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神经损害者的食管胃分离是否为胃底折叠术的替代疗法

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世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 40-40页

作者： Goyal A. khalil B. Choo K. 郭战宏 Department of Paediatric Surgery Royal Liverpool Children's Hospital Alder Hey L12 2AP Liverpool United Kingdom

Background/Purpose: Gastroesophageal reflux is common in children with severe neurological impairment. Fundoplication may produce symptomatic improvement but has a high failure rate. Esophagogastric dissociation (EGD) is an alternative procedure for treatment of gastroesophageal reflux. The aim of this study is to evaluate the results of EGD in our institution and compare them with a neurologically matched group of children who had Nissen fundoplication. Methods: Twenty consecutive patients who had EGD were retrospectively evaluated and the results were compared with a neurologically matched group of 20 consecutive patients who had Nissen fundoplication. Results: Twenty patients had EGD, 17 as a primary procedure. There was no operative mortality but 5 have died of other causes. Resolution of reflux-associated symptoms occurred in all patients. Of the 15 survivors, 5 remain on antireflux medication. Twenty patients had fundoplication. There was no operative mortality, but 8 patients have died of other causes. Failure occurred in 5 patients necessitating further surgery. Of the 10 unreoperated survivors, 6 remain on antireflux medication. Conclusions: Esophagogastric dissociation is an effective antireflux procedure when compared with fundoplication. It has a lower failure rate. We recommend EGD as a primary procedure in selected children with severe neurological impairment.

关键词：胃底折叠术神经损害抗反流药物胃食管反流神经学生存者

产前超声确定主动脉缩窄的危险因素:系统评价和荟萃分析

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中华高血压杂志 2017年第2期25卷 123-123页

作者：刘莉叶鹏 Familiari A Morlando M khalil AA Sven-Erik S Scala C Rizzo G Del Sordo G Vassallo C Flacco ME Manzoli L Lanzone A Scambia G Acharya G D'Antonio F

主动脉缩窄（coarctation of the aorta,CoA）的产前诊断仍然具有挑战性,并受高频率的假阳性诊断的影响。该项研究的目的是确定相关性强度,并量化不同超声显像数据在预测产前CoA的诊断准确性。方法：检索Medline,Embase,Cinahl和Cochran... 详细信息

主动脉缩窄（coarctation of the aorta,CoA）的产前诊断仍然具有挑战性,并受高频率的假阳性诊断的影响。该项研究的目的是确定相关性强度,并量化不同超声显像数据在预测产前CoA的诊断准确性。方法：检索Medline,Embase,Cinahl和Cochrane数据库,进行系统评价和荟萃分析。结果：共检索文章794篇,

关键词：主动脉缩窄荟萃分析产前超声危险因素系统 Cochrane Medline 产前诊断

子宫切除术手术路径的改变:对所有功能性子宫出血尝试性应用一种经阴道途径方法的结局

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世界核心医学期刊文摘（妇产科学分册） 2006年第9期2卷 35-35页

作者： Olá h K.S. khalil M. 党慧敏 Obsterics and Gynaecology Warwick Hospital Lakin RoadWarwick CV34 6BW United Kingdom

Objective: To assess the effectiveness of a policy of performing a vaginal hysterectomy for as many cases of dysfunctional uterine bleeding without uterine prolapse as possible between 1997 and 2003. Study design: The study was prospective, with retrospective analysis of data. Setting: Warwick Hospital. Population: Eighty-seven women in a district hospital serving a population of 270,000 in South Warwick shire. Methods: During 1997 and 2003, an effort was made to perform as many hysterectomies vaginally as possible, with oophorectomy where necessary, in women with dysfunctional uterine bleeding in the absence of prolapse. The trends of the three different operations, total abdominal hysterectomy, sub-total abdominal hysterectomy and vaginal hysterectomy over the 7- year period were analysed. Main outcome measures: The ability to undertake surgery successfully, complications rates, length of hospital stay and changes in surgical practice. Results: Over this 7- year period, it has proved possible to change the emphasis from abdominal to vaginal hysterectomy for dysfunctional uterine bleeding. In 1997, the most common operation for dysfunctional uterine bleeding (72.7% ) was subtotal hysterectomy ± bilateral salpingo-oophorectomy, followed by (27.3% ) total abdominal hysterectomy ± bilateral salpingo-oophorectomy. No cases were undertaken vaginally. By 2003, however, the trend had completely reversed, with the only procedure undertaken being vaginal hysterectomy ± bilateral salpingooophorectomy. There is no evidence that such an approach increases the complication rate, and the recovery rate from surgery is improved with a tendency towards earlier discharge in the vaginal surgery group. Conclusion: The vaginal approach is possible for an average gynaecologist working in a district general hospital, with no additional complications and an improved recovery rate for patients.

关键词：经阴道子宫切除术功能性子宫出血阴道途径输卵管卵巢切除术手术路径经腹子宫全切术经腹全子宫切除术子宫次全切术

妊娠早期胎儿单纯性胸腔积液合并(或隐藏的)其他疾病或异常

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 35-35页

作者： khalil B.A. Jesudason E.C. Featherstone N.C. 李丹

Isolated fetal hydrothorax is an uncommon finding on routine prenatal ultrasou nd and is associated with a variable prognosis. We believe this is the first rep ort of a patient whose antenatal hydrothorax was associated with both congenital diaphragmatic hernia and congenital pulmonary lymphangiectasia. This rare combi nation caused significant problems in diagnosis and subsequent treatment.

关键词：妊娠早期胸腔积液先天性膈疝淋巴管扩张

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外周静脉导管中镍引发系统性接触性皮炎

世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 49-49页

作者： Raison- Peyron N. Guillard O. khalil Z. 冯义国 Department of Dermatology and Allergology Montpellier University Hospital 80 avenue Augustin Fliche 34 295 Montpellier Cedex 5 France

Nickel- elicited systemic contact dermatitis is a well- known entity, although it is far less common than allergic contact dermatitis. In most of the cases, the main way of nickel administration is oral. Clinical manifestations are miscellaneous including pompholyx, diffuse exanthema, flexural dermatitis or baboon syndrome. Systemic nickel dermatitis induced by venous catheters is very uncommon, but it is probably underdiagnosed. We report here 2 patients with diffuse recurrent maculopapular rash corresponding to nickel- elicited systemic contact dermatitis. They were both perfused during the last episode with the assistance of a peripheral polyurethane venous catheter during or just before the cutaneous eruption. At the base of the catheter, there was a small metallic eyelet on which dimethylglyoxime test was positive, indicating a release of nickel. Then, we measured nickel release in normal use conditions and found high nickel levels, although the manufacturer denied that nickel could be released. This diagnosis is important to know because such exanthema often occurred during postoperative or postpartum period. Its frequency is probably underestimated because it is often considered as a cutaneous drug reaction. To our knowledge, only 2 cases have been reported in the literature.

关键词：外周静脉导管镍皮炎药物反应弥漫性红斑斑丘疹汗疱疹文献报道丁二酮肟正常使用状态于术

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头位-非头位双胎妊娠为分娩方式

世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 58-58页

作者： Usta I.M Rechdan J.B khalil A.M Nassar A.H 朱晓明

To compare the neonatal outcome of vaginally delivered (VD) to that of abdomin ally delivered (CS) vertex-nonvertex (Vx/NVx)-twins. Vx/NVx live nonanomalous twin gestations ≥25 weeks delivered from 1984 to 2000 were divided into two gro ups: VD (N=138), and CS (N=79). The outcome of the second twin was compared. The vaginal delivery rate for the Vx/NVx twins was 63.6%. The median Apgar scores at 1 and 5 min, respectively, were significantly lower in VD [7 (0-9) and 9 (1 -10)] compared to CS [8 (2-10) and 9 (2-10)]. The neonatal mortality was also higher in VD (109/1000 vs. 38/1000, p=0.040). Differences in the 1-min Apgar s cores persisted when infants <1500 g were excluded. All other neonatal outcome v ariables studied including respiratory distress syndrome, necrotizing enterocoli tis, intraventricular hemorrhage, trauma, seizures, and length of nursery stay w ere similar. On logistic regression analysis, vaginal delivery of Vx/NVx twins m arginally increased low 5-min Apgar scores and neonatal deaths. Vaginal deliver y in vertex-nonvertex twins was achieved in 63.6%of cases at the expense of a higher incidence of low 1-and 5-min Apgar scores and neonatal death.

关键词：双胎妊娠阴道分娩率脑室内出血保育室时间情况呼吸窘迫综合征

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疣状银屑病:银屑病的一种特殊临床病理变异

世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 45-45页

作者： khalil F.K. Keehn C.A. Saeed S. Morgan M.B. 罗素菊 Dr.16124 Chastain Road Odessa FL 33556 United States

Psoriasis is capable of presenting in a variety of clinical and pathologic guises including a rarely described variant variably termed hypertrophic or verrucous psoriasis. Herein, we describe the clinical and pathologic attributes of a large series of patients with this unusual variant of psoriasis and distinguish it from other entities in the differential diagnosis. The histopathologic features and clinical and demographic attributes of a series of 12 cases from 12 patients were reviewed by a single dermatopathologist (MM). The 12 patients consisted of 7 males and 5 females with an average age of 61.8 years (males 38- 93 years, females 41- 71 years). Eight of the patients were Caucasian, 3 Hispanic and 1 African- American. Six of the lesions were located on the knees, 4 involved the elbows, and 2 were seen on the dorsum of the hands (metacarpal- phalangeal joint). The clinical appearance of the lesions consisted of flesh- toned to white mammillated plaques (8 cases) and coalesced papules (4 cases). Each of the biopsies showed regular psoriasiform epidermal hyperplasia with acanthosis, hyperkeratosis, and either spongiform neutrophilic or Munro micro- abscesses. In addition, each showed papillomatosis with bowing of the peripheral rete ridges toward the center of the lesion (buttressing). At high power, epidermal neutrophils were seen in particular surmounting the tips of the suprapapillary plates with accompanying serum. Hypergranulosis and koilocytic change were not observed in any of the lesions. Human papilloma virus (HPV) immunostaining and periodic acid Schiff (PAS) special staining for fungi were negative. Verrucous psoriasis is a distinctive variant of psoriasis with overlapping clinical and pathologic features that might prompt consideration of verruca vulgaris. The presence of epidermal papillomatosis and epidermal buttressing seen in these lesions is reminiscent of the histologic features of verruca vulgaris. Similarly, the presence of coalesced papules might prompt clinical consideration of verruca vu

关键词：疣状银屑病寻常疣表皮突乳头瘤样增生海绵状脓疱皮损周围病理学特点角化过度皮肤病理学高加索人

胸部低毫安CT结合基于模型的迭代重建算法在诊断肺移植后早期胸膜-肺并发症的准确性研究

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国际医学放射学杂志 2016年第6期 703-703页

作者： M.P.Debray G.Dauriat A.khalil S.Leygnac S.Tubiana A.Grandjean 郑文松 Department of Radiology AP-HPBichat-Claude Bernard Hospital

摘要目的比较应用基于模型迭代重建算法(MBIR)的低剂量、低毫安胸部CT(RD-CT)和应用自适应统计迭代算法(ASIR)的标准剂量胸部CT(SD-CT)在肺移植后早期并发

关键词：肺移植胸部躯干肺并发症迭代重建算法基于模型胸膜 CT

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定量磁化率图对多发性硬化的应用价值

国际医学放射学杂志 2013年第4期 373-373页

作者： C. Langkammer T. Liu M. khalil C. Enzinger M. Jehna S. Fuchs 苏亚文 Department of Neurology Medical University of GrazAuenbruggerplatz 22 8036 Graz Austria

目的在多发性硬化(MS)病人的基底节区应用定量磁化率图(QSM),并将其与对疾病严重程度的临床及形态学测量非常敏感的R2*图进行比较。材料与方法本项研究经地方伦理委员会批准,所有受试者均签署知情同意书。68例病人(26例为临床孤立综合征... 详细信息

目的在多发性硬化(MS)病人的基底节区应用定量磁化率图(QSM),并将其与对疾病严重程度的临床及形态学测量非常敏感的R2*图进行比较。材料与方法本项研究经地方伦理委员会批准,所有受试者均签署知情同意书。68例病人(26例为临床孤立综合征,42例为复发-缓解型MS)和23例对照受试者行3TMR成像。应用三维多回波扰相梯度回波序列分别重建出磁化率图与R2*图。测量基底节区的平均磁化率和平均R2*率,采用方差分析比较MS不同类型(临床孤立综合征,MS)与对照组的测量值,采用回归分析确定独立预测因素。结果与对照组相比,MS病人及孤立综合征病人的基底节区磁化率增高(更高的顺磁性)。R2*图对组间差异的敏感性较QSM更低。磁化率的最强预测因子是年龄。磁化率随神经功能缺损程度加重而增高(r=0.34,P<0.01),并随灰质(r=-0.35,P<0.01)和皮质(r=-0.35,P<0.005)的正常体积减少而降低。结论 QSM检测基底节区MS相关组织变化的敏感性优于R2*图。应用QSM已经可以观察到临床孤立综合征病人的组织变化,而R2*图却不能,这说明QSM可作为疾病最早期的敏感预测指标。

关键词：多发性硬化基底节区 MS 病人临床孤立综合征磁化率