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Levels of evidence and grades of recommendation supporting European society for medical oncology clinical practice guidelines

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Oncology Research 2024年第5期32卷 807-815页

作者： MARKO SKELiN BRUNA PERKOV-STiPiČiN SANJA VUŠKOViĆ MARiNAŠANDRK PLEHAČEK ane ba.ić DAViDŠARČEViĆ MAJA iLiĆ iVAN KREČAK Pharmacy Department General Hospital ofŠibenik-Knin CountyŠibenikCroatia Faculty of Medicine University of RijekaRijekaCroatia Undergraduate Study in Nursing University of Applied SciencesŠibenikCroatia Department of Oncology University Hospital Center ZagrebZagrebCroatia Pharmacies Joukhadar Sveta NedeljaCroatia Pharmacies Prima Pharme ZagrebCroatia Pharmacy Department General Hospital ZadarZadarCroatia Pharmacy Department General Hospital PulaPulaCroatia Department of internal Medicine General Hospital ofŠibenik-Knin CountyŠibenikCroatia

background:The European Society for Medical Oncology(ESMO)guidelines are among the most comprehensive and widely used clinical practice guidelines(CPGs)***,the level of scientific evidence supporting ESMO CPG recommendations has not been systematically *** study assessed ESMO CPG levels of evidence(LOE)and grades of recommendations(GOR),as well as their trends over time across various cancer ***:We manually extracted every recommendation with the infectious Diseases Society of America(iDSA)classification from each *** examined the distribution of LOE and GOR in all available ESMO CPG guidelines across different topics and cancer ***:Among the 1,823 recommendations in the current CPG,30%were classified as LOEⅠ,and 43%were classified as GOR ***,there was a slight decrease in LOEⅠ(−2%)and an increase in the proportion of GOR A(+1%)in the current CPG compared to previous *** proportion of GOR A recommendations based on higher levels of evidence such as randomized trials(LOEⅠ–Ⅱ)shows a decrease(71%vs.63%,p=0.009)while recommendations based on lower levels of evidence(LOEⅢ–Ⅴ)show an increase(29%vs.37%,p=0.01)between previous and current *** the current versions,the highest proportion of LOEⅠ(42%)was found in recommendations related to pharmacotherapy,while the highest proportion of GOR A recommendations was found in the areas of pathology(50%)and diagnostic(50%)*** variability in LOEⅠand GOR A recommendations and their changes over time was observed across different cancer ***:One-third of the current ESMO CPG recommendations are supported by the highest level of *** well-designed randomized clinical trials are needed to increase the proportion of LOEⅠand GOR A recommendations,ultimately leading to improved outcomes for cancer patients.

关键词： ESMO guidelines Clinical practice guidelines Level of evidence Grade of recommendation

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Crystal Structures of Two New Monoprotonated Products of 1,4,7 trimethyl-1,4,7-triazacyclononane: （Me3〔9〕aneN3H）(SO3CF3) and （Me3〔9〕aneN3H）i

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Chinese Journal of Structural Chemistry 2000年第1期19卷 48-52页

作者： DENG Dao Lia * ZHANG Yan Hui a DAi Cong Yun a ZENG Hong a YAN Zhi Qing a YE Chang Qing a Ronald Ha\|Ge ba (Unilever Research SiOC, 354 Fenglin Road, Shanghai 200032. China) b (Unilever Research Laboratorium, Olivier van Noor Unilever Research SiOC 上海 2 0 0 0 32 Unilever Research Laboratorium 荷兰 Vlaardinge

Two new monoprotonated products of macrocyclic polyamine 1,4,7 trimethyl 1,4,7 triazacyclononane(Me 3〔9〕aneN 3), (Me 3〔9〕aneN 3H)(SO 3CF 3) 1 (C 10 H 22 N 3O 3SF 3, M r =321.36) and (Me 3〔9〕aneN 3H)i 2 (C 9H 22 N 3i, M r =299.20) were obtained by the reactions of Me 3〔9〕aneN 3 and yttrium triflate or ytterbium diiodide as the unexpected products. The crystal structures of compounds 1 and 2 have been determined. Crystal 1 is orthorhombic, space group P2 12 12 1(#19), a =12.609(3), b=13.531(1), c=9.225(3) , V=1573.9(7)  3, Z=4, D c= 1.356 g/cm 3, μ =2.47 cm -1 , F (000)=680 and R=0.052, R w =0.052 for 807 unique reflections with i>2σ(i) . Crystal 2 belongs to the orthorhombic system with space group P2 12 12 1(#19), a=11.417(2), b=13.099(3), c=8.762(2) , V=1310.5(4)  3, Z=4, D c =1\^516 g/cm 3, μ =24.14 cm -1 , F (000)=600 and R=0.035, R w =0.042 for 1427 unique reflections with i>3σ(i) . The two structures contain the same cyclic framework in which the acid proton is bonded to an amine nitrogen. This proton exhibits strong intramolecular hydrogen bonds with the other two nitrogen atoms. The methyl groups are directed away from the ring cavity. The bond distance between acid proton and an amine nitrogen in compound 2 is extremely short. The bond angles for 1 and 2 also exhibit obvious diversity inside of triazacyclononae.

关键词： formation crystal structure protonation triazacyclononane

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归芪补血口服液对失血性贫血小鼠血象的影响

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海峡药学 2017年第12期29卷 22-24页

作者：林彩霞王捷马劼许立拔高玲巫玲玲蒋伟哲孔晓龙广西医科大学南宁530021 广西医科大学制药厂南宁530021 广西医科大学第一附属医院南宁530021

目的探讨归芪补血口服液对失血性贫血小鼠血象的影响。方法将72只KM小鼠随机分成正常对照组、模型组、硫酸亚铁组和归芪补血口服液高、中、低剂量组,每组12只,雌雄各半,1日灌胃1次,连续灌胃28天,给药23天后,除正常对照组外,其余组别采... 详细信息

目的探讨归芪补血口服液对失血性贫血小鼠血象的影响。方法将72只KM小鼠随机分成正常对照组、模型组、硫酸亚铁组和归芪补血口服液高、中、低剂量组,每组12只,雌雄各半,1日灌胃1次,连续灌胃28天,给药23天后,除正常对照组外,其余组别采用尾静脉放血法,连续放血3天,造成失血性贫血动物模型,末次给药后30min取血,观察给药后各组小鼠血象指标和脏器系数。结果小鼠造成失血性贫血模型后,归芪补血口服液可显著升高血象红细胞总数、血红蛋白含量、红细胞容积、网织红细胞计数、血小板总数、白细胞总数(P<0.05),可有效抑制免疫器官的萎缩和抑制体重减轻(P<0.05)。结论归芪补血口服液有良好的补血效果,同时具有免疫器官保护作用。

关键词：失血性贫血归芪补血口服液益气补血

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