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Fat clearance and conventional fixation identified ypN0 rectal cancers following intermediate neoadjuvant radiotherapy have similar long-term outcomes

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 877-886页

作者： Nan Chen Ting-Ting Sun Zhong-wu Li Yun-Feng Yao Lin Wang ai-Wen wu Department of Gastrointestinal Surgery Peking University Cancer HospitalBeijing 100142China Department of Pathology Peking University Cancer HospitalBeijing 100142China

BACKGROUND As a prognostic factor for colorectal cancer,lymph node(LN)status,particularly the number of LN harvested,has been demonstrated to be essential in the evaluation of quality control in terms of surgical *** chemoradiation,however,decreases the LN ***,certain approaches(such as fat clearance or methylene blue)has drawn significant attention in order to raise LN *** To compare the long-term oncologic outcome of ypN0 rectal cancer identified using fat clearance(FC)or conventional fixation(CF)following 30 Gy in 10 fractions(30 Gy/10f)of neoadjuvant radiotherapy(nRT).METHODS Three hundred and eighty-two patients with resectable and locally advanced rectal cancer were treated by 30 Gy/10f intermediate nRT(biologically equivalent dose of 36 Gy)plus total mesorectal *** specimen fixation methods(FC or CF)were non-randomly *** ypN0 status was identified in 124 and 101 patients in the FL and CF groups,*** endpoints were local recurrence-free survival(LRFS)and cancer-specific survival(CSS).RESULTS The median follow-up of patients was 5.1 *** median numbers of retrieved LNs in the FC and CF groups were 19.5(range,4-47)and 12(range,0-44),respectively,with a significant difference(P=0.000).The percentages of patients with 12 or more retrieved nodes were 82.3%and 50.5%(101/159)in the FC and CF groups,respectively,with a significant difference(P=0.000).The LRFS at 5 years were 95.7%and 94.6%in the FC and CF groups,respectively,without statistical difference(P=0.819).The CSS at 5 years were 92.0%and 87.2%in the FC and CF groups,respectively,without statistical difference(P=0.482).CONCLUSION For patients with ypN0 rectal cancer who underwent 30 Gy/10f preoperative radiotherapy,the increased retrieval of LNs using fat clearance is not associated with survival *** time-consuming fixation method has a low efficacy as a routine practice.

关键词： Neoadjuvant radiotherapy Rectal cancer Fat clearance Survival Lymph node Conventional fixation

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Corrosion resistance properties of colored zirconium conversion coating and powder coating on cold-rolled steel

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Rare Metals 2023年第3期42卷 1005-1010页

作者： ai-Hua wu Yao-Zu Wang Tong-Kuan Xu Zhi Li Sheng-Ji Luan Feng-Zuo Qu Shenzhen Key Laboratory of Environment Simulation and Pollution Control PKU-HKUST Shenzhen-HongKong InstitutionShenzhen 518057China Faculty of Light Industry and Chemical Engineering Dalian Polytechnic UniversityDalian 116034China

Jiuhe Corporation developed a new surface pretreatment for producing a phosphate-free and colored zirconium conversion coating on cold-rolled steel(CRS).Scanning electron microscopy(SEM)and energy-dispersive spectroscopy(EDS)were applied to study the surface morphology and elemental composition of the golden yellow-colored conversion *** trochemic al impedance spectroscopy(EIS)was used to investigate the electrochemical performance of the conversion coatings with different *** corrosion resistance properties of the powder coatings were characterized using the neutral salt spray test(NSS)and the tape adhesion *** EIS and NSS results demonstrate that the colored zirconium conversion coatings exhibit excellent corrosion resistance properties compared with the bare *** golden yellow-colored conversion coating has a maximum EIS value(748Ω·cm^(2))and achieves 0 mm degree of corrosion,as stipulated by EN ISO *** paper proposes a hypothesis concerning the ZrO_(2)-(β-FeOOH)-polymer conversion reaction to explain the color changes.

关键词： Surface pretreatment Colored conversion coating Zirconium oxide Powder coating Corrosion protection

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Experimental research in leaching of copper-bearing tailings enhanced by ultrasonic treatment

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Journal of China University of Mining and Technology 2008年第1期18卷 98-102页

作者： ZHANG Jie wu ai-xiang WANG Yi-ming CHEN Xue-song School of Resources and Safety Engineering Central South University Changsha Hunan 410083 China School of Civil and Environment Engineering Beijing University of Science and Technology Beijing 100083 China

On the basis of an experiment in ultrasonic enhanced ammonia leaching of tailings, the effect of ultrasonic waves on copper dissolution was studied. The mechanism of ultrasonic enhanced tailing leaching was analyzed and a technique of ultrasonic enhanced pipe leaching of tailings was proposed. The results show that tailings with ultrasonic treatment can leach up to 89.5% of Cu, which is 13.5% more than those without the treatment. Ultrasonic technology is capable of improving leaching rates and the overall recovery of tailing leaching. Impact waves and micro jet streams can strip and erode affected surfaces of tailing particles to create new active surfaces and disturbances can intensify mass transfer processes in "dead zones". The technique of ultrasonic enhanced pipe leaching of tailings is a combination of existing agitation enhancement with ultrasonic enhancement and can improve mineral recovery.

关键词： ultrasonic treatment tailings leaching pipe active surfaces mass transfer

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Optimization and mechanism of surfactant accelerating leaching test

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Journal of Central South University 2016年第5期23卷 1032-1039页

作者：艾纯明吴爱祥王贻明侯春来 College of Safety Science and Engineering Liaoning Technical University School of Civil and Environment Engineering University of Science and Technology Beijing

To solve the problem of slow leaching speed of copper,surfactant was added into lixivium as leaching agent in the *** on physical chemistry and seepage flow mechanics,the leaching mechanics of surfactant was *** solution surface tension and surfactant adsorbing on the surface of ore have a significant impact on the surface wetting *** leaching rate for response,the study screened out three main factors by Plackett-Burman design method:the sulfuric acid concentration,surfactant concentration and *** these three factors,the surfactant concentration is the most important contributor to leaching *** obtaining the experiment center by the steepest ascent experiment,a continuous variable surface model was built by response surface *** solving quadratic polynomial equation,optimal conditions for leaching were finally obtained as follows:the sulfuric acid concentration was 60 g/L,the surfactant concentration was 0.00914 mol/L,and the temperature was 45 °*** leaching rate was 66.81% in the optimized leaching conditions,which was close to the predicted value,showing that regression result was good.

关键词： surfactant optimization leaching response surface

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SDG714 Regulates Specific Gene Expression and Consequently Affects Plant Growth via H3K9 Dimethylation

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Journal of Integrative Plant Biology 2010年第4期52卷 420-430页

作者： Bo Ding Yan Zhu Zhong-Yuan Bu Wen-Hui Shen Yu Yu ai-wu Dong State KeyLaboratory of Genetic Engineering Institute of Plant Biology School of Life Sciences Fudan University Shanghai 200433 China Institut de Biologie Moleculaire des Plantes du CNRS Universite Louis Pasteur de Strasbourg 67084 Strasbourg Cedex France B. Ding and Y. Zhu contributed equally to this paper

Histone lysine methylation is known to be involved in the epigenetic regulation of gene expression in all eukaryotes including plants. Here we show that the rice SDG714 is primarily responsible for dimethylation but not trimethylaUon on histone H3K9 in vivo. Overexpression of YFP-SDG714 in Arabidopsis significantly inhibits plant growth and this inhibition is associated with an enhanced level of H3K9 dimethylation. Our microarray results show that many genes essential for the plant growth and development were downregulated in transgenic Arabidopsis plants overexpressing YFP-SDG714. By chromatin immunoprecipitation analysis, we show that YFP-SDG714 is targeted to specific chromatin regions and dimethylate the H3Kg, which is linked with heterochromatinization and the downregulation of genes. Most interestingly, when YFP-SDG714 production is stopped, the inhibited plants can partially restore their growth, suggesting that the perturbation of gene expression caused by YFP-SDG714 is revertible. Taken together, our results point to an important role of SDG714 in H3K9 dimethylation, suppression of gene expression and plant growth, and provide a potential method to regulate gene expression and plant development by an on-off switch of SDG714 expression.

关键词： HISTONES GENE expression ARABIDOPSIS PLANT growth METHYLATION

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Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 323-331页

作者： Peng-Ju Chen Lin Wang Yi-Fan Peng Nan Chen ai-Wen wu Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Gastrointestinal Cancer Center Unit Ⅲ Peking University Cancer Hospital and Institute

BACKGROUND Malignant bowel obstruction(MBO)is a common event for end-stage gastrointestinal cancer *** studies had demonstrated manifestations and clinical management of MBO with mixed *** still lack reports of the surgical treatment of *** To analyze the short-term outcomes and prognosis of palliative surgery for MBO caused by gastrointestinal *** A retrospective chart review of 61 patients received palliative surgery between January 2016 to October 2018 was performed,of which 31 patients underwent massive debulking surgery(MDS)and 30 underwent ostomy/by-pass surgery(OBS).The 60-d symptom palliation rate,30-d morbidity and mortality,and overall survival rates were compared between the two *** The overall symptom palliation rate was 75.4%(46/61);patients in the MDS group had significantly higher symptom palliation rate than OBS group(90%vs 61.2%,P=0.016).Patients with colorectal cancer who were in the MDS group showed significantly higher symptom improvement rates compared to the OBS group(overall,76.4%;MDS,61.5%;OBS,92%;P=0.019).However,patients with gastric cancer did not show a significant difference in symptom palliation rate between the MDS and OBS groups(OBS,60%;MDS,80%;P=1.0).The median survival time in the MDS group was significantly longer than in the OBS group(10.9 mo vs 5.3 mo,P=0.05).CONCLUSION For patients with MBO caused by peritoneal metastatic colorectal cancer,MDS can improve symptom palliation rates and prolong survival,without increasing mortality and morbidity rates.

关键词： Gastrointestinal neoplasms Malignant bowel obstruction Metastasis Palliative surgery Prognosis Quality of life

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INVESTIGATION ON THE FLOW STABILITY OF NEWTONIAN FLUID IN ECCENTRIC ANNULUS VIA THE AXIAL RECIPROCATION OF THE INNER TUBE

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Journal of Hydrodynamics 2007年第6期19卷 671-676页

作者： YUAN ai-wu CUI Hai-qing GAO Tao Management Institute Tianjin University Tianjin 300072 China Department of Petroleum Engineering Daqing Petroleum Institute Daqing 163318 China Daqing Exploration and Development Institute Daqing 163712 China

The governing equation, together with the formulas of the averaged flux and the stability parameter for Newtonian fluid flowing in eccentric annulus via the axial reciprocation of the inner tube was established in the bipolar coordinate system. Numerical calculation was conducted for the measurement of water flow using the formulas above, of which the results agree well with the experimental data. It is shown that the flow instability can be induced by the increase of the stroke, the frequency, and the eccentricity of annulus, making the sucker rod more susceptible to partial abrasion. Some protecting methods, including adding centralizers, adjusting the stroke and frequency, are proposed to protect the sucker rod from the partial abrasion, and satisfactory results have been achieved in the oilfields.

关键词： eccentric annulus axial reciprocation flow stability partial abrasion

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Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis

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Asian Pacific Journal of Tropical Biomedicine 2023年第2期13卷 70-79页

作者： Ying-Zhi Li ai-Ping wu Dan-Dan Wang Pan-Pan Yang Bin Sheng Department of Rehabilitation Medicine Zhejiang HospitalHangzhou 310007ZhejiangChina Department of Emergency Medicine Zhejiang Provincial People’s HospitalHangzhou 310014ZhejiangChina

Objective: To evaluate the effect of salidroside on oxygen and glucose deprivation(OGD)-treated NT2 cells and its underlying mechanisms of ***: Retinoic acid was used to induce the differentiation of NT2 cells into neurons. The effects of salidroside on survival, apoptosis, inflammatory response, and oxidative stress of neurons undergoing OGD were evaluated. Using precursor cells as controls, the effect of salidroside on the differentiation progression of OGDtreated cells was evaluated. In addition, the effect of erastin, a ferroptosis inducer, on NT2 cells was examined to investigate the underlying mechanisms of neuroprotective action of ***: Salidroside alleviated the effects of OGD on neuronal survival, apoptosis, inflammation, and oxidative stress, and promoted NT2 cell differentiation. Moreover, salidroside prevented ferroptosis of OGD-treated cells, which was abolished following erastin treatment, indicating that ferroptosis mediated the regulatory pathway of ***: Salidroside attenuates OGD-induced neuronal injury by inhibiting ferroptosis and promotes neuronal differentiation.

关键词： Salidroside Rhodiola rosea Ferroptosis Oxygen and glucose deprivation Neuronal differentiation Ischemic stroke

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Unsaturated flow and solute transport in a porous column using spherical ore particles

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International Journal of Minerals,Metallurgy and Materials 2014年第2期21卷 113-121页

作者： Xiu-xiu Miao ai-xiang wu Bao-hua Yang Jin-zhi Liu Sheng-hua Yin Hong-jiang Wang Key Laboratory of High-Efficient Mining and Safety of Metal Mines (Ministry of Education) University of Science and Technology Beijing School of Information Science and Engineering Hunan International Economics University College of Information Technology Shanghai Ocean University

This paper dealt with the development of a two-dimensional （2D） mathematical model for column leaching and confirmed the important simulation parameters through experiment. The unsaturated state of the variably saturated flow column and the solute transport of copper ions were studied during leaching. The fluid flow problem was handled using the Richards equation on the premise of an ambient pressure column air, where the van Genuchten formulas were applied to define the nonlinear relationships of pressure head with the retention and permeability properties. The ore column permeability test gave a varied hydraulic conductivity, which was analyzed in the model. In the solute transport problem, the copper ion concentration was solved using the advection-diffusion-reaction equation whose reaction term was determined by the joint analysis of experimental copper leaching rate and the shrinking core model. Particle-and column-scale leaching tests were carried out to illustrate the difference and connection of copper extraction in both processes. This fluid flow and solute transport cou-pled model was determined through the finite element method using the numerical simulation software, COMSOL Multiphysics.

关键词： mathematical models leaching unsaturated flow solute transport

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Solid-liquid state pressure bonding of Si_3N_4 ceramics with aluminum based alloys and its mechanism

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中国有色金属学会会刊：英文版 2001年第2期11卷 177-182页

作者：邹贵生吴爱萍任家烈 Department of Mechanical Engineering Tsinghua University

Solid liquid state pressure bonding of Si 3N 4 ceramics with aluminum based alloys, which contain a small amount of intermetallic compounds Al 3Ti or Al 3Zr, was investigated. With this new method, the heat resistant properties of the bonding zone metal are improved, and the joints’ strengths at high temperature is increased. The joints’ shear strength at room temperature and at 600 ℃ reach 126～133 MPa and 32～34 MPa, respectively, with suitable bonding pressure. The reaction between aluminum and Si 3N 4 ceramics, which produces Al Si N O type compounds is the dominant interfacial reaction, while the reactions between the second active element Ti or Zr in the aluminum based alloys and Si 3N 4 ceramics also occur to some extend. [

关键词： solid liquid state pressure bonding Si 3N 4 ceramics intermetallic compounds high temperature properties

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