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Journal of Iron and Steel Research International 2012年第10期19卷 64-73页

作者： G subhash Chander G Madhusudhan Reddy A Venugopal Rao Swarna Bharathi Institute of Science and Technology Khammam 507002APIndia Defense Metallurgical Research Laboratory Kanchanbagh 500058APIndia

Fundamental investigation of continuous drive friction welding of austenitic stainless steel (AISI 304) and low alloy steel (AISI 4140) is described. The emphasis is made on the influence of rotational speed on the microstructure and mechanical properties such as hardness, tensile strength, notch tensile strength and impact toughness of the dissimilar joints. Hardness profiles across the weld show the interface is harder than the respective parent metals. In general, maximum peak hardness is observed on the stainless steel side, while other peak hardness is on the low alloy steel side. A trough in hardness distribution in between the peaks is located on the low alloy steel side. Peak hardness on the stainless steel and low alloy steel side close to the interface increases with a decrease in rotational speed. All transverse tensile joints fractured on stainless steel side near the interface. Notch tensile strength and impact toughness increase with increase in rotational speed up to 1 500 r/min and decrease thereafter. The mechanism of influence of rotational speed for the observed trends is discussed in the torque, displacement characteristics, heat generation, microstructure, fractography and mechanical properties.

关键词： friction welding dissimilar metal joint austenitic stainless steel low alloy steel microstructure impact toughness tensile strength

Thickness Dependent Physical Properties of Thermally Evaporated Nanocrystalline CdSe Thin Films

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Acta Metallurgica Sinica(English Letters) 2015年第10期28卷 1299-1304页

作者： Anuradha Purohit subhash Chander Satya Pal Nehra Mahendra Singh Dhaka Department of Physics Mohanlal Sukhadia University Centre of Excellence for Energy and Environmental Studies Deenbandhu Chhotu Ram University of Science and Technology Microelectronics Research Center Iowa State University of Science and Technology

This paper presents a study on thickness dependent physical properties of cadmium selenide thin films. The films of thickness 445, 631 and 810 nm were deposited employing thermal evaporation technique on glass and ITO-coated glass substrates followed by thermal annealing in air atmosphere at 200 °C. These films were subjected to X-ray diffractometer, UV-Vis spectrophotometer, scanning electron microscopy（SEM） and electrometer for structural, optical,surface morphological and electrical analysis respectively. The structural analysis reveals that the films are nanocrystalline in nature with cubic phase and preferred orientation（111）. The crystallographic parameters such as lattice constant, interplanar spacing, grain size, internal strain, dislocation density, number of crystallites per unit area and texture coefficient are calculated and discussed. The optical band gap is found in the range 1.75-1.92 e V and observed to increase with *** SEM study shows that the annealed films are uniform, fully covered and well defined. The electrical analysis shows that the conductivity is varied with film thickness and found within the order of semiconductor behavior.

关键词： Thin films X-ray diffraction Optical properties Electrical properties Evaporation

Variations in body melanisation, ovariole number and fecundity in highland and lowland populations of Drosophila melanogaster from the Indian subcontinent

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Insect Science 2008年第6期15卷 553-561页

作者： subhash Rajpurohit Ravi Parkash Seema Ramniwas Shama Singh Department of Biochemistry and Genetics Maharshi Dayanand University Rohtak 124001 India

We investigated geographical variations in three fitness-related traits （body melanisation, ovariole number and fecundity） in laboratory-reared offspring of 10 populations of Drosophila melanogaster. The populations were collected from adjacent lowland and highland localities （-80-100 km apart） in the tropical as well as subtropical regions （11.15-31.06°N） covering a linear distance about 3 000 kilometers from south to north on the Indian subcontinent. Persistence of within- as well as between-population differences at 21 ℃ suggest that observed variations in fitness-related traits have a genetic basis. Populations from higher altitudes showed consistently higher trait values （1.4-fold increase） as compared with their corresponding lowland populations. By contrast, latitudinal variations were about two-fold higher across the entire continent. Along latitude as well as altitude, population means showed higher correlation values （r 〉 0.98） between all the three fitness traits. However, on the basis of within-population analysis （assorted darker and lighter flies）, changes in body melanisation were significantly correlated with fecundity but not with ovariole number. Thus, analysis of within-population trait variability should be preferred as compared with data on population means for adaptive significance of fitness-related traits. In the present study, the role of climatic selection is evident from regression analysis with changes in annual average temperature of the sites of origin of populations along latitude as well as altitude.

关键词： altitude body melanisation Drosophila melanogaster fecundity latitude ovariole number

Chemical characteristics of trace metals in PM10 and their concentrated weighted trajectory analysis at Central Delhi,India

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Journal of Environmental Sciences 2017年第5期29卷 184-196页

作者： subhash Chandra Monika J.Kulshrestha Ruchi Singh Nahar Singh CSIR-National Physical Laboratory New Delhi 110012 India. Academy of Scientific and Innovative Research (AcSIR) CSIR - National Physical Laboratory (CSIR-NPL) Campus New Delhi 110012 India Present address: Shriram Institute for Industrial Research Delhi 110007 India.

Trace metals associated with PM10 aerosols and their variation during day and nighttime as well as during different seasons have been studied for the year 2012. PCA analysis suggested5 PCs,which accounted for 86.8% cumulative variance. PC1 accounted for 30% with a significant loading of metals of anthropogenic origin,while PC2 showed 28% variance with the loading of metals of crustal origin. These trace metals showed seasonal distinct day and night time characteristics. The concentrations of Cu,Pb,and Cd were found to be higher during nighttime in all the seasons. Only Fe was observed with significantly higher mean concentrations during daytime of all seasons except monsoon. The highest mean values of Cu,Cd,Zn,and Pb during post-monsoon might be attributed to winds advection over the regions of waste/biomass burning and industrial activities in Punjab and Haryana ***,concentration weighted trajectory analysis suggested that metals of crustal origin were contributed by long-range transport while metals of anthropogenic and industrial activities were contributed by regional/local source regions.

关键词： Trace metals Potential source regions Backward trajectory Principal component analysis

Self-renewal of peripheral nerve resident macrophage:does it represent a unique activation status?

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Neural Regeneration Research 2022年第5期17卷 999-1000页

作者： Maricris Bautista anand Krishnan Department of Anatomy Physiologyand PharmacologyCollege of MedicineUniversity of SaskatchewanSaskatoonSKCanada Cameco MS Neuroscience Research Centre(CMSNRC) University of SaskatchewanSaskatoonSKCanada

Macrophages are immune cells of myeloid origin and are present in almost all *** perform a wide variety of functions contributing to tissue development,homeostasis,pathogenesis,and repair(Wynn et al.,2013).Strikingly,macrophages residing at different tissues,and at different compartments of an individual tissue,demonstrate enormously diverse molecular characteristics(Gordon and Taylor,2005).

关键词： al. homeostasis macrophage

Variations in bark thickness and sapwood density of Calophyllum inophyllum provenances in Australia and in Sri Lanka

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Journal of Forestry Research 2011年第3期22卷 399-402页

作者： subhash Hathurusingha Nanjappa Ashwath Centre for Plant and Water Science CQ University Bruce highway Rockhampton 4702 Australia

Sapwood density and bark thickness of Calophyllum inophyllum L. （a multipurpose durable timber species） were studied in various locations in Northern Australia and in Sri Lanka. Measurements were taken non-destructively by using core sampling and bark gauge. From each provenance, 4–15 mature trees having girth at breast height over bark （GBHOB） at 100–150 cm were selected on the basis of the population size. Significant （p0.05） hemispheric and provenance variations in bark thickness were found. Variations in the bark thickness are influenced by environmental variables. Variations in sapwood density were less pronounced compared to that of bark thickness. Variations in sapwood density are likely to be governed by genotypic variations.

关键词： bark thickness Calophyllum inophyllum provenance variations sapwood density

Calophyllum inophyllum: recalcitrant or intermediate seed?

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Journal of Forestry Research 2012年第1期23卷 103-107页

作者： subhash Hathurusingha Nanjappa Ashwath Centre for Plant and Water Science CQ University Rockhampton 4702 Australia

We studied seed storage behaviour of a multipurpose tree Calophyllum inophyllum （Clusiaseae）. Seeds were collected at Roslyn bay （2307′60＂ S, 150°43′60＂ E） Central Queensland. Seed drying and desieeation tolerance tests were carried out according to International Seed Testing Association （ISTA） rules. We found C. inophyllum seeds to be recalcitrant and vulnerable to chilling injury, hence, unsuited for cold storage. C. inophyllum seeds maintained their viability for an appreciable period （〉 8 months） if stored in wanner environments.

关键词： Calophyllum inophyllum germination moisture content recalcitrant storage longevity seed storage behaviour

Coordination Nanoparticles Formed by Fluorescent 2-Aminopurine and Au^(3+): Stability and Nanozyme Activities

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Journal of Analysis and Testing 2019年第3期3卷 219-227页

作者： anand Lopez Juewen Liu Department of Chemistry Waterloo Institute for NanotechnologyUniversity of WaterlooWaterlooON N2L 3G1Canada

Nucleobase-metal coordination polymers(CPs)have been the target of much recent research owing their interesting properties and ease of *** nucleobases are nonfluorescent,and 2-aminopurine(2AP)is a strongly fluorescent analog of *** this work,we compared the CPs formed by adenine,2AP and adenosine with various *** Au3+produced CP nanoparticles with both adenine and *** products were similar in terms of size,suggesting that the position of the exocyclic amine is unimportant for coordination with *** 2AP is fluorescent,the dissolution of the nanoparticles in the presence of various chemicals including KCN,GSH,iodide,bromide and chloride,was studied and compared to fluorescent adenosine-Au *** appears that the 2AP CP was more robust than the adenosine one since even chloride can quench the fluorescence of the adenosine/Au ***,the adenine and 2AP nanoparticles exhibited weak oxidase-like activity for oxidation of TMB possibly by the Au3+exposed on the surface.

关键词： Coordination nanoparticles Nucleotides Gold Nanozymes

Synthesis, Thermal, Electrical and Catalytic Studies of Some Transition Metal Polychelates of Bis-bidentate Schiff Base

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Chinese Journal of Chemistry 2007年第2期25卷 154-158页

作者： BANSOD, Ashish ASWAR, anand Department of Chemistry S.G.B. Amravati University Amravati -444602 (MS.) India

Polychelates of Mn（Ⅱ）, Fe（Ⅱ）, Co（Ⅱ）, Ni（Ⅱ）, Cu（Ⅱ）, Zn（Ⅱ） and Cd（Ⅱ） with the bis salen-type ligand derived from 4,4＇-bis[（salicylaldehyde-5）azo]biphenyl and 1,4-diaminobutane have been synthesized. All the polychelalls have been characllrized by elemental analysis, magnetic susceptibility measurements, IR, electronic spectra and thennogravirncuic studies. All the complexes isolated in solid stall are dark coloured and insoluble in water and common organic solvents. The ligand behaves as a bis-bidentall molecule coordinating through the phenolic oxygen and azomethine nitrogen atoms. The thermal decomposition of these metal complexes was investigated by thermogravimetric analysis and data have been analyzed for kinetic parameters using Broido equation. The solid-state electrical conductivity of the ligand and its polychelalls in the form of compressed pellet was studied in the temperaturc range from 313 to 413 K All the polychelalls were found to show semiconducting nature. The Mn（Ⅱ）, Fe（Ⅱ）, Co（Ⅱ） and Ni（Ⅱ） polychelalls have been assessed for the catalytic epoxidation of styrene.

关键词： Schiff base polychelate TGA solid-state conductivity catalytic activity

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel anand P.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of Technology BostonMA 02139USA Present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKM2