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Complementary Feeding and Growth of Infant and Young Child in China

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Biomedical and Environmental Sciences 2008年第3期21卷 264-268页

作者： SU-YING CHANG WU HE chun-ming chen Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To understand the status and problems of complementary feeding and to explore the strategy of improving complementary feeding for infants and young children in China. Method Data of urban and rural children were selected from the China Food and Nutrition Surveillance System （CFNSS） dataset to describe the status of complementary feeding and growth of children. Logistic Regression was used to analyze the relationship between child growth and the complementary feeding pattern. Results Applications of foods that come from animals, vegetable/fruit and dairy product in complementary feeding were negatively correlated to the prevalence of stunting and underweight. Attributable risk （AR） of no application of vegetable/fruit in complementary feeding to stunting was 30.2%, to underweight 35.4%; AR of no application of foods from animal products in complementary feeding to stunting was 28.2%, to underweight 11.7%; and the AR of no application of diary products in complementary feeding to stunting was 27.4%, to underweight was 15.9%. Conclusion Complementary feeding contributed to the improvement of infants and young children growth in China. There is an urgent need to develop health education in the public on infants and young children complementary feeding, in the mean time, it is pressing to pay attention and take actions to develop and promote affordable, acceptable, and accessible fortified complementary food in rural areas of China.

关键词： Infants Children Complementary feeding Growth

E-commerce business model mining and prediction

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Frontiers of Information Technology & Electronic Engineering 2015年第9期16卷 707-719页

作者： Zhou-zhou HE Zhong-fei ZHANG chun-ming chen Zheng-gang WANG Department of Information Science and Electronic Engineering Zhejiang University Alibaba Group

We study the problem of business model mining and prediction in the e-commerce context. Unlike most existing approaches where this is typically formulated as a regression problem or a time-series prediction problem, we take a different formulation to this problem by noting that these existing approaches fail to consider the potential relationships both among the consumers （consumer influence） and among the shops （competitions or collaborations）. Taking this observation into consideration, we propose a new method for e-commerce business model mining and prediction, called EBMM, which combines regression with community analysis. The challenge is that the links in the network are typically not directly observed, which is addressed by applying information diffusion theory through the consumer-shop network. Extensive evaluations using Alibaba Group e-commerce data demonstrate the promise and superiority of EBMM to the state-of-the-art methods in terms of business model mining and prediction.

关键词： E-commerce Business model prediction Consumer influence Social network Sales prediction

Effects of Nutrient Fortified Complementary Food Supplements on Anemia of Infants and Young Children in Poor Rural of Gansu

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Biomedical and Environmental Sciences 2009年第3期22卷 194-200页

作者： YU-YING WANG chun-ming chen FU-ZHEN WANG MEI JIA KE-AN WANG Chinese Center for Disease Control and Prevention Beijing 100050 China Health Supervision Institute Health Department of Gansu Province 730000 Nestle (China) Co. Ltd. Beijing 100016 China

Objective To assess the effectiveness of complementary food supplements with protein and multi-micronutrients on hemoglobin and anemia in infants and young children. Methods In 5 poor counties of Gansu, 984 children aged 6-12 months were enrolled and divided into two groups. In addition to the usual home-made complementary food, all the children were fed one sachet of either Formula Ⅰ or Formula Ⅱ supplements each day. Protein and micronutrients were provided in Formula Ⅰ, while the same energy intake was secured in Formula Ⅱ as in Formula Ⅰ. A massive dose of vitamin A was supplemented to all the children every 6 months. Hemoglobin test was done at the same time. Results Prevalence of anemia was about 35% in both Formula Ⅰ and Formula Ⅱ group at baseline, and there were no differences in hemoglobin concentration between the two groups, During the 6-month and 12-month supplementation, hemoglobin of children in Formula Ⅰ group was higher than that in Formula Ⅱ group （P〈0.05）, and hemoglobin increase in Formula Ⅰ group was significantly higher than that in Formula Ⅱ group （P〈0.001）. After 6- and 12-mouth supplementation, the prevalence of anemia in Formula Ⅰ group dropped to 19.1% and 8.2% respectively, and it was 28.0% and 12.4% in Formula 2 group. The prevalence of anemia in Formula Ⅰ group was significantly lower than that in Formula Ⅱ group （P〈0.05）. After adjusting age and hemoglobin level at baseline, the hemoglobin increase at age of 24 months in formula 1 group was higher （10.7 g/L vs 7.9 g/L, P〈0.0001）. Conclusion Micronutrient fortified complementary food supplements, with large-dose vitamin A, is effective for children aged 6-12 months in terms of iron deficiency prevention.

关键词： Food fortification Complementary food supplements Infants and young children Hemoglobin Iron deficiency anemia

Effect of In-home Fortification of Complementary Feeding on Intellectual Development of Chinese Children

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Biomedical and Environmental Sciences 2010年第2期23卷 83-91页

作者： chun-ming chen, YU-YING WANG, AND SU-YING CHANG Chinese Center for Disease Control and Prevention, Beijing 100050, China Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To explore the effect of in-home fortification of complementary feeding on intellectual development of Chinese children aged below 24 months. Methods One thousand and four hundred seventy eight children aged 4-12 months were recruited and divided into study groups （formula 1 group and formula 2 group） and control group. In two study groups, in addition to the usual complementary food, children were fed with a sachet of fortified food supplement each day. Protein and micronutrients were provided in formula 1 group. Formula 2 group had the same energy intake as the formula 1 group . In addition to measurement of physical growth and detection of hemoglobin level, Development Quotient （DQ） or Intelligence Quotient （IQ） was assessed. Results The DQ of children aged below 24 months was 97.2, 95.5, and 93.8 in formula 1 group, formula 2 group and control group, respectively, and the differences were statistically significant （P〈0.05）. The DQ of children in formula 1 group, formula 2 group, and control group was 92.7, 90.4, and 88.3 respectively in the first follow up showing statistically significant differences （P〈0.05）. And, DQ of children in formula 1 group, formula 2 group and control group were 96.7, 94.5, and 93.7 respectively in the second follow up, showing statistically significant differences （P〈0.05）. FulI-IQ of children in the formula 1 group was 3.1 and 4.5 points higher than that in formula 2 group and in control group respectively. Verbal IQ of children in the formula 1 group was 2.1 and 5 points higher than that in formula 2 group and control group respectively. Performance IQ was 2.5 and 3.1 points higher than that in formula 2 group and control group respectively. All above mentioned comparisons were statistically significant. Conclusion Fortification of complementary feeding showed persistent effect on intelligence development of young children which could persist to 6 years of age. The critical time for correction of anemia could be under 18 m

关键词： Complementary feeding Supplement Development Anemia Infant

Combination of serum tumor markers dickkopf-1,DCP and AFP for the diagnosis of primary hepatocellular carcinoma

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Asian Pacific Journal of Tropical Medicine 2017年第4期10卷 387-391页

作者： Qi-Fan Qin Jie Weng Gan-Xin Xu chun-ming chen Chang-Ku Jia Department of General Surgery Lingao County People’s Hospital Department of Hepatobiliary & Pancreatic Surgery the First Affiliated Hospital of Hainan Medical University Department of Hepatobiliary & Pancreatic Surgery Hangzhou First People’s HospitalNanjing Medical University

Objective:To evaluate the detection accuracy of the biomarkers dickkopf-1,DCP and AFP as a serum biomarker panel by comparing the sensitivity of the panel with those of the individual ***:The study was composed of three groups,one with HCC patients,one with non-HCC liver diseases and one with healthy *** AFP was measured using a chemiluminescence assay and serum dickkopf-1 and DCP were measured with *** sensitivity and specificity of the biomarkers were analyzed as single parameters and as a serum ***:The HCC group showed higher levels of dickkopf-1,DCP and AFP than the other two groups(P0.05) than *** also had better sensitivity(74.42%vs.58.13%.P0.05).The combination of the biomarkers as a scrum panel produced much better sensitivity(93.02%) and specificity(78.00%) than each of the markers individually(P<0.05).Conclusion:The combination of *** and dickkopf-1 as a biomarker panel can significantly improve the detection power with much higher sensitivity and specificity for HCC than any of the biomarkers *** tests are convenient and inexpensive,and may serve as a valuable addition to current options for the diagnosis of HCC.

关键词： Tumor markers Diagnosis Primary hepatocellular carcinoma

Report on Childhood Obesity in China (2) Verification of BMI Classification Reference for Overweight and Obesity in Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2006年第1期19卷 1-7页

作者： GUAN-SHENG MA YAN-PING LI XIAO-QI HU ZHAO-HUI CUI XIAO-GUANG YANG and chun-ming chen National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention 29 Nan wei Road Beijing 100050 China Chinese Center for Disease Control and Prevention 27 Nan wei Road Beijing 100050 China

Objective To verify Working Group for Obesity in China （WGOC） recommended body mass index （BMI） classification reference for overweight and obesity in Chinese children and adolescents using the data of 2002 China Nationwide Nutrition and Health Survey. Methods PediaWic metabolic syndrome （MetS） and abnormality of each risk factor for MetS were defined using the criteria for US adolescents. Definition of hyper-TC, LDL, and dyslipidemia in adults was applied as well. The average level and abnormality rate of the metabolic indicators were described by BMI percentiles and compared with general linear model analysis. Receiver operating characteristic analysis was used to summarize the potential of BMI to discriminate between the presence and absence of the abnormality of these indicators. Results There was neither significantly increasing nor significantly decreasing trend of biochemical parameter levels in low BMI percentile range （〈65th）. Slight increasing trend from the 75th and a significant increase were found when BMI≥85th percentile. In general, the prevalence of the examined risk factors varied slightly when BMI percentile〈75th, and substantial increases were consistently seen when BMI percentile≥75th. As an indicator of hyper-TG, hypertension and MetS, the sensitivity and specificity were equal at the point of BMI〈75th percentile, and the Youden＇s index of risk factors also reached peak point before 75th percentile except for MetS. When the BMI percentile was used as the screening indicator of MetS, Youden＇s index reached peak point at 85th percentile, just the point in the ROC graph that was nearest to the upper left comer. Conclusion The BMI classification reference for overweight and obesity recommended by WGOC is rational to predict and prevent health risks in Chinese children and adolescents. Lower screening cut-off points, such as 83th percentile or 80th percentile, should not be excluded when they are considered as overweight criteria in future interventi

关键词： BMI classification Verification Child China Obese

Efficacy of Different Iron Fortificants in Wheat Flour in Controlling Iron Deficiency

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Biomedical and Environmental Sciences 2009年第2期22卷 118-121页

作者： JIAN HUANG JING SUN WEN-XIAN LI LI-JUAN WANG AN-Xu WANG JUN-SHENG HUO JUN-SHI chen and chun-ming chen Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China Nanyang Wancheng District Center of Disease Control and Prevention Nanyang 473009 Henan China

Objective To observe the different impacts of electrolytic iron, FeSO4, and NaFeEDTA on body iron store of anemic school students. Methods Four hundreds anemic students at the age of 11-18 years were divided into four groups. Of which, three consumed different iron fortificants from wheat flour as food vehicle for six months and one consumed non-fortified flour （control）. The fortification level of electrolytic iron, FeSO4, and NaFeEDTA was 60 mg Fe/kg, 30 mg Fe/kg, and 20 mg Fe/kg, respectively. Blood samples were collected at 0, 2, 4, and 6 months and hemoglobin （Hb）, serum ferritin （SF）, and transferrin receptor （TfR） were measured. Results The hemoglobin levels in three intervention groups increased, the increments of Hb in the NaFeEDTA group were significantly higher than that in the other groups. SF and TfR levels increased in the tested groups and body iron store in the NaFeEDTA group was higher than that in the other groups. These parameters did not show any significant changes in the control group. Conclusion NaFeEDTA and FeSO4 tortified wheat flour has positive impacts on iron status in anemic students and NaFeEDTA is more effective than FeSO4, while electrolytic iron is less effective in improving iron store in anemic students.

关键词： Body iron Iron deficiency anemia Wheat flour Fortification Electrolytic iron FeSO4 NaFeEDTA

Construction of a Metallacyclopentadiene Ring through the Attack of Carbanions to M≡C Bond Followed by C—H Activation

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Chinese Journal of Chemistry 2024年第3期42卷 235-242页

作者： chun Tang Shengjie Zhang Zhengyu Lu Qian Li ming Luo Dafa chen Haiping Xia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringCollaborative Innovation Center of Chemistry for Energy MaterialsXiamen UniversityXiamenFujian361005 China Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis Department of ChemistrySouthern University of Science and TechnologyShenzhenGuangdong518055 China

Metallacyclopentadienes are important metallacycles and regarded as intermediates in many reactions,therefore,new methods to achieve them are *** this study,a formal[3+2]method,through the reactions of an osmapentalyne with benzyl carbanions,was *** reactions underwent a nucleophilic attack of carbanions to the Os≡C bond,followed by C—H activation to form the five-membered osmacyclopentadiene *** of the reactions were carried out at room temperature,the substituents on the aromatic rings of benzyl carbanions are diverse,and the resulting products contain an Os—H bond,representing a novel type of 10C-carbolong *** work provides a new convenient route to construct metallacyclopentadienes,which is expected to further promote the development of such a type of substances.

关键词： Metallacyclopentadiene Carbolong chemistry Osmium C–H activation Nucleophilic addition

Elastic three-dimensional phononic topological insulators with Dirac hierarchy

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 54-62页

作者： Shao-Yong Huo Qiu-Shuang Yang Jiu-Jiu chen Hong-Kang Li Long-Chao Yao Fu-chun He chun-ming Fu College of Mechanical Engineering University of South ChinaHengyang 421001China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China

Three-dimensional(3D)phononic topological insulators(TIs)featuring two-dimensional(2D)surface states and one-dimensional(1D)hinge states have opened up a new route for multi-dimensional robust wave transport,providing unprecedented methods for integrated acoustic sensors and energy harvesting ***,aiming at the elastic 3D phononic TI with gapless surface states and hinge states,the realization of elastic 3D phononic TIs with gapless surface states and hinge states is a significant challenge due to the complicated multi-mode polarization of elastic waves in 3D *** this study,we demonstrate an elastic 3D phononic TI with a Dirac hierarchy by elaborately operating the corresponding spatial symmetries of the chiral honeycomb ***,a 3D double Dirac cone of elastic wave can be achieved by doubling the lattice along the outof-plane direction to fold two iso-frequency Weyl *** topological phase transitions and 2D gapless two-fold Dirac surface states of elastic wave are realized by breaking the half-lattice spatial translation ***,based on the Brillouin zone folding along the in-plane direction,the 2D gapless two-fold surface Dirac cones are folded into four-fold surface Dirac ***,by inducing the relative radius of adjacent holes to break the in-plane spatial inversion symmetry,the fourfold surface Dirac cones are gapped and associated with a surface state inversion,in which the gapless 1D hinge Dirac dispersion is *** research offers a route for engineering the hierarchies of TIs in 3D elastic wave systems and provides new possibilities for designing 3D ultrasonic devices with unconventional functions.

关键词： Dirac topological hierarchy