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Chemical and biological features of the saline Lake Krasnovishnevoye(Baraba,Russia)in comparison with Lake Malinovoe(Kulunda,Russia):a reconnaissance study

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Journal of Oceanology and Limnology 2018年第6期36卷 1993-2001页

作者： Anastasia KOMOVA Anna MELNIKOVA Zorigto NAMSARAEV Roman ROMANOV Vera STRAKHOVENKO Ekaterina OVDINA Nadezhda ermolaeva National Research Centre“Kurchatov Institute” Moscow 123182Russia Central Siberian Botanical Garden of the Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090Russia V.S.Sobolev Institute of Geology and Mineralogy of the Russian Academy of Sciences Novosibirsk 630090Russia Institute for Water and Environmental Problems Siberian Branch of the Russian Academy of SciencesBarnaul 656038Russia

The Baraba and Kulunda steppes are located in southwestern Siberia in an area with an arid continental climate. This paper presents results of the first study of the hypersaline Lake Krasnovishnevoye(Baraba steppe, TDS(total dissolved solids)=297 g/L, pH 7.88). The major chemical, mineralogical and biological features of the lake were studied and compared to those of Lake Malinovoe, a typical saline neutral lake of Kulunda steppe(TDS=396 g/L, pH 7.63). The phytoplankton composition and the culturable diversity of anoxygenic phototrophic bacteria from Lake Krasnovishnevoye correspond to the ones in the Kulunda lakes. Nevertheless, the peculiarities of water composition and regime of Lake Krasnovishnevoye reduce the biodiversity to prokaryotes and unicellular algae.

关键词： saline and soda lakes hydrochemistry hydrobiology phytoplankton zooplankton anoxygenic phototrophic bacteria

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Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

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Genomics, Proteomics & Bioinformatics 2020年第4期18卷 430-442页

作者： Akash Srivastava Emanuel Barth Maria A.ermolaeva Madlen Guenther Christiane Frahm Manja Marz Otto W.Witte Hans-Berger Department of Neurology University Hospital JenaFriedrich Schiller University Jena07747 JenaGermany Bioinformatics/High Throughput Analysis Friedrich Schiller University Jena07743 JenaGermany FLI Leibniz Institute for Age Research 07745 JenaGermany

Aging is a complex process that can be characterized by functional and cognitive decline in an individual. Aging can be assessed based on the functional capacity of vital organs and their intricate interactions with one another. Thus, the nature of aging can be described by focusing on a specific organ and an individual itself. However, to fully understand the complexity of aging,one must investigate not only a single tissue or biological process but also its complex interplay and interdependencies with other biological processes. Here, using RNA-seq, we monitored changes in the transcriptome during aging in four tissues(including brain, blood, skin and liver) in mice at9 months, 15 months, and 24 months, with a final evaluation at the very old age of 30 *** identified several genes and processes that were differentially regulated during aging in both tissue-dependent and tissue-independent manners. Most importantly, we found that the electron transport chain(ETC) of mitochondria was similarly affected at the transcriptome level in the four tissues during the aging process. We also identified the liver as the tissue showing the largest variety of differentially expressed genes(DEGs) over time. Lcn2(Lipocalin-2) was found to be similarly regulated among all tissues, and its effect on longevity and survival was validated using its orthologue in Caenorhabditis elegans. Our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue’s specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism.

关键词： Aging RNA-seq analysis Inflammaging Electron transport chain Tissue aging

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A simple method to model the reduced environment of lake bottom sapropel formation

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Chinese Journal of Oceanology and Limnology 2017年第4期35卷 956-966页

作者： Olga L.GASKOVA Vera D.STRAKHOVENKO Nadezhda I.ermolaeva Eugene Yu.ZARUBINA Ekaterina A.OVDINA V.S.Sobolev Institute of Geology and Mineralogy Siberian Branch of the Russian Academy of Sciences Novosibirsk State University Institute for Water and Environmental Problems Siberian Branch of the Russian Academy of Sciences

The Kambala and Barchin brackish lakes （Baraba steppe, southern West Siberia） contain an organic-rich sapropel layer that was formed in oxygen-depleted waters. We measured the bulk sediment elemental composition, the water chemistry and determined the mineralogical composition and predominant biota species （Diatoms and Cyanobacteria in phytoplankton community respectively） in the lakes. The result indicates that the first lake has a siliceous type of sapropel and the second a carbonaceous one. A computer thermodynamic model was developed for chemical interaction in water-bottom sediment systems of the Kambala and Barchin Lakes. The surface sodium bicarbonate waters are supersaturated with respect to calcite, magnesite （or low Mg-calcite）, quartz and chlorite with minor strontianite, apatite and goethite （pH 8.9-9.3, Eh 0.3 V）. Nevertheless, it is shown that during sapropel deposition, deep silt waters should be anoxic （Eh〈0 V）. The virtual component CH20 has been used to create an anoxic environment suitable for pyrite formation due to the biotic community impact and abiotic reduction. Thermodynamic calculation has shown that silt water is not necessarily euxinic （anoxic and sulfidic）. Depending on Eh, sulfate sulfur can dominate in solution, causing the formation of gypsum together with pyrite. An attempt was made to find a reason for solution supersaturation with respect to Ca and Mg ions due to their complexation with humic acids.

关键词： brackish lakes sapropel sediments mineral composition silica calcite thermodynamic calculations

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国际投资法中公平公正待遇条款适用研究

国际投资法中公平公正待遇条款适用研究

作者： ermolaeva Evelina 中南财经政法大学

学位级别：硕士

投资条约中作出的公平公正待遇保证已成为有关主体提出主张最多、最具综合性和争议性的话题。将国际法领域众多学者、实务界人士及其他人员的观察结合起来可形成既具现实意义又具理论价值的观点。公正公平待遇是衡量外国投资者与东道国... 详细信息

投资条约中作出的公平公正待遇保证已成为有关主体提出主张最多、最具综合性和争议性的话题。将国际法领域众多学者、实务界人士及其他人员的观察结合起来可形成既具现实意义又具理论价值的观点。公正公平待遇是衡量外国投资者与东道国政府间关系的一项标准,它表明东道国政府愿意在公正和平等的条件下允许外国资本进入本国市场。与此同时,在国际实践中并未形成关于它的单一定义。本文的主要任务之一就是通过解释努力化解这种情况带来的困难。众所周知,理解其内容对于提高其操作性来说也十分重要。本文主要探究国际投资法中的公正公平待遇条款及其适用方面的争议问题。现在,公平公正待遇条款实际上在所有投资条约的仲裁程序中都发挥着核心作用,投资仲裁庭则将该条款适用于各级政府部门实施的更为广泛的行为。尽管如此,仲裁庭和批评者经常谴责公平公正待遇条款具有模糊性和缺乏透明度,质疑这一待遇标准的可预测性、该待遇标准的法理的一致性,乃至质疑其规则内容。因此,学术探讨和仲裁实践中的核心问题是,东道国在与外国投资者进行经贸往来的过程中需要如何行事方符合作为法律标准的公平公正待遇条款。首先,公平公正待遇条款在内容构成上包括以下规则:(1)(东道国)投资制度须包含如(东道国须)尊重投资者合理期望的义务、(东道国须)确保其外资管制法具有“稳定性”和“透明度”的义务,以及(东道国须)“诚信”行事的义务等内容;(2)涉及不当行为的规则:(东道国)有责任对歧视、强制、胁迫和骚扰等行为加以限制;(3)与程序问题有关的规则:(东道国须)确保“正当程序”和不允许“拒绝司法”等。其次,值得注意的是,很难严格地将公平公正待遇条款归入《国际法院规约》第38条所建议的某一类别。由于公平公正待遇条款往往措辞含糊,法院在评判公平公正待遇条款下义务是否得到遵守时存在只考虑到投资者期望,而不充分考虑东道国政治责任、社会义务和主权的风险。第三,尽管最近的条约(如《综合性经济贸易条约》CETA)发生了重大变化,但许多现有的国际投资协定仍然保留了具有不可控因素的公平公正待遇条款。条约的具体表述、背景、谈判历史或缔约方意图都可能影响对公平公正待遇条款的解释。国际投资协定的适用方式一般是将公平公正待遇条款与国际法的一般原则联系起来;将公平公正待遇条款与习惯国际法规定的外国人待遇的最低标准或额外的实质性内容联系起来。目前的仲裁实践表明,所有类型的政府行为,包括立法、行政和司法,都有潜在可能被认定为违反了公平公正待遇条款。有鉴于此,为改进公平公正待遇条款适用中对它的理解,笔者建议:首先,围绕外国投资法律制度的性质和构成这种制度的标准的争论已经持续了数个世纪,迄今仍未终结。关于公平公正待遇条款争论的一个重要部分涉及其在国际法渊源体系中的归类。其次,在描述公平公正待遇条款的结构内容时,必须注意避免对其进行过于宽泛的解释,这种解释可能对东道国造成不当歧视。东道国确保提供稳定法律制度的义务上升为国际法规范后,其极端后果是严重限制国家的主权,使东道国无法自行决定其国内法律秩序。第三,为解决国际投资争端解决中与公平公正待遇条款解释有关的操作性问题,适宜的做法是将公平公正待遇标准解释为条约规则,其内容应根据条款在上下文中的通常含义以及条约的目的和宗旨确定。若在条约中明确表示将公平公正待遇条款的内容限于(或等同于)一项最低限度国际标准,在解释某一特定条约时就有正当理由将其视为一项最低限度国际标准或其构成要素。第四,为了提高俄罗斯缔结国际投资条约的质量,俄罗斯宜在条约中直接详细说明公平公正待遇条款的内容(就如北美自由贸易协定和涉及美国和加拿大的双边投资条约那样)。这种做法将对公平公正待遇条款的可能解释有所限制,从而使俄罗斯与外国投资者的争端在结果上更具有可预测性。

关键词：国际投资法公平与公正待遇条款条约的解释国际投资争端解决中心国际投资协定

低合金钢、不锈钢和铝合金在氯化钠溶液中的腐蚀研究

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低合金钢、不锈钢和铝合金在氯化钠溶液中的腐蚀研究

作者： ermolaeva Elina（伊琳娜）北京化工大学

学位级别：硕士

Experimental Study of Efficiency of Tertapeptide Lysil-Glutamyl-Aspartyl- Proline Using the Model of Benign Prostatic Hyperplasia

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Modern Research in Inflammation 2014年第3期3卷 108-112页

作者： Tatyana Gennadyevna Borovskaya Tatyana Ivanovna Fomina Juliya Aexandrovna Shchemerova Marina Evgenyevna Poluektova Anna Vladimirovna Vychuzhanina Svetlana Ivanovna Kamalova Lubov Aexandrovna ermolaeva The Goldberg Research Institute of Pharmacology Tomsk Russia

Experimental evaluation of efficiency of a new prostatotropic medication tertapeptide lysil-glutamyl-aspartyl-proline (Lys-Glu-Asp-Pro)?in treatment of benign prostatic hyperplasia was performed in Wistar rats. The efficiency of the medication was compared with that one of injections of the?Serenoa repensextract. The investigation showed the statistically significant decrease in the square of the epithelium of acini. The same effect of similar severity was obtained when the?Serenoa repens?extract was applied. Tertapeptide Lys-Glu-Asp-Pro, in difference from?Serenoa repens?extract, also resulted in weight loss and volume decrease of the prostate gland.

关键词： Benign Prostatic Hyperplasia Rats Tertapeptide Lysil-Glutamyl-Aspartyl-Proline

Antimicrobial Activity of Wild Plant Seed Extracts against Human Bacterial and Plant Fungal Pathogens

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American Journal of Plant Sciences 2017年第7期8卷 1572-1592页

作者： Valentina I. Pushkareva Marina P. Slezina Tatyana V. Korostyleva Larisa A. Shcherbakova Ekaterina A. Istomina Svetlana A. ermolaeva Olga A. Ogarkova Tatyana I. Odintsova Gamaleya Research Center of Epidemiology and Microbiology Russian Academy of Medicinal Sciences Moscow Russia Vavilov Institute of General Genetics Russian Academy of Sciences Moscow Russia All-Russian Research Institute of Phytopathology Russian Academy of Sciences Bolshie Vyazemy Russia

Five wild plant species belonging to different families (Chenopodium album, Plantago major, Elytrigia elongata, Filipendula ulmaria and Nigella sativa) widely spread in Russian Federation and the former USSR were evaluated for their ability to inhibit growth of two important human food-borne pathogens (Escherichia coli O157:H7 and Listeria monocytogenes strain EGD-e) and eight plant pathogens (Alternaria alternata, Alternaria tenuissima, Bipolaris sorokiniana, Stagonospora nodorum, Fusarium solani, Fusarium oxysporum, Fusarium culmorum and Phytophtora infestans). To isolate biologically active compounds from seeds, a step-wise procedure including extraction with hexane, ethyl acetate, ethanol, and 10% acetic acid followed by reversed-phase HPLC was developed. Using disc-diffusion assay, the highest activity against E. coli O157:H7 was observed with extracts from F. ulmaria (hexane and ethyl acetate extracts and the unbound RP-HPLC fraction) and P. major (ethyl acetate extract and the unbound RP-HPLC fraction);E. elongate (the unbound RP-HPLC fraction) was less active. The extracts from P. major and E. elongate (the unbound RP-HPLC fractions) were equally highly active against L. monocytogenes, while those of F. ulmaria (the unbound RP-HPLC fraction) and N. sativa (hexane and ethyl acetate extracts) were less active against this pathogen. The dynamics of L. monocytogenes EGD-е and E. coli O157:H7 growth in the presence of two most potent extracts (RP-HPLC-unbound fractions of P. major and E. elongate and the hexane extract of F. ulmaria) was studied.

关键词： Plant Extracts Antibacterial Activity Human Food-Borne Pathogens Antifungal Activity Plant Pathogenic Fungi

Experimental studying of the drug efficiency Prostamax in the therapy of chronic aseptic prostatitis and its complications

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Modern Research in Inflammation 2013年第3期2卷 54-58页

作者： Tatyana Gennadyevna Borovskaya Angelina Vladimirovna Pakhomova Anna Vladimirovna Vychuzhanina Marina Evgenyevna Poluektova Tatyana Ivanovna Fomina Lubov Aexandrovna ermolaeva Juliya Aexandrovna Schemerova Oleg Konstantinovich Granstrem Evgeniy Anatolyevich Neplochov Research Studies Institute of Pharmacology SO The Russian Academy of Medical Science Tomsk Russia

The treatment of one of the most common urological diseases, a chronic aseptic prostatitis, is an exigeant problem. Used methods of pharmacotherapy are insufficiently effective and after treatment, as a rule, there comes a recrudescence. The efficiency of new prostatotropic agent Prostamax is studied in the present work, this drug is related to bioregulator peptides at experimental chronic aseptic inflammation of prostate gland. It is established that Prostamax reduces intensity of signs of a chronic inflammation (swelling, hyperemia of vessels, lymphoid infiltration), prevents development of sclerotic and atrophic processes. It is shown that the agent intensifies sexual activity of animals. Efficiency of the preparation Prostamax surpasses that among widespread prostatotropic agents derived from the extract of Serenoa repens and prostate of animals.

关键词： Chronic Aseptic Prostatitis Prostamax Rats