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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

Proximal Femur Bionic Nail (PFBN): A Panacea for Unstable Intertrochanteric Femur Fracture

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Engineering 2024年第6期37卷 152-158页

作者： kaixuan Zhang Wei Chen Yingze Zhang School of Medicine Nankai UniversityTianjin 300071China Department of Orthopedic Surgery of Hebei Province The Third Hospital of Hebei Medical UniversityShijiazhuang 050051China Key Laboratory of Biomechanics of Hebei Province Orthopaedic Research Institute of Hebei ProvinceShijiazhuang 050051China National Health Commission(NHC)Key Laboratory of Intelligent Orthopeadic Equipment The Third Hospital of Hebei Medical UniversityShijiazhuang 050051China Chinese Academy of Engineering Beijing 100088China

With the aging population,intertrochanteric femur fracture in the elderly has become one of the most serious public health issues and a hot topic of research in trauma *** to the limitations of internal fixation techniques and the insufficient mechanical design of nails,the occurrence of complications delays patient recovery after surgical *** of a proximal femur bionic nail(PFBN)based on Zhang’s N triangle theory provides triangular supporting fixation,which dramatically decreases the occurrence of complications and has been widely used for clinical treatment of unstable intertrochanteric femur fracture *** this work,we developed an equivalent biomechanical model to analyze improvement in bone remodeling of unstable intertrochanteric femur fracture through PFBN *** results show that compared with proximal femoral nail antirotation(PFNA)and InterTan,PFBN can dramatically decrease the maximum strain in the proximal *** on Frost’s mechanostat theory,the local mechanical environment in the proximal femur can be regulated into the medium overload region by using a PFBN,which may render the proximal femur in a state of physiological overload,favoring post-operative recovery of intertrochanteric femur fracture in the *** work shows that PFBN may constitute a panacea for unstable intertrochanteric femur fracture and provides insights into improving methods of internal fixation.

关键词： Intertrochanteric femur fracture Internal fixation Proximal femur bionic nail(PFBN) Biomechanics Bone remodeling

Target detection method for moving cows based on background subtraction

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International Journal of Agricultural and Biological Engineering 2015年第1期8卷 42-49页

作者： Zhao kaixuan He Dongjian College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina

Target detection is the fundamental work for perceiving the behavior of cows using video analysis *** videos captured in farming scenes often suffer from a complex background,which leads to difficulty in detecting the target and inconvenience in the subsequent images *** this study,a method was proposed to detect the moving target accurately for cows based on background ***,the bounding rectangle of cows was calculated using the frames difference method to extract the local background in frames,which were averaged and spliced into one image as the entire background ***,the size and location of a cow’s body were determined by the bounding rectangle of cows,and the body area was tracked through the video by the binary ***,the summation coefficients on RGB channels were adjusted to improve the contrast between the target and background ***,taking the body area in every frame as reference area,the performance of target detection was evaluated by the reference area to determine the optimal summation coefficients on RGB channels,and then background subtraction was processed again to finish the detection.A total of 129 videos were used to test the detection algorithm,and the accuracy of the algorithm was 88.34%,which was 24.85%higher than the classical background subtraction *** study shows that the algorithm proposed in this study is feasible to detect the target accurately and timely when cows are walking straight in the farming environment under natural light,and this method can improve the detection performance and is an extension to the classical background subtraction method.

关键词： moving cows target detection background subtraction image analysis target tracking video analysis

Towards storable and durable Zn-MnO_(2) batteries with hydrous tetraglyme electrolyte

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Journal of Energy Chemistry 2023年第5期80卷 432-441,I0010页

作者： kaixuan Ma Gongzheng Yang Chengxin Wang State Key Laboratory of Optoelectronic Materials and Technologies School of Materials Science and EngineeringSun Yat-sen(Zhongshan)UniversityGuangzhou 510275GuangdongChina

Aqueous rechargeable zinc-based batteries have attracted increasing interest and been considered potential alternatives for state-of-the-art lithium-ion batteries because of the low cost and high *** cathode materials have been gradually developed and demonstrated excellent electrochemical ***,the complex electrochemistry,inevitable hydrogen release,and zinc corrosion severely hinder the practical *** most concerned Zn-MnO_(2)batteries still suffer from the Mn dissolution and formation of *** adding organic solvents to inhibit the activity of water molecules,the hydrous organic electrolytes provide a sound solution for eliminating the unfavorable *** we report a tetraethylene glycol dimethyl ether-based hydrous organic electrolyte consisting of LiClO_(4)·3H_(2)O and Zn(ClO4)2·6H2O,and a birnessite-type MnO_(2)cathode material for Zn-MnO_(2)*** Li+/Zn2+ions co-(de)insertion mechanism is ascertained by the structural and morphological *** electrostatic interaction between inserted ions and crystal structure is reduced effectively by employment of monovalent Li+ions,which ensures structural stability of cathode *** tetraglyme electrolyte inhibits the activity of water molecules and thus avoids the formation of byproduct Zn_(4)ClO_(4)(OH)7·Meanwhile,highly stable Zn plating/stripping for over 1500 h,an average coulombic efficiency of>99%in long-term cycling,and ultralong storage life(the cells can work well after stored over 1 year)are simultaneously realized in the novel *** from these aspects,the Zn-MnO_(2)batteries manifest high specific capacity of 132 mA h g^(-1),an operating voltage of 1.25 V,and a capacity retention of>98%after 1000 cycles at a current density of 200 mA g^(-1).

关键词： Energy storage Zn battery δ-MnO_(2) Hydrous tetraglyme electrolytes Long life

Visualization of oxygen vacancies in nanomaterials

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Science China Materials 2024年第11期67卷 3753-3754页

作者： Wenchao Bi kaixuan Wang Guozhong Cao Department of Physics College of ScienceUniversity of Shanghai for Science and TechnologyShanghai 200093China Departments of Materials Science and Engineering and Chemical Engineering University of WashingtonSeattleWA 98195-2120USA

Oxygen vacancies are one of the most common *** are imperfections in the regular geometrical arrangement of the atoms in crystalline *** are point defects,linear defects,plane defects and volume defects in *** an elemental crystal,point defects are formed when atoms are removed from the position that should be filled in the crystal,creating vacancies,or when atoms occupy interstitial sites where no atom would ordinarily appear,causing interstitialcy[1].

关键词： crystal removed arrangement

Estimation of surface geometry on combustion characteristics of AP/HTPB propellant under rapid depressurization

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Defence Technology（防务技术） 2024年第3期33卷 546-558页

作者： kaixuan Chen Zhenwei Ye Xiaochun Xue Yonggang Yu School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina School of Science Hangzhou Dianzi UniversityHangzhou 310018ZhejiangChina

The 2D sandwich model serves as a potent tool in exploring the influence of surface geometry on the combustion attributes of Ammonium perchlorate/Hydroxyl-terminated polybutadiene(AP/HTPB)propellant under rapid pressure *** thickness of the sandwich propellant is derived from slicing the 3D random particle packing,an approach that enables a more effective examination of the micro-flame *** analysis of the predicted burning characteristics has been performed with experimental *** findings demonstrate a reasonable agreement,thereby validating the precision and soundness of the *** on the typical rapid depressurization environment of solid rocket motor(initial combustion pressure is 3 MPa and the maximum depressurization rate is 1000 MPa/s).A-type(a flatter surface),B-type(AP recesses from the combustion surface),and C-type(AP protrudes from the combustion surface)propellant combustion processes are numerically *** comparison of the evolution of gas-phase flame between 0.1 and 1 ms,it is discerned that the flame strength and form created by the three sandwich models differ significantly at the beginning stage of depressurization,with the flame structures gradually becoming harmonized over *** are drawn by comparison extinction times:the surface geometry plays a pivotal role in the combustion process,with AP protrusion favoring combustion the most.

关键词： AP/HTPB propellant BDP model Rapid pressure decay Burning surface geometry

Climatic implications in earlywood and latewood width indices of Chinese pine in north central China

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Journal of Forestry Research 2024年第3期35卷 143-153页

作者： kaixuan Yang Junzhou Zhang Haowen Fan Yuan Yan College of Geographic Sciences Qinghai Normal UniversityXining 810016People's Republic of China Key Laboratory of Tibetan Plateau Land Surface Processes and Ecological Conservation(Ministry of Education) Xining 810016People's Republic of China Key Laboratory of Western China's Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730030People's Republic of China Gansu Liancheng Forest Ecosystem Field Observation and Research Station Lanzhou UniversityLanzhou 730333People's Republic of China School of Geography and Information Engineering University of GeoscienceWuhan 430074People's Republic of China

Latewood width(LWW)indices of trees are considered a reliable proxy of summer precipitation in the Northern ***,the strong coupling and high correlation between earlywood width(EWW)and LWW indices often prevent registration of climate signals of the LWW *** this study,328-year-long earlywood width and latewood width chronologies were developed from Chinese pine at two sites in the Hasi Mountains,north central *** climate responses of these chronologies were analyzed and the LWW index used to derive sum-mer precipitation *** analyses showed that LWW was particularly influenced by earlywood growth and recorded stronger climate signals of the previous year as EWW,rather than those of the current year with infrequent summer climate ***,after removing the effect of earlywood growth using a simple regression model,the adjusted LWW chronology(LWW_(adj))showed a strong relationship with July precipitation in dry *** suggests that the LWW_(adj) chronology has the potential to be used to investigate long-term variability in summer precipitation in drought-limited regions.

关键词： Dendroclimatology Latewood width Climate response Summer precipitation Earlywood effect

Loading direction dependence of asymmetric response of pyramidal slip in rolled AZ31 magnesium alloy

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Journal of Magnesium and Alloys 2023年第10期11卷 3634-3641页

作者： Yuzhi Zhu Dewen Hou kaixuan Chen Zidong Wang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Micron School of Materials Science and Engineering Boise State UniversityBoiseID 83725United States Center for Nanoscale Materials Argonne National LaboratoryLemontIL 60439United States

Textured magnesium alloys usually exhibit anisotropic mechanical behavior due to the asymmetric activation of different twinning and slipping *** work focuses on the pyramidal slip responses of rolled AZ31 magnesium alloy under two loading conditions,compressive and tensile loading along the normal *** the condition where the compressive loading direction is closely parallel to the c-axis of the unit cell,tensile twinning and basal slips are prohibited, dislocations then active and tend to accumulate at grain boundaries and form dislocation ***,these dislocations exhibit zigzag morphologies,which result from the cross-slip from {10■1} first-order pyramidal plane to {11■2} second-order pyramidal plane,then back to {10■1} first-order pyramidal *** the condition where tensile twins are prevalent,{10■1} first-order and {11■2} second-order pyramidal dislocations are favorable to be *** types of dislocations behave climb-like dissociations onto the basal plane,forming zigzag dislocations.

关键词： Magnesium pyramidal slip Asymmetry Cross-slip

Data driving design of high-entropy alloys for lightweight and dynamic applications

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 10-24页

作者： kaixuan Cui Junwei Qiao Peter KLiaw Yong Zhang State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Materials Science and Engineering University of TennesseeKnoxville TN 37996USA

The topic of high-entropy alloys is one of the focus for both physics and materials ***-entropy alloys were usually defined as solid solution alloys,while the solid solution is different from the traditional terminal solid solution,because the solid solution without solvent element is the dominant *** discovery of high-entropy alloys greatly extended the composition space and the possibility of creating unique micro-and nano-level structures,which can meet the demands of lightweight and dynamic *** relationship between the phases and the parameters for the high-entropy alloys is rather *** data driving design can screen the specific high-entropy *** correlation between the composition and properties of highentropy alloys can be discovered by material genetic engineering and data science.

关键词： phase-formation rules materials genetic engineering lightweight high-entropy alloys dynamic properties

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