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Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin

World Journal of Gastroenterology 2007年第34期13卷 4615-4619页

作者： Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan Li Kin-Wah Chu Peter WC Fung Nagy Habib Farzin farzaneh Rui-An Xu Molecular Medicine Engineering Research Center of the Ministry of Education Institute of Molecular Medicine Huaqiao University Quanzhou362021 Fujian Province China Department of Medicine Hong Kong University Hong Kong China Department of Pharmacy Chicago UniversityUnited States Department of Transplantation Imperial College London United Kingdom Department of Haematological & Molecular Medicine King's College London London SE5 9NUUnited Kingdom

AIM： TO investigate the inhibitory effect of kallistatin （KAL） on angiogenesis and HCT-116 xenograft tumor growth.METHODS： Heterotopic subcutaneous injection of 2 Seven days later, 2 x 1011 injected intratumorally （n tumors were induced by x 106 HCT-11 cells in mice. rAAV-GFP or rAAV-KAL was = 5 for each group）. The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density （MVD） by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining.RESULTS： Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% （171 ＋ 52 mm^3） at d 21 after virus infection compared to the control group （776 ＋ 241 mm^3）. Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL, rAAV-KAL also decreased the proportion of proliferating cells （Ki-67 positive cells） in tumors compared with the control group.CONCLUSION： rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer.

关键词： Kallistatin Adeno-associated virus Angiogenesis inhibitors Colon Neoplasm

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Serum 17β-estradiol and oral dryness feeling in menopause

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Health 2011年第5期3卷 258-262页

作者： farzaneh Agha-Hosseini Iraj Mirzaii-Dizgah 不详

The aim of this study was to compare serum 17β-estradiol of menopausal women with/without Oral Dryness (OD) feeling, and evaluate the re-lationship between serum 17β-estradiol and severity of OD feeling. A case-control study was carried out on 70 selected menopausal women aged 40 - 77 years with or without OD feeling (35 as case, 35 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The serum 17β-estradiol concentration was measured by an enzyme immunoassay kit (ELISA). Statistical analysis of Student’s t-test and Spearman correlation coefficient was used. The mean serum concentration of 17β-estradiol was significantly lower in case than control. There was a significant negative correlation between XI score and concentration of 17β-estradiol in menopausal women (r = –0.311, P = 0.004). It seems that there is a negatively slight correlation between OD feeling severity and serum 17β-estradiol in menopausal women.

关键词： Menopause Oral Dryness Feeling 17β-Estradiol Serum

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BVRI photometric observations,light curve solutions and orbital period analysis of BF Pav

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Research in Astronomy and Astrophysics 2021年第8期21卷 193-202页

作者： Atila Poro Fahri Alicavus Eduardo Fernández-Lajús Fatemeh Davoudi PegahSadat MirshafieKhozani Mark G.Blackford Edwin Budding Behjat Zarei Jalalabadi Jabar Rahimi farzaneh Ahangarani Farahani The International Occultation Timing Association Middle East section Iran Astronomy Department of the Raderon Lab BurnabyBCCanada Canakkale Onsekiz Mart University Faculty of Arts and SciencesDepartment of Physics17020CanakkaleTurkey Canakkale Onsekiz Mart University Astrophysics Research Center and Ulupnar Observatory17020CanakkaleTurkey Instituto de Astrofisica de La Plata(CCT La Plata-CONICET-UNLP) La PlataArgentina Facultad de Ciencias Astronomicas y Geofisicas Universidad Nacional de La PlataPaseo del BosqueB1900FWALa PlataArgentina Variable Stars South(VSS) Congarinni ObservatoryCongarinniNSW2447Australia Carter Observatory 40 Salamanca RdKelburnWellington 6012New Zealand

A new ephemeris,period change analysis and light curve modeling of the W UMa-type eclipsing binary BF Pav are presented in this *** curves of the system taken in BVRI filters from two observatories,in Australia and Argentina,were modeled using the Wilson-Devinney *** results of this analysis demonstrate that BF Pav is a contact binary system with a photometric mass ratio q=1.460 ± 0.014,a fillout factor f=12.5%,an inclination of 87.97 ± 0.45 deg and a cold spot on the secondary *** applying the distance modulus formula,the distance of BF Pav was calculated to be d=268 ± 18 pc which is in good agreement with the Gaia EDR3 *** obtain an orbital period increase at a rate of 0.142 s century-1 due to a quadratic trend in the O-C ***,an alternative sudden period jump probably occurred which could be interpreted as a rapid mass transfer from the lower mass star to its companion of about ΔM=2.45 × 10-6 M⊙.Furthermore,there is an oscillatory behavior with a period of 18.3±0.3 *** BF Pav does not seem to have significant magnetic activity,this behavior could be interpreted as the light-time effect caused by an undetected third body in this *** this case,the probability for the third body to be a low mass star with M≥ 0.075 M⊙or a brown dwarf is 5.4% and 94.6% *** we assume i’=90°,a3=8.04±0.33 *** mass of the secondary component was also determined following two different methods which result close to each other.

关键词： techniques:photometric binaries:eclipsing stars:individual(BF Pav)

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Fault Diagnosis Based on MultiKernel Classification and Information Fusion Decision

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Computer Technology and Application 2013年第8期4卷 404-409页

作者： Mohammad Reza Vazifeh Pan Hao farzaneh Abbasi School of Computer Science and Technology Wuhan University of Technology Wuhan 430070 China

In machine learning and statistics, classification is the a new observation belongs, on the basis of a training set of data problem of identifying to which of a set of categories （sub-populations） containing observations （or instances） whose category membership is known. SVM （support vector machines） are supervised learning models with associated learning algorithms that analyze data and recognize patterns, used for classification and regression analysis. The basic SVM takes a set of input data and predicts, for each given input, which of two possible classes fon^as the output, making it a non-probabilistic binary linear classifier. In pattern recognition problem, the selection of the features used for characterization an object to be classified is importance. Kernel methods are algorithms that, by replacing the inner product with an appropriate positive definite function, impticitly perform a nonlinear mapping 4~ of the input data in Rainto a high-dimensional feature space H. Cover＇s theorem states that if the transformation is nonlinear and the dimensionality of the feature space is high enough, then the input space may be transformed into a new feature space where the patterns are linearly separable with high probability.

关键词： Fault diagnosis wavelet-kernel information fusion multi classification.

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A Comparative Trial: The Safety and Clinical Efficacy of PEG 3350 and Liquid Paraffin in Management of Chronic Functional Constipation in Children

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International Journal of Clinical Medicine 2012年第5期3卷 383-386页

作者： Abbaslou Parvin Abbaslou farzaneh Hosseini Nasab Ali Department of pediatric gastroenterology Afzalipour Hospital Kerman University of Medical Sciences Kerman Iran Department of pediatric infectious disease Afzalipour Clinical Research Unit Afzalipour Hospital Kerman University of Medical Sciences Kerman Iran Depatment of Pediatrics Afzalipour Hospital Kerman University of Medical Sciences Kerman Iran

Background: Constipation is one of the most common problems in the pediatric age group. In the vast majority, chronic constipation is idiopathic or functional. In addition to education and behavioral changes, disimpaction and maintenance treatment with medications are the main pillars of successful outcome. The medications are variably effective and have potential side effects. Objectives: The current clinical trial was designed to evaluate clinical efficacy of polyethylene glycol (PEG) 3350 and liquid paraffin in chronic functional constipation. Besides, subjects were followed carefully for the side effects. Material and Methods: This study was involved 110 children suffering from chronic functional constipation. They were placed into two different groups, randomly. Each group was treated with PEG 3350 or liquid paraffin. The clinical efficacy and side effects were monitored. Results: After disimpaction with bisacodyl suppositories or combined with Mineral oil enemas in hard fecal impaction, maintenance therapy with PEG 3350 or liquid paraffin was started. The treatment duration and efficacies were not different between the two groups. Furthermore, serious adverse drug reaction was not observed. The family history of constipation and presence of incontinence were two worse prognostic factors. Conclusion: No difference was observed between PEG 3350 and liquid paraffin in chronic functional constipation in children in terms of their efficacies. They are safe and effective medications in this age group.

关键词： Children Constipation Liquid Paraffin Polyethylene Glycol

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Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury

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World Journal of Gastroenterology 2017年第25期23卷 4508-4516页

作者： Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii Department of Surgery Medicine University of California Departments of Surgery Institute of Health Biosciences the University of Tokushima

To investigate the hypothesis that treatment with dimethyl fumarate (DMF) may ameliorate liver ischemia/reperfusion injury (I/RI). METHODSRats were divided into 3 groups: sham, control (CTL), and DMF. DMF (25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase (ALT) and malondialdehyde (MDA) levels, adenosine triphosphate (ATP), NO × metabolites, anti-oxidant enzyme expression level, anti-inflammatory effect, and anti-apoptotic effect were determined. RESULTSHistological tissue damage was significantly reduced in the DMF group (Suzuki scores: sham: 0 ± 0; CTL: 9.3 ± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT (DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA (DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content (DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity (DMF 7.8 ± 0.4 mU/mL vs CTL 6.0 ± 0.5 mU/mL, P = 0.01) and level of endothelial nitric oxide synthase expression (DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes (catalase and glutamate-cysteine ligase modifier subunit and lower levels of key inflammatory mediators (nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group. CONCLUSIONDMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI.

关键词： Inflammation Reactive oxidative stress Nrf2 Ischemia Dimethyl fumarate Liver

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Effects of Nitrogen Sources on Nitrate Reductase Activity and Some Physiological Parameters in Psyllium （Plantago ovata F.） under Salinity Stress

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Journal of Agricultural Science and Technology 2011年第4期5卷 412-419页

作者： M. Heidaril, H. Steppuhn F. farzaneh Plant Breeding Faculty of Agronomy University of Zabol P.O. Box 98615-538 Iran Agriculture and Agri-Food Canada Swift Current Saskatchewan S9H 3X2 Canada Department of Plant Biology University of Golestan Golestan 49138-15739 Iran

The effects of three nitrogen sources （ammonium, nitrate and ammonium＋nitrate） and three salt treatments （0, 100 and 200 mM NaCl） on nitrate reductase activity, proline, soluble protein and carbohydrate contents in psylliom （Plantago ovata） plants were Studied. The nitrate reductase activity tended to increase when NO3- was included in the root-zone solution, but decrease as salinity increased. All N sources stimulated plant growth and nutrient uptake. Shoot and root dry matter tended to decrease as salinity increased, but less so when both NH4＋ and NO3- were present. Shoot biomass accumulated to significantly greater quantities under the mixed-N treatments than when produced using either NH4＋ or NO3- N-form alone. Although not statistically significant, the root biomasses showed a similar tendency. Generally, leaf proline and soluble shoot carbohydrate contents increased with increasing salinity in contrast to soluble protein which decreased regardless of the N source. Under salinity conditions, the concentration of Na＋ in shoot and root tissues was highest in ammonium-N treatment, while that of K＋ was highest in the mixed-N treatment.

关键词： Salinity stress biomass nitrate reductase Plantago ovata nitrogen form.

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First Report of Polymelia in a DSH Kitten in Tehran,Iran

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Journal of Pharmacy and Pharmacology 2020年第2期8卷 68-71页

作者： Mahmood Akbarian Milad Borhani Noushin Zabihi farzaneh Azizi Islamic Azad University Science and Research BranchTehranIran

Congenital malformations are intrinsic structural abnormalities and variations of organs,tissue and/or body systems that can occur during the embryonic development of all animal species,and may be partial or *** in humans is a rare condition with little information about its *** is no categorization of data on its occurrence along with other congenital *** are few reports of this occurring in cows,sheep,amphibians,reptiles,birds,dogs and *** Jan 2018,a DSH(Short Hair Domestic)kitten found on a street was referred to a veterinary hospital in Tehran with symptoms of rigid mass and deformity in the pelvic *** lateral and ventrodorsal positioning,the case was sent to the radiology department and examined under the plain *** included two underdeveloped hindlimbs associated with normal left hindlimb showing the congenital deformity and malformations,deformity and underdevelopment of right hemipelvis,the fusion of first and second lumbar vertebrae and kyphosis due to lumbar vertebrae *** the radiological examinations,the results show that the rigid mass was actually the third hindlimb and the condition is called *** is the first reported case of polymelia in a domestic shorthair cat in Tehran,Iran.

关键词： DSH Polymelia Tehran.

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覆冰棒板间隙直流电晕放电试验及测量

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高电压技术 2006年第5期32卷 1-3,34页

作者：冯杰司马文霞余德芬杨庆赖向平张建辉 M farzaneh 重庆大学电气工程学院高电压与电工新技术教育部重点实验室重庆400044 加拿大魁北克大学西库提米分校CIGELE

研究结果表明,在带电情况下覆冰绝缘子表面冰棱并未完全桥接,在覆冰绝缘子串两端的伞裙之间存在一定的空气间隙。为了研究这种空气间隙对放电发展的影响,提出了冰棒-冰板空气间隙模型。设计了紫外线成像仪CoroCAM IV+和基于虚拟仪器LabV... 详细信息

研究结果表明,在带电情况下覆冰绝缘子表面冰棱并未完全桥接,在覆冰绝缘子串两端的伞裙之间存在一定的空气间隙。为了研究这种空气间隙对放电发展的影响,提出了冰棒-冰板空气间隙模型。设计了紫外线成像仪CoroCAM IV+和基于虚拟仪器LabVIEW相结合的电晕测量系统。通过对冰棒-冰板空气间隙电晕放电脉冲的测量,证明该测试系统性能良好,能够满足试验测试要求。同时为下一步深入开展覆冰电极系统内空气间隙电晕放电的机理研究提供了试验平台。

关键词：覆冰空气间隙电晕放电紫外成像仪虚拟仪器

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低气压下直流正极性冰电极电晕特性研究

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中国电机工程学报 2007年第27期27卷 13-18页

作者：司马文霞冯杰杨庆赖向平余德芬 M.farzaneh 张建辉重庆大学电气工程学院高电压与电工新技术教育部重点实验室重庆市沙坪坝区400044 加拿大魁北克大学西库提米分校CIGELE

覆冰将改变绝缘介质的放电过程,导致电力系统绝缘性能下降,为深入研究覆冰绝缘子串中空气间隙的电晕放电特性,基于冰棱–冰板电极系统,通过脉冲电流传感器和紫外线成像仪CoroCAMIV+揭示了气压对起晕电压、放电模式、放电波形及其幅值等... 详细信息

覆冰将改变绝缘介质的放电过程,导致电力系统绝缘性能下降,为深入研究覆冰绝缘子串中空气间隙的电晕放电特性,基于冰棱–冰板电极系统,通过脉冲电流传感器和紫外线成像仪CoroCAMIV+揭示了气压对起晕电压、放电模式、放电波形及其幅值等的影响。通过数学分析提出表征不同大气压下不同间隙长度时起晕电压的修正公式,分析和讨论气压对放电脉冲及其幅值的影响。理论分析表明,随着气压的降低,覆冰空气间隙起晕电压呈幂函数或指数函数降低,特征指数同间隙长度相关。试验结果与理论分析一致,进一步揭示了覆冰环境下电晕放电的特性。

关键词：直流低气压覆冰电晕特性

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