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Military traumatic brain injury:a challenge straddling neurology and psychiatry

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Military Medical Research 2022年第6期9卷 686-704页

作者： ling-zhuo Kong Rui-Li Zhang Shao-Hua Hu Jian-Bo Lai Department of Psychiatry the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China the Key Laboratory of Mental Disorder's Management in Zhejiang Province Hangzhou 310003China Brain Research Institute of Zhejiang University Hangzhou 310003China Zhejiang Engineering Center for Mathematical Mental Health Hangzhou 310003China MOE Frontier Science Center for Brain Science and Brain-Machine Integration Zhejiang UniversityHangzhou 310003China

Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible effect of the war. In this review, we begin by examining related military research, summarizing the related epidemiological data, neuropathology, and the research achievements of diagnosis and treatment technology, and discussing its comorbidity and sequelae. To date, advances in neuroimaging and molecular biology have greatly boosted the studies on military traumatic brain injury(TBI). In particular, in terms of pathophysiological mechanisms, several preclinical studies have identified abnormal protein accumulation, blood–brain barrier damage, and brain metabolism abnormalities involved in the development of TBI. As an important concept in the field of psychiatry, TBI is based on organic injury, which is largely different from many other mental disorders. Therefore, military TBI is both neuropathic and psychopathic, and is an emerging challenge at the intersection of neurology and psychiatry.

关键词： Shellshock Military Traumatic brain injury Diagnosis Treatment Comorbidity

Atomically Dispersed Dual‑Metal Sites Showing Unique Reactivity and Dynamism for Electrocatalysis

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Nano-Micro Letters 2023年第8期15卷 192-204页

作者： Jun‑Xi Wu Wen‑Xing Chen Chun‑Ting He Kai Zheng Lin‑ling zhuo Zhen‑Hua Zhao Jie‑Peng Zhang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022People’s Republic of China Energy&Catalysis Center School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China

The real structure and in situ evolution of catalysts under working conditions are of paramount importance,especially for bifunctional ***,we report asymmetric structural evolution and dynamic hydrogen-bonding promotion mechanism of an atomically dispersed *** of Co/Ni-doped MAF-4/ZIF-8 yielded nitrogen-doped porous carbons functionalized by atomically dispersed Co–Ni dual-metal sites with an unprecedented N8V4 structure,which can serve as an efficient bifunctional electrocatalyst for overall water *** importantly,the electrocatalyst showed remarkable activation behavior due to the in situ oxidation of the carbon substrate to form C–OH *** functional theory calculations suggested that the flexible C–OH groups can form reversible hydrogen bonds with the oxygen evolution reaction intermediates,giving a bridge between elementary reactions to break the conventional scaling relationship.

关键词： Metal-organic frameworks Atomically dispersed catalyst Hydrogen bond Overall water splitting

GUHDELINES FOR CORRECT ENGLISH SPELling

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青海民族大学学报（教育科学版） 1989年第2期18卷 40-43页

作者： WANG zhuo-ling

An English learner usually meets some problems when spelling words.A person who wishes to improve his spelling must systemtically attack onthe problem. Teachers can help their students by introducing word gamesand spelling activities. Some textbooks provide useful exercises. But thelearning always renains the task of the students. How can an Englishlearner spell words correctly? Are there any rules to apply? Here are

关键词： learner exercises correctly apply skill meaningful beginning explain introducing retain

Transient vacuolar changes of the crystalline lens in patients using a dispersive ophthalmic viscosurgical device

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1794-1799页

作者： Yue Zhou Wan Chen Yu Zhang zhuo-ling Lin Jing Li Hui Chen Wei-Rong Chen State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina

AIM:To report the clinical prognosis and pathological findings of accidental lens vacuolar changes in eyes with intraoperative exposure to a dispersive ophthalmic viscosurgical device(OVD).METHODS:Two patients who developed transient lens vacuolar changes during uneventful persistent pupillary membrane(PPM)removal surgery were presented and followed *** event was speculated to be associated with an intraoperative dispersive OVD DisCoVisc(hyaluronic acid 1.6%-chondroitin sulfate 4.0%)***,to provide the pathological basis for our speculation,another four cataract patients were randomly exposed to different OVDs,and their anterior lens capsules were investigated with transmission electron microscopy(TEM).RESULTS:After months,the subcapsular vacuoles in both PPM cases were gradually disappeared without visual *** the cataract patients,similar lens changes were observed intraoperatively in those exposed to a dispersive DisCoVisc but not a cohesive OVD IVIZ(sodium hyaluronate gel 1.0%).In addition,marked ultrastructural changes,including chromatin condensation,extensive cytoplasmic vacuoles,and obvious intercellular space between lens epithelial cells in the anterior lens capsules of all eyes exposed to DisCoVisc,were observed by ***:The lens vacuolar changes may be associated with a dispersive OVD ***,it is not preferable to use dispersive OVDs in patients with transparent lenses or without the intention of lens *** addition,close follow-ups instead of immediate lens extraction are recommended for the occurrence of similar lens lesions.

关键词： vacuolar change crystalline lens ophthalmic viscosurgical devices lens epithelial cells transmission electron microscopy

Long noncoding RNA ZNFX1-AS1 promotes the invasion and proliferation of gastric cancer cells by regulating LIN28 and CAPR1N1

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World Journal of Gastroenterology 2022年第34期28卷 4973-4992页

作者： Zhong-ling zhuo Hai-Peng Xian Yu-Jing Sun Yan Long Chang Liu Bin Liang Xiao-Tao Zhao Department of Clinical Laboratory Peking University People’s HospitalBeijing 100044China The Key Laboratory of Geriatrics Peking University Fifth School of Clinical MedicineBeijing 100730China Department of Clinical Laboratory Peking University International HospitalBeijing 100044China Department of Gastrointestinal Surgery Peking University People’s HospitalBeijing 100044China

BACKGROUND Long noncoding RNA(lncRNA)ZNFX1-AS1(ZFAS1)is a newly discovered lncRNA,but its diagnostic value in gastric cancer is *** To investigate the potential role of ZFAS1 in gastric cancer and to evaluate the clinical significance of ZFAS1 as a biomarker for gastric cancer *** Quantitative real-time polymerase chain reaction(qRT-PCR)was used to screen for gastric cancer-associated lncRNAs in gastric cancer patients,gastric stromal tumor patients,gastritis or gastric ulcer patients,and healthy *** between ZFAS1 expression and clinicopathological features were *** biological effects of ZFAS1 on the proliferation,migration,and invasion of gastric cancer cells were studied by MTT,colony formation,and transwell migration *** potential mechanism of ZFAS1 was demonstrated using enzyme-linked immunosorbent assay and *** relationship between ZFAS1 and tumorigenesis was demonstrated using in vivo tumor formation *** The plasma level of lncRNA ZFAS1 was significantly higher in preoperative patients with gastric cancer than in individuals in the other 4 *** expression of ZFAS1 was significantly associated with lymph node metastasis,advanced TNM stage,and poor ***1 regulated the proliferation,migration,and invasion of gastric cancer cells and regulated the growth of gastric cancer cells in ***28 and CAPRIN1 were identified as key downstream mediators of ZFAS1 in gastric cancer *** LncRNA ZFAS1 promoted the invasion and proliferation of gastric cancer cells by modulating LIN28 and CAPRIN1 expression,suggesting that ZFAS1 can be used as a potential diagnostic and prognostic biomarker in gastric cancer.

关键词： Long noncoding RNA ZNFX1-AS1 Gastric cancer Biomarker Invasion Proliferation

Pannexin 1,a large-pore membrane channel,contributes to hypotonicity-induced ATP release in Schwann cells

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Neural Regeneration Research 2021年第5期16卷 899-904页

作者： Zhong-Ya Wei Hui-Lin Qu Yu-Juan Dai Qian Wang zhuo-Min ling Wen-Feng Su Ya-Yu Zhao Wei-Xing Shen Gang Chen Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Anesthesiology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Pannexin 1(Panx 1),as a large-pore membrane channel,is highly permeable to ATP and other signaling *** studies have demonstrated the expression of Panx 1 in the nervous system,including astrocytes,microglia,and ***,the distribution and function of Panx 1 in the peripheral nervous system are not *** the function of Panx 1 pharmacologically(carbenoxolone and probenecid)or with small interfering RNA targeting pannexins can greatly reduce hypotonicity-induced ATP *** of Schwann cells with a Ras homolog family member(Rho)GTPase inhibitor and small interfering RNA targeting Rho or cytoskeleton disrupting agents,such as nocodazole or cytochalasin D,revealed that hypotonicity-induced ATP release depended on intracellular RhoA and the *** findings suggest that Panx 1 participates in ATP release in Schwann cells by regulating RhoA and the cytoskeleton *** study was approved by the Animal Ethics Committee of Nantong University,China(No.S20180806-002)on August 5,2018.

关键词： ATP cytoskeleton injury neuron pannexin 1 peripheral nerve Ras homolog family member A Schwann cells

Visual outcomes of surgical and conservative treatment in children with small posterior polar cataracts and posterior lenticonus

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 64-71页

作者： Hui Chen Wan Chen Xiang-Hua Wu zhuo-ling Lin Jing-Jing Chen Xiao-Yan Li Wei-Rong Chen Hao-Tian Lin State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Center for Precision Medicine Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM:To compare the visual outcomes of children with small(≤3 mm)posterior polar cataracts(PPC)and posterior lenticonus who had cataract extraction surgery with the visual outcomes of those who were managed ***:Children who initially had small PPC and posterior lenticonus who were followed up over 1-year period were retrospective reviewed in the *** receiving surgery were compared with those receiving conservative *** axial length,keratometry,refraction,bestcorrected visual acuity(BCVA),and strabismus measurements were *** morphology,i.e.,the location,size,and depth of the cataract lesion,was measured with a Scheimpflug imaging *** help control for baseline differences in the groups,patients were matched with controls by propensity score ***:The study evaluated 60 patients(30 in the surgery group and 30 in the conservative therapy group)after matching by propensity *** who underwent cataract surgery showed greater BCVA improvements(0.36±0.24 logMAR)than patients who were treated without surgery(0.22±0.26 logMAR;P=0.036).Surgery was effective in patients with a rear projection length(RPL)less than 1.0 mm and a pretreatment BCVA worse than 0.52 ***:Children with small PPC and posterior lenticonus who undergo cataract surgery experience greater BCVA improvements than those managed *** patients presenting with a RPL less than 1.0 mm and a pretreatment BCVA of 0.52 logMAR or worse may benefit from surgery.

关键词： posterior polar cataracts posterior lenticonus visual outcomes Pentacam

Acute myocardial infarction in twin pregnancy after assisted reproduction:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4294-4302页

作者： Ni-Ni Dai Rong Zhou Yan-ling zhuo Li Sun Ming-Yue Xiao Si-Jing Wu Hai-Xu Yu Qiu-Yu Li Department of Respiratory and Critical Care Medicine Peking University Third HospitalBeijing 100191China Department of Sleep Medicine Peking University Sixth HospitalBeijing 100191China Department of Rehabilitation Beijing United Family Rehabilitation HospitalBeijing 100016China Department of Cardiology Beijing Anzhen hospitalBeijing 100029China Department of Cardiology Peking University Third HospitalBeijing 100191China

BACKGROUND Acute myocardial infarction(AMI)during pregnancy is rare,especially in twin pregnancy,and it can endanger the lives of the mother and *** for conventional cardiovascular risk factors,pregnancy and assisted reproduction can increase the risk of AMI during *** develops secondary to different etiologies,such as coronary spasm and spontaneous coronary artery *** SUMMARY A 33-year-old woman,with twin pregnancy in the 31st week of gestation,presented to the hospital with intermittent chest tightness for 12 wk,aggravation for 1 wk,and chest pain for 4 *** with the electrocardiogram and hypersensitive troponin results,she was diagnosed with acute ST-elevation myocardial *** the patient had no related medical history,she presented several risk factors,such as age greater than 30 years,assisted reproduction,and *** diagnosis,the patient received antiplatelet and anticoagulant *** section and coronary angiography performed 7 d later showed stenosis and thrombus shadow of the right coronary *** receiving medication,the patient was in good *** This case suggests that,with the widespread use of assisted reproductive technology,more attention should be paid to perinatal healthcare,especially when chest pain occurs,to facilitate early diagnosis and intervention of AMI,and the etiology of AMI in pregnancy needs to be differentiated,especially between coronary spasm and spontaneous coronary artery dissection.

关键词： Acute myocardial infarction Twin pregnancy Assisted reproduction Coronary spasm Spontaneous coronary artery dissection Case report

批判性思维视域下外语课程思政的融入实践——以《基础日语》课程为例

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西藏大学学报（社会科学版） 2024年第2期39卷 234-240页

作者：卓凌集美大学外国语学院福建厦门361021

不论是课程思政的目标还是人才培养的能力目标都指向思维的塑造。批判性思维正是全面、深入获取知识并完成内化、迁移和升华的必要途径。文章以《基础日语》课程思政为切入点,探讨在批判性思维视域下,通过优化外语课程教学目标设计、重... 详细信息

不论是课程思政的目标还是人才培养的能力目标都指向思维的塑造。批判性思维正是全面、深入获取知识并完成内化、迁移和升华的必要途径。文章以《基础日语》课程思政为切入点,探讨在批判性思维视域下,通过优化外语课程教学目标设计、重构教学内容、革新教学模式和完善课程思政评价体系等举措进行课程思政实践的路径。

关键词：批判性思维基础日语课程思政