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GW842166X Alleviates Osteoarthritis by Repressing LPS-mediated Chondrocyte Catabolism in Mice

Current Medical Science 2022年第5期42卷 1046-1054页

作者： Wan-ran HUANG Jun-xue TU ai-qing qiao Li-jia CHEN Department of Pharmacy The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325000China

Objective To explore the role and underlying mechanism of GW842166X on osteoarthritis and osteoarthritis-associated abnormal *** The extracted mouse chondrocytes were treated with GW842166X followed by lipopolysaccharide(LPS).The chondrocytes were divided into the control group,LPS group,LPS+50 nmol/L GW842166X group,and LPS+100 nmol/L GW842166X *** cytotoxicity of GW842166X was tested using the CCK-8 *** blot,RT-qPCR,and ELISA were applied to evaluate the expression of the inflammatory biomarkers in mouse *** expression of extracellular matrix molecules was detected by the Western blot,RT-qPCR,and ***,the activity of NF-κB was checked by the Western blot and *** mouse Hulth models were generated to examine the in vivo effects of GW842166X on *** and eosin staining,safranin O/fast green staining,and immunohistochemistry were applied to detect the histological *** GW842166X below 200µmol/L had no cytotoxicity on the mouse ***-induced high expression of TGF-β1,IL-10,TNF-α,and IL-6 was significantly reduced by *** addition,GW842166X upregulated the expression of aggrecan and collagen type III,which was downregulated after the LPS *** upregulated expression of ADAMTS-5 and MMP-13 by LPS stimulation was dropped in response to the GW842166X ***,LPS decreased the IκBαexpression in the cytoplasm and increased the nuclear p65 ***,these changes were reversed by the GW842166X ***,the damages in the knees caused by the Hulth surgery in mice were restored by *** GW842166X impeded the LPS-mediated catabolism in mouse chondrocytes,thereby inhibiting the progression of osteoarthritis.

关键词： GW842166X lipopolysaccharide osteoarthritis chondrocyte catabolism cartilage extracellular matrix

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Asymmetric Synthesis of N-(Diphenylphosphinyl)furfurylamine by the Enantioselective Alkylation of Furfurylimine

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Chinese Chemical Letters 2005年第9期16卷 1147-1150页

作者： Hai Le ZHANG Xiao Mei ZHANG Xin LI ai qiao MI Xin CUI Yao Zhong JIANG Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboraotry of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041

Optically active N-（diphenylphosphinyl）furfurylamines 2 with good ee values were obtained by the enantioselective addition of dialkylzincs to furfuryl imine 1 in the presence of chiral aminoalcohol derivatives and o... 详细信息

关键词： Asymmetric dialkylzinc N-(diphenylphosphinyl)furfurylarnine.

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Identification of the Sex of Earlier Embryos from Generic Hybrids of Chicken-Quail by Wpkci

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Agricultural Sciences in China 2008年第4期7卷 497-501页

作者： qiao ai-jun MA Wen-xia LI Da-quan MENG Qing-mei College of Animal Science and Technology Shihezi University Shihezi 832003 P.R.China

In this study, a protocol was developed to identify the sex of earlier embryos of chicken （♂）-quail （♀） hybrids and successfully tested the sex proportion of each period （66-120 h）. We acquired cross bred eggs by artificial insemination, hatched them in the same batch according to the standard hatching condition of chicken, and collected earlier living embryos at 66, 72, 78, 84, 90, 96, 102, 108, 114, and 120 h randomly. We adopted RT-PCR protocol and multiple PCR, made the known sex quail as the external control, employed fl-actin as the internal control, and used primers that were designed according to conservative area of gene Wpkci of quail to identify the sex of earlier hybrid embryos. The results indicated that the primer of Wpkci can be used to identify the sex of hybrid embryos accurately; there were more male than female in earlier embryos, the sex proportion of earlier embryos compared with academic numerical value was significantly different （P〈0.01）, and there was no difference between different periods （P〉0.05）. In the present study, we concluded that a simple, fast, credible and stable protocol to identify the sex of earlier hybrids embryos had been established by using primer of Wpkci; in earlier embryos, the death rate of female was higher than that of male and there was no fluctuant peak.

关键词： chicken quail hybrids embryos sex identification

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Pricing Guaranteed Minimum Death Benefits with Dollar Cost Averaging Under Time-changed Le′vy Models

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Acta Mathematicae Applicatae Sinica 2024年

作者： Jia-ming WANG Mei-qiao ai Zhi-min ZHANG College of Mathematics and Statistics Chongqing University

In this paper, we propose an efficient and accurate method for pricing Guaranteed Minimum Death Benefit (GMDB) under time-changed Le′vy processes. Suppose that the GMDB payoff depends on a dollar cost averaging (DCA) style periodic investment, and the activity rate process in stochastic time change is modeled by a square-root process. We develop a recursive method to derive the closed form valuation formula by using the frame duality projection method. Numerical examples are reported for demonstrating the effectiveness of our approach and illustrating the interplay between contract parameters and the valuation.

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Asymmetric carbonyl addition with the homochiral ketimine derived from (+) or (-)-pinanone and benzylamine

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Chinese Journal of Chemistry 1990年第6期8卷 561-567页

作者： MI ai-qiao CHEN Yuan-Wei WANG Jing YANG Gui-Shu JIANG Yao-Zhong Chengdu Institute of Organic Chemistry Academia SinicaChengdu 610015

The carbonyl addition of the pinanone ketimine derived from (+) or (-)-2-hydroxy-pinan- 3-one and benzylamine has been studied and the optically active α,β-substituted-β-aminoethanol deriva- tives were obtained in ... 详细信息

关键词： OC pinanone and benzylamine

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Diastereoselective alkylation of the (+)-ketopinic acid ketimine derived from benzylamine

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Chinese Journal of Chemistry 1990年第6期8卷 542-548页

作者： DENG Jin-Gen HU Wen-Hao LIU Gui-Lan MI ai-qiao JIANG Yao-Zhong Chengdu Institute of Organic Chemistry Academia SinicaChengdu 610015

Alkylation of the ketimine 2 obtained from condensation of (+)-ketopinic acid and benzyla- mine with a variety of alkylating agents gives the products whose trends in diastereomeric excesses (1- 100% O. P.) appear to correlate with the structure and reactivity of electrophilic agents. Using excess n-butyl lithium and allylic or benzylic halides, β-alkylation occured.

关键词： Diastereoselective alkylation of the ketopinic acid ketimine derived from benzylamine acid

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Optimization of Cross-section of Stent Wire in Trapezoidal Shape for the Treatment of Intracranial Aneurysm

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Chinese Journal of Biomedical Engineering(English Edition) 2012年第4期21卷 176-182页

作者： ZHANG Yun qiao ai-Ke College of Life Science and Bioengineering Beijing University of Technology

Grant sponsor： National Natural Science Foundation of China; grant number： 10972016 and 81171107; grant sponsor： Natural Science Foundation of Beijiug; grant number： 3092004

关键词： intracranial aneurysm endovascular stent generalized regressionneural network (GRNN) genetic algorithm (GA) hemodynamies

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Copper-Catalyzed Enantioselective Synthesis of α-Hydroxyamine Using Monodentate Phosphoramidites

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有机化学 2004年第Z1期24卷 43-44页

作者： DONG,Lin CUN,Lin-Feng GONG,Liu-Zhu MI,ai-qiao JIANG,Yao-Zhong Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041

　　Development of new methods for the introduction of a nitrogen atom to a carbonyl group is still the most important synthetic target. Cu-catalyzed addition of organozinc reagents to α,β-unsaturated carbonyl compounds has been the subject of intensive investigation.[1] Moreover, trapping of the intermediate Zn-enolates has been achieved using nitrosobenzene. To demonstrate the feasibility of developing enantioselective variants of these tandem C-C bond formations,α,β-unsaturated substrates a～d was subjected to standard reaction conditions using Feringa's (L1*, L2*) and our own phosphoramidite ligands (L3*, L4*). In this reaction, medium to high levels of enantioselectivities were observed.……

关键词： carbonyl compounds methods for

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Stereoselective Synthesis of (Z)-2-Acylamido-4-phenylcrotonates

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Chinese Chemical Letters 2000年第7期11卷 567-570页

作者： Yi Nong XIE Fan Min FU ai qiao MI Yao Zhong JIANG(Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences,Chengdu 610041) Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China

Two practical methods for highly stereoselective synthesis of (Z)-2-acylamido-4-phenylcrotonates 2a similar to b have been developed. The key step in the first route was how to control the acid-catalyzed isomerization of condensation mixtures of alpha-keto ester 5 with carbomite. In the second route the key step was reduction of oxime 8, derived from alpha-keto ester 5, with iron powder in the presence of acetic anhydride.

关键词： (Z)-alpha,beta-dehydroamino acids stereoselective synthesis E -> Z isomerization Fe/Ac2O reduction of oxime

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三种截面支架对动脉瘤血流动力学影响的比较研究

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医用生物力学 2012年第2期27卷 220-226页

作者：曾堃乔爱科北京工业大学生命科学与生物工程学院北京100124

目的提出不同于传统支架的三角形网丝截面支架,并对其进行数值模拟,比较圆形、矩形、三角形截面支架在动脉瘤内的血流动力学效果。方法构建3个有支架植入的动脉瘤模型,分别为圆形(CM型)、矩形(RM型)和三角形(TM型)截面支架模型,并与1个... 详细信息

目的提出不同于传统支架的三角形网丝截面支架,并对其进行数值模拟,比较圆形、矩形、三角形截面支架在动脉瘤内的血流动力学效果。方法构建3个有支架植入的动脉瘤模型,分别为圆形(CM型)、矩形(RM型)和三角形(TM型)截面支架模型,并与1个无支架的动脉瘤模型(UM型)对照。在相同的边界条件下,利用有限单元法对4个模型进行流固耦合数值模拟。结果 RM型比TM型和CM型的速度更低、流阻更高、流转时间更长,所以矩形、三角形、圆形截面支架血液流动的影响效果依次降低。在削弱壁面切应力大小、降低壁面切应力波动性方面,RM型比TM型和CM型更加显著,但CM型和TM型的壁面升压低于RM型。壁面应力分布和变形结果表明动脉瘤沿远侧壁生长的可能性大于近侧壁,瘤顶破裂的风险最大。结论 3种截面支架展示了不同的血流动力学,这些结果为血管内支架的结构设计和优化提供了有意义的参考依据。

关键词：血管内支架动脉瘤血流动力学流动阻力切应力数值模拟

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