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Endoscopic reduction of colocolonic intussusception due to metastatic malignant melanoma:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5816-5820页

作者： Kengo Kasuga Taku Sakamoto Hiroyuki Takamaru Masau Sekiguchi masayoshi Yamada Naoya Yamazaki Taiki Hashimoto Toshio Uraoka Yutaka Saito Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan Cancer Screening Center National Cancer Center HospitalTokyo 104-0045Japan Department of Dermatologic Oncology National Cancer Center HospitalTokyo 104-0045Japan Division of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Department of Gastroenterology and Hepatology Gunma University Graduate School of MedicineMaebashi 371-8511GunmaJapan

BACKGROUND Intussusception rarely causes intestinal obstruction in *** malignant melanoma is the main cause of intussusception of the small intestine among ***,malignant melanoma rarely causes intussusception of the ***,emergent surgery is usually performed for such ***,we report a case of a patient with colocolonic intussusception caused by a malignant melanoma,for which endoscopic reduction and elective surgery were *** SUMMARY The patient was a 64-year-old woman who underwent multiple surgeries and received chemotherapy and immunotherapy for a malignant *** immunotherapy,she had abdominal pain,diarrhea,and bloody *** examination and laboratory studies did not reveal any findings that warranted emergent *** tomography revealed intussusception in the descending colon without intestinal necrosis and *** was reduced endoscopically,and elective surgery was *** This report suggests that endoscopic reduction and elective surgery constitute a treatment option for colocolonic intussusception of metastatic malignant melanomas.

关键词： Metastatic malignant melanoma Intussusception Colon Nonsurgical management Endoscopic reduction Case report

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Symposium Lecture

Symposium Lecture

A User Proprietary Obfuscate System for Positions Sharing in Location-Aware Social Networks

2005'海峡两岸植物生理与分子生物学教学研讨会

作者： masayoshi MAESHIMA Graduate School of Bioagricultural Sciences Nagoya University Nagoya 464-8601 Japan

＜正＞1.1. Teaching of Plant Physiology in Japan Plant physiology is one of the fundamental subjects for students in the life science courses. In our university, graduate students learn biochemistry, chemistry, physics, organic chemistry, microbiology, molecular biology, genetic engineering, and nutritional biochemistry and then learn plant physiology in the third year. I will talk about the textbooks of Plant Physiology including Plant Molecular Biology and Plant Biochemistry and the contents of lecture.

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Journal of Computer and Communications 2015年第5期3卷 7-20页

作者： Wei Cherng Cheng masayoshi Aritsugi Computer Science and Electrical Engineering Graduate School of Science and Technology Kumamoto University Kumamoto Japan

A user’s trajectory can be maliciously monitored by adversaries when they share the positions in location-aware social networking applications which require users to update their own locations continuously. An adversary infers user’s locations from the trajectories, and gleans user’s private information through them via location-aware social networking applications and public available geographic data. In this paper, we propose a user proprietary obfuscate system to suit situations for position sharing and location privacy preserving in location-aware social network. Users transform the public available geographic data into personal obfuscate region maps with pre-defined profile to prevent the location leaking in stationary status. Our obfuscation with size restricted regions method tunes user’s transformed locations fitting into natural movement and prevents unreasonable snapshot locations been recorded in the trajectory.

关键词： Location Privacy Obfuscate Region Maps Location-Aware Positions Sharing

Direct Synthesis of Graphene on Silicon at Low Temperature for Schottky Junction Solar Cells

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Journal of Materials Science and Chemical Engineering 2021年第10期9卷 1-9页

作者： Sudip Adhikari Rucheng Zhu masayoshi Umeno C’s Techno Inc. Co-Operative Research Center for Advanced Technology Nagoya Science Park Nagoya Japan Engineering Department Chubu University Kasugai Japan

Graphene thin films synthesized directly at low temperature (550˚C) on silicon substrate by microwave (MW) surface wave plasma (SWP) chemical vapor deposition (CVD) using the cover on substrates for avoiding plasma emission ultraviolet ray’s effect during film deposition. Analytical methods such as Raman spectroscopy, Transmission electron microscopy (TEM) and Scanning electron microscopy (SEM), four-point probe method, and JASCO V-570 UV/VIS/NIR spectrophotometer were employed to characterize the properties of the graphene films. Here, we report that it is possible to grow graphene directly on the silicon substrate (without using catalyst) due to the high radical density of MW SWP CVD. Furthermore, we fabricated graphene/silicon Schottky junction solar cells with an efficiency of up to 6.39%. Compared to conventional silicon solar cells, the fabrication process is greatly simplified;just graphene is synthesized directly on n-type crystalline Si substrate at low temperate.

关键词： Graphene Direct Synthesis Microwave Plasma CVD Photovoltaics

Photovoltaic Characteristics of Iodine-doped Amorphous Carbon Thin Films Grown by Microwave Surface-Wave Plasma CVD

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Photovoltaic Characteristics of Iodine-doped Amorphous Carbo...

MK615 decreases RAGE expression and inhibits TAGE-induced proliferation in hepatocellular carcinoma cells

第十五届国际光伏科学与工程大会

作者： masayoshi Umeno Department of Electronics and Information Engineering Chubu UniversityKasugai 487-8501Japan

This paper reports the effects of iodine (Ⅰ) doping on the optical, structural and photovoltaic properties of amorphous carbon (a-C) thin-films grown on silicon and quartz substrates by microwave surface wave plasma chemical vapor deposition at low temperature (<100°C). For film deposition, Ar and CH4 were used as plasma source gases. The undoped and I-doped (post deposition doping) films were characterized by UV/VIS/NIR spectroscopy, Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and current-voltage measurements. The optical band gap of the undoped film (3.4 eV) dropped to 0.9 eV after I-doping. The XPS results confirmed the successful doping of I in the a-C film. The Raman results indicated I-induced graphitization in the doped-film. The photovoltaic measurements show that the open-circuit voltage (V) and short-circuit current density (J) of I-doped a-C film deposited on n-type silicon substrate under light illumination (AM 1.5, 100 mW/cm) were approximately 177 mV and 1.15μA respectively and the fill factor was found to be 0.217. The use of a-C in photovoltaic solar cells is still in its infancy due to complicated microstructure of carbon bondings, high defect density, low photoconductivity and difficulties in controlling conduction type. Further research is underway to realize cheap, reasonably high efficiency and environmental friendly a-C based solar cells.

关键词： Amorphous carbon thin films Iodine doping Photovoltaic properties Solar cells

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World Journal of Gastroenterology 2010年第42期16卷 5334-5341页

作者： Yuhki Sakuraoka Tokihiko Sawada Toshie Okada Takayuki Shiraki Yoshikazu Miura Katsuya Hiraishi Tatsushi Ohsawa Masakazu Adachi Jun-ichi Takino masayoshi Takeuchi Keiichi Kubota Second Department of Surgery Dokkyo Medical UniversitySchool of MedicineKitakobayashi 880MibuShimotsugaTochigi 321-0293Japan Public Health Dokkyo Medical UniversitySchool of MedicineKitakobayashi 880MibuShimotsugaTochigi 321-0293Japan AdaBio Co.Ltd.21-1 Kenzaki-machiTakasakiGunma 370-0883Japan Department of Life Pharmacy Faculty of Pharmaceutical SciencesHokuriku UniversityHo-3Kanagawa-machiKanazawaIshikawa 920-1181Japan

AIM:To investigate the proliferative effect of advanced glycation end-products(AGEs) and the role of their cellular receptor(RAGE) on hepatocellular carcinoma(HCC) cells,and the inhibitory effects of MK615,an extract from Japanese apricot,against AGEs were also ***:Two HCC cell lines,HuH7 and HepG2,were *** of RAGE was investigated by poly-merase chain reaction,Western blotting,and flow cytemetry(FACS).The effect of MK615 on RAGE expression was also evaluated by *** proliferative effects of a control(unglycated bovine serum albumin),glucosederived AGEs(Glc-AGE),and glyceraldehyde-derived AGEs(Glycer-AGE),and the anti-proliferative effect of MK615 against AGEs,were evaluated using MTT ***:Expression of RAGE was confirmed at both the mRNA and protein levels in both HuH7 and *** revealed that the level of RAGE expression was higher in HuH7 than in *** with 0.1 μg/mL MK615 decreased the expression level of RAGE from 24.3% to 3.7% in HuH7 and from 6.2% to 4.8% in *** growth indices for the control,Glc-AGE,and Glycer-AGE were 1.06 ± 0.08,0.99 ± 0.04,and 1.38 ± 0.05,respectively,in HuH7(P = 0.037),and were 1.03 ± 0.04,1.04 ± 0.03,and 1.07 ± 0.05,respectively,in HepG2(P > 0.05).When the cells were cultured simultaneously with Glycer-AGE and MK615,MK615 abrogated the proliferative effect of Glycer-AGE in ***:Only Glycer-AGE has a proliferative effect on HuH7,which expresses a higher level of ***615 suppresses the proliferative effect of GlycerAGE on HuH7 by decreasing the expression of RAGE.

关键词： Hepatocellular carcinoma Receptor of advanced glycation end-product Advanced glycation endproducts MK615 Toxic advanced glycation end-products

Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第29期23卷 5379-5385页

作者： Masayuki Miyazaki masayoshi Yada Kosuke Tanaka Takeshi Senjyu Takeshi Goya Kenta Motomura Motoyuki Kohjima Masaki Kato Akihide Masumoto Kazuhiro Kotoh Department of Hepatology Iizuka Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical Science Kyushu University Department of Hepatology Harasanshin Hospital

AIM To investigate the factors influenced the efficacy of tolvaptan(TLV) in liver *** We retrospectively enrolled 61 consecutive patients with refractory hepatic ascites. All of them had been treated with furosemide and spironolactone before admission, and treated with TLV for 7 d in our hospital. The effect of TLV was defined by the rate of body weight loss, and the factors that influenced TLV efficacy were analyzed using multiple *** Coexistent hepatocellular carcinoma(HCC) was the only significant predictive variable that attenuated the efficacy of TLV. In stratified analysis, high doses of furosemide decreased the efficacy of TLV in patients with HCC, and increased efficacy in those without HCC. In the latter, a high Child-Pugh-Turcotte score had a positive influence and a high concentration of lactate dehydrogenase had a negative influence on the effectiveness of *** Development of ascites may differ between patients with liver failure and those with HCC progression. A sufficient preceding dose of furosemide decreases diuretic effect of TLV.

关键词：腹水 Tolvaptan Furosemide 肝硬化 Hepatocellular 癌

Mechanisms underlying ^(18)F-fluorodeoxyglucose accumulation in colorectal cancer

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World Journal of Radiology 2016年第11期8卷 880-886页

作者： Kenji Kawada masayoshi Iwamoto Yoshiharu Sakai Department of Surgery Graduate School of MedicineKyoto University

Positron emission tomography(PET) with ^(18)F-fluorodeoxyglucose(FDG) is a diagnostic tool to evaluate metabolic activity by measuring accumulation of FDG, an analogue of glucose, and has been widely used for detecting small tumors, monitoring treatment response and predicting patients' prognosis in a variety of cancers. However, the molecular mechanism of FDG accumulation into tumors remains to be investigated. It is well-known that most cancers are metabolically active with elevated glucose metabolism, a phenomenon known as the Warburg effect. The underlying mechanisms for elevated glucose metabolism in cancer tissues are complex. Recent reports have indicated the potential of FDG-PET/CT scans in predicting mutational status(e.g., KRAS gene mutation) of colorectal cancer(CRC), which suggests that FDG-PET/CT scans may play a key role in determining therapeutic strategies by non-invasively predicting treatment response to anti-epidermal growth factor receptor(EGFR) therapy. In this review, we summarize the current findings investigating the molecular mechanism of ^(18)F-FDG accumulation in CRC.

关键词： 18 F-fluorodeoxyglucose-positron 排放断层摄影术 Colorectal 癌症葡萄糖新陈代谢 Mutational 地位 KRAS

(–)-Epigallocatechingallate Interferes RANKL/RANK Signal Pathway and Induces Apoptosis during Osteoclastogenesis in RAW264 Cell

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Food and Nutrition Sciences 2014年第2期5卷 107-116页

作者： Ran Zhao masayoshi Kamon Kazuichi Sakamoto Graduate School of Life and Environmental Sciences University of Tsukuba Tsukuba Japan Graduate School of Life and Environmental Sciences University of Tsukuba Tsukuba Japan Center for Genomic Medicine The Saitama Medical Research University Hidakashi Japan.

Green tea catechin, (–)-epigallocatechin-3-gallate [(–)-EGCG], was found to increase osteogenic functioning in mesenchymal stem cells. This study qualified EGCG, the strongest inhibitory efficiency for receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-activated osteoclastogenesis among other green tea catechins for RAW264, a murine preosteoclast cell line. Moreover, EGCG inhibited tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cell formation dose dependently in both single culture and co-culture systems, the expression of transcription factor, nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) and some osteoclastic genes. Especially, EGCG exhibited a strong inhibitory effect on the expression levels of RANK, the receptor of RANKL, and OSCAR, a key co-stimulator of the RANKL/RANK signal. Simultaneously, apoptotic genes expression and Hoechst staining revealed that EGCG induced apoptosis in RAW264. Taken together, these data suggest that the inhibitory effect of EGCG to osteoclastogenesis is associated with a down regulation of RANKL/RANK signal, and increased apoptosis of preosteoclasts.

关键词： (–)-Epigallocatechin-3-Gallate RANK Osteoclastogenesis Apoptosis