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现代肿瘤医学 2009年第3期17卷 586-588页

作者：张正良范开席山东省潍坊市冶源干部疗养院山东临朐262605 山东省肿瘤医院东区山东济南250031

kai1基因是近年来发现的一个新的肿瘤转移抑制基因,其表达产物能与多种转录因子结合,对肿瘤的转移产生抑制作用。本文对kai1基因与消化系统恶性肿瘤关系的研究进行简要综述。

关键词： kai1基因消化系统肿瘤转移

m6a甲基转移酶METTL3调控kai1/CD82表达介导垂体神经内分泌肿瘤细胞生物学行为的机制研究

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天津医药 2023年第8期51卷 785-790页

作者：郑锴罗秀玲张玮豪刘宇利李玉明廖尚高贵州医科大学附属医院神经外科 550004 贵州医科大学附属医院头颈肿瘤科 550004 贵州医科大学药学院

目的研究m6a甲基转移酶METTL3调控kai1/CD82表达介导垂体神经内分泌肿瘤细胞增殖、迁移与侵袭的机制。方法通过实时荧光聚合酶链反应(qPCR)和蛋白免疫印迹测定大鼠垂体细胞、大鼠垂体神经内分泌肿瘤细胞系GH3和MMQ中的METTL3与kai1/CD8... 详细信息

目的研究m6a甲基转移酶METTL3调控kai1/CD82表达介导垂体神经内分泌肿瘤细胞增殖、迁移与侵袭的机制。方法通过实时荧光聚合酶链反应(qPCR)和蛋白免疫印迹测定大鼠垂体细胞、大鼠垂体神经内分泌肿瘤细胞系GH3和MMQ中的METTL3与kai1/CD82表达水平。体外培养GH3细胞,将其随机分为对照组、METTL3过表达质粒组、METTL3空质粒组、METTL3 siRNA组、METTL3 siRNA阴性对照组,经分组转染后,通过qPCR和蛋白免疫印迹检测各组细胞METTL3与kai1/CD82表达;通过CCK-8实验检测各组细胞活力;通过细胞划痕、Transwell侵袭实验检测各组细胞迁移侵袭情况;通过甲基化RNA免疫共沉淀(MeRIP)实验检测各组细胞kai1/CD82 m6A甲基化修饰情况。结果相比大鼠垂体细胞,大鼠垂体神经内分泌肿瘤细胞系GH3及MMQ中的METTL3蛋白及mRNA表达水平明显升高,kai1/CD82蛋白及mRNA表达水平明显降低(Pkai1/CD82 m6A甲基化水平升高(Pkai1/CD82蛋白及mRNA表达水平降低(Pkai1/CD82 m6A甲基化水平降低(Pkai1/CD82蛋白及mRNA表达水平升高(Pkai1/CD82 m6A甲基化水平,促进kai1/CD82mRNA转录表达,抑制垂体神经内分泌肿瘤细胞增殖、侵袭及迁移。

关键词：垂体肿瘤神经内分泌瘤甲基转移酶类 Kangai-1蛋白质甲基化 m6a甲基转移酶甲基转移酶样3

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The Dynamics of a Stochastic SEITR Model for Tuberculosis with Incomplete Treatment

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Acta Mathematicae Applicatae Sinica 2025年第1期41卷 99-113页

作者： Xiao-dong WANG kai WANG Department of Medical Engineering and Technology Xinjiang Medical UniversityUrumqiXinjiang 830017China

In this paper,a stochastic SEITR model is formulated to describe the transmission dynamics of tuberculosis with incompletely *** conditions for the existence of a stationary distribution and extinction are *** addition,numerical simulations are given to illustrate these analytical *** and numerical results show that large environmental perturbations can inhibit the spread of tuberculosis.

关键词： tuberculosis stationary distribution extinction

胃癌中kai1蛋白表达与临床病理特征的相关性

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肿瘤预防与治疗 2009年第1期22卷 13-15页

作者：张正良范开席卢玉山山东省潍坊市冶源干部疗养院山东省肿瘤医院东区

目的:探讨kai1蛋白在胃癌中的表达及其与临床病理特征的相关性。方法:应用S-P免疫组化法检测50例胃癌及13例胃良性病变和7例正常胃黏膜组织中kai1蛋白的表达情况。结果:胃癌组织中kai1蛋白的表达率为22%,显著低于胃良性病变(84.6%)(P<0.... 详细信息

目的:探讨kai1蛋白在胃癌中的表达及其与临床病理特征的相关性。方法:应用S-P免疫组化法检测50例胃癌及13例胃良性病变和7例正常胃黏膜组织中kai1蛋白的表达情况。结果:胃癌组织中kai1蛋白的表达率为22%,显著低于胃良性病变(84.6%)(Pkai1蛋白的阳性率呈降低趋势(T1为66.7%,T2为23.5%,T3为15.0%,T4为0);有淋巴结转移的胃癌组织中kai1蛋白阳性率(13.2%)低于无淋巴结转移的胃癌组织(50.0%);kai1蛋白的表达与肿瘤的大小、部位及患者的年龄、性别无关。结论:在胃癌的进展过程中kai1蛋白表达逐渐降低。kai1蛋白表达降低在胃癌的浸润、转移过程中起着重要的作用。检测kai1蛋白可能成为监测胃癌进展及临床上判断其预后的重要参考指标。

关键词： kai1蛋白胃癌免疫组织化学

A Novel Control Strategy Based onπ-VSG for Inter-Face Converter in Hybrid Microgrid

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Energy Engineering 2025年第2期122卷 471-492页

作者： kai Shi Dongyang Yang Department of Electrical Engineering Jiangsu UniversityZhenjiang21200China

The rapid development of new energy power generation technology and the transformation of power electronics in the core equipment of source-grid-load drives the power system towards the“double-high”development pattern of“high proportion of renewable energy”and“high proportion of power electronic equipment”.To enhance the transient performance of AC/DC hybrid microgrid(HMG)in the context of“double-high,”aπtype virtual synchronous generator(π-VSG)control strategy is applied to bidirectional interface converter(BIC)to address the issues of lacking inertia and poor disturbance immunity caused by the high penetration rate of power electronic equipment and new ***,the virtual synchronous generator mechanical motion equations and virtual capacitance equations are used to introduce the virtual inertia control equations that consider the transient performance of HMG;based on the equations,theπ-type equivalent control model of the BIC is ***,the inertia power is actively transferred through the BIC according to the load fluctuation to compensate for the system’s inertia ***,theπ-VSG control utilizes small-signal analysis to investigate howthe fundamental parameters affect the overall stability of the HMG and incorporates power step response curves to reveal the relationship between the control’s virtual parameters and transient ***,the PSCAD/EMTDC simulation results show that theπ-VSG control effectively improves the immunity of AC frequency and DC voltage in the HMG system under the load fluctuation condition,increases the stability of the HMG system and satisfies the power-sharing control objective between the AC and DC subgrids.

关键词： Hybrid AC/DC microgrid electromotive force of DC motor interface converter virtual synchronous generator control

Spatial confinement:An effective strategy to improve H_(2)O and SO_(2) resistance of the expandable graphite-modified TiO_(2)-supported Pt nanocatalysts for CO oxidation

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Journal of Environmental Sciences 2025年第2期148卷 57-68页

作者： Hongtai Zhu Wenge Qiu RuiWu kai Li Hong He Key Laboratory of Beijing on Regional Air Pollution Control Beijing Key Laboratory for Green Catalysis and SeparationBeijing University of TechnologyBeijing 100124China Advanced E-Catal.Corporation Ltd.Beijing 100025China

The expandable graphite(EG)modified TiO_(2) nanocomposites were prepared by the high shearmethod using the TiO_(2) nanoparticles(NPs)and EG as precursors,in which the amount of EG doped in TiO_(2) was 10 wt.%.Followed by the impregnation method,adjusting the pH of the solution to 10,and using the electrostatic adsorption to achieve spatial confinement,the Pt elementswere mainly distributed on the exposed TiO_(2),thus generating the Pt/10EG-TiO_(2)-10 *** best CO oxidation activity with the excellent resistance to H_(2)O and SO_(2) was obtained over the Pt/10EG-TiO_(2)-10 catalyst:CO conversion after 36 hr of the reaction was ca.85%under the harsh condition of 10 vol.%H_(2)O and 100 ppm SO_(2) at a high gaseous hourly space velocity(GHSV)of 400,000 hr−*** properties of the catalystswere characterized by various *** results showed that the electrostatic adsorption,which riveted the Pt elements mainly on the exposed TiO_(2) of the support surface,reduced the dispersion of Pt NPs on EG and achieved the effective dispersion of Pt NPs,hence significantly improving CO oxidation activity over the Pt/10EG-TiO_(2)-10 *** 10 wt.%EG doped in TiO_(2) caused the TiO_(2) support to form a more hydrophobic surface,which reduced the adsorption of H_(2)O and SO_(2) on the catalyst,greatly inhibited deposition of the TiOSO4 and formation of the PtSO4 species as well as suppressed the oxidation of SO_(2),thus resulting in an improvement in the resistance to H_(2)O and SO_(2) of the Pt/10EG-TiO_(2)-10 catalyst.

关键词： Expandable graphite Electrostatic adsorption Titania supported platinum CO oxidation Resistance to H_(2)O and SO_(2)

Electrospraying Si/SiO_(x)/C and Sn/C nanosphere arrays on carbon cloth for high-performance flexible lithium-ion batteries

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Journal of Semiconductors 2025年第1期46卷 234-243页

作者： Di Chen Rui Li Chunxue Liu kai Jiang School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China College of Physics and Mathematics University of Science and TechnologyBeijing 100083China Falculty of Hepato-Pancreato-Biliary Surgery Chinese PLA General HospitalInstitute of Hepatobiliary Surgery of Chinese PLA& Key Laboratory of Digital Hepetobiliary SurgeryChinese PLABeijing 100853China

Exploring electrode materials with larger capacity,higher power density and longer cycle life was critical for developing advanced flexible lithium-ion batteries(LIBs).Herein,we used a controlled two-step method including electrospraying followed with calcination treatment by CVD furnace to design novel electrodes of Si/Si_(x)/C and Sn/C microrods array consisting of nanospheres on flexible carbon cloth substrate(denoted as Si/Si_(x)/C@CC,Sn/C@CC).Microrods composed of cumulated nanospheres(the diameter was approximately 120 nm)had a mean diameter of approximately 1.5μm and a length of around 4.0μm,distributing uniformly along the entire woven carbon *** of Si/Si/Si_(x)/C@CC and Sn/C@CC products were synthesized as binder-free anodes for Li-ion battery with the features of high reversible capacity and excellent *** Si/Six/C electrode exhibited high specific capacity of about 1750 mA∙h∙g^(−1)at 0.5 A∙g^(−1)and excellent cycling ability even after 1050 cycles with a capacity of 1388 mA∙h∙g^(−1).Highly flexible Si/Si_(x)/C@CC//LiCoO_(2)batteries based on liquid and solid electrolytes were also fabricated,exhibiting high flexibility,excellent electrical stability and potential applications in flexible wearable electronics.

关键词： electrospraying Si/SiO_(x)/C Sn/C lithium-ion batteries

kai1蛋白和CD40蛋白的表达与胃癌临床病理因素及预后的关系

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中华普通外科杂志 2007年第12期22卷 928-931页

作者：范开席于金明张维东贾青王家林杨锡贵山东省肿瘤医院内二科济南250117 山东省肿瘤医院放疗科济南250117 山东省医学科学院基础所山东省肿瘤医院科研科济南250117

目的检测kai1蛋白和CD40蛋白在胃癌中的表达情况，并分析其与胃癌的临床病理特征及预后的关系。方法应用免疫组织化学sP方法，检测64例胃癌标本中kai1蛋白和CD40蛋白的表达情况。结果在本组胃癌中的kai1蛋白阳性表达率为22％。kai1蛋白... 详细信息

目的检测kai1蛋白和CD40蛋白在胃癌中的表达情况，并分析其与胃癌的临床病理特征及预后的关系。方法应用免疫组织化学sP方法，检测64例胃癌标本中kai1蛋白和CD40蛋白的表达情况。结果在本组胃癌中的kai1蛋白阳性表达率为22％。kai1蛋白的表达与胃癌的分化程度呈正相关，与浸润深度、淋巴结转移和临床分期呈负相关。kai1蛋白阳性表达的14例中生存期大于5年者10例，占71％，阴性表达的50例中生存期大于5年者10例，占20％，两者之间的差异有统计学意义（x^2=42．426，P=0．000）；CD40蛋白在胃癌组织中的阳性表达率为34％。CD40蛋白阳性表达与胃癌的远处转移及临床分期有关。CD40蛋白阳性表达的22例中生存期大于5年者3例，占14％，阴性表达的42例中生存期大于5年者17例，占41％，两者之间差异有统计学意义（x^2=4，841，P=0．028）。结论kai1蛋白与胃癌的分化、浸润及转移有关；CD40蛋白可能有助于胃癌的转移评估、判断预后和指导治疗。

关键词：胃肿瘤基因表达病理学临床预后

A fast amplitude preserving three-parameter 3D parabolic Radon transform and its application on multiple attenuation

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Petroleum Science 2025年第1期22卷 163-177页

作者： Ji-Tao Ma kai-Ge Zhao Zhen Liao College of Geophysics China University of Petroleum (Beijing) State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing) CNPC Key Laboratory of Geophysical Prospecting China University of Petroleum (Beijing)

Seismic wavefields propagate through three-dimensional(3D) space, and their precise characterization is crucial for understanding subsurface structures. Traditional 2D algorithms, due to their limitations, are insufficient to fully represent three-dimensional wavefields. The classic 3D Radon transform algorithm assumes that the wavefield's propagation characteristics are consistent in all directions, which often does not hold true in complex underground media. To address this issue, we present an improved 3D threeparameter Radon algorithm that considers the wavefield variation with azimuth and provides a more accurate wavefield description. However, introducing new parameters to describe the azimuthal variation also poses computational challenges. The new Radon transform operator involves five variables and cannot be simply decomposed into small matrices for efficient computation; instead, it requires large matrix multiplication and inversion operations, significantly increasing the computational load. To overcome this challenge, we have integrated the curvature and frequency parameters, simplifying all frequency operators to the same, thereby significantly improving computation efficiency. Furthermore,existing transform algorithms neglect the lateral variation of seismic amplitudes, leading to discrepancies between the estimated multiples and those in the data. To enhance the amplitude preservation of the algorithm, we employ orthogonal polynomial fitting to capture the amplitude spatial variation in 3D seismic data. Combining these improvements, we propose a fast, amplitude-preserving, 3D threeparameter Radon transform algorithm. This algorithm not only enhances computational efficiency while maintaining the original wavefield characteristics, but also improves the representation of seismic data by increasing amplitude fidelity. We validated the algorithm in multiple attenuation using both synthetic and real seismic data. The results demonstrate that the new algor

关键词： Three-parameter 3D Radon Orthogonal polynomial Amplitude-preserving Multiple attenuation

Effect of chlorination and ultraviolet on the adsorption of pefloxacin on polystyrene and polyvinyl chloride

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Journal of Environmental Sciences 2025年第3期149卷 21-34页

作者： Yanan Li Yaning Wu kai Guo Weiqin Wu Meijing Yao School of Environmental Science and Engineering Taiyuan University of TechnologyShanxi 030600China

During thewater treatment process,chlorination and ultraviolet(UV)sterilization can modify microplastics(MPs)and alter their physicochemical properties,causing various changes between MPs and other *** this study,the impact of chlorination and UV modification on the physicochemical properties of polystyrene(PS)and polyvinyl chloride(PVC)were investigated,and the adsorption behavior of pefloxacin(PEF)before and after modificationwas *** effect of pH,ionic strength,dissolved organicmatter,heavymetal ions and other water environmental conditions on adsorption behavior was *** results showed that PS had a higher adsorption capacity of PEF than PVC,and the modification increased the presence of O-containing functional groups in the MPs,thereby enhancing the adsorption capacity of both *** had a more significant impact on the physicochemical properties of MPs compared to UV irradiation within the same time period,leading to better adsorption performance of *** optimal pH for adsorption was found to be 6,and NaCl,sodium alginate and Cu2+would inhibit adsorption to varying degrees,among which the inhibition caused by pH was the *** and UV modification would weaken the inhibitory effect of environmental factors on the adsorption of PEF by *** main mechanisms of adsorption involved electrostatic interaction and hydrogen *** study clarified the effects of modification on the physicochemical properties of MPs,providing reference for subsequent biotoxicity analysis and environmental protection studies.

关键词： Microplastics Chlorination Ultraviolet Pefloxacin Adsorption mechanism