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Sinapic acid ameliorates D-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways

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World Journal of Gastroenterology 2021年第7期27卷 592-608页

作者： Mushtaq ahmad Ansari Mohammad Raish Yousef A Bin Jardan ajaz ahmad Mudassar Shahid SheikhFayaz ahmad Nazrul Haq Mohammad Rashid Khan Saleh A Bakheet Department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia

BACKGROUND Sinapic acid(SA)has been shown to have various pharmacological properties such as antioxidant,antifibrotic,anti-inflammatory,and anticancer activities.Its mechanism of action is dependent upon its ability to curb free radical production and protect against oxidative stress-induced tissue injuries.AIM To study the hepatoprotective effects of SA against lipopolysaccharide(LPS)/Dgalactosamine(D-GalN)-induced acute liver failure(ALF)in rats.METHODS Experimental ALF was induced with an intraperitoneal(i.p.)administration of 8μg LPS and 800 mg/kg D-GalN in normal saline.SA was administered orally once daily starting 7 d before LPS/D-GalN treatment.RESULTS Data showed that SA ameliorates acute liver dysfunction,decreases serum levels of alanine transaminase(ALT),and aspartate aminotransferase(AST),as well as malondialdehyde(MDA)and NO levels in ALF model rats.However,pretreatment with SA(20 mg/kg and 40 mg/kg)reduced nuclear factor kappalight-chain-enhancer of activated B cells(NF-κB)activation and levels of inflammatory cytokines(tumor necrosis factor-αand interleukin 6).Also,SA increased the activity of the nuclear factor erythroid-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling pathway.CONCLUSION In conclusion,SA offers significant protection against LPS/D-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-κB.

关键词： Sinapic acid D-galactosamine/lipopolysaccharide Oxidative stress Fulminant hepatitis Antioxidant Nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways

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GC/MS-based differential metabolic profiling of human peptic ulcer disease to study Helicobacter pylori-induced metabolic perturbations

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BIOCELL 2021年第5期45卷 1299-1311页

作者： GAGANJOT GUPTA DEEPAK BANSAL ANSHULA SHARMA TAWSEEF ahmad ATUL SACHDEV ajaz ahmad HAMED A.EL-SEREHY BALJINDER KAUR Department of Biotechnology Punjabi UniversityPatiala147002India Department of General Medicine Government Medical College and HospitalChandigarh160047India Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer.Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H.pylori-induced pathogenicity.The rationale of the study is to explore the underlying distinct metabolic mechanisms of H.pylori-induced PUD and to identify potential biomarkers for disease diagnosis and associated risks using Gas chromatography/mass spectrometry.GC/MS-based analytical method was used to compare metabolic profiles of healthy controls(N=20)and peptic ulcer patients(N=45).Acquired metabolomic data were analyzed by constructing a diagnostic model using principal component analysis and a non-parametric two-tailed paired Wilcoxon analysis to identify disease-specific metabolic biomarkers.A total of 75 low-molecular-weight endogenous metabolites were detected during comparative metabolomic analysis of PUD vs.healthy gut tissues,among which 16 metabolites are being proposed to be diagnostic markers of Human PUD.Perturbations related to amino acids,carbohydrates,fatty acids,organic acids,and sterol metabolism were significantly revealed during this differential metabolomic profiling.Results convincingly suggest that metabolic profiles can contribute immensely in early diagnosis of the disease and understanding molecular mechanisms of disease progression for predicting novel drug targets for prophylactic and anaphylactic measures.

关键词： Peptic ulcer disease Gastric cancer Helicobacter pylori Metabolic profiling Perturbations Stomach ulcers

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Enhanced photocatalytic degradation of organic dyes from aqueous environment using neodymium-doped mesoporous layered double hydroxide

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Journal of Rare Earths 2022年第10期40卷 1554-1563页

作者： ajaz ahmad Wani Amjad Mumtaz Khan Yahiya Kadaf Manea Mansour A.S.Salem Department of Chemistry Aligarh Muslim UniversityAMUAligarh202002India

Neodymium-doped Zn-Al layered double hydroxide(Nd/Zn-Al LDH) with excellent photocatalytic activity was prepared by a one-step hydrothermal method. The morphology and physicochemical properties of as-synthesized photocatalysts were well analyzed by Fourier transform infrared(FT-IR), X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), photoluminescence(PL), UV-diffuse reflectance spectroscopy(UV-DRS), and Brunauer-Emmett-Teller(BET)surface analysis. Doping Nd^(3+) into Zn-Al LDH enhances the overall catalytic activity of the nanocomposite, like better electron-hole pair separation, increase in interplanar distance, fast electron transfer, and large surface area. The as-prepared nanocomposite shows excellent degradation of three different dyes under visible light irradiation. The degradation efficiency of these dyes follows the order of Congo red > rose Bengal > fast green. Furthermore, liquid chromatography-mass spectrometry(LC-MS)was employed to propose a possible photocatalytic degradation pathway for Congo Red and Rose Bengal dyes by Nd/Zn-Al LDH. With the help of radical trapping experiments, it is revealed that during the photoexcitation process, the primary reactive intermediates are hydroxyl radicals.

关键词： Organic pollutants Degradation Multifunctional Mesoporous LC-MS Rare earths

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Study of impact materials of akhnoor meteor crater in Jammu and Kashmir (India)

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Natural Science 2011年第6期3卷 426-429页

作者： Naseer Iqbal ajaz ahmad Tabasum Masood M. N Vahia Department of Physics University of Kashmir Srinagar India

A sample of Akhnoor meteor crater, which fell on 2nd January 2009 in Jammu District, Jammu & Kashmir, India, has been analyzed for ele-mental composition by Spectroscopic tech-niques. Concentrations of 17 major, minor and trace elements were determined. The authentic-ity of the meteorite sample was established by comparing its composition with those of stan-dard meteorites/chondrite. The classification of the sample has been made by comparing the abundances and concentration ratios of ele-ments with other known meteorites.

关键词： Meteor Impact Creator Stony Meteorite

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Variable stars in M37

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Research in Astronomy and Astrophysics 2018年第12期18卷 111-122页

作者： ajaz ahmad Dar Padmakar Singh Parihar Parvej Saleh Manzoor ahmad Malik Department of Physics University of KashmirHazratbal 190006Srinagar-J&KIndia Department of Physics Islamia College of Science and CommerceHawalSrinagar-19002J&KIndia Indian Institute of Astrophysics Koramagala-560034BangaloreIndia Applied Sciences Department GowhatiUniversity of AssamIndia

The CCD photometric observations of open star cluster M37(NGC 2099) were carried out up to a limiting magnitude of V ～ 20 in both B and V filters to search for variable stars using a 2k×4k CCD and the 1.3 m telescope at the Vainu Bapu Observatory, Kavalur.A total of 314 stars were in the first observing run, out of which 60 were identified as variables.Eight out of the identified 60 variables are classified as W UMa binary stars.For model fitting, we used PHOEBE based on the W-D code to estimate the physical parameters of these newly detected W UMa binaries that theoretically best match the observed light curves.

关键词： techniques:photometric astronomical instrumentation methods and techniques astrometry and celestial mechanics (stars:) binaries:eclipsing

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Binary star detection in the open cluster King 1 field

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Research in Astronomy and Astrophysics 2020年第3期20卷 185-191页

作者： Parvej Reja Saleh Debasish Hazarika ajaz ahmad Dar Padmakar Singh Parihar Eeshankur Saikia Department of Applied Sciences Gauhati University-781014AssamIndia Department of Physics University of Kashmir-190006Srinagar-J&KIndia Indian Institute of Astrophysics Koramagala-560034BangaloreIndia

A rarely studied open cluster,King 1 is observed using the 1.3-m telescope equipped with a 2 k×4 k CCD at Vainu Bappu Observatory,India.We analyze the photometric data obtained from CCD observations in both B and V bands.Out of 132 detected stars in the open cluster King 1 field,we have identified four stellar variables,and two among them are reported as newly detected binary systems.The parallax values from Gaia DR2 suggest that the open cluster King 1 is in the background of these two detected binary systems,falling along the same line of sight,giving rise to different parallax values.Periodogram analysis was carried out using Phase Dispersion Minimization(PDM)and the Lomb-Scargle(LS)method for all the detected variables.PHysics Of Eclipsing Binari Es(PHOEBE)is extensively employed to model various stellar parameters of both the detected binary systems.Based on the modeling results obtained from this work,one of the binary systems is reported for the first time as an Eclipsing Detached(ED)and the other as an Eclipsing Contact(EC)binary of W-type W UMa.

关键词： galaxies photometry-galaxies clusters individual(King 1)-(stars:)binaries eclipsing-methods observational

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Multiplicity dependence of the freezeout parameters in high energy hadron-hadron collisions

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Chinese Physics C 2024年第5期48卷 124-133页

作者： Muhammad ajaz Majid Shehzad Muhammad Waqas Haifa I.Alrebdi Mohammad Ayaz ahmad Antalov Jagnandan Shawn Jagnandan Murad Badshah Jalal Hasan Baker Abdul Mosawir Quraishi Department of Physics Abdul Wali Khan University MardanMardan 23200Pakistan School of Mathematics Physics and Optoelectronic EngineeringHubei University of Automotive TechnologyShiyan 442002China Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Mathematics Physics and StatisticsFaculty of Natural SciencesUniversity of Guyana101110 GeorgetownGuyananSouth America Department of Physics Faculty of ScienceUniversity of TabukTabukKingdom of Saudi Arabia Department of Electrical Engineering College of EngineeringQassim UniversityUnaizahSaudi Arabia

We examined the transverse momentum(pT)spectra of various identified particles,encompassing both light-flavored and strange hadrons(π++π−,K++K−,p+p¯,ϕ,K0s,Λ+Λ¯,Ξ−+Ξ¯+,andΩ−+Ω¯+),across different multiplicity classes in proton-proton collisions(p-p)at a center-of-mass energy of s√=7 TeV.Utilizing the Tsallis and Hagedorn models,parameters relevant to the bulk properties of nuclear matter were extracted.Both models exhibit good agreement with experimental data.In our analyses,we observed a consistent decrease in the effective temperature(T)for the Tsallis model and the kinetic or thermal freeze-out temperature(T0)for the Hagedorn model,as we transitioned from higher multiplicity(class-I)to lower multiplicity(class-X).This trend is attributed to the diminished energy transfer in higher multiplicity classes.Additionally,we observed that the transverse flow velocity(βT)experiences a decline from class-I to class-X.The normalization constant,which represents the multiplicity of produced particles,was observed to decrease as we moved toward higher multiplicity classes.While the effective and kinetic freeze-out temperatures,as well as the transverse flow velocity,show a mild dependency on multiplicity for lighter particles,this dependency becomes more pronounced for heavier particles.The multiplicity parameter for heavier particles was observed to be smaller than that of lighter particles,indicating a greater abundance of lighter hadrons compared to heavier ones.Various particle species were observed to undergo decoupling from the fireball at distinct temperatures:lighter particles exhibit lower temperatures,while heavier ones show higher temperatures,thereby supporting the concept of multiple freeze-out scenarios.Moreover,we identified a positive correlation between the kinetic freeze-out temperature and transverse flow velocity,a scenario where particles experience stronger collective motion at a higher freeze-out temperature.The reason for this positive correlation is that,as the multiplicity increases,more energy is

关键词： multiplicity dependence collective properties thermal energy

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Photometry and spectroscopy ofⅡPeg,IM Peg and UX Ari

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Research in Astronomy and Astrophysics 2018年第9期18卷 79-88页

作者： ajaz ahmad Dar Padmakar Singh Parihar Manzoor ahmad Malik Department of Physics University of KashmirHazratbal 190006 Srinagar-J&KIndia Department of Physics Islamia College of Science and CommerceHawalSrinagar-19002J&KIndia Indian Institute of Astrophysics Koramagala-560034BangaloreIndia

Ⅴ band photometry of three RS CVn stars,Ⅱ Peg, IM Peg and UX Ari, is carried out to study the physical properties of these variables. We verified the significant and regular optical photometric variability to be present in all three stars. The strong photometric variability and emission of Hα and Ca Ⅱ H ＆ K using high resolution optical spectroscopy with the Hanle Echelle Spectrograph （HESP）, which operates in conjunction with the Himalayan Chandra Telescope, verify the strong chromospheric activity which is present in RS CVn stars. The photometric studies of Ⅱ Peg, UX Ari and IM Peg were subjected to light curve analysis for spot parameters using a two-starspot model.

关键词： RS CVn star spots chromospherically active

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A Point-Specific Site for Placement of Epigastric Port in Iaparoscopic Management of Gallbladder Disease: An Observational Study

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Surgical Science 2013年第7期4卷 309-312页

作者： Mushtaq Chalkoo Shahnawaz Ahangar Faud Sadiq Baqal Alfar Ah Nafae Muntakhab Nafae Raiees ahmad Malla ajaz ahmad Mallar Department of Surgery Government Medical College Srinagar India

Backgound: Laparoscopic cholecystectomy has revolutionized the world in the surgical management of benign gallbladder disease. However, for any procedure to learn properly, anatomy becomes a major concern. Aims and Objectives: We present a point, a convenient site, speedily accessible by our maneuver of placing epigastric port on the patient. Materials and Methods: This is an outcome of an observation with the prospective study of 100 patients irrespective of age, sex, body habitus and severity of gallstone disease. Our point for epigastric port satisfies all the criteria for an ideal port. Results: Our general observation with majority of patients with this point specific epigastric port placement was that it is easy to locate, needs less thrust on trocar for creation, stays on the linea alba, is easily maneuverable facilitates safe, easy and speedy dissection, causes less portal bleeds and is easy to angulate towards the right of falciform ligament. Conclusion: The point specific epigastric port conveys many benefits to the operating surgeon in terms of easy location, adds safety and speed to the procedure, causes less portal bleeds, needs less thrust and is easy to angulate to the right of the falciform ligament adding technical ease to the surgeon. It is easy to be learnt, taught and practiced by the young surgeons.

关键词： Laparoscopic Cholecystectomy Epigastric Port Point Specific Anatomy

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Synthesis and Characterization of Antimony（III） Complexes of Thioamides, and Crystal Structure of {[Sb（Imt）2Cl2]2（u2-lmt）}Cl2 （Imt=Imidazolidine-2-thione）

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Chinese Journal of Chemistry 2011年第2期29卷 254-258页

作者： ajaz Humayun Hussain Sajjad Altaf Muhammad Stoeckli-Evans Helen Isab Anvarhusein Mahmood Rashid Altaf Shahnila ahmad Saeed Department of Chemistry University of Engineering and Technology Lahore 54890 Pakistan Institute of Physics University of Neuchdtel Rue Emile-Argand 11 CH-2009 Neuchatel Switzerland Department of Chemistry King Fahd University of Petroleum and Minerals Dhahran 31261 Saudi Arabia Division of Science and Technology University of Education Township Lahore Pakistan

Antimony（III） complexes of thioamides [thioamides=thiourea （Tu）, N,N＇dimethylthiourea （Dmtu）, tetramethylthiourea （Tmtu）, imidazolidine-2-thione （Imt） and diazinane-2-thione （Diaz）] with the general formulae, Sb（thione）nCl3 （n= 1, 2, 2.5, 3） were prepared and characterized by elemental analysis, IR and NMR （1H, 13C） spectroscopic methods. The spectral data of the complexes are consistent with the coordination of the thiones to antimony（III）. The crystal structure of one of them, {[Sb（Imt）2Cl2]2（u2-Imt）}Cl2 （1）, was determined by X-ray crystallography, which shows that the complex is dinuclear consisting of two [Sb（Imt）2Cl2] units bridged by an Imt molecule. In 1, the antimony atom is bonded to two chlorine atoms, two sulfur atoms of coordinated Imt molecules and one sulfur atom of a bridging Imt molecule. The antimony environment can be considered to be distorted octahedral with one Cl- ion weakly bound to antimony.

关键词： antimony（III） complex thioamide crystal structure spectroscopy

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