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Concurrent hetero-/homo-geneous electrocatalysts to bi-phasically mediate sulfur species for lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第6期93卷 663-668,I0016页

作者： Rui-Bo LingHu Jin-Xiu Chen Jin-Hao Zhang Bo-Quan Li qing-Shan Fu Gulnur Kalimuldina Geng-Zhi sun Yunhu Han long Kong Xi’an Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi’an 710129ShaanxiChina Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816JiangsuChina Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China department of Mechanical and Aerospace Engineering School of Engineering and Digital SciencesNazarbayev UniversityKabanbay Batyr Ave.53Astana 010000Kazakhstan

Expediting redox kinetics of sulfur species on conductive scaffolds with limited charge accessible surface is considered as an imperative approach to realize energy-dense and power-intensive lithium-sulfur(Li-S)*** this work,the concept of concurrent hetero-/homo-geneous electrocatalysts is proposed to simultaneously mediate liquid-solid conversion of lithium polysulfides(LiPSs)and solid lithium disulfide/sulfide(Li_(2)S_(2)/Li_(2)S)propagation,the latter of which suffers from sluggish reduction kinetics due to buried conductive scaffold surface by extensive deposition of Li_(2)S_(2)/Li_(2)*** selected model material to verify this concept is a two-in-one catalyst:carbon nanotube(CNT)scaffold supported iron-cobalt(Fe-Co)alloy nanoparticles and partially carbonized selenium(C-Se)*** Fe-Co alloy serves as a heterogeneous electrocatalyst to seed Li_(2)S_(2)/Li_(2)S through sulphifilic active sites,while the C-Se sustainably releases soluble lithium polyselenides and functions as a homogeneous electrocatalyst to propagate Li_(2)S_(2)/Li_(2)S via solution *** bi-phasic mediation of the sulfur species benefits reduction kinetics of LiPS conversion,especially for the massive Li_(2)S_(2)/Li_(2)S growth scenario by affording an additional solution directed route in case of conductive surface being largely *** strategy endows the Li-S batteries with improved cycling stability(836 mA h g^(-1)after 180 cycles),rate capability(547 mA h g^(-1)at 4 C)and high sulfur loading superiority(2.96 mA h cm^(-2)at 2.4 mg cm^(-2)).This work hopes to enlighten the employment of bi-phasic electrocatalysts to dictate liquid-solid transformation of intermediates for conversion chemistry batteries.

关键词： Lithium-sulfur batteries Electrocatalysis Lithium polysulfides Sulfur cathode Energy density

First-principle study of interaction of H2 and H2O molecules with （ZnO）_n（n=3-6） ring clusters

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Progress in Natural Science:Materials International 2010年第1期20卷 30-37页

作者： Hua-peng CHEN~1,Jian-ning DING~(2,3),Ning-yi YUAN~2,Xiu-qin wang~2,Cheng-lung CHEN~4,Duan WENG~(1*) 1.department of Materials Science and Engineering,tsinghua Universtiy,beijing 100084,china 2.Center for Low-dimensional Materials,Micro-nano Devices and System, Jiangsu Polytechnic university,Changzhou 213164,china 3.Key Laboratory of New Energy Source,Changzhou 213164,china 4.department of Chemistry,National sun Yat-sen university,Kaohsiung 80424,Taiwan,china [a] department of Materials Science and Engineering Tsinghua Universtiy Beijing 100084 China [b] Center for Low-dimensional Materials Micro-nano Devices and System Jiangsu Polytechnic University Changzhou 213164 China [c] Key Laboratory of New Energy Source Changzhou 213164 China [d] department of Chemistry National Sun Yat-sen University Kaohsiung 80424 Taiwan China

A density functional calculation was performed to investigate the impact of hydrogen and water molecules on zinc oxide clusters（ZnO）n=3-6…X,where X=H2and *** calculated binding energies were corrected for the basis set superposition error （BSSE）.The structural parameters and chemical hardness were calculated for the complexes of zinc oxide clusters and guest *** strength values of the interaction between the clusters and the guest molecules were analyzed based on the topological properties of atoms in molecules（aiM）theory of *** stereo electronic interactions inside the ZnO clusters were analyzed in detail using the natural bond orbital（NBO）analysis.

关键词： density functional theory zinc oxide clusters atoms in molecules

The validity of serum ferritin levels in predicting cardiovascular events of metabolic dysfunction-associated steatotic liver disease patients may need more consideration

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 755-756页

作者： Jie Yang qing Liu Jie Li Chao sun department of Gastroenterology Tianjin Medical University General Hospital Airport HospitalTianjinChina department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjinChina department of Infectious Diseases Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingChina

We read with great interest the informative study by Armandi et al.,which shed light on the potential role of serum ferritin in predicting the long-term prognosis of patients with metabolic dysfunction-associated steatotic liver disease(1).However,there remain certain facets requiring in-depth investigation and *** of all,the study found that integrating stepwise increased ferritin thresholds(215.5 and 272µg/L)into predictive models can improve the performance of fibrosis-4(FIB-4)and Non-Alcoholic Fatty Liver Disease Fibrosis Score(NFS)in the longitudinal risk assessment of liver-related events and overall ***,it has been suggested that metabolic hyperferritinaemia(MHF)appears to exhibit a male predominance(2,3).Since the study primarily comprised male participants(65%),it raises the query of whether the ferritin threshold based on the entire population can accurately predict risks within female ***,a sex-specific analysis is warranted to ensure a more precise evaluation.

关键词： Metabolic dysfunction-associated steatotic liver disease(MASLD) serum ferritin cardiovascular events

The genetic load for hereditary hearing impairment in Chinese population and its clinical implication

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Journal of Otology 2009年第2期4卷 98-105页

作者： wang Qiu-ju 1,2, RAO Shao-qi 1, 3, GUO Yu-fen 4, LI qing-zhong 5, ZHAO Hui 1, ZHAO Li-dong 1, YUAN Hu 1, ZONG Liang 1, LIU Qiong 1, ZHAO Ya-li 6, wang Da-yong 1, HAN Ming-kun 1, JI Yu-bin 1, LI Jian-qiang 1, LAN Lan 1, YANG Wei-yan 1, SHEN Yan 2,6, HAN Dong-yi 1 1 department of Otorhinolaryngology-Head and Neck Surgery, and Institute of Otolaryngology, Chinese People’s Liberation Army General Hospital, beijing, 100853 china 2 Chinese National Human Genome Center, beijing, 100176 china 3 department of Medical Statistics and Epidemiology, School of Public Health, sun Yat-Sen university, Guangzhou, 510080, china 4 department of Otorhinolaryngology, Head and Neck Surgery, Second Hospital of Lanzhou university, Lanzhou 730030, china 5 department of Otolaryngology, EYE & ENT hospital of Fudan university, Shanghai, 200031,china 6 Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, beijing, 100005 china department of Otorhinolaryngology–Head and Neck Surgery and Institute of Otolaryngology Chinese People’s Liberation Army General Hospital Beijing 100853 China Chinese National Human Genome Center Beijing 100176 China department of Medical Statistics and Epidemiology School of Public Health Sun Yat–Sen University Guangzhou 510080 China department of Otorhinolaryngology Head and Neck Surgery Second Hospital of Lanzhou UniversityLanzhou 730030 China department of Otolaryngology EYE & ENT hospital of Fudan University Shanghai 200031China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100005 China

Objective To understand the genetic load in the Chinese population for improvement in diagnosis, prevention and rehabilitation of deafness. Methods DNA samples, immortalized cell lines as well as detailed clinical and audiometric data were collected through a national genetic resources collecting network. Two conventional genetic approaches were used in the studies. Linkage analysis in X chromosome and autosomes with microsatellite markers were performed in large families for gene mapping and positional cloning of novel genes. Candidate gene approach was used for screening the mtDNA 12SrRNA, GJB2 and SLC26A4 mutations in population -based samples. Results A total of 2,572 Chinese hearing loss families or sporadic cases were characterized in the reported studies, including seven X-linked, one Y-linked, 28 large and multiplex autosomal dominant hearing loss families, 607 simplex autosomal recessive hereditary hearing loss families, 100 mitochondrial inheritance families, 147 GJB2 induced hearing loss cases, 230 cases with enlarged vestibular aqueduct (EVA) syndrome, 169 sporadic cases with auditory neuropathy, and 1,283 sporadic sensorineural hearing loss cases. Through linkage analysis or sequence analysis, two X-linked families were found transmitting two novel mutations in the POU3F4 gene, while another X -linked family was mapped onto a novel locus, nominated as AUNX1 (auditory neuropathy, X-linked locus 1). The only Y-linked family was mapped onto the DFNY1 locus(Y-linked locus 1, DFNY1). Eight of the 28 autosomal dominant families were linked to various autosomal loci. In population genetics studies, 2,567 familial cases and sporadic patients were subjected to mutation screening for three common hearing loss genes: mtDNA 12S rRNA 1555G, GJB2 and SLC26A4. The auditory neuropathy cases in our samples were screened for OTOF gene mutations. Conclusions These data show that the Chinese population has a genetic load on hereditary hearing loss. Establishing personalize

关键词： Hereditary hea ring loss linkage analysis DFNY1 AUNX1 auditory neuropathy enlarged vestibular aqueduct senserineural hearing loss genetic epidemiology

In vitro derivation of functional insulin-producing cells from human embryonic stem cells

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Cell Research 2007年第4期17卷 333-344页

作者： Wei Jiang~(1,*) Yan Shi~(1,5,*) Dongxin Zhao~1 Song Chen~1 Jun Yong~1 Jing Zhang~2 Tingting qing~1 Xiaoning sun~(1,3) Peng Zhang~1 Mingxiao Ding~1 Dongsheng Li~4 Hongkui Deng~(1,2,3) ~1department of Cell Biology and Genetics,College of Life Sciences,Peking university,beijing 100871,china ~2beijing Laboratory Animals Research Center,beijing 100012,china ~3Laboratory of Chemical Genomics,Shenzhen Graduate School of Peking Universit,the university Town,Shenzhen 518055,china ~4provincial Kev Laboratory of Embryonic Stem Cell Research,Tai-He Hospital Yunyang Medical College,32 S.Renmin Rd.,Shiyan 442000,china departmentofCellBiologyandGenetics CollegeofLifeSciencesPekingUniversityBeijing100871China beijingLaboratoryAnimalsResearchCenter Beijing100012China LaboratoryofChemicalGenomics ShenzhenGraduateSchoolofPekingUniv

The capacity for self-renewal and differentiation of human embryonic stem(ES)cells makes them a potential source forgeneration of pancreatic beta cells for treating type I diabetes ***,we report a newly developed and effectivemethod,carried out in a serum-free system,which induced human ES cells to differentiate into insulin-producing *** A was used in the initial stage to induce definitive endoderm differentiation from human ES cells,as detectedby the expression of the definitive endoderm markers Sox 17 and ***,all-trans retinoic acid(RA)wasused to promote pancreatic differentiation,as indicated by the expression of the early pancreatic transcription factorspdr1 and *** maturation in DMEM/F12 serum-free medium with bFGF and nicotinamide,the differentiatedcells expressed islet specific markers such as C-peptide,insulin,glucagon and *** percentage of C-peptide-posi-tive cells exceeded 15%.The secretion of insulin and C-peptide by these cells corresponded to the variations in *** transplanted into renal capsules of Streptozotocin(STZ)-treated nude mice,these differentiated human EScells survived and maintained the expression of beta cell marker genes,including C-peptide,pdx1,glucokinase,nkx6.1,IAPP,pax6 and *** percent of the transplanted nude mice exhibited apparent restoration of stable euglycemia;and the corrected phenotype was sustained for more than six *** new method provides a promising in vitro dif-ferentiation model for studying the mechanisms of human pancreas development and illustrates the potential of usinghuman ES cells for the treatment of type I diabetes mellitus.

关键词： human embryonic stem cell direct differentiation insulin-producing cell diabetes

ES细胞体外定向分化为成熟肝细胞的实验研究

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生物化学与生物物理进展 2004年第6期31卷 518-522页

作者：胡安斌蔡继业郑启昌洪岸何晓青戴云单于潘运龙李凌松暨南大学生命科学院广州510632 华中科技大学同济医学院附属协和医院肝胆外科中心武汉430022 中山大学医学院广州510080

探讨了肝细胞在胚胎干细胞 (EScell)体外诱导分化系统中成熟分化的条件、机制及其鉴定方法 .利用TGF ,bFGF、HGF等细胞生长因子进行BALB/c小鼠ES细胞向肝细胞方向的定向诱导 .利用反转录聚合酶链反应 (RT PCR)、免疫细胞化学 (ICC)和放... 详细信息

探讨了肝细胞在胚胎干细胞 (EScell)体外诱导分化系统中成熟分化的条件、机制及其鉴定方法 .利用TGF ,bFGF、HGF等细胞生长因子进行BALB/c小鼠ES细胞向肝细胞方向的定向诱导 .利用反转录聚合酶链反应 (RT PCR)、免疫细胞化学 (ICC)和放射免疫法 (RIA)动态检测肝细胞特异性基因和蛋白AFP ,ALB ,G6P ,TAT ,CK8,CK18等在培养体系中的表达 ,并测定肝细胞的尿素合成功能 ,最后测定肝细胞分化率 .结果 ,肝细胞特异基因AFP ,ALB ,G6P和TAT最早分别于第 3、 9、 11、 13天表达 ,肝细胞特异蛋白AFP ,CK8,CK18和ALB最早分别于第 7、 9、 9和 11天开始表达 .第 12天开始检测到尿素出现 ,浓度为 8 3μmol/L ,并随培养时间延长而浓度逐渐增加 .最后 ,测得生长因子诱导组肝细胞的分化率为 32 % ,对照组肝细胞分化率为 8% .说明肝细胞可以在ES细胞体外诱导分化系统中出现并成熟分化 ,bFGF、HGF、OSM等可以明显提高细胞分化率和成熟度 ,有望成为解决肝功能替代疗法中细胞来源问题的新希望 .

关键词：胚胎干细胞肝细胞定向分化

Perioperative toripalimab plus neoadjuvant chemotherapy might improve outcomes in resectable esophageal cancer:an interim analysis of a phase Ⅲ randomized clinical trial

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Cancer Communications 2024年第10期44卷 1214-1227页

作者： Yan Zheng Guanghui Liang Dongfeng Yuan Xianben Liu Yufeng Ba Zimin Qin Sining Shen Zhenxuan Li Haibo sun Baoxing Liu Quanli Gao Peng Li Zongfei wang Shilei Liu Jianping Zhu Haoran wang Haibo Ma Zhenzhen Liu Fei Zhao Jun Zhang He Zhang Daoyuan Wu Jinrong Qu Jie Ma Peng Zhang Wenjie Ma Ming Yan Yongkui Yu qing Li Jiangong Zhang Wenqun Xing department of Thoracic Surgery The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Immunotherapy The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Endoscopy The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Pathology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Radiology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Biobank The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Strategic Development The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Statistics LinkDoc Technology Co.LtdBeijingP.R.China department of Cancer Epidemiology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouP.R.China

Background:In the era of immunotherapy,neoadjuvant immunochemotherapy(NaiC)for the treatment of locally advanced esophageal squamous cell carcinoma(ESCC)is used clinically but lacks of high-level clinical *** study aimed to compare the safety and long-term efficacy of NaiC followed byminimally invasive esophagectomy(MIE)with those of neoadjuvant chemotherapy(NAC)followed by ***:A prospective,single-center,open-label,randomized phase Ⅲ clinical trial was conducted at Henan Cancer Hospital,Zhengzhou,*** were randomly assigned to receive either neoadjuvant toripalimab(240mg)plus paclitaxel(175 mg/m^(2))+cisplatin(75 mg/m^(2))(toripalimab group)or paclitaxel+cisplatin alone(chemotherapy group)every 3 weeks for 2 *** surgery,the toripalimab group received toripalimab(240 mg every 3 weeks for up to 6 months).The primary endpoint was event-free survival(EFS).The pathological complete response(pCR)and overall survival(OS)were key secondary *** events(AEs)and quality of life were also ***:Between May 15,2020 and August 13,2021,252 ESCC patients ranging fromT1N1-3M0 to T2-3N0-3M0were enrolled for interim analysis,with 127 in the toripalimab group and 125 in the chemotherapy *** 1-year EFS rate was 77.9%in the toripalimab group compared to 64.3%in the chemotherapy group(hazard ratio[HR]=0.62;95%confidence interval[CI]=0.39 to 1.00;P=0.05).The 1-year OS rates were 94.1%and 83.0%in the toripalimab and chemotherapy groups,respectively(HR=0.48;95%CI=0.24 to 0.97;P=0.037).The patients in the toripalimab group had a higher pCR rate(18.6%vs.4.6%;P=0.001).The rates of postoperative Clavien-Dindo grade Ⅲb or higher morbidity were 9.8%in the toripalimab group and 6.8%in the chemotherapy group,with no significant difference observed(P=0.460).The rates of grade 3 or 4 treatment-related AEs did not differ between the two groups(12.5%versus 12.4%).Conclusions:The interim results of this ongoing trial showed that in resec

关键词： esophageal squamous cell carcinoma minimally invasive esophagectomy neoadjuvant chemotherapy neoadjuvant immunochemotherapy survival

Advancing index-based climate risk assessment to facilitate adaptation planning:Application in Shanghai and Shenzhen,china

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Advances in Climate Change Research 2022年第3期13卷 432-442页

作者： Zhan TIAN Xin-Yang LYU Huan ZOU Hong-long YANG Laixiang sun Maria sunyer PINYA qing-Chen CHAO ai-qing FENG Ben SMITH School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Shanghai Institute of Technology Shanghai 200235China School of Finance and Management SOAS University of LondonLondon WC1H 0XGUK Shenzhen National Climate Observatory of Meteorological Bureau of Shenzhen Municipality Shenzhen 518040China department of Geographical Sciences University of MarylandCollege Park MD 20742USA Arup Group Limited London W1T 4BQUK National Climate Center China Meteorological AdministrationBeijing 10081China china Meteorological Administration Climate Studies Key Laboratory Beijing 100081China

One of the key issues in climate risk management is to develop climate resilient infrastructure so as to ensure safety and sustainability of urban functioning systems as well as mitigate the adverse impacts associated with increasing climate ***,conventional methods of assessing risks do not fully address the interaction of various subsystems within the city system and are unable to consolidate diverse opinions of various stakeholders on their assessments of sector-specific risks posed by climate *** address this gap,this study advances an integrated-systems-analysis tool-Climate Risk Assessment of Infrastructure Tool(CRaiT),and applies it to analyze and compare the extent of risk factor exposure and vulnerability over time across five critical urban infrastructure sectors in Shanghai and Shenzhen,two cities that have distinctive geo-climate profiles and histories of infrastructure *** results show significantly higher level of variation between the two cities in terms of vulnerability levels than that of *** specifically,the sectors of critical buildings,water,energy,and information&communication in Shenzhen have significantly higher vulnerability levels than Shanghai in both the 2000s and the *** further discussed the vulnerability levels of subsystems in each sector and proposed twelve potential adaptation options for the roads system based on four sets of criteria:technical feasibility,flexibility,co-benefits,and policy *** application of CRaiT is bound to be a knowledge co-production process with the local experts and *** knowledge co-production process highlights the importance of management advancements and nature-based green solutions in managing climate change risk in the future though differences are observed across the efficacy categories due to the geographical and meteorological conditions in the two *** study demonstrates that this knowledge co-creation process is valuable

关键词： Climate risk assessment Megacities Resilient urban infrastructures Subsystem Knowledge co-creation process china

Autophagy-dependent ferroptosis may play a critical role in early stages of diabetic retinopathy

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World Journal of Diabetes 2024年第11期15卷 2189-2202页

作者： Wen-Jie sun Xue-Dong An Yue-Hong Zhang Shan-Shan Tang Yu-Ting sun Xiao-Min Kang Lin-Lin Jiang Xue-Fei Zhao qing Gao Hang-Yu Ji Feng-Mei Lian department of Endocrinology Guang’anmen HospitalBeijing 100053China department of Endocrinology Fangshan Hospital of Beijing University of Chinese MedicineBeijing 102400China department of Endocrinology Changchun University of Chinese MedicineChangchun 130117Jilin ProvinceChina

Diabetic retinopathy(DR),as one of the most common and significant microvascular complications of diabetes mellitus(DM),continues to elude effective targeted treatment for vision loss despite ongoing enrichment of the understanding of its pathogenic mechanisms from perspectives such as inflammation and oxidative *** studies have indicated that characteristic neuroglial degeneration induced by DM occurs before the onset of apparent microvascular *** order to comprehensively grasp the early-stage pathological changes of DR,the retinal neurovascular unit(NVU)will become a crucial focal point for future research into the occurrence and progression of *** on existing evidence,ferroptosis,a form of cell death regulated by processes like ferritinophagy and chaperone-mediated autophagy,mediates apoptosis in retinal NVU components,including pericytes and ganglion ***-dependent ferroptosis-related factors,including BECN1 and FABP4,may serve as both biomarkers for DR occurrence and development and potentially crucial targets for future effective DR *** aforementioned findings present novel perspectives for comprehending the mechanisms underlying the early-stage pathological alterations in DR and open up innovative avenues for investigating supplementary therapeutic strategies.

关键词： Diabetic retinopathy Diabetes mellitus Retinal neurovascular unit Autophagy-dependent ferroptosis Early stage Mechanisms