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A Fully Actuated System Approach for Stabilization of Discrete-Time Multiple-Input Nonlinear Systems with Distinct Input Delays

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Journal of Systems Science & Complexity 2022年第2期35卷 670-687页

作者： wu ai-Guo ZHANG Jie JI Youzhou Harbin Institute of Technology(Shenzhen) Shenzhen 518055China HIT wuhu Robot Technology Research Institute Wuhu 241008China

In this paper,the problem of stabilization is considered for discrete-time multiple-input nonlinear systems with distinct input delays law based on the fully actuated system *** order to compensate the input delays,a prediction scheme is presented to predict future states based on the closed-loop linear ***,a stabilizing law is constructed for nonlinear delayed systems by replacing the future states in the control law for the corresponding delay-free systems with their ***,numerical examples are given to verify the effectiveness of the proposed approach.

关键词： Fully actuated system approach input delays nonlinear systems prediction scheme

Multilinear singular integrals and commutators in variable exponent Lebesgue spaces

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Applied Mathematics(A Journal of Chinese Universities) 2010年第1期25卷 69-77页

作者： HUANG ai-wu XU Jing-shi Department of Mathematics Hunan Normal University Changsha 410081 China

Boundedness of multilinear singular integrals and their commutators from products of variable exponent Lebesgue spaces to variable exponent Lebesgue spaces are obtained. The vector-valued case is also considered.

关键词： Multilinear singular integral commutator variable exponent Lebesgue space BMO function,maximal operator.

Targeting KRAS G12C mutations in colorectal cancer

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Gastroenterology Report 2023年第1期11卷 4-13页

作者： Ming-He Zhao ai-Wen wu Key Laboratory of Carcinogenesis and Translational Research Ministry of EducationUnit IIIGastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijingP.R.China

With the advent of Kirsten rat sarcoma viral oncogene homologue G12C(KRAS G12C)inhibitors,RAS is no longer considered *** the suppression of RAS,new therapeutic approaches have been ***,current clinical studies have indicated therapeutic resistance after short-lived tumour *** to preclinical studies,this might be associated with acquired genetic alterations,reactivation of downstream pathways,and stimulation for upstream *** this review,we aimed to summarize current approaches for combination therapy to alleviate resistance to KRAS G12C inhibitors in colorectal cancer with a focus on the mechanisms of therapeutic *** also analysed the relationship between various mechanisms and therapeutic resistance.

关键词： KRAS G12C drug resistance colorectal neoplasms combination therapy

Chitosan nanoparticles crosslinked by glycidoxypropyltrimethoxysilane for pH triggered release of protein

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Chinese Chemical Letters 2009年第1期20卷 79-83页

作者： ai wu Pan Bei Bei wu Jian Min wu Department of Chemistry Zhejiang University Hangzhou 310027 China Hospital of Zhefiang University Hangzhou 310058 China

pH-responsive-chitosan nanoparticles for the control release of protein drug were prepared by combining two-step crosslinking method, in which chitosan was subsequently crosslinked by sodium tripolyphosphate （TPP） and glycidoxypropyltrimethoxysilane （GPTMS）. Compared with TPP crosslinked chitosan particles, the two-step crosslinked nanoparticles were not only pH-responsive but also more stable in wide pH range. Fluorescein isothiocyanate （FITC） labeled anti-human-IgG antibody was used as a model protein drug for evaluating the control release profile of the nano-carrier. The amount of released antibody increased from 5.6% to 50% when the pH of solution shifted from 7.4 to 6.0. The results suggest the possible application of the nanoparticles as pH- responsive drug delivery materials.

关键词： Chitosan Nanoparticles pH-response Drug delivery Controlled release Protein

Accelerating leaching of copper ore with surfactant and the analysis of reaction kinetics

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International Journal of Minerals,Metallurgy and Materials 2019年第3期26卷 274-281页

作者： Chun-ming ai Ping-ping Sun ai-xiang wu Xun Chen Chao Liu College of Safety Science and Engineering Liaoning Technical University Key Laboratory of Ministry of Education of China for Efficient Mining and Safety of Metal Mines University of Science and Technology Beijing Wanbao Mining Limited

To solve the problem of low permeability and lower extraction rates of high-mud ores, a surfactant was added as a penetrant to the pregnant leaching solution during column leaching tests. On the basis of the theories of physical chemistry and seepage flow mechanics, the mechanism by which seepage is enhanced under the effects of the surfactant was analyzed. The results show that the action modes of the surfactant were divided into four aspects: changing the wettability of the ore, reducing the viscosity of the leaching solution, adsorbing onto the surface of ore, and enhancing the permeability effect. The findings of column leaching tests demonstrated that permeability was substantially improved by the surfactant. In the later period of leaching, the permeability coefficient was two times higher than that of the control group. Meanwhile, the ore extraction rate increased by approximately 10%. During the leaching process, the surface tension of the solution did not substantially change, and that of the solution with surfactant increased slightly. The kinetics analysis of ore column leaching illustrated that the leaching processes were controlled by both internal diffusion(principal factor) and chemical reaction.

关键词： surfactant permeability reaction kinetics leaching

Effect of particle gradation characteristics on yield stress of cemented paste backfill

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International Journal of Minerals,Metallurgy and Materials 2020年第1期27卷 10-17页

作者： Hai-yong Cheng Shun-chuan wu Xiao-qiang Zhang ai-xiang wu Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming 650093China Key Laboratory of Ministry of Education of China for Efficient Mining and Safety of Metal Mines Beijing 100083China

Along with slurry concentration and particle density,particle size distribution(PSD)of tailings also exerts a significant influence on the yield stress of cemented paste,a non-Newtonian *** this work,a paste stability coefficient(PSC)was proposed to characterize paste gradation and better reveal its connection to yield *** coefficient was proved beneficial to the construction of a unified rheological model,applicable to different materials in different mines,so as to promote the application of rheology in the pipeline transportation of *** the results,yield stress showed an exponential growth with increasing PSC,which reflected the proportion of solid particle concentration to the packing density of granular media in a unit volume of slurry,and could represent the properties of both slurry and granular *** was found that slurry of low PSC contained extensive pores,generally around 20μm,encouraging free flow of water,constituting a relatively low yield *** contrast,slurry of high PSC had a compact and quite stable honeycomb structure,with pore sizes generally<5μm,causing the paste to overcome a higher yield stress to flow.

关键词： paste backfill grading theory yield stress paste stability coefficient microscale

Visualization of flow behavior in ore-segregated packed beds with fine interlayers

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International Journal of Minerals,Metallurgy and Materials 2020年第7期27卷 900-909页

作者： Lei-ming Wang Sheng-hua Yin ai-xiang wu Key Laboratory of Ministry of Education for High-Efficient Mining and Safety of Metal University of Science and Technology BeijingBeijing 100083China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Department of Materials Engineering University of British Columbia309-6350 Stores RoadVancouver V6T 1Z4BCCanada

Ore particles,especially fine interlayers,commonly segregate in heap stacking,leading to undesirable flow paths and changeable flow velocity fields of packed *** tomography(CT),COMSOL Multiphysics,and MATLAB were utilized to quantify pore structures and visualize flow behavior inside packed beds with segregated fine *** formation of fine interlayers was accompanied with the segregation of particles in packed *** particles reached the upper position of the packed beds during *** revealed that the average porosity of fine interlayers(24.21%)was significantly lower than that of the heap packed by coarse ores(37.42%),which directly affected the formation of flow ***,the potential flow paths in the internal regions of fine interlayers were *** flowed and bypassed the fine interlayers and along the sides of the packed *** velocity also indicated that the flow paths easily gathered in the pore throat where flow velocity(1.8×10^-5 m/s)suddenly *** stagnant regions with a flow velocity lower than 0.2×10^-5 m/s appeared in flow paths with a large diameter.

关键词： fine interlayer flow behavior computed tomography segregation preferential flow

Towards personalized perioperative treatment for advanced gastric cancer

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World Journal of Gastroenterology 2014年第33期20卷 11586-11594页

作者： Ru-Lin Miao ai-Wen wu Key Laboratory of Carcinogenesis and Translational Research Ministry of Education Department of Gastrointestinal Surgery Peking University Cancer Hospital Beijing Cancer Hospital and Institute

Gastric cancer is one of the most frequently diagnosed cancers worldwide. Although the rate of gastric cancer has declined dramatically over the past decades in most developed Western countries, it has not declined in East Asia. Currently, a radical gastrectomy is still the only curative treatment for gastric cancer. Over the last twenty years, however, surgery alone has been replaced by a multimodal perioperative approach. To achieve the maximum benefit from the perioperative treatment, a thorough evaluation of the tumor must first be performed. A complete assessment of gastric cancer is divided into two parts: staging and histology. According to the stage and histology of the cancer, perioperative chemotherapy or radiochemotherapy can be implemented, and perioperative targeted therapies such as trastuzumab may also play a role in this field. However, perioperative treatment approaches have notbeen widely accepted until a series of clinical trials were performed to evaluate the value of perioperative treatment. Although multimodal perioperative treatment has been widely applied in clinical practice, personalization of perioperative treatment represents the next stage in the treatment of gastric cancer. Genomic-guided treatment and efficacy prediction using molecular biomarkers in perioperative treatment are of great importance in the evolution of treatment and may become an ideal treatment method.

关键词： Gastric cancer Pre-therapeutic evaluation Perioperative chemotherapy Perioperative radiochemotherapy Perioperative target therapy

Improved delay-range-dependent stability criteria for continuous linear systems with time-varying delay

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Improved delay-range-dependent stability criteria for contin...