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Chinese Journal of Chemical Engineering 2021年第4期34卷 454-461页

作者： Abdul Samad Muhammad Imran Din Mahmood Ahmed saghir ahmad Institute of Chemistry University of the PunjabLahore 54590Pakistan Renacon Pharma Limited Lahore 54600Pakistan

The aim of the study was to synthesize zinc oxide nanoparticles(ZnONPs)composite with clay by a novel route and then to explore the capability of composite of ZnONPs and silty clay(SC)as adsorbents for Pb(II)eradication from aqueous media by batch adsorption *** effect of different operating factors like temperature,pH,dose and time of contact on the adsorption process were studied to optimize the ***,Freundlich,Dubinin-Radushkevich(DR)and Temkin isotherms were applied for the interpretation of the *** R^(2)and q values obtained from Langmuir model suggested that the process is best interpreted by this *** values of adsorption capacity(qm)noted were 12.43 mg·g^(-1) and 14.54 mg·g^(-1)on SC and ZnONPsSC *** kinetic studies exposed that pseudo second order(PSO)kinetics is followed by the processes suggesting that more than one steps are involved to control the rate of *** thermodynamic variables such as change in free energy(AGe),change in enthalpy(AH9)and change in entropy(ASe)were *** data suggested that Pb(II)adsorption on SC and ZnONPsSC are spontaneous,endothermic and feasible processes.

关键词： Adsorption Isotherm Kinetics Silty clay Thermodynamic

Genetic effects conferring heat tolerance in upland cotton(Gossypium hirsutum L.)

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Journal of Cotton Research 2019年第1期2卷 56-63页

作者： SALMAN Muhammad ZIA Zia Ullah RANA Iqrar ahmad MAQSOOD Rana Haroon ahmad saghir BAKHSH Ali AZHAR Muhammad Tehseen Department of Plant Breeding & Genetics University of Agriculture FaisalabadPakistan Cotton Research Institute Multan Pakistan Centre of Agricultural Biochemistry and Biotechnology University of Agriculture Faisalabad Pakistan Department of Plant Breeding & Genetics Ghazi University DG Khan Pakistan

Background:Climate change and particularly global warming has emerged as an alarming threat to the crop productivity of field crops and exerted drastic effects on the cropping *** of cotton has been dropped down to one million bales from 1.4 million bales since 2015 in Pakistan due to the increase in temperature at critical growth stages,i.e.,flowering and boll *** in view the importance of cotton in the country,this study was conducted to investigate the genetic effects conferring heat tolerance in six populations(P1,P2,F1,F2,BC1 and BC2)developed from cross-1 and cross-2,i.e.,VH-282×FH-142 and DNH-40×***:The results revealed that cross-1 performed better in heat stress as compared with cross-2 for majority of the traits *** weight and ginning outturn(GO-T)were highly effected under heat stress and had negative correlation with Relative cell injury(RCI).Boll weight,fiber length,fiber strength and fiber fineness were under the control of non-additive gene action,whereas RCI was controlled by additive gene *** values of genetic advance coupled with higher values of broad sense heritability for these traits except RCI confirmed the role of non-additive genetic *** types of epistasis were recorded for fiber strength in cross-1 in normal ***,complementary type of non-allelic interaction was recorded for fiber strength under normal condition,fiber fineness and RCI under heat stressed condition in ***,boll weight,GOT and fiber length in populations derived from cross-2 in normal condition were also under the influence of complementary type of non-allelic *** differences among values of mid parent and better parent heterosis for boll weight in both normal and heat stress condition provided the opportunity to cotton breeders for utilization of this germplasm for improvement of this trait through exploitation of heterosis ***:Cross-1 perfo

关键词： Heat stress Heritability Heterosis Relative cell injury Upland cotton

Hypoxia tolerance studies for yield,fiber and physiological traits in cotton(Gossypium hirsutum L.)

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Journal of Cotton Research 2018年第2期1卷 27-34页

作者： HUSSAIN Altaf FAROOQ Jehanzeb ahmad saghir MAHMOOD Abid SADIQ M.Attiq ZAFAR Ullah Zafar ATHAR Habib-Ur-Rehman Cotton Research Station Cotton Research Station Ayub Agricultural Research Station Cotton Research Institute Ayub Agricultural Research Institute Institute of Pure and Applied Biology Bahauddin Zakariya University

Background： Hypoxia tolerance studies in cotton are very rare in Pakistan. Unpredicted and excessive rainfalls result in severe losses to cotton crop in many regions of the country due to lack of hypoxia tolerance in current cotton varieties. The genotypes that can tolerate flooding are not reported earlier. The studies were conducted to explore hypoxia tolerance in local germplasm which will help to develop hypoxia tolerant cotton varieties. Method： An experiment with randomized complete different cotton varieties. The genotypes were given conditions. blocks was designed to study the hypoxia tolerance in two treatments i.e., water logged and non-water logged Results： The genotypes showed significant variability for yield, fiber and physiological traits. The hypoxia studies revealed that there is significant reduction for plant height in water sensitive genotype LRA-5166. The genotype MNH-786 showed better yield and MNH-556 showed superior ginning outturn percentage under water logged conditions. Staple length, strength and micronaire values also decreased under hypoxia. Similar pattern of negative effects were observed for Chlorophyll a, b contents and chl a/b ratio. Two hypoxia tolerant cultivars CIM-573 and MNH-564 had significantly higher chlorophyll a （1.664, 1.551） than other cultivars under both normal and waterlogged conditions. There was a significant decrease in total free amino acids in all genotypes/cultivars due to waterlogging. Free amino acid contents were significantly higher in two waterlogging sensitive cultivars, CEDIX and N-KRISHMA, than other cultivars under both non-waterlogged and waterlogged conditions. Waterlogging caused a significant reduction in shoot soluble proteins and increase in shoot proline. The genotype LRA-5166 was the highest in shoot soluble proteins content and showed significant decrease in shoot proline. Conclusions： With respect to yield MNH-786 showed better results and regarding ginning outturn percentage MNH-556 exhibite

关键词： Hypoxia Proline content Cotton Chlorophyll Physiology Tolerance

Effect of aspirin on glucose-D transport in intestine of rat

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海南医学院学报 2009年第2期15卷 107-110页

作者： Mazhar Mushtaq Farah Deeba Khan M.Naeem Akhtar saghir ahmad Jafri Mehboob Bari Biochemistry Dept Medical FacultyUniversity of Lahore Institute of Molecular Biology and Biotechnology University of Lahore

Objective: The present study was designed to evaluate the effect a commonly prescribed Non Steroidal Anti Inflammatory Drug(NSAID) *** on brush border membrane in terms of changes in the intestinal transport level of glucose which is monosaccharide with absolute requirement in the body and hence its absorption is directly proportional on the morphology of the intestinal ***: Albino rats(Rattus Norvegicus) were divided into two different groups,Group I(Control),Group II(aspirin-treated,50 mg aspirin/kg of body weight).The treatment was continued for 28 *** the 29th day after overnight fasting,intestine was removed from animals of both *** in transport of glucose-D in intestine were ***: The results indicated a significant decrease in the transport of glucose-D in aspirin treated group as compared to the control ***: Cautious use of NSAID is recommended in commonly observed symptom such as headache and to those patients who are given as a prophylaxis for thrombosis.

关键词：阿司匹林葡萄糖传递过程小肠药物分析

Fungicide tolerant Bradyrhizobium japonicum mitigate toxicity and enhance greengram production under hexaconazole stress

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Journal of Environmental Sciences 2019年第4期31卷 92-108页

作者： Mohammad Shahid Mohd.saghir Khan Department of Agricultural Microbiology Faculty of Agricultural SciencesAligarh Muslim University

Bacterial strain RV9 recovered from greengram nodules tolerated 2400 μg/mL of hexaconazole and was identified by 16 S rDNA sequence analysis as Bradyrhizobium japonicum(KY940048). Strain RV9 produced IAA(61.6 μg/mL), ACC deaminase(51.7 mg/(protein·hr)), solubilized TCP(105 μg/mL), secreted 337.6 μg/mL EPS, and produced SA(52.2 μg/mL) and 2,3-DHBA(28.3 μg/mL). Exopolysaccharides produced by strain RV9 was quantified and characterized by SEM, AFM, EDX and FTIR. Beyond tolerance limit,hexaconazole caused cellular impairment and reduced the viability of strain RV9 revealed by SEM and CLSM. Hexaconazole distorted the root tips and altered nodule structure leading thereby to reduction in the performance of greengram. Also, the level of antioxidant enzymes, proline, TBARS, ROS and cell death was increased in hexaconazole treated *** images revealed a concentration dependent increase in the characteristic green and blue fluorescence of hexaconazole treated roots. The application of B. japonicum strain RV9 alleviated the fungicide toxicity and improved the measured plant characteristics. Also,rhizobial cells were localized inside tissues as revealed by CLSM. Colonization of *** strain RV9 decreased the levels of CAT, POD, APX, GPX and TBARS by 80%, 5%,13%, 13% and 19%, respectively over plants grown at 80 μg/(hexaconazole·kg) soil. The ability to detoxify hexaconazole, colonize plant tissues, secrete PGP bioactive molecules even under fungicide pressure and its unique ability to diminish oxidative stress make *** an attractive choice for remediation of fungicide polluted soils and to concurrently enhance greengram production under stressed environment.

关键词： Hexaconazole toxicity Greengram Bradyrhizobium japonicum Cellular damage Nodule ultrastructure Oxidative stress

Overview, prevention and management of chemotherapy extravasation

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World Journal of Clinical Oncology 2016年第1期7卷 87-97页

作者： Firas Y Kreidieh Hiba A Moukadem Nagi S El saghir Division of Hematology-Oncology Department of Internal Medicine American University of Beirut Medical Center Breast Center of Excellence NK Basile Cancer Institute American University of Beirut Medical Center

Chemotherapy extravasation remains an accidental complication of chemotherapy administration and may result in serious damage to patients. We review in this article the clinical aspects of chemotherapy extravasation and latest advances in definitions, classification, pre-vention, management and guidelines. We review the grading of extravasation and tissue damage according to various chemotherapeutic drugs and present an update on treatment and new antidotes including dexrazoxane for anthracyclines extravasation. We highlight the importance of education and training of the oncology team for prevention and prompt pharmacological and non-pharmacological management and stress the availability of new antidotes like dexrazoxane wherever anthracyclines are being infused.

关键词： Chemotherapy Extravasation Vesicant Tissue damage Dimethyl sulfoxide Dexrazoxane Antidote Hyaluronidase

Stability analysis of different cotton genotypes under normal and water-deficit conditions

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Journal of Integrative Agriculture 2019年第6期18卷 1257-1265页

作者： Muhammad Riaz Jehanzeb Farooq saghir Ahmed Muhammad Amin Waqas Shafqat Chattha Maria Ayoub Riaz Ahmed Kainth Cotton Research Station Faisalabad 38850Pakistan Cotton Research Institute Multan 66000Pakistan Nuclear Institute for Food and Agriculture (NIFA) Tarnab Peshawar 446Pakistan

Cotton plant observes significant reduction in seed cotton yield when subjected to water *** find out genotypes having better drought tolerance,seven genotypes of Gossypium hirsutum *** tested under two moisture levels,i.e.,normal and water deficit stress conditions at five locations of Punjab,Pakistan(Faisalabad,Sahiwal,Vehari,Rahim Yar Khan,and Bahawalpur)in 2013 and ***×environment interaction(GEI)was studied using the genotype main effects and genotype by environment interaction(GGE)biplot and additive main effect and multiplicative interaction *** genotypes G3(7001/11)and G6(FH-942)were stable under normal condition,while under drought condition,the stable genotype was G5(FH-326)when analysed using additive main effects and multiplicative interaction(AMMI)biplot *** GGE biplot analysis on the basis of best performance revealed that under normal condition the genotypes,G1(L-13/10)and G2(FH-2056/10),carrying the common position in ***,under water deficit stress condition,G5 was the best adaptive genotype at all five *** the same way,ranking of genotypes showed that the G5 was the ideal genotype under both ***,it is concluded that the genotype G5(FH-326)was found best for water deficit stress condition and can be cultivated under water scarce areas of Punjab.

关键词： upland cotton yield stability adaptability water stress Pakistan irrigation

Copper vacancy activated plasmonic Cu3-xSnS4 for highly efficient photocatalytic hydrogen generation:Broad solar absorption,efficient charge separation and decreased HER overpotential

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Nano Research 2021年第10期14卷 3358-3364页

作者： Nazakat Ali Tsegaye Tadesse Tsega Yucai Cao saghir Abbas Wenjing Li Asma Iqbal Hira Fazal Zhiling Xin Jiantao Zai Xuefeng Qian Shanghai Electrochemical Energy Devices Research Center School of Chemistry and Chemical Engineering and State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Polyolefins and Catalysis Shanghai Key Laboratory of Catalysis Technology for Polyolefins(Shanghai Research Institute of Chemical Industry Co.Ltd.)Shanghai 200062China Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power Shanghai University of Electric Power2103 Pingliang RoadShanghai 200090China

Broad absorption spectra with efficient generation and separation of available charge carriers are indispensable requirements for promising semiconductor-based photocatalysts to achieve the ultimate goal of solar-to-fuel ***,Cu_(3-x)SnS_(4)(x=0-0.8)with copper vacancies have been prepared and fabricated via solvothermal *** obtained copper vacancy materials have extended light absorption from ultraviolet to near-infrared-II region for its significant plasmonic ***-resolved photoluminescence shows that the vacancies can simultaneously optimize charge carrier dynamics to boost the generation of long-lived active electrons for photocatalytic *** functional theory calculations and electrochemical characterizations further revealed that copper vacancies in Cu_(3-x)SnS_(4)tend to enhance hydrogen’s adsorption energy with an obvious decrease in its H_(2)evolution reaction(HER)***,without any loadings,the H_(2)production rate was measured to be 9.5 mmol·h^(-1)·g^(-1).The apparent quantum yield was measured to be 27%for wavelengthλ>380 *** solar energy conversion efficiency was measured to be 6.5%under visible-near infrared(vis-NIR)(λ>420 nm).

关键词： hydrogen evolution reaction photocatalysis Cu_(3-x)SnS_(4) copper vacancy plasmon

The Invasive Species of Walhalla Area in Columbus, Ohio

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Open Journal of Ecology 2016年第11期6卷 659-666页

作者： Mohannad G. Al-saghir Department of Environmental and Plant Biology Ohio University Zanesville Zanesville Ohio USA

Invasive species are plants, animals, or pathogens that are non-native (or alien) to the ecosystem under consideration and whose introduction causes or is likely to cause harm. Invasive species can harm both the natural resources in an ecosystem as well as threaten human use of these resources. Walhalla is an urban wooded ravine area (10 acre area) in the middle of Columbus, Ohio. Many residents are actually actively planting new invasive species in a misguided attempt to prevent erosion on their property. Other properties are suffering from not-so-benign neglect, as the existing trees are slowly succumbing to insect infestation and rot (because of moisture trapped by ivy, etc.) and no new saplings are emerging to replace them (because of the thick ground cover). In both of these instances, it’s proving to be difficult to convince the landowners that they’re causing more harm than good—the local soil & water conservation people are all too eager to reinforce the notion that the ground must be covered with a blanket of impenetrable invasive species in order to prevent erosion. The objectives of this study were to collect and identify the invasive species in Walhalla area in order to educate the residents about these species and its impact on their properties and gardens;moreover, using the findings of this project to develop a plan to remove these dangerous species. This survey has documented 18 invasive species in 18 families. Two notable invasive species were found in this area, Alliaria petiolata (M. Bieb.) Cavara & Grande and Hedera helix L. (English Ivy). The found invasive species have an abundant growth in the studied area. The studied area has had no previous botanical collecting. Therefore, the area was in an urgent need to be inventoried and analyzed in order to identify and document its invasive species. Moreover, these identified species will be used for educational purposes for the residents of this area and well rounded plan is developed to remove these

关键词： Walhalla Flora Invasive Species Inventory Ohio

Germline pathogenic variants among high hereditary risk patients with breast and ovarian cancer and unaffected subjects in Lebanese Arab women

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World Journal of Clinical Oncology 2024年第12期15卷 1481-1490页

作者： Hiba A Moukadem Mohammad A Fakhreddine Nada Assaf Nadine Safi ahmad Al Masry Monita Al Darazi Rami Mahfouz Nagi S El saghir Division of Hematology/Oncology Department of Internal MedicineAmerican University of Beirut Medical CenterBeirut 11072020Lebanon Department of Pathology and Laboratory Medicine American University of Beirut Medical CenterBeirut 1001Lebanon

BACKGROUND The prevalence of germline pathogenic variants in high hereditary risk breast and/or ovarian cancer patients and unaffected subjects referred for testing is an unmet need in low and middle-income *** To determine the prevalence of germline pathogenic variants in high hereditary risk patients with breast and/or ovarian cancer and unaffected *** We retrospectively reviewed records of patients and unaffected subjects referred for germline pathogenic variant testing due to high hereditary risk between *** was collected and analyzed on Excel *** In total,358 individuals were included,including 257 patients and 101 unaffected individuals with relatives with breast or ovarian *** prevalence of breast cancer susceptibility gene(BRCA)1/2 pathogenic variants was 8.63%(19/220)in patients with breast cancer,and 15.1%(5/33)in those with ovarian *** the 25 of 220 patients with breast cancer tested by next-generation sequencing,3 patients had pathogenic variants other than BRCA1/*** highest risk was observed in those aged 40 years with breast cancer and a positive family history,where the BRCA1/2 prevalence was 20.1%(9/43).Among the unaffected subjects,31.1%(14/45)had the same BRCA1/2 pathogenic variants in their corresponding *** the subjects referred because of a positive family history of cancer without known hereditary factors,5.35%(3/56)had pathogenic variants of BRCA1 and *** c.131G>T nucleotide change was noted in one patient and two unrelated unaffected subjects with a BRCA1 pathogenic *** This study showed a 8.63%prevalence of pathogenic variants in patients with breast cancer and a 15.1%prevalence in patients with ovarian *** the relatives of patients with BRCA1/2 pathogenic variants,31%tested positive for the same variant,while 5.3%of subjects who tested positive due to a family history of breast cancer had a BRCA pathogenic variant.

关键词： Breast cancer Ovarian cancer Breast cancer susceptibility gene 1/2 Germline pathogenic variant High hereditary risk