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Enzymatic digestibility of pretreated dewaxed bamboo residues as feedstock for bioethanol production

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Systems Microbiology and Biomanufacturing 2022年第4期2卷 716-722页

作者： Sabeela Beevi Ummalyma Karki Baibhav anamika singh Institute of Bioresources and Sustainable Development(IBSD) A National Institute Under Department of BiotechnologyGovt.of IndiaTakyelpatImphalManipur 795001India

Due to abundant availability,biofuel production from bamboo residues is gaining *** biomass and its residues are widely available in the north-eastern part of India,which can be sustainably exploited for green energy *** aim of the present study was to evaluate the pretreatments of dewaxed bamboo residues with dilute alkali(NaOH),and dilute acid,and the effect of pretreatment on biomass hydrolysis was performed with a commercial enzyme(Zytex).Results showed that maximum fermentable sugars were 490 mg/g obtained from 10%biomass with 0.6%(w/v)of alkali,and acid pretreated biomass produced 320 mg/g of sugars from 2%(w/v)acid with 10%*** in biomass structure during the pretreatment process are correlated with FTIR,SEM,and component analysis for lignin,cellulose,and *** studies of the hydrolysate showed that the yield of ethanol was 77%of the theoretical maximum at 36 *** indicate the scope of utilization of bamboo residues as substrates for biofuels,and alkaline pretreatment is an effective pretreatment process for bioethanol production.

关键词： Bamboo Pretreatment Enzymatic hydrolysis Bioethanol production

Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical stimulation

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Bioactive Materials 2021年第8期6卷 2231-2249页

作者： anamika singh Alok Raghav Parvaiz Ahmad Shiekh Ashok Kumar Biomaterial and Tissue Engineering Group Department of Biological Sciences and BioengineeringIndian Institute of Technology KanpurKanpur208016UPIndia Centre for Nanosciences Indian Institute of Technology KanpurKanpur208016UPIndia Centre for Environmental Sciences and Engineering Indian Institute of Technology KanpurKanpur208016UPIndia

Diabetic peripheral neuropathy(DPN)is a long-term complication associated with nerve dysfunction and uncontrolled *** spite of new drug discoveries,development of effective therapy is much needed to cure ***,we have developed a combinatorial approach to provide biochemical and electrical cues,considered to be important for nerve *** derived from bone marrow mesenchymal stromal cells(BMSCs)were fused with polypyrrole nanoparticles(PpyNps)containing liposomes to deliver both the cues in a single delivery *** developed DPN rat model and injected intramuscularly the fused exosomal system to understand its long-term therapeutic *** found that the fused system along with electrical stimulation normalized the nerve conduction velocity(57.60±0.45 m/s)and compound muscle action potential(16.96±0.73 mV)similar to healthy control(58.53±1.10 m/s;18.19±1.45 mV).Gastrocnemius muscle morphology,muscle mass,and integrity were recovered after ***,we also observed paracrine effect of delivered exosomes in controlling hyperglycemia and loss in body weight and also showed attenuation of damage to the tissues such as the pancreas,kidney,and *** work provides a promising effective treatment and also contribute cutting edge therapeutic approach for the treatment of DPN.

关键词： Exosomes Bone marrow mesenchymal stromal cells Polypyrrole Diabetes mellitus Diabetic peripheral neuropathy

Coronaviruses:An overview with special emphasis on COVID-19 outbreak with musculoskeletal manifestations

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World Journal of Orthopedics 2021年第9期12卷 620-628页

作者： Sabir Ali Ajai singh Nayeem Sharief Manish Yadav Salma Siddiqui Vaishnavi Pandey Archana Raikwar anamika singh Department of Paediatric Orthopaedics King George’s Medical UniversityLucknow 226003Uttar PradeshIndia

An acute respiratory illness caused by a novel coronavirus,namely,severe acute respiratory syndrome coronavirus 2,the virus that causes coro-navirus disease 2019(COVID-19),began spreading across China in late December *** disease gained global attention as it spread *** the COVID-19 pandemic began,many studies have focused on the impact of the disease on conditions such as diabetes,cardiovascular disease,pulmonary disorders,and renal ***,few studies have focused on musculoskeletal disorders related to COVID-19 *** this review,we update the current knowledge on the coronavirus with special reference to its effects during and after the pandemic on musculoskeletal aliments,which may inform clinical practice.

关键词： Coronaviruses COVID-19 Musculoskeletal Infection Pandemic Orthopaedics

Anti-cancer effects of sitagliptin,vildagliptin,and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation

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BIOCELL 2022年第12期46卷 2645-2657页

作者： POOJA JAISWAL VERSHA TRIPATHI ANSHUL ASSAIYA DHARMENDRA KASHYAP RAHUL DUBEY anamika singh JANESH KUMAR HEM CHANDRA JHA RAJESH SHARMA AMIT KUMAR DIXIT HAMENDRA singh PARMAR School of Biotechnology Devi Ahilya UniversityIndore452001India Laboratory of Membrane Protein Biology National Centre for Cell SciencePune411007India Department of Biosciences and Biomedical Engineering Indian Institute of TechnologyIndore452020India Department of Biotechnology IPS AcademyIndore452012India School of Pharmacy Devi Ahilya UniversityIndore452001India Central Council for Research in Ayurvedic Sciences Kolkata263645India

Triple-negative breast cancer(TNBC)cell line MDA-MB-231 is known for Warburg metabolism and defects in *** the other hand,dipeptidyl peptidase-IV(DPP-IV)inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis,but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell *** have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase(AMPK),which activates the downstream transcription factors PGC-1α,PGC-1β,or FOXO1 for mitochondrial biogenesis;above-mentioned incretin-based therapies are also known to activate *** study evaluated the effects of sitagliptin,vildagliptin,and exendin-4 on MDA-MB-231 cells and the underlying changes in mitochondrial biogenesis,were *** with sitagliptin(100μM),vildagliptin(100μM),and exendin-4(10 nM)for 72 h to MDA-MB-231 cells led to a decrease in viability indicated by MTT assay,cell migration by scratch,and transwell migration assays,accompanied with marginal reduction in cell numbers along with the apoptotic appearance,the rate of apoptosis,and decreased lactate content in conditioned *** changes in the cancer phenotype were accompanied by an increase in the mitochondrial DNA to nuclear DNA ratio,increased MitoTracker green and red staining,and increased expression of transcription factors PGC-1α,NRF-1,NRF-2,TFAM,and ***-treatment of cells with these incretin-based drugs followed by 48 h treatment with 1μM doxorubicin increased doxorubicin sensitivity as observed by a decrease in viability by MTT ***,sitagliptin,vildagliptin,and exendin-4 exert their beneficial effects on TNBC cells via an increase in mitochondrial biogenesis that helps to switch Warburg metabolism into anti-Warburg *** response was in the order of:sitagliptin>vildagliptin>ex

关键词： Sitagliptin Vildagliptin Exendin-4 Apoptosis Migration Viability Chemo-sensitivity Mitochondrial biogenesis

An overview and experimental analysis of WO3/TiO2 composite with enhanced electrochromic properties for smart windows application

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Tungsten 2024年第4期6卷 732-747页

作者： Ayesha Khan Mayur A.Gaikwad Jin Hyeok Kim anamika Kadam The Institute of Science Dr.Homi Bhabha State University Optoelectronics Convergence Research Center and Department of Materials Science and Engineering Chonnam National University

Internationally,standards for electrochromic（EC） requirements in smart window applications have been established,with ongoing global initiatives aimed at elevating them to highly advanced *** paper covers a comprehensive investigation of the structural,optical,morphological,and electrochemical properties of WO3/TiO2composite ***,an experimental analysis of WO3/TiO2was envisaged by a two-step ***,WO3thin films were hydrothermally deposited onto indium-doped tin oxide-coated glass substrates using an aqueous solution of Na2WO4·2H2O at a pH value of ***,a layer of TiO2was electrodeposited onto the WO3thin films.X-ray diffraction analysis confirmed the successful formation of WO3/TiO2composite films,with the WO3phase exhibiting a hexagonal tunnel *** electron microscopy revealed the formation of porous nanorods（NRs） of WO3,uniformly coated with TiO2,resulting in a porous morphology of the WO./*** EC performance of the WO3/TiO2films was thoroughly assessed through cyclic voltammetry and chronoamperometry measurements over a potential window ranging from-2.0 to+1.2 V（versus Ag/AgCl） in a 0.5 mol·L-1LiClO4-PC *** WO3/TiO2composite films exhibited cathodic electrochromism,characterized by a reversible color change from dark blue to *** improved EC performance in comparison to pure WO3films is attributed to enhanced double ion/electron insertion and extraction ***,the WO3/TiO2composite films demonstrated excellent optical modulation properties,with a significant modulation at 633 nm（46.87%）.The coloration efficiency reached a high value of 193.25 cm2·C-1,indicating their potential for practical EC ***,the WO3/TiO2composite films displayed exceptional EC stability,with no significant degradation observed over 2500 cyclic voltammetry *** superior EC performance can be attributed to the synergistic effect between the hexagonal WO3NRs

关键词： Electrochromism Smart window Stability WO3/TiO2

Acute paroxysmal cold hemoglobinuria upon dengue fever:A case report

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Journal of Acute Disease 2024年第3期13卷 121-124页

作者： Momin Majed Abdul Basit Aluri anamika Syed Arfa Ashrafunnisa Rahul Dev singh Rathore Department of Laboratory Medicine Yashoda HospitalHyderabadIndia Department of Pediatrics and Neonatology Yashoda HospitalHyderabadIndia

Rationale:Dengue fever is capable of inciting the formation of transient polyclonal antibodies directed at red blood cell antigens,resulting in complement-mediated hemolysis,leading to intravascular hemolysis and ***’s concern:A 12-year-old male patient who recovered from dengue fever a week ago had red blood cell agglutination,spherocytes,and engulfment of red blood cells(erythrophagocytosis)by monocytes and neutrophils on routine hematological peripheral blood *** unexpected blood smear results prompted the lab physicians to investigate autoimmune hemolytic anemia,which revealed a monospecific positive direct antiglobulin test for complement(C3d,C3b)and the presence of Donath-Landsteiner ***:Paroxysmal cold hemoglobinuria(PCH),secondary to dengue ***:Oxygen supplements,antibiotics,intravenous immunoglobulins,steroid therapy,and packed cell transfusions were ***:The patient’s condition was improved following the ***:Post-dengue PCH is a rare complication that requires a thorough peripheral smear examination for erythrophagocytosis,as advanced hematology analyzers fail to detect such findings.

关键词： Paroxysmal cold hemoglobinuria Dengue Erythrophagocytosis Donath-Landsteiner test Treatment

Exploring the Latest Trends in AI Technologies: A Study on Current State, Application and Individual Impacts

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Journal of Computer and Communications 2024年第8期12卷 21-36页

作者： Md Ahsan Ullah Imran Mustakim Bin Aziz anamika Tiwari Sanchita Saha Ashok Ghimire Department of Business Administration Westcliff University 17877 Von Karman Ave 4th Floor Irvine CA 92614 United States

Artificial Intelligence (AI) offers immediate insights to penetrate the overwhelming volume of everyday security warnings. The current body of research mostly examines the use of AI in the field of cyber security, but it does not adequately address the visual inspection of AI applications. The advent of AI has led to noticeable structural changes in the field of cyber security. This study facilitates the advancement of theory about artificial intelligence (AI) across several fields. It assists researchers in determining research paths and serves as a resource for corporations and governments to strategize the use of AI in areas such as cyber security, education, healthcare, and work-life balance. Numerous nations, organizations, and writers are intricately linked via cooperation and citation networks. Artificial intelligence is an academic discipline focused on the research and advancement of computer systems, robots, and other creations that possess human-like intelligence, which is defined by cognitive powers, learning capabilities, and adaptability. This research aimed to evaluate the present trajectory and influence of Artificial Intelligence (AI) on education, healthcare, cybersecurity, and work-life balance. Based on an initial examination, this research focused on evaluating the use and impact of AI in many domains, using a specific narrative and framework. The findings of this study will enable researchers to comprehend the prevailing pattern and the influence of people on the integration of AI into daily life.

关键词： Artificial Intelligence Cybersecurity Healthcare AI on Education Work-Life Balance

Applying the Technology Acceptance Model (TAM) in Information Technology System to Evaluate the Adoption of Decision Support System

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Journal of Computer and Communications 2024年第8期12卷 242-256页

作者： Md Azhad Hossain anamika Tiwari Sanchita Saha Ashok Ghimire Md Ahsan Ullah Imran Rabeya Khatoon Department of Business Administration International American University 3440 Wilshire Blvd STE 1000 Los Angeles CA 90010 United States Department of Business Administration Westcliff University 17877 Von Karman Ave 4th Floor Irvine CA 92614 United States

With the beginning of the information systems’ spreading, people started thinking about using them for making business decisions. Computer technology solutions, such as the Decision Support System, make the decision-making process less complex and simpler for problem-solving. In order to make a high-quality business decision, managers need to have a great deal of appropriate information. Nonetheless, this complicates the process of making appropriate decisions. In a situation like that, the possibility of using DSS is quite logical. The aim of this paper is to find out the intended use of DSS for medium and large business organizations in USA by applying the Technology Acceptance Model (TAM). Different models were developed in order to understand and predict the use of information systems, but the information systems community mostly used TAM to ensure this issue. The purpose of the research model is to determine the elements of analysis that contribute to these results. The sample for the research consisted of the target group that was supposed to have completed an online questionnaire about the manager’s use of DSS in medium and large American companies. The information obtained from the questionnaires was analyzed through the SPSS statistical software. The research has indicated that, this is primarily used due to a significant level of Perceived usefulness and For the Perceived ease of use.

关键词： Information Technology Decision Support System Business Organization in USA Technology Acceptance Model

Variation in seed morphometric characters, oil content and azadirachtin content of seeds, in vitro shoot cultures and callus cultures among different populations of Azadirachta indica

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Journal of Forestry Research 2018年第1期29卷 121-127页

作者： Fatima Shirin anamika Rai Neelu singh Genetics and Plant Propagation Division Tropical Forest Research Institute PO RFRC Non-Wood Forest Produce Division Tropical Forest Research Institute PO RFRC

We studied seed morphometric characters, oil content and azadirachtin content in a medicinally important and insect repellent tree species Azadirachta indica ***. Ten populations were selected from two central Indian states of Madhya Pradesh and Chhattisgarh and twenty candidate plus trees were selected from each population based on tree attributes. Azadirachtin content was estimated in seeds, in vitro shoots and callus cultures through HPLC. Significant variation（p ／ 0.05） was observed in seed morphometric characters, oil content and azadirachtin content among the ten populations. Maximum value for 100 seed weight was obtained in seeds of Raigarh（30.51 g） which was on par with seeds of Bargi（28.37 g）and Chhatarpur（26.36 g）. The ratio of highest kernel to seed was also obtained in seeds of Raigarh（60.11%）.Kernels from Chhatarpur population recorded the highest oil content（24.20%）, which was equal to that in Sihore（23.75%） and Katni（21.75%）. We recorded highly significant variation in azadirachtin content in seed samples,in vitro shoot samples and callus cultures. Maximum azadirachtin was present in the seeds of Gwalior（0.882%）which was on par with azadirachtin content in seeds of Chhatarpur, Katni, Sihore, Shahdol and *** azadirachtin in the in vitro shoots was present in the cultures of Gwalior（0.218%） which was statistically on par with Sihore（0.176%）. Similarly, in callus cultures of nodal segments maximum azadirachtin was recorded in the Gwalior population（0.033%） which was statistically on par with Sihore（0.028%）. The trees of Gwalior and Sihore populations can be produced in large numbers through vegetative propagation to obtain seeds with higher azadirachtin content.

关键词： Azadirachtin In vitro Seed morphometric characters Populations Variation