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Previous hepatitis B viral infection–an underestimated cause of pancreatic cancer

World Journal of Gastroenterology 2022年第33期28卷 4812-4822页

作者： Sergey Batskikh Sergey Morozov alexey Dorofeev Zanna Borunova Dmitry Kostyushev Sergey Brezgin Anastasiya Kostyusheva Vladimir Chulanov Department of Hepatology Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia Department of Gastroenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Department of Scientific and Clinical Laboratory Research Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia Laboratory of Genetic Technologies Sechenov UniversityMoscow 119435Russia Division of Biotechnology Scientific Center for Genetics and Life SciencesSirius University of Science and TechnologySochi 354340Russia Laboratory of Genetic Technologies and Translational Research National Medical Research Center for Tuberculosis and Infectious Diseases of Ministry of Health of RussiaMoscow 127994Russia

BACKGROUnD The etiology of pancreatic cancer remains unclear. This limits the possibility of prevention and effective treatment. Hepatitis B virus(HBV) is responsible for the development of different types of cancer, but its role in pancreatic cancer is still being *** To assess the prevalence of previous HBV infection and to identify viral biomarkers in patients with pancreatic ductal adenocarcinoma(PDAC) to support the role of the virus in etiology of this *** The data of 130 hepatitis B surface antigen-negative subjects were available for the final analysis,including 60 patients with PDAC confirmed by cytology or histology and 70 sex-and age-matched controls. All the participants were tested for HBV biomarkers in blood [antibody to hepatitis B core antigen(anti-HBc), antibody to hepatitis B surface antigen(anti-HBs) and HBV DnA], and for those with PDAC, biomarkers in resected pancreatic tissues were tested(HBV DnA, HBV pregenomic RnA and covalently closed circular DnA). We performed immunohistochemistry staining of pancreatic tissues for hepatitis B virus X antigen and Ki-67 protein. non-parametric statistics were used for the *** Anti-HBc was detected in 18/60(30%) patients with PDAC and in 9/70(13%) participants in the control group(P = 0.029). Accordingly, the odds of PDAC in anti-HBc-positive subjects were higher compared to those with no previous HBV infection(odds ratio: 2.905, 95% confidence interval: 1.191-7.084, standard error 0.455). HBV DnA was detected in 8 cases of PDAC and in 6 of them in the pancreatic tumor tissue samples only(all patients were anti-HBc positive). Blood HBV DnA was negative in all subjects of the control group with positive results of the serum anti-HBc test. Among 9 patients with PDAC, 5 revealed signs of replicative competence of the virus(covalently closed circular DnA with or without pregenomic RnA) in the pancreatic tumor tissue samples. Hepatitis B virus X antigen expression and active cell

关键词： Hepatitis B virus Previous hepatitis B Occult hepatitis B virus infection Pancreatic cancer Pancreatic ductal adenocarcinoma

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CATALYTIC PROPERTIES OF nAnOFIBROUS CARBOn In SELECTIVE OXIDATIOn OF HYDROGEn SULPHIDE

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China Particuology 2006年第2期4卷 70-72页

作者： Gennady G. Kuvshinov Vasiliy V. Shinkarev alexey M. Glushenkov Maxim n. Boyko Dmitriy G. Kuvshinov Department of Chemical Engineering Novosibirsk State Technical University Pr.Karla Marksa 20 Novosibirsk Russia Group of catalytic technologies of carbon materials synthesis Boreskov Institute of Catalysis Pr.Akademika Lavrentieva 5 Novosibirsk Russia

nanofibrous carbonaceous materials （nFC） as a new class of materials having many applications, can catalyze the selective oxidation of H2S to sulfur. The correlation between nFC structure and its activity and selectivity in H2S oxidation was determined. It is demonstrated that selectivity can be improved if nFC with more ordered structure be synthesized and the portion of the original catalyst in carbon be reduced by increasing the carbon accumulated in the catalyst.

关键词： nanostructure carbon nanofiber carbon nanotubes carbon yield selective oxidation of the hydrogen sulfide oxygen excess

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Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood–brain barrier by sound

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Chinese Optics Letters 2017年第9期15卷 2-6页

作者： O.Semyachkina-Glushkovskaya A.Abdurashitov A.pavlov A.Shirokov n.navolokin O.pavlova A.Gekalyuk M.Ulanova n.Shushunova A.Bodrova E.Saranceva A.Khorovodov I.Agranovich V.Fedorova M.Sagatova A.E.Shareef C.Zhang D.Zhu V.Tuchin Saratov national Research State University Saratov 410012Russia Yuri Gagarin State Technical University of Saratov Saratov 410054Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of SciencesSaratov 410049Russia Saratov State Medical University Saratov 410012Russia Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and Technology(HUST)Wuhan 430074China Key Laboratory for Biomedical Photonics HUSTMinistry of EducationWuhan 430074China national Research Tomsk State University Tomsk 634050Russia Institute of Precision Mechanics and Control Russian Academy of SciencesSaratov 410028Russia

The cerebral blood flow（CBF） alterations related to sound-induced opening of the blood–brain barrier（BBB） in adult mice are studied using laser speckle contrast imaging（LSCI） and wavelet analysis of vascular *** results clearly show that the opening of the BBB is accompanied by the changes of venous but not microvessel circulation in the brain. The elevation of the BBB permeability is associated with the decrease of venous CBF and the increase of its complexity. These data suggest that the cerebral veins rather than microvessels are sensitive components of the CBF related to the opening BBB.

关键词： BBB Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood brain barrier by sound

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Effect of intra-abdominal pressure on respiratory function in patients undergoing ventral hernia repair

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World Journal of Critical Care Medicine 2013年第2期2卷 9-16页

作者： Konstantin M Gaidukov Elena n Raibuzhis Ayyaz Hussain alexey Y Teterin alexey A Smetkin Vsevolod V Kuzkov Manu LnG Malbrain Mikhail Y Kirov Department of Anesthesiology and Intensive Care Medicine Northern State Medical University Department of Anesthesiology and Intensive Care Medicine City Hospital #1 of Arkhangelsk Department of General Surgery City Hospital #1 of Arkhangelsk Intensive Care Unit and High Care Burn Unit Ziekenhuis Netwerk Antwerpen ZNA Campus Stuivenberg

AIM: To determine the influence of intra-abdominal pressure(IAP) on respiratory function after surgical repair of ventral hernia and to compare two different methods of IAP measurement during the perioperative period. METHODS: Thirty adult patients after elective repair of ventral hernia were enrolled into this prospective *** monitoring was performed via both a balloontipped nasogastric probe [intragastric pressure(IGP), Ci MOn, Pulsion Medical Systems, Munich, Germany] and a urinary catheter [intrabladder pressure(IBP), Uno Meter Abdo-Pressure Kit, Uno Medical, Denmark] on five consecutive stages:(1) after tracheal intubation(AI);(2) after ventral hernia repair;(3) at the end of surgery;(4) during spontaneous breathing trial through the endotracheal tube; and(5) at 1 h after tracheal extubation. The patients were in the complete supine position during all study ***: The IAP(measured via both techniques) increased on average by 12% during surgery compared to AI(P nd by 43% during spontaneous breathing through the endotracheal tube(P n parallel, the gradient between РаСО2 and Et CO2 [Р(а-et)CO2] rose significantly, reaching a maximum during the spontaneous breathing trial. The PаO2/Fi O2 decreased by 30% one hour after tracheal extubation(P = 0.02). The dynamic compliance of respiratory system reduced intraoperatively by 15%-20%(P nificant correlation between IGP and IBP(r = 0.65-0.81, P n bias varying from-0.19 mm Hg(2SD 7.25 mm Hg) to-1.06 mm Hg(2SD 8.04 mm Hg) depending on the study stage. Taking all paired measurements together(n = 133), the median IGP was 8.0(5.5-11.0) mm Hg and the median IBP was 8.8(5.8-13.1) mm Hg. The overall r2 value( n = 30) was 0.76(P nd and Altman analysis showed an overall bias for the mean values per patient of 0.6 mm Hg(2SD 4.2 mm Hg) with percentage error of 45.6%. Looking at changes in IAP between the different study stages

关键词： Intra-abdominal pressure Gastric pressure Bladder pressure Intra-abdominal hypertension Hernia Oxygenation Respiratory function

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Changes in bioenergetics and neuroprotective properties ofmesenchymal stromal cells after LPS treatment

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BIOCELL 2024年第12期48卷 1827-1834页

作者： ELMIRA YAKUPOVA VALEnTInA BABEnKO alexey BOCHARnIKOV KSEnIYA FEDULOVA DEnIS SILACHEV EGOR PLOTnIKOV A.n.Belozersky Research Institute of Physico-Chemical Biology Lomonosov Moscow State UniversityMoscow119991Russia V.I.Kulakov national Medical Research Center of Obstetrics Gynecology and PerinatologyMoscow117997Russia

Background: The active use of stem and progenitor cells in the therapy of various diseases requires thedevelopment of approaches for targeted modification of their properties. One such approach is the induction of a prooranti-inflammatory phenotype. Methods: In this study, we investigated the effect of a pro-inflammatoryenvironment in vitro on multipotent mesenchymal stromal cells (MSC) by incubation with lipopolysaccharide (LPS).iCELLigence real-time cell analysis system was used for monitoring cell culture growth. Cell energy metabolism wasassessed using the Seahorse XFp Analyzer. For the rat stroke experiment, we used a photoinduced thrombosis (PT)model;after 24 h of surgery, vehicle or MSC or LPS-treated MSC was injected i.v. With magnetic resonance imaging(MRI) we evaluated the volume of ischemic brain injury. For the effect of MSC on neurological deficit after PT weused three methods: limb placement test, cylinder test, and beam-walking test. Results: LPS exposure led to asignificant increase in cell growth rate and to changes in their energy metabolism: glycolytic activity increasedsignificantly in the MSC, and non-glycolytic acidification also increased, while basic respiratory parameters weremaintained. With MRI we didn’t reveal changes in the volume of brain damage between all rat groups. neurologicaldeficit was less only with using untreated MSC injection. Conclusion: Using LPS-treated MSC in the therapy ofischemic stroke in rats, we did not observe an increase in the neuroprotective properties of the cells, but instead notedsome decrease in their therapeutic efficacy. We attribute these changes to the formation of a pro-inflammatoryphenotype in MSC.

关键词： Cell therapy Lipopolysaccharide Stroke neuroprotection Bioenergetics Inflammation Glycolysis

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An efficient synthetic approach towards new 5,5'-diaryl-2,2'-bipyridine-based fluorophores

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Chinese Chemical Letters 2017年第5期28卷 1099-1103页

作者： alexey P.Krinochkin Dmitry S.Kopchuk nikolay V.Chepchugov Grigory A.Kim Igor S.Kovalev Matiur Rahman Grigory V.Zyryanov Adinath Majee Vladimir L.Rusinov Oleg n.Chupakhin Ural Federal University Yekaterinburg 620002Russian Federation Postovsky Institute of Organic Synthesis of RAS(Ural Division) Yekaterinhurg 620990Russian Federation Department of Chemistry Visva-Bharati(A Central University)Santiniketan 731235India

An efficient approach has been developed for the synthesis of 5,5＇-diaryl-2,2＇-bipyridines via their 1,2,4-triazine *** notable advantages of the present method are：The possibility of varying the aromatic substituents in the positions 5 and 5＇ of bipyridine core and the possibility for obtaining 2,2＇-bipyridines bearing a fused cyclopentene core to increase the solubility in organic *** 5,5＇-diaryl-2,2＇-bipyridines exhibited an intense emission in a range of ca.422-521 nm in acetonitrile solution;depending on the nature of the aromatic substituents and the presence of annulated cyclopentene *** from that,the significant bathochromic shifts of the both absorption and emission maxima were observed in comparison with a number of previously described similar *** some cases the significant increasing of the fluorescence quantum yields took place.

关键词： 2 2'-Bipyridines 1 2 4-Triazines Aza-Diels-Alder reaction Fluorescence

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Gallium-containing magnesium alloy for potential use as temporary implants in osteosynthesis

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Journal of Magnesium and Alloys 2020年第2期8卷 352-363页

作者： Viacheslav Bazhenov Andrey Koltygin Alexander Komissarov Anna Li Vasiliy Bautin Regina Khasenov alexey Anishchenko Alexander Seferyan Julia Komissarova Yuri Estrin Foundry Department National University of Science and Technology"MISiS"Leninsky pr.4119049 MoscowRussian Federation Laboratory of Hybrid nanostructured Materials National University of Science and Technology"MlSiS"Leninsky pr.4119049 MoscowRussian Federation Department of Metallurgy of Steel New Production Technologies and Protection of MetalsNational University of Science and Technology"MISiS"Leninsky pr.4119049 MoscowRussian Federation Department of Materials Science and Engineering Monash UniversityClayton VIC 3800Australia Department of Mechanical Engineering The University of Western AustraliaCrawleyWA 6009Australia

In recent years magnesium alloys have been studied intensively with a view to their potential use in bioresorbable medical *** the present work the microstructure and the corrosion properties of a new bioresorbable Mg-4 wt%Ga-4 wt%Zn alloy and its variants with low Ca,nd or Y additions were *** alloys are of interest due to the efficacy of gallium as an element inhibiting bone resorption,osteoporosis,Paget's disease,and other illnesses.A severe plastic deformation technique of equal channel angular pressing(ECAP)was shown to provide the alloys with favorable mechanical *** addition,a desirable low rate of degradation in a simulated body fluid(Hanks'solution)was achieved.

关键词： Bioresorbable materials Magnesium alloys Gallium ECAP Hanks'solution Simulated body fluid

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A new species of nanohyla(Anura:Microhylidae)from the lowland forests of southern Vietnam

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Zoological Research 2023年第4期44卷 732-736页

作者： Vladislav A.Gorin alexey V.Trofimets Svetlana S.Gogoleva Le Xuan Dac nikolay A.Poyarkov Department of Vertebrate Zoology Lomonosov Moscow State UniversityMoscow 119991Russia Joint Vietnam-Russia Tropical Science and Technology Research Centre Cau GiayHanoi 122000Vietnam A.n.Severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscow 119071Russia

DEAR EDITOR,We describe a new species of nanohyla from the Song Hinh Protected Forest in Phu Yen Province,southern Vietnam,based on an integrative taxonomic *** new species represents a divergent lineage(16S rRnA gene uncorrected P-distance>5.3%),which clearly differs from any other nanohyla species based on a series of morphological characters,most notably the presence of white spots on the top of its ***,nanohyla albopunctata *** characterized by small body size(male snout-vent length(SVL)18.2-20.2 mm);moderately slender body habitus;rounded snout;distinct tympanum;rounded canthus rostralis;loreal region slightly concave;skin on dorsum tubercular,ventral surfaces smooth;mid-vertebral skin ridge and dorsomedial stripe absent;superciliary tubercles absent.

关键词： Morphological Vietnam slightly

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Gold Supported on Metal Oxides for Carbon Monoxide Oxidation

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nano Research 2011年第2期4卷 180-193页

作者： Sonia A. C. Carabineiro nina Bogdanchikova Miguel Avalos-Borja alexey Pestryakov Pedro B. Tavares Jose L. Figueiredo Laboratário de Catálise e Materiais Associate Laboratory LSRE/LCM Departamento de Engenharia Química Faculdade de Engenharia Universidade do Porto 4200-465 Porto Portugal Universidad nacional Autónoma de México Centro de Nanociencias y Nanotecnologia Carretera Tijuana-Ensenada 22800 Ensenada Baja California México Tomsk Polytechnic University 30 Lenin Avenue Tomsk 634050 Russia Universidade de Trás-os-Montes e Alto Douro Centro de Quimica-Vila Real Departamento de Química 5001-911 Vila Real Portugal

Au has been loaded （1% wt.） on different commercial oxide supports （CuO, La2O3, Y2O3, niO） by three different methods： double impregnation （DIM）, liquid-phase reductive deposition （LPRD）, and ultrasonication （US）. Samples were characterised by n2 adsorption at -196℃, high-resolution transmission electron microscopy, selected area electron diffraction, energy dispersive X-ray spectrometry, high-angle annular dark-field imaging （Z-contrast）, X-ray diffraction, and temperature programmed reduction. CO oxidation was used as a test reaction to compare the catalytic activities. The best results were obtained with Au loaded by DIM on the niO support, with an activity of 7.2 × 10^（-4） molco·gAu^（-1）·s^（-1） at room temperature. This is most likely related to the Au nanoparticle size being the smallest in this catalyst （average 4.8 nm）, since it is well known that gold particle size determines the catalytic activity. Other samples, having larger Au particle sizes （in the 2-12 nm range, with average sizes ranging from 4.8 to 6.8 nm）, showed lower activities. nevertheless, all samples prepared by DIM had activities （from 1.1 × 10^（-4） to 7.2 × 10^（-4） molco·gAu^（-1）·S^（-1）, at room temperature） above those reported in the literature for gold on similar oxide supports. Therefore, this method gives better results than the most usual methods of deposition-precipitation or co-precipitation.

关键词： Gold heterogeneous catalysis oxidation electron diffraction X-ray diffraction

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The identification of individuals with hatchery and natural origin in a mixed sample of Amur River chum salmon by Otolith microchemistry

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Aquaculture and Fisheries 2023年第3期8卷 341-350页

作者： Pavel B.Mikheev Denis V.Kotsyuk Elena V.Podorozhnyuk Vsesolod n.Koshelev Atbkyh I.nikiforov Tatiana A.Sheina alexey Yu.Puzik Mikhail A.Baklanov Khabarovsk Branch of the Federal State Budget Scientific Institution“Russian Federal Research Institute of Fisheries and Oceanography”(“KhabarovsknIRO”) Khabarovsk680038Russia Federal State Budget Educational Institution of Higher Education“Perm State national Research University”(PGnIU) Perm614990Russia Moscow State Institute(University)of International Relations Ministry of Foreign Affairs of the Russian FederationMoscow117454Russia

We estimated the proportion of hatchery and natural fall spawning chum salmon returning to the Amur River using chemical markers specific to hatchery-origin *** used otolith microchemistry technique to identify fish with artificial origin among returning ***,we found that juveniles of artificial origin had higher values of the Sr:Ca molar ratio of the otoliths’edge zone compared with juveniles of natural origin,what can be related to the use of rearing feed produced from raw materials of marine origin rich in *** we observed that most of the spawners from Anyuisky Hatchery and from the Amur River mouth at the start of the spawning migration has also the higher value of Sr:Ca molar ratio of the juvenile zone of ***,adults with higher values of the Sr:Ca molar ratio are characterized by a skewed right in the peak of the age ***,the age structure and phenological shift in the time of spawning migration of individuals with higher value of the used chemical marker corresponds to results of studies on hatchery-produced chum salmon completed at different parts on northern *** results of this study will be used in the management of Amur fall chum salmon fisheries,and also demonstrates the necessity of the development of specific measures for increasing the survival of juvenile anadromous salmonids released at large rivers and exposed to prolonged freshwater migration to the *** a further application of the methodology,we plan to identify the markers specific to each of the hatcheries and main spawning tributaries belonging to Amur River *** will be an important step in the evaluation of the contribution of different stocks in mixed fisheries and also in the estimation of the effect of hatchery releases on naturally spawning stocks of Amur fall *** to,our results may indicate the applicability of this approach for the determination of artificial-origin fish in a mixed sample of the Amur fall

关键词： Otolith microchemistry LA ICP-MS Chum salmon Identification of origin in a mixed sample Hatchery releases

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