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Neoadjuvant chemotherapy for locally advanced gastric cancer:With or without radiation

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World Journal of Gastrointestinal Surgery 2012年第2期4卷 27-31页

作者： ai-Wen wu Jia-Fu Ji ai-Wen wu Jia-Fu Ji Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Gastrointestinal Surgery Peking University Cancer Hospital Beijing Cancer Hospital and Institute Beijing 100142 China

The role of perioperative chemotherapy for gastric cancer has been established for gastric cancers in their advanced *** most parts of the world,even in Japan and Korea,local recurrence of gastric cancer following curative resection remains a *** radiation be added to chemotherapy to achieve better local and regional control? What is the current evidence? What are the concerns regarding neoadjuvant chemoradiation in terms of safety,efficacy and survival benefit? After a serious review of the literature,the authors conclude that it is still too early to get a definitive answer but radiation seems *** may bring a higher pathological response ***,more high level clinical trials are needed to confirm the role of radiotherapy in the neoadjuvant setting or to ascertain subsets of patients who may benefit from *** is of note that surgeons should pay attention to possible complicated circumstances following radiotherapy,maintain proper nutrition status and minimize the occurrence of postoperative *** few data are available in Japan and Korea,interpretation and implementation of neoadjuvant radiation or chemoradiation should be done with caution.

关键词： Stomach Neoplasm Treatment Radiation Neoadjuvant

Surgical outcomes of bladder augmentation: A comparison of three different augmentation procedures

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World Journal of Clinical Cases 2020年第15期8卷 3240-3248页

作者： Xiao-Gang Sun Ruo-Yi Wang Jia-Long Xu Dian-Guo Li Wei-Xiu Chen Jin-Liang Li Jian Wang ai-wu Li Department of Pediatric Surgery Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Pediatric Surgery The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina

BACKGROUND Augmentation cystoplasty is indispensable in many pediatric diseases,especially neurogenic *** methods and materials are used to augment the bladder,and these methods are associated with different shortcomings and *** The present study reported the mid-term outcomes of patients undergoing various bladder augmentation procedures in a single institution,and assessed whether seromuscular cystoplasty lined with urothelium(SCLU)provided better urodynamic results than auto-augmentation(AA).METHODS A retrospective review of 96 patients undergoing various augmentation methods between 2003 and 2018 was *** patients were divided into three groups according to the type of augmentation,and their outcomes were *** patients developed neurogenic bladder due to myelomeningocele or sacrococcygeal *** clinical data of all patients were *** The mean ages at surgery in the three groups(standard cystoplasty[SC],SCLU,AA)were 10.8,7.5,and 4.8 years,respectively,with mean follow-ups of 36,61,and 36 mo,*** mean preoperative and postoperative bladder capacities of the SC,SCLU,and AA groups were 174±11.7 vs.387±13.7(Pain complications of the SC group were recurrent urinary tract infections(8%)and bladder calculi(6%).Re-augmentation was done in patients in the SCLU(8)and AA(3)*** SC provided sufficient bladder capacity and improved compliance with acceptable *** AA and SCLU,the patients acquired limited increases in bladder capacity and compliance with a high rate of *** with AA,SCLU did not yield be

关键词： Neurogenic bladder Child Surgery Urodynamics Augmentation cystoplasty Auto-augmentation

KNAT7 positively regulates xylan biosynthesis by directly activating IRX9 expression in Arabidopsis

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Journal of Integrative Plant Biology 2018年第6期60卷 514-528页

作者： Jun-Bo He Xian-Hai Zhao Ping-Zhou Du Wei Zeng Cherie T.Beahan Yu-qi Wang Hui-Ling Li Antony Bacic ai-Min wu State Key Laboratory for Conservation and utilization of Subtropical Agro-bioresources South China Agricultural UniversityGuangzhou 510642China Guangdong Key Laboratory for Innovative Development and utilization of Forest Plant Germplasm College of Forestry and Landscape ArchitectureSouth China Agricultural UniversityGuangzhou 510642China College of Life Sciences South China Agricultural UniversityGuangzhou 510642China ARC Centre of Excellence in Plant Cell Walls School of BioSciencesThe University of MelbourneParkville VIC 3010Australia Boyce Thompson Institute for Plant Research IthacaNY 14853USA Provincial Key Laboratory of Agrobiology Jiangsu Academy of Agricultural SciencesNanjing 210014China

Xylan is the major plant hemicellulosic poly- saccharide in the secondary cell wall. The transcription factor KNOTTED-LIKE HOMEOBOX OF ARABIDOPSIS THALIANA 7 （KNAT7） regulates secondary cell wall biosynthesis, but its exact role in regulating xylan biosynthesis remains unclear. Using transactivation analyses, we demonstrate that KNAT7 activates the promoters of the xylan biosynthetic genes, IRREGULAR XYLEM 9 （IRX9）, IRX10, IRREGULAR XYLEM 14-LIKE （IRX14L）, and FRAGILE FIBER 8 （FRAS）. The knat7 T-DNA insertion mutants have thinner vessel element walls and xylary fibers, and thicker interfascicular fiber walls in inflorescence stems, relative to wild-type （WT）. KNAT7 over- expression plants exhibited opposite effects. Glycosyl linkage and sugar composition analyses revealed lower xylan levels in knat7 inflorescence stems, relative to WT; a finding supported by labeling of inflorescence walls with xylan-specific antibodies. The knat7 loss-of-function mutants had lower transcript levels of the xylan biosynthetic genes IRX9, IRX10, and FRAS, whereas KNAT7 overexpression plants had higher mRNA levels for IRX9, IRX10, IRX14L, and FRA8. Electrophoretic mobility shift assays indicated that KNAT7 binds to the IRX9 promoter. These results support the hypothesis that KNAT7 positively regulates xylan biosynthesis.

关键词： Vincent Bulone AlbaNova University Centre Sweden

RETREATMENT WITH FLUDARABINE AND CYCLOSPORINE FOR ONE CASE OF REFRACTORY PURE RED CELL APLASIA

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Chinese Medical Sciences Journal 2008年第1期23卷 60-62页

作者： Guang-sheng He Xiang Zhang De-pei wu ai-ning Sun Miao Miao Xiu-li Wang Zheng-ming Jin Department of Clinical Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of Health Jiangsu Insititute of Hematology the First Affiliated Hospital of Soochow University Suzhou 215006

MANY cases of pure red cell aplasia （PRCA） were mediated by over-function of immune cells, and responded well to immunosuppressive therapy. Sometimes refractory cases also arose. Fludarabine is an analogue of adenosine resistant to deamination which is widely used for B-chronic lymphocytic leukemia （CLL） and other hematological malignancies.^2 As a strong immunosuppressive agent, fludarabine has generally been used in nonmyeloblative conditioning regimens for hematopoietic stem cells transplantation for hematological malignancies and severe aplastic anemia recently.^3 In this study,

关键词： pure red cell aplasia refractory fludarabine

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长江科学院水工岩石力学与工程应用研究进展

长江科学院院报 2021年第10期38卷 104-111页

作者：邬爱清长江科学院水利部岩土力学与工程重点实验室武汉430010

结合长江科学院岩石力学专业10余年来已有研究成果,综述了长江科学院在水工岩石力学与工程应用研究的新进展,包括基础理论与数值方法、岩石力学试验方法与技术、岩体地应力测量技术与地应力场、岩体地球物理与超前探测技术、岩体及结构... 详细信息

结合长江科学院岩石力学专业10余年来已有研究成果,综述了长江科学院在水工岩石力学与工程应用研究的新进展,包括基础理论与数值方法、岩石力学试验方法与技术、岩体地应力测量技术与地应力场、岩体地球物理与超前探测技术、岩体及结构锚固与加固技术以及在岩体工程中应用与实践等方面。叙述了在认识岩体、利用岩体和加固岩体过程中,水工岩石力学未来面临的持续挑战。最后指出未来研究的核心问题,包括岩石力学的非线性属性问题、连续-非连续介质力学问题、跨尺度力学特性评价问题、多场耦合问题以及高地震烈度动力条件岩石力学研究等。

关键词：岩石力学水工岩石力学研究进展工程应用研究综述长江科学院

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全球化下我国集群企业的合作关系演变

科学学研究 2006年第3期24卷 374-380页

作者：邬爱其浙江大学管理学院浙江杭州310027

本文运用来自浙江省5个典型产业集群的企业问卷调查资料,实证发现集群企业的合作关系在全球化背景下发生了深刻的变化,本地的生产协作关系持续增强,本地合作的规范化程度明显改进,本地长期合作意愿显著增强,国外合作关系日渐多样化,新... 详细信息

本文运用来自浙江省5个典型产业集群的企业问卷调查资料,实证发现集群企业的合作关系在全球化背景下发生了深刻的变化,本地的生产协作关系持续增强,本地合作的规范化程度明显改进,本地长期合作意愿显著增强,国外合作关系日渐多样化,新产品概念引入、产品研发和生产工艺设计方面的跨国合作日渐增加。低成本和灵活性是集群企业开展本地合作的主要原因,市场拓展和技术学习则是集群企业进行国际合作的主要原因。这就要求我国集群企业将本地网络和全球网络当作全球化下企业成长的重要动力来源,并通过动态调整合作关系有效整合利用两者的资源优势。

关键词：集群企业合作关系本地网络全球网络

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基于高阶残差量化的光谱二值编码新方法

光谱学与光谱分析 2019年第10期39卷 3013-3020,3027页

作者：康孝岩张爱武首都师范大学三维信息获取与应用教育部重点实验室北京100048 首都师范大学空间信息技术教育部工程研究中心北京100048

光谱二值和多值编码技术能够实现目标光谱的快速匹配、识别和分类等应用,但这类量化编码方法会损失大量的光谱细节信息,且不能解码出与原始光谱近似的重构光谱,应用有限。为了解决上述问题,提出一种高阶残差量化的光谱编码新方法HOBC(hi... 详细信息

光谱二值和多值编码技术能够实现目标光谱的快速匹配、识别和分类等应用,但这类量化编码方法会损失大量的光谱细节信息,且不能解码出与原始光谱近似的重构光谱,应用有限。为了解决上述问题,提出一种高阶残差量化的光谱编码新方法HOBC(high-order binary coding)。首先,对光谱向量进行去均值的规范化处理,得到值域为(-1,1)的光谱序列;然后,求解规范化光谱的±1编码、编码系数和残差(即一阶残差);基于一阶残差,逐阶解算2至K阶残差的±1编码及其系数;最后得到K个编码序列及其系数,即为HOBC的编码结果。选择典型波谱库数据集,对比光谱0/1二值编码BC01(binary coding with 0 and 1)、光谱分析编码SPAM(spectral analysis manager)、二值/四值混合编码SDFC(spectral derivative feature coding)和DNA四值编码等4种方法,进行了光谱量化编码和解码重构实验,分别统计了光谱形状特征和斜率特征编码的信息熵和存储量、光谱形状特征编码与原始光谱之间的光谱矢量距离SVD(spectral vector distance)、谱间Pearson相关系数SCC(spectral correlation coefficient)和光谱角SAM(spectral angle mapping)。结果表明,在编码存储量上,HOBC的1~4阶编码分别与以上4种编码相等;在编码信息熵上,HOBC的1~2阶编码分别与BC01和SPAM相等,而HOBC的3~4阶编码分别高于SDFC和DNA编码;在SCC上,HOBC1阶编码与BC01相等,而2~4阶编码均分别优于SPAM,SDFC和DNA编码;在SAM方面,HOBC 1~4阶编码均分别明显优于4种对比方法;4种对比方法不能明确解码重构,而HOBC可简便重构出与原始光谱近似的解码序列,且SVD逐阶递减。进一步,基于临泽草地试验站公开光谱数据集,进行了10类地物目标的光谱编码和监督分类实验,实验结果表明,在Kappa系数,总体分类精度和平均分类精度等3种性能评价指标上,HOBC均明显优于4种对比方法,尤其是,HOBC 4阶编码优于原始光谱的分类性能;对样本数量较少且类间相似性较高的难分类地物,HOBC亦具有优于其他算法的鲁棒性。说明HOBC编码在大幅压缩数据量的同时,其编码序列能保留较高的信息量,且具有较高的光谱可分性,可用于光谱高精度快速识别和分类;其解码重构序列与原始光谱序列具有较高的相似性,理论上可适用于目标识别和分类等应用。

关键词：高阶残差量化光谱编码二值编码四值编码 DNA编码

Geological suitability of natural sponge body for the construction of sponge city——a case study of Shuanghe Lake district in Zhengzhou airport zone

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Journal of Groundwater Science and Engineering 2023年第2期11卷 146-157页

作者： Yong-jun Su Hui Tang ai-min wu Xue-ping Dai Shuang Liu Hong-wei Liu Heng Kuang School of Geophysics&Geomatics China University of GeosciencesWuhan 430074China Tianjin Center China Geological SurveyTianjin 300170China Henan Acdemy of Geology Zhengzhou 450000China China Geological Survey Beijing 100037China China University of Petroleum-Beijing at Karamay Karamay 834000XinJiangChina

Natural and geological environmental conditions have an important impact on the planning and construction of sponge *** paper analyzes geological factors that influence the usage of natural sponge bodies,taking the Shuanghe lake district of Zhengzhou airport zone as an *** evaluation system with seven factors has been established and the weights of these factors are determined using the analytic hierarchy process(AHP)*** analysis is then carried out on all factors using GIS to evaluate the geological suitability of the construction of the sponge *** results show that geologically suitable area for city construction in Shuanghe lake district accounts for 12.3%,relatively suitable area accounts for 76.1%,and relatively unsuitable area accounts for 11.6%.For suitable and relatively suitable areas,we should make full use of the advantages of surface infiltration,vadose zone transportation and aquifer storage to build a sponge city infrastructure with geological engineering as the main component,supplemented by engineering measures such as surface water storage and drainage,and jointly establish a sustainable urban hydrological *** less suitable areas,artificial rain and flood control works,such as roof garden,should be *** findings of this paper can serve as an important reference for sponge city planning and construction not only in the research area but also in other regions with similar geological conditions.

关键词： Natural sponge bodies Low impact development Rain flood control Hierarchy analysis

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企业创新网络构建与演进的影响因素实证分析

科学学研究 2006年第1期24卷 141-149页

作者：邬爱其浙江大学管理学院浙江杭州310027

企业创新网络是动态复杂环境下企业增强竞争力的重要途径,有效的企业创新网络会随着企业内外部条件的变化而演变。对浙江省331家企业的实证分析表明,企业创新网络的构建和演进要受到企业和企业家两个层面因素的影响,企业的进取型战略意... 详细信息

企业创新网络是动态复杂环境下企业增强竞争力的重要途径,有效的企业创新网络会随着企业内外部条件的变化而演变。对浙江省331家企业的实证分析表明,企业创新网络的构建和演进要受到企业和企业家两个层面因素的影响,企业的进取型战略意图、网络导向的人力资源管理、开放的组织文化、整合度较高的内部交流结构、充足的内部资源配备、较高的信任感和强有力的承诺、以及企业家的性别、出生地、年龄、教育程度、职业背景、合作意识和扩张愿望,会影响到企业创新网络的范围扩展、关系强化和长期化。

关键词：企业创新网络影响因素网络演进网络特征