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Cancer-associated fibroblasts of colorectal cancer: Translationalprospects in liquid biopsy and targeted therapy

BIOCELL 2023年第10期47卷 2233-2244页

作者： ELYN AMIELA SALLEH YEONG YEH LEE andee dzulkarnaen zakaria NUR ASYILLA CHE JALIL MARAHAINI MUSA Human Genome Centre School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Internal Medicine School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Surgery School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia

Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts(CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component ofthe tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectalcarcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patientsurvival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinicalapplications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected inblood samples, have been proposed to help in determining patient prognosis and enables the detection of cancerthrough liquid biopsy. Liquid biopsy is gaining traction as it is non-invasive, allows frequent and easy sampling, andshows concordance to tissue biopsy analysis. In addition, CAF-targeted therapy is currently being studied extensivelyto be used as one of the treatment avenues for CRC. Various mechanisms of CAF-targeted therapy have beenreported, including blocking the signaling pathways involving CAFs and cancer cells, thus abolishing the CAF-tumorcell crosstalk and subsequently hindering tumorigenesis. These translational applications of cCAFs and utilization ofCAFs as key targets for CRC therapy, although still in the early phases of development, will potentially improve CRCpatient management in the future.

关键词： Activated fibroblast Colon cancer Liquid biopsy Precision medicine

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A Multidisciplinary Approach in Management of Breast Cancer: Case Study and Literature Reviews

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Journal of Cancer Therapy 2013年第7期4卷 7-11页

作者： andee dzulkarnaen zakaria Nur Farhana Abd Salam Wan Zainira Wan Zain Mohd Nizam Hashim School of Medical Sciences Universiti Sains Malaysia Kubang Kerian Kelantan Malaysia

The diagnosis of breast cancer can cause a significant anxiety in someone’s life. The care of the breast cancer patient requires in many centres. The care of breast cancer patient is undertaken as a joint venture between the surgeon, medical oncologist, radiotherapist, pathologist and allied health professionals such as the clinical nurse specialist as well as counsellors. This is a case of a 39-years-old Malay woman presented to HUSM with a history of ulcerating breast lump with bloody pus discharge on the right breast. An initial mammogram study showed lesion suspicious of malignancy, and histopathological examination was consistent with invasive ductal carcinoma. She received neoadjuvant chemotherapy before proceeding to right modified radical mastectomy with axillary clearance and immediate chest wall reconstruction. Detailed discussion on the diagnosis, treatment, surgical intervention and progress of the patient with reference to available literature reviews are presented.

关键词： Breast Cancer Multidisciplinary Approach Reconstructive Surgery

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