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Uncoupling protein 2 deficiency of non-cancerous tissues inhibits the progression of pancreatic cancer in mice

Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 190-199页

作者： Denis Revskij Jakob Runst Camilla Umstätter Luise Ehlers Sarah Rohde Dietmar Zechner Manuela Bastian Brigitte Müller-Hilke Georg Fuellen Larissa Henze hugo Murua Escobar Christian Junghanss Axel Kowald Uwe Walter Rüdiger Köhling Olaf Wolkenhauer Robert Jaster Department of Medicine Ⅱ Division of GastroenterologyRostock University Medical CenterRostockGermany Rudolf-Zenker-Institute of Experimental Surgery Rostock University Medical CenterRostockGermany Institute of Clinical Chemistry and Laboratory Medicine Rostock University Medical CenterRostockGermany Facility for Cell Sorting and Cell Analysis and Institute of Immunology Rostock University Medical CenterRostockGermany Institute for Biostatistics and Informatics in Medicine and Ageing Research Rostock University Medical CenterRostockGermany Department of Medicine Clinic ⅢHematologyOncologyPalliative MedicineRostock University Medical CenterRostockGermany Department of Neurology Rostock University Medical CenterRostockGermany Oscar LangendorffInstitute of Physiology Rostock University Medical CenterRostockGermany Department of Systems Biology and Bioinformatics University of RostockRostockGermany

Background: Pancreatic ductal adenocarcinoma(PDAC) is a disease of the elderly mostly because its development from preneoplastic lesions depends on the accumulation of gene mutations and epigenetic alterations over time. How aging of non-cancerous tissues of the host affects tumor progression, however, remains largely unknown. Methods: We took advantage of a model of accelerated aging, uncoupling protein 2-deficient( Ucp2 knockout, Ucp2 KO) mice, to investigate the growth of orthotopically transplanted Ucp2 wild-type(WT) PDAC cells(cell lines Panc02 and 6606PDA) in vivo and to study strain-dependent differences of the PDAC microenvironment. Results: Measurements of tumor weights and quantification of proliferating cells indicated a significant growth advantage of Panc02 and 6606PDA cells in WT mice compared to Ucp2 KO mice. In tumors in the knockout strain, higher levels of interferon-γ m RNA despite similar numbers of tumor-infiltrating T cells were observed. 6606PDA cells triggered a stronger stromal reaction in Ucp2 KO mice than in WT animals. Accordingly, pancreatic stellate cells from Ucp2 KO mice proliferated at a higher rate than cells of the WT strain when they were incubated with conditioned media from PDAC cells. Conclusions: Ucp2 modulates PDAC microenvironment in a way that favors tumor progression and implicates an altered stromal response as one of the underlying mechanisms.

关键词： Pancreatic cancer Orthotopic model Uncoupling protein 2 Fibrosis

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Ultra-broadband near-infrared NOPAs based on the nonlinear crystals Bi BO and YCOB

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High Power Laser Science and Engineering 2020年第3期8卷 6-15页

作者： Mario Galletti hugo Pires Victor Hariton Joana Alves Pedro Oliveira Marco Galimberti Goncalo Figueira GoLP/Instituto de Plasmas e Fusao Nuclear Instituto Superior TecnicoUniversidade de Lisboa1049-001 LisboaPortugal Central Laser Facility Science and Technology Facilities CouncilRutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcotUK INFN-LNF Via Enrico Fermi 5400044 FrascatiItaly

We evaluate and demonstrate ultra-broadband near-infrared noncollinear optical parametric amplification in two nonlinear crystals,bismuth borate(Bi BO)and yttrium calcium oxyborate(YCOB),which are not commonly used for this application.The spectral bandwidth is of the microjoule level;the amplified signal is≥200 nm,capable of supporting sub-10 fs pulses.These results,supported by numerical simulations,show that these crystals have a great potential as nonlinear media in both low-energy,few-cycle systems and high peak power amplifiers for terawatt to petawatt systems based on noncollinear optical parametric chirped pulse amplification(NOPCPA)or a hybrid.

关键词： ultrafast laser high power laser nonlinear optics ultra-broadband noncollinear OPA YCOB and Bi BO nonlinear crystal

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Metamorphism and exhumation of basement gneiss domes in the Quadrilátero Ferrífero:Two stage dome-and-keel evolution?

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Geoscience Frontiers 2019年第5期10卷 1765-1787页

作者： Kathryn Cutts Cristiano Lana Fernando Alkmim Federico Farina hugo Moreira Viviane Coelho Applied Isotope Research Group Departamento de GeologiaEscola de MinasUniversidade Federal de Ouro PretoMorro do Cruzeiro35400-000Ouro PretoMGBrazil Department of Earth Sciences University of GenevaRue des Maraihers 131205GenevaSwitzerland School of Earth and Environmental Sciences University of PortsmouthBurnaby BuildingBurnaby RoadPortsmouthPO1 3QLUK

The presence of dome-and-keel provinces in Archean cratons has been connected with the initiation of plate tectonics on Earth as these features are most commonly observed in Archean rocks.The Quadrilátero Ferrífero in Brazil has been identified as a Paleoproterozoic dome-and-keel province for more than three decades.The prevailing model suggests that it formed during the Rhyacian Transamazonian orogeny,making it unique among dome-and-keel provinces.However,a lack of appropriate lithologies,datable minerals and the metamorphic overprint of later orogenesis has resulted in a cryptic metamorphic record for the formation of this dome-and-keel province.A clinopyroxene-bearing migmatite from the core of the Bacao dome has peak P-T conditions of 5-7 kbar and 700-750 ℃ and a published age of ca.2730 Ma based on U-Pb ages of zircon from leucosomes,suggesting that this age represents the migmatisation event.A fine-grained epidote-albite-titanite assemblage overprints the coarse-grained clinopyroxene and amphibole,giving P-T conditions of 8-9 kbar and 550℃ with an associated titanite age of ca.2050 Ma.A garnet-bearing amphibolite sample also from the core of the dome has peak P-T conditions of 7-8 kbar and 650-700℃,and texturally late titanite from this sample produces an age of ca.2060 Ma.Three additional samples were collected from the edges of the dome.A garnet-gedrite bearing felsic schist produces peak P-T conditions of 8-9 kbar and 650-700℃ on a clockwise P-T evolution.This sample has a U-Pb zircon age of ca.2775 Ma,which could date metamorphism or be the age of its volcaniclastic protolith.Texturally unconstrained titanite from the sample gives an age of ca.2040 Ma.A garnet-bearing amphibolite that occurs as a boudin within the felsic schist gives both zircon and titanite ages of ca.2050 Ma and has peak P-T conditions of 5-6 kbar and 650-700 ℃ on a near isobaric P-T path.An amphibolite dike,observed to cross-cut the felsic schist produces a zircon U-Pb age of ca.2760 Ma.Altogether this data suggests that the samples

关键词： Sao Francisco Craton Zircon U-Pb Titanite U-Pb Phase diagrams Dome-and-keel

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He nailed it: Nail gun injury to the transverse colon

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Laparoscopic, Endoscopic and Robotic Surgery 2020年第3期3卷 85-89页

作者： hugo J.R.Bonatti University of Maryland Community Medical Group EastonMD 21601USA Meritus Surgical Specialists HagerstownMD 21742USA

Nail guns are widely used in powerful tools.Injuries with these devices may be devastating due to the significant force they can deploy.A unique case of a 55-year-old male with accidental nail gun injury to the abdomen,which was managed by laparoscopic colostomy creation using the puncture site with secondary reversal after several months is reported.

关键词： Colon perforation Nail gun Laparoscopy

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Structural Health Monitoring of Different Geometry Structures With Optical Fiber Sensors

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Photonic Sensors 2012年第4期2卷 357-365页

作者： Paulo ANTUNES hugo RODRIGUES Rui TRAVANCA Licinio FERREIRA Humberto VARUM Paulo ANDRE Instituto de Telecomunicacoes Campus de Santiago 3810-193 Aveiro Portugal Departamento de Fisica Universidade de Aveiro Campus de Santiago 3810-193 Aveiro Portugal Departamento de Engenharia Civil Universidade de Aveiro Campus de Santiago 3810-193 Aveiro Portugal

在这份报纸，我们描述几结构监视的结构的健康，与不同几何学，材料和行为，用光纤维传感器。那些研究试图处于监视的结构的健康表明如此的技术的可行性，与对光纤维技术固有的所有优点。

关键词：结构健康监测光纤传感器几何结构光纤技术几何形状

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Photovoltaic-based DC microgrid with partial shading and fault tolerance

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Journal of Modern Power Systems and Clean Energy 2019年第2期7卷 340-349页

作者： Carlos CORREA-BETANZO hugo CALLEJA Carlos AGUILAR Adolfo R.LOPEZ-NUNEZ Elías RODRIGUEZ Electronics Department National Center for Research and Development of Technology62490 CuernavacaMorelosMexico Electronics Department Technological Institute of Celaya38010 CelayaGuanajuatoMexico

Partial shading is a common problem that affects bus regulation in DC microgrids with several photovoltaic(PV) modules as energy sources, as a result of reduced solar irradiance reaching the modules.The problem can be mitigated by incorporating batteries, but if they are not included, appropriate control strategies must be used. This paper presents a new approach in a PV-based DC microgrid, which provides a high-quality bus voltage regulation in islanding mode, without being affected by partial shading or problems associated with PV module connection and disconnection. The solution proposed herein ensures a proper voltage regulation without being affected by problems such as failures in PV modules or mismatch between them. Besides, it can help to prevent PV partial shade stress by disconnecting the affected modules. A further advantage of the approach is the flexibility to connect more PV modules. The advantages of this approach were verified in a 200 W prototype.

关键词： Photovoltaic Microgrid Partial shading Fault Control strategy

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Diurnal Cycle of Heating and Water Vapor in the Metropolitan Area of Porto in Portugal

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Journal of Geographic Information System 2022年第1期14卷 61-77页

作者： hugo Abi Karam Jorge Fernando Soares Gonçalves Augusto José Pereira Filho Departamento de Meteorologia Instituto de Geociências Universidade Federal do Rio de Janeiro (IGEO-UFRJ) Rio de Janeiro Brazil IBERMETEO Coimbra Portugal Departamento de Ciências Atmosféricas Instituto de Astronomia Geofísica e Ciências Atmosféricas Universidade de S&#227 o Paulo (IAG-USP) S&#227 o Paulo Brazil

In this work, it is investigated the Urban Heat Island (UHI) using conservative thermodynamic variables observed by surface weather stations on the Metropolitan Area of Porto (Oporto) in Portugal, under adiabatic conditions at the surface. These conditions are usually present and associated with the development of a mixture layer into the diurnal Convective Boundary Layer (CBL), which residual layer in the late afternoon defines the initial state for the development of the nocturnal UHI. Both the spatial structure and temporal variation of potential temperature and specific humidity were considered, along the hours and days of the year, from a statistical point of view, resulting in hourly climatology. Details of the hourly evolution of the meteorological variables on the Oporto surface are presented and discussed. Results show a seasonal variation of the potential temperature up to 17°C throughout the year, which is associated with horizontal thermal gradients that can control and trigger mesoscale circulations such as sea-land, urban and valley-mountain breezes.

关键词： Metropolitan Area of Porto (Oporto) Climatology Urban Heat Island Development Urban Boundary Layer Mesoscale Atmospheric Circulations

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Assessment of posterior vitreous detachment on enhanced high density line optical coherence tomography

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 165-167页

作者： Yu Cheol Kim Mariana Harasawa Frank S Siringo hugo Quiroz-Mercado Department of Ophthalmology University of Colorado Schoolof MedicineRocky Mountains Lions Eye InstituteAurora 80045USA Department of Ophthalmology University of Colorado School of MedicineDenver Health Medical CenterDenver 80204USA Department of Ophthalmology Keimyung University School of MedicineDongsan Medical CenterDaegu 41931Korea

The state of the vitreo-retinal interface affects various retinal diseases, and the presence or absence of a posterior vitreous detachment （PVD） is one of the most important factors. As such, various studies studyin... 详细信息

关键词： line PPVP PVD Assessment of posterior vitreous detachment on enhanced high density line optical coherence tomography Figure high

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Holocene variations of wildfire occurrence as a guide for sustainable management of the northeastern Canadian boreal forest

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Forest Ecosystems 2015年第3期2卷 190-196页

作者： Ahmed El-Guellab hugo Asselin Sylvie Gauthier Yves Bergeron Adam A.Ali NSERC/UQAT/UQàM Industrial Chair in Sustainable Forest Management Université du Québec en Abitibi-Témiscamingue Natural Resources Canada Canadian Forest Service – Laurentian Forestry Centre Centre for Bio-Archeology and Ecology (UMR5059 CNRS) Université Montpellier 2

Background: Cumulative impacts of wildfires and forest harvesting can cause shifts from closed-crown forest to open woodland in boreal ecosystems. To lower the probability of occurrence of such catastrophic regime shifts,forest logging must decrease when fire frequency increases, so that the combined disturbance rate does not exceed the Holocene maximum. Knowing how climate warming will affect fire regimes is thus crucial to sustainably manage the forest. This study aimed to provide a guide to determine sustainable forest harvesting levels, by reconstructing the Holocene fire history at the northern limit of commercial forestry in Quebec using charcoal particles preserved in lake sediments.Methods: Sediment cores were sampled from four lakes located close to the northern limit of commercial forestry in Quebec. The cores were sliced into consecutive 0.5 cm thick subsamples from which 1 cm3 was extracted to count and measure charcoal particles larger than 150 microns. Age-depth models were obtained for each core based on accelerator mass spectroscopy(AMS) radiocarbon dates. Holocene fire histories were reconstructed by combining charcoal counts and age-depth models to obtain charcoal accumulation rates and, after statistical treatment,long-term trends in fire occurrence(expressed as number of fires per 1000 years).Results: Fire occurrence varied between the four studied sites, but fires generally occurred more often during warm and dry periods of the Holocene, especially during the Holocene Thermal Maximum(7000–3500 cal. BP), when fire occurrence was twice as high as at present.Conclusions: The current fire regime in the study area is still within the natural range of variability observed over the Holocene. However, climatic conditions comparable to the Holocene Thermal Maximum could be reached within the next few decades, thus substantially reducing the amount of wood available to the forest industry.

关键词： Fire occurrence Holocene Boreal forest Northern li

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Immunotherapy in triple-negative breast cancer:A literature review and new advances

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World Journal of Clinical Oncology 2022年第3期13卷 219-236页

作者： Guillermo Arturo Valencia Patricia Rioja Zaida Morante Rossana Ruiz hugo Fuentes Carlos A Castaneda Tatiana Vidaurre Silvia Neciosup Henry L Gomez Department of Medical Oncology Instituto Nacional de Enfermedades NeoplásicasLima 15036Peru

Triple-negative breast cancer(TNBC)is a highly complex,heterogeneous disease and historically has limited treatment options.It has a high probability of disease recurrence and rapid disease progression despite adequate systemic treatment.Immunotherapy has emerged as an important alternative in the management of this malignancy,showing an impact on progression-free survival and overall survival in selected populations.In this review we focused on immunotherapy and its current relevance in the management of TNBC,including various scenarios(metastatic and early-neoadjuvant,adjuvant-),new advances in this subtype and the research of potential predictive biomarkers of response to treatment.

关键词： Triple-negative breast cancer Early disease Immunotherapy Biomarkers Metastatic disease

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