaluated. Results: The study included 30 patients each undergoing Coronary artery bypass graft (CABG) with need of great saphenous vein harvesting which was done by EVH and OVH. Demographic variables were well-matched between the two groups in terms of age, while a significant difference in gender distribution was observed. Obesity and smoking were more prevalent in the OVH group, and EVH was associated with a higher mean number of grafts compared to OVH. Conversion to an open technique occurred in a portion of the EVH cases, and infection rates did not significantly differ between the EVH and OVH groups. However, the incidence of postoperative bleeding was significantly higher in the EVH group. Conclusion: This study provides valuable insights into the demographic, intraoperative, and postoperative variables associated with EVH and OVH techniques. EVH demonstrated advantages in terms of reduced infection rates compared to OVH. However, the higher incidence of postoperative bleeding associated with EVH raises concerns about potential risks.

关键词： Endoscopic Vein Harvesting (EVH) Open Vein Harvesting (OVH) Coronary Artery Bypass Grafting (CABG) Great Saphenous Vein (GSV) Surgical Outcomes

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Electromagnetic effects on the orbital motion of a charged spacecraft

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Research in Astronomy and Astrophysics 2014年第5期14卷 589-600页

作者： Yehia ahmed Abdel-Aziz khalil Ibrahim khalil National Research Institute of Astronomy and Geophysics (NRIAG) Helwan Cairo 11721Egypt Department of Mathematics Hail University Hail 2440 Kingdom of Saudi Arabia

This paper deals with the effects of electromagnetic forces on the orbital motion of a spacecraft. The electrostatic charge which a spacecraft generates on its surface in the Earth＇s magnetic field will be subject to a perturbative Lorentz force. A model incorporating all Lorentz forces as a function of orbital elements has been developed on the basis of magnetic and electric fields. This Lorentz force can be used to modify or perturb the spacecraft＇s orbits. Lagrange＇s planetary equations in the Gauss variational form are derived using the Lorentz force as a perturbation to a Keplerian orbit. Our approach incorporates orbital inclination and the true anomaly. The numer- ical results of Lagrange＇s planetary equations for some operational satellites show that the perturbation in the orbital elements of the spacecraft is a second order perturba- tion for a certain value of charge. The effect of the Lorentz force due to its magnetic component is three times that of the Lorentz force due to its electric component. In addition, the numerical results confirm that the strong effects are due to the Lorentz force in a polar orbit, which is consistent with realistic physical phenomena that occur in polar orbits. The results confirm that the magnitude of the Lorentz force depends on the amount of charge. This means that we can use artificial charging to create a force to control the attitude and orbital motion of a spacecraft.

关键词： space vehicles -- atmospheric effects -- celestial mechanics -- kine-matics and dynamics

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A New Kind of Generalized Pythagorean Fuzzy Soft Set and Its Application in Decision-Making

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 2861-2871页

作者： Xiaoyan Wang ahmed Mostafa khalil College of BigData Huanghai UniversityQingdaoChina Department of Mathematics Faculty of ScienceAl-Azhar UniversityAssiut71524Egypt

The aim of this paper is to introduce the concept of a generalized Pythagorean fuzzy soft set(GPFSS),which is a combination of the generalized fuzzy soft sets and Pythagorean fuzzy *** of important operations of GPFSS including complement,restricted union,and extended intersection are *** basic properties of GPFSS are ***,an algorithm of GPFSSs is given to solve the fuzzy soft ***,a comparative analysis between the GPFSS approach and some existing approaches is provided to show their reliability over them.

关键词： Pythagorean fuzzy set generalized Pythagorean fuzzy soft set algorithm decision making

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Spatial Correlation Module for Classification of Multi-Label Ocular Diseases Using Color Fundus Images

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Computers, Materials & Continua 2023年第7期76卷 133-150页

作者： Ali Haider Khan Hassaan Malik Wajeeha khalil Sayyid Kamran Hussain Tayyaba anees Muzammil Hussain Department of Software Engineering Faculty of Computer SciencesLahore Garrison UniversityLahorePakistan Department of Computer Science School of Systems and TechnologyUniversity of Management and TechnologyLahore54000Pakistan Department of Computer Science&Information Technology University of Engineering and Technology(UET)PeshawarPakistan Department of Computer Science TIMES InstituteMultan60000Pakistan Department of Software Engineering School of Systems and TechnologyUniversity of Management and TechnologyLahore54000Pakistan

To prevent irreversible damage to one’s eyesight,ocular diseases(ODs)need to be recognized and treated *** fundus imaging(CFI)is a screening technology that is both effective and *** to CFIs,the early stages of the disease are characterized by a paucity of observable symptoms,which necessitates the prompt creation of automated and robust diagnostic *** traditional research focuses on image-level diagnostics that attend to the left and right eyes in isolation without making use of pertinent correlation data between the two sets of *** addition,they usually only target one or a few different kinds of eye diseases at the same *** this study,we design a patient-level multi-label OD(PLML_ODs)classification model that is based on a spatial correlation network(SCNet).This model takes into consideration the relevance of patient-level diagnosis combining bilateral eyes and multi-label ODs ***_ODs is made up of three parts:a backbone convolutional neural network(CNN)for feature extraction i.e.,DenseNet-169,a SCNet for feature correlation,and a classifier for the development of classification *** DenseNet-169 is responsible for retrieving two separate sets of attributes,one from each of the left and right *** then,the SCNet will record the correlations between the two feature sets on a pixel-by-pixel *** the attributes have been analyzed,they are integrated to provide a representation at the patient *** the whole process of ODs categorization,the patient-level representation will be *** efficacy of the PLML_ODs is examined using a soft margin loss on a dataset that is readily accessible to the public,and the results reveal that the classification performance is significantly improved when compared to several baseline approaches.

关键词： Ocular disease multi-label spatial correlation CNN eye disease

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An energetic nano-fiber composite based on polystyrene and 1,3,5-trinitro-1,3,5-triazinane fabricated via electrospinning technique

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Defence Technology(防务技术) 2023年第9期27卷 1-8页

作者： Mahmoud Abdelhafiz ahmed K.Hussein Waleed F.khalil ahmed Elbeih Military TechnicalCollege(MTC) KobryElkobbahCairoEgypt Safety FuelCycleDepartment NRSRCEgyptianAtomicEnergyAuthority(EAEA)CairoEgypt

Electrospinning is a simple technique used to fabricate polymeric nano-fibrous *** nano-fibers have found a wide range of valuable applications in the biomedical ***,it has not been utilized with solid high explosives ***,the electrospinning technique has been used to fabricate polystyrene(PS)/1,3,5-trinitro-1,3,5-triazinane(RDX)composite *** governed electrospinning parameters,voltage,distance from the collector,flow rate,mandrel rotating speed,time,and solution concentration,that greatly affect the morphology of the obtained nanofibers were *** fabricated PS/RDX nano-fibers were characterized using scanning electron microscopy(SEM),X-ray diffractometer(XRD),and Fourier Transform Infrared(FTIR)*** impact and friction sensitivities of PS/RDX were also *** thermal behavior of the prepared composite and the pure materials were studied by the thermal gravimetric analysis technique(TGA).SEM results proved the fabrication of PS/RDX fibers in the nano-size via *** spectroscopy confirmed the existence of the characteristic functional groups of both PS and RDX in the composite *** sharp peaks showed the conversion of amorphous PS into crystalline shape via electrospinning and also confirmed the formation of PS/RDX *** PS fibers absorbed the heat and increased the onset decomposition of the pure RDX from 181.5 to 200.7℃in the case of PS/RDX ***,PS/RDX nano-fibers showed the relatively low impact and friction sensitivities of 100 J and 360 N *** results could introduce PS/RDX nanofibrous composite in the field of explosives detection with high levels of safety.

关键词： Electrospinning Nano-fibers 1,3,5-Trinitro-1,3,5-triazinane(RDX) Polystyrene(PS) Sensitivity

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