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Hidden stage of intracranial hemorrhage in newborn rats studied with laser speckle contrast imaging and wavelets

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Journal of Innovative Optical Health Sciences 2015年第5期8卷 99-106页

作者： alexey n.pavlov Arkady S.Abdurashitov Olga n.pavlova Valery V.Tuchin Olga S.Sindeeva Sergey S.Sindeev Oxana V.Semyachkina-Glushkovskaya Department of Physics Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Department of Biology Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia

Using the laser speckle contrast imaging and wavelet-based analyses,we investigate a latent("hidden")stage of the development of intracranial hemorrhages(ICHs)in newborn *** apply two measures based on the continuous wavelet-transform of blood flow velocity in the sagittal sinus,namely,the spectral energy in distinct frequency ranges and a multiscality degree characterizing complexity of experimental *** show that the wavelet-based multifractal formalism reveals changes in the cerebrovascular blood flow at the development of ICH.

关键词： Cerebral blood flow laser speckle contrast imaging stress wavelet-analysis complexity

Characterization of cerebral blood flow dynamics with multiscale entropy

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Journal of Innovative Optical Health Sciences 2017年第5期10卷 85-93页

作者： alexey n.pavlov Arkady S.Abdurashitov Olga n.pavlova Maria V.Ulanova Anastasia A.Bodrova natalia A.Shushunova Alexander P.Khorovodov Oxana V.Semyachkina-Glushkovskaya Yuri Gagarin State Technical University of Saratov 77 Politechnicheskaya Street Saratov 410054Russia Saratov national Research State University 83 Astrakhanskaya Street Saratov 410012Russia

Based on the laser speckle contrast imaging(LSCI)and the multiscale entropy(MSE),we study in this work the blood flow dynamics at the levels of cerebral veins and the surrounding network of microcerebral *** discuss how the phenylephrine-related acute peripheral bypertension is refected in the cerebral circulation and show that the observed changes are scale dependent,and they are signifcantly more pronounced in microcerebral vessels,while the macrocerebral dynamics does not demonstrate authentic inter-group *** also consider the permeability of blood-brain barrier(BBB)and study its opening caused by sound *** show that alterations associated with the BBB opening can be revealed by the analysis of blood flow at the level of macrocerebral vessels.

关键词： Cerebral blood flow laser speckle contrast imaging arterial pressure complexity

Synaptic mechanisms of cadmium neurotoxicity

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neural Regeneration Research 2021年第9期16卷 1762-1763页

作者： Andrei n.Tsentsevitsky alexey M.Petrov Laboratory of Biophysics of Synaptic Processes Kazan Institute of Biochemistry and BiophysicsFederal Research Center“Kazan Scientific Center of RAS”2/31 Lobachevsky StreetBox 30Kazan420111Russia University 49 Butlerova StreetKazan420012Russia

Cadmium(Cd) is a toxic heavy metal ubiquitously distributed in the environment(water, air, food, smoke) with extreme ability to accumulate in the human body due to its delayed clearance(half-life time 15–30 years).

关键词： cadmium extreme accumulate

On Splitting of the normalizer of a Maximal Torus in E6(q)

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Algebra Colloquium 2019年第2期26卷 329-350页

作者： alexey Galt alexey Staroletov Sobolev Institute of Mathematics Novosibirsk Russia

Let G be a finite group of Lie type E6 over Fq (adjoint or simply connected) and W be the Weyl group of G. We describe maximal tori T such that T has a complement in its algebraic normalizer n(G, T). It is well known that for each maximal torus T of G there exists an element w ∈ W such that n(G, T )/T ■ CW(w). When T does not have a complement isomorphic to CW(w), we show that w has a lift in n(G, T) of the same order.

关键词： finite group of Lie type maximal torus algebraic normalizer split extension

Photodynamic diagnostics of early gastric cancer:Complexity measures of gastric microcirculation and new model of metastatic adenocarcinoma of rat stomach

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Journal of Innovative Optical Health Sciences 2019年第2期12卷 64-73页

作者： alexey pavlov Ekaterina Borisova Olga pavlova Ilana Agranovich Alexander Khorovodov Andrey Terskov Aysel Mamedova Maria Klimova Latchezar Avramov Oxana Semyachkina-Glushkovskaya Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Institute of Electronics Bulgarian Academy of Sciences Tsarigradsko Chaussee Blvd.72Sofia 1784Bulgaria

The detection of early gastric cancer that often develops asymptomatically is crucial for improving patient *** photodynamic diagnosis(PDD)of gastric cancer using 5-aminolevulinic acid/protoporphyrin IX(5-ALA/PpIX)has been reported in several ***,the selectivity of PDD of gastric tumor is poor with often false-positive results that require the development of new methods to improve PDD for early gastric ***,a measure of the complexity of gastric microcirculation(multi-scale entropy,MSE)and the detrendedfluctuation analysis(DFA)were applied as additional tools to detect early gastric cancer in *** this experimental study,we used our original model of metastatic adenocarcinoma in the stomach of a *** induce a gastric tumor,we used a long-term combination(for 9 months,which is 1/2 of the life of rats)of two natural factors,such as chronic stress(overpopulation being typical for modern cities)and the daily presence of nitrites in food and drinks,which are common ingredients added to processed meat andfish to help preserve *** results clearly show that both methods,namely,PDD using 5-ALA/PpIX and complexity/correlation analysis,can detect early gastric cancer,which was confirmed by histological ***-cancerous areas in the stomach were detected as an intermediatefluorescent signal or MSE level between normal and malignant lesions of the ***,in some cases,PDD with 5-ALA/PpIX produced a false-positivefluorescence of exogenousfluorophores due to its accumulation in benign and inflammatory areas of the *** fact indicates that the PDD itself is not sufficient for the correct diagnosis of gastric cancer,and the use of additional characteristics,e.g.,complexity measures or scaling exponents,can significantly improve the diagnostic accuracy of PDD of gastric cancer that should be confirmed in further clinical studies and applications.

关键词： Experimental model of gastric cancer in animals highly heterogeneous adenocarcinoma photodynamic diagnosis complexity measures gastric microcirculation

Optical in vivo and ex vivo imaging of glioma cells migration via the cerebral vessels:Prospective clinical application of the beta2-adrenoreceptors blockade for glioma treatment

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 98-107页

作者： Olga pavlova Alexander Shirokov Alexander Fomin nikita navolokin Andrey Terskov Alexander Khorovodov Anton namykin alexey pavlov Valery Tuchin Oxana Semyachkina-Glushkovskaya Interdisciplinary Center of Critical Technologies in Medicine Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences13 Entuziastov Ave.Saratov 410049Russia Saratov State Medical University 112 Bolshaya Kazachia Str. Saratov 410012Russia Department of Optics and Biophotonics Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Yuri Gagarin State Technical University of Saratov 77 Politechnicheskaya Str. Saratov 410054Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control of RAS 24 Rabochaya Str.Saratov 410028Russia Laboratory of Biophotonics Tomsk State University 36 Lenin's Ave.Tomsk 634050Russia

Malignant gliomas are highly invasive tumors that 1use the cerebral vessels for invasion due to high vascular fragility of the blood--brain barrier(BBB).On one hand,glioma is characterized by the BBB disruption,on the other hand,drug brain delivery via the BBB is a big challenge in glioma *** limited information about vascular changes associated with glioma growth is a reason of slow progress in prevention of glioma ***,we present in vrivo and er vrivo study of the BBB disruption and glioma cells(GCs)migration in rats using fuorescence and confocal *** uncovered a local breach in the BBB in the main tumor mass but not within the border of normal and malignant cells,where the BBB was impermeable for high weight *** migr ation of GCs were observed via the cerebral vessels with the intact BBB that was associated with macrophages *** mechanisms underlying glioma progression remain umknown but there is an evidence that the sympathetic nervous system(SnS)via activation of vascular beta2-adrenoreceptors(B2-ADRs)can play an important role in tumor *** results clearly show an increase in the expression of vascular B2-ADRs and production of the beta arrestin-1-co-factor of B2-ADRs signaling pathway in rats with *** blockade of B2-ADRs reduces the BBB disruption,macrophages infiltration,GCs migration and increases survival *** data suggest that the blockade of B2-ADRs may be a novel adjuvant therapeutic strategy to reduce glioma progression and prevent metastasis。

关键词： Glioma macrophages blood-brain barrier beta-2 adrenoreceptors bet a arrestin-1

Growth of carbon nanotube arrays on various CtxMey alloy films by chemical vapour deposition method

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Journal of Materials Science & Technology 2018年第3期34卷 472-480页

作者： Pawel Mierczynski Sergey V.Dubkov Sergey V.Bulyarskii Alexander A.pavlov Sergey n.Skorik alexey Yu Trifonov Agnieszka Mierczynska Eugene P.Kitsyuk Sergey A.Gavrilov Tomasz P.Maniecki Dmitry G.Gromov Institute of General and Ecological Chemistry Lodz University of TechnologyZeromskiego 116Lodz 90-924Poland national Research University of Electronic Technology Shokin SquareZelenogradMoscow 124498Russia Institute of nanotechnology of Microelectronics of the RAS INMEMoscow 11-9991Russia Scientific-Manufacturing Complex'Technological Center' ZelenogradMoscow 124498Russia Scientific Research Institute of Physical Problems named after F V.Lukin Proezd 4806.6ZelenogradMoscow 124460Russia The Australian Wine Research Institute Waite PrecinctHartley Grove cnr Paratoo RoadUrrbrae AdelaideSA 5064Australia

Carbon nanotube （CnT） arrays were fabricated on Ct-Me-n-（O） alloys with content of Ct in the range of 6-40 at.% by chemical vapour deposition. The Ct was a catalytic metal from the group of the following elements： ni, Co, Fe, Pd, while Me was a transition metal from the group of IV-VII of the periodic table （where Me=Ti, V, Cr, Zr, nb, Mo, Ta, W, Re）. Carbon nanotubes were found to grow efficiently on the alloy surface with its composition containing Ti, V, Cr, Zr, Hf, nb or Ta. The growth of CnTs was not observed when the alloy contained W or Re. Additions of oxygen and nitrogen in the alloy facilitated the formation of oxynitrides and catalyst extrusion on the alloy surface. Replacement of the metals in alloy composition affected the diameter of the resulting CnTs. The obtained results showed that the alloy films of varying thickness （10-500 nm） may be used for the CnTs growth. The resulting CnT material was highly homogenous and its synthesis reproducible.

关键词： Carbon nanotubes Amorphous alloys Chemical vapour deposition Catalytic processes Thin films

OPTICAL PROPERTIES OF SKIn,SUBCUTAnEOUS,AnD MUSCLE TISSUES:A REVIEW

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Journal of Innovative Optical Health Sciences 2011年第1期4卷 9-38页

作者： alexey n.BASHKATOV ELInA A.GEnInA VALERY V.TUCHIn Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410028Russia

The development of optical methods in modern medicine in the areas of diagnostics,therapy,and surgery has stimulated the investigation of optical properties of various biological tissues,since the efficacy of laser treatment depends on the photon propagation and fluence rate distribution within irradiated *** this work,an overview of published absorption and scattering properties of skin and subcutaneous tissues measured in wide wavelength range is *** principles of measurements of the tissue optical properties and techniques used for processing of the measured data are outlined.

关键词： Absorption coefficient scattering coefficient anisotropy factor reduced scattering coefficient refractive index

Flexible surface-enhanced Raman scattering-active substrates based on nanofibrous membranes

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nano Research 2018年第9期11卷 4468-4488页

作者： Ekaterina S. Prikhozhdenko Daniil n. Bratashov Dmitry A. Gorin alexey M. Yashchenok Remote Controlled Theranostic Systems Lab Education and Research Institute of Nanostructures and Biosystems Saratov State University 83 As trakhanskaya Str. Saratov 410012 Russia Skoltech Center for Photonics and Quantum Materials Skolkovo Institute of Science and Technology Skolkovo Innovation Center 3 Nobel Str. Moscow 143026 Russia

Surface-enhanced Raman scattering （SERS） has emerged as an excellent analytical tool for the effective detection and fingerprint identification of various chemicals. Recently, significant progress has been made in the fabrication of SERS-active substrates using simple, inexpensive, and affordable methods. The full potential of universal SERS diagnostics will likely be realized with the development of approaches and devices capable of effectively detecting analytes on various surfaces as well as in multicomponent media. In addition, the combination of implantable or wearable SERS-active substrates and remote portable devices enables real-time diagnostics that ideally fit the concept of personalized medicine. In this paper, we summarize recent achievements in fabricating flexible SERS substrates made of cellulose paper, polymer membranes, and textile fibrous films. Emphasis is placed on the in-situ extraction and detection of various chemicals in real-world surfaces and complex media using flexible nanofibrous SERS platforms. The potential SERS applications and future perspectives in on-site diagnostics are also discussed.

关键词： paper electrospun membrane fabric surface-enhanced Ramanspectroscopy on-site diagnostics swabbing